Genetic approaches to assessing evidence for a T helper type 1 cytokine defect in adult asthma

American Journal of Respiratory and Critical Care Medicine

Volumn 169, Issue 9, 2004, Pages 1007-1013

  Birkisson, Illugi F ^a   Halapi, Eva ^a   Bjornsdottir, Unnur S ^a   Shkolny, Dana L ^a   Adalsteinsdottir, Elva ^a   Arnason, Thor ^a   Gislason, David ^a   Gislason, Thorarinn ^a   Gulcher, Jeffrey ^a   Stefansson, Kari ^a   Hakonarson, Hakon ^a,b  

^a UNIVERSITY OF ICELAND   (Iceland)

^b DECODE GENETICS   (Iceland)

Author keywords

Asthma; Expression; Genetics; Linkage; Polymorphism

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; MESSENGER RNA;

ADULT; ARTICLE; ASTHMA; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC DISORDER; GENETIC LINKAGE; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MEDICAL ASSESSMENT; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TH1 CELL;

EID: 11144354407     PISSN: 00030805     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200302-228oc     Document Type: Article

References (33)

1. Holgate ST. Genetics and environmental interactions in allergy and asthma. J Allergy Clin Immunol 1999;104:1139-1146.
2. Kauffmann F, Dizier MH, Annesi-Maesano I, Bousquet J, Charpin D, Demenais F, Echocard D, Feingold J, Gormand F, Grimfeld A, et al. EGEA (Epidemiological study on the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness and Atopy): descriptive characteristics. Clin Exp Allergy 1999;29:17-21.
3. Barnes PJ. Pathophysiology of asthma. Br J Clin Pharmacol 1996;42:3-10.
4. Djukanovic R. Asthma: a disease of inflammation and repair. J Allergy Clin Immunol 2000;105:522-526.
5. Murphy KM, Ouyang W, Szabo SJ, Jacobson NG, Guler ML, Gorham JD, Gubler U, Murphy TL. T helper differentiation proceeds through Stat1-dependent, Sta4-dependent and Stat4-independent phases. Curr Top Microbiol Immunol 1999;238:13-26.
6. Nakanishi K, Yoshimoto T, Tsutsui H, Okamura H. Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu. Cytokine Growth Factor Rev 2001;12:53-72.
7. Wills-Karp M. IL-12/IL-13 axis in allergic asthma. J Allergy Clin Immunol 2001;107:9-18.
8. Camporota L, Holloway JW. Interleukin-12 and allergic tissue response. Clin Exp Allergy 1999;29:1298-1300.
9. Matsui I, Kaneko H, Fukao T, Teramoto T, Inoue R, Watanabe M, Kasahara K, Kondo N. Mutations of the IL-12 receptor β2 chain gene in atopic subjects. Biochem Biophys Res Commun 1999;266:551-555.
10. Eborah KT, Sharon EH, Kristine EW, Judy LB, William LT, Joseph PS, Kyriaki D, Samuel JG, John PL. Autocrine regulation of IL-12 receptor expression is independent of secondary IFN-γ secretion and not restricted to T and NK cells. J Immunol 1999;163:5257-5264.
11. Robinson D, Hamid Q, Bentley A, Ying S, Kay AB, Durham SR. Activation of CD4+ T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in broncho alveolar lavage after allergen inhalation challenge in patients with atopic asthma. J Allergy Clin Immunol 1993;92:313-324.
12. Cockcroft DW, Killian DN, Mellon JJA, Hargreave FE. Bronchial reactivity to inhaled histamine: asthma method and clinical survey. Clin Exp Allergy 1977;7:235-243.
13. Palmquist M, Balder B, Lindholm NB, Löwhagen O, Plasekke P, Sundberg R, Funsalter A. Hyperreactivitet hos 420 patienter med nydebuterad astma. Hygiea 1988;97:108.
14. Gulcher JR, Kristjansson K, Gudbjartsson H, Stefansson K. Protection of privacy by third-party encryption in genetic research in Iceland. Eur J Hum Genet 2000;8:739-742.
15. Kong A, Gudbjartsson DF, Sainz J, Jonsdottir GM, Gudjonsson SA, Richardsson B, Sigurdardottir S, Barnard J, Hallbeck B, Masson G, et al. A high-resolution recombination map of the human genome. Nat Genet 2002;31:241-247.
16. Arngrímsson R, Sigurardóttir S, Frigge ML, Bjarnadóttir RI, Jónsson T, Stefánsson H, Baldursdóttir A, Einarsdóttir AS, Palsson B, Snorradóttir S, et al. A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13. Hum Mol Genet 1999;8:1799-1805.
17. Gulcher JR, Stefansson K. Population genomics: laying the groundwork for genetic disease modeling and targeting. Clin Chem Lab Med 1998;36:523-527.
18. Broman KW, Murray JC, Sheffield VC, White RL, Weber JL. Comprehensive human genetic maps: individual and sex-specific variation in recombination. Am J Hum Genet 1988;63:861-869.
19. Dib C, Faure S, Fizames C, Samson D, Drouot N, Vignal A, Millasseau P, Marc S, Hazan J, Seboun E, et al. A comprehensive map of the human genome based on 5264 microsatellites. Nature 1996;380:152-154.
20. Gudbjartsson DF, Jonasson K, Frigge ML, Kong A. Allegro, a new computer program for multipoint linkage analysis. Nat Genet 2000;25:12-13.
21. Kong A, Cox NJ. Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet 1997;61:1179-1188.
22. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES. Parametric and non-parametric analysis: a unified multipoint approach. Am J Hum Genet 1996;58:1347-1363.
23. Whittemore AS, Halpern J. A class of tests for linkage using affected pedigree members. Biometrics 1994;50:118-127.
24. Chou CC, Huang MS, Hsieh KH, Chiang BL. Reduced IL-12 level correlates with decreased IFNγ secreting T cells but not natural killer cell activity in asthmatic children. Ann Allergy Asthma Immunol 1999;82:479-484.
25. Kondo N, Matsui E, Kaneko H, Fukao T, Teramoto T, Inoue R, Watanebe M, Kasahara K, Morimoto N. Reduced interferon-gamma production and mutation of the interleukin-12 receptor beta(2) chain gene in atopic subjects. Int Arch Allergy Immunol 2001;124:117-120.
26. Morahan G, Huang D, Wu M, Holt BJ, White GP, Kendall GE, Sly PD, Holt PG. Association of IL-12 B promoter polymorphism with severity of atopic and non-atopic asthma in children. Lancet 2002;360:455-459.
27. Tomita K, Lim S, Hanazawa T, Usmani O, Stirling R, Chung KF, Barnes PJ, Adcock IM. Attenuated production of intracellular IL-10 and IL-12 in monocytes from patients with severe asthma. Clin Immunol 2002;102:258-266.
28. Yokoe T, Suzuki N, Minoguchi K, Adachi M, Sakane T. Analysis of IL-12 receptor beta 2 chain expression of circulating T lymphocytes in patients with atopic asthma. Cell Immunol 2001;208:34-42.
29. van der Pouw Kraan TC, Boeije LC, de Groot ER, Stapel SO, Snijders A, Kapsenberg ML, van der Zee JS, Aarden LA. Reduced production of IL-12 and IL-12 dependent IFN-γ release in patients with allergic asthma. J Immunol 1997;158:5560-5565.
30. Darnell JE Jr. STATs and gene regulation. Science 1997;277:1630-1635.
31. Izuhara K, Umeshita-Suyama R, Akaiwa M, Shirakawa T, Deichmann KA, Arima K, Hamasaki N, Hopkin JM. Recent advances in understanding how interleukin 13 signals are involved in the pathogenesis of bronchial asthma. Arch Immunol Ther Exp (Warsz) 2000;48:505-512.
32. Pravica V, Brogan IJ, Hutchinson IV. Rare polymorphism in the promoter regions of the human interleukin-12 p35 and interleukin-12 p40 subunits genes. Eur J Immunogenet 2000;27:35-36.
33. Hall MA, McGlinn E, Coakley G, Fisher SA, Boki K, Middleton D, Kaklamani E, Moutsopoulos H, Loughran TP Jr, Ollier WER, et al. Genetic polymorphism of IL 12 p40 gene in immune mediated disease. Genes Immun 2000;1:219-224.