메뉴 건너뛰기




Volumn 178, Issue 8, 2007, Pages 5010-5017

Germinal center helper T cells are dual functional regulatory cells with suppressive activity to conventional CD4+ T cells

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; B LYMPHOCYTE; CD4+ CD57+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; GERMINAL CENTER; HELPER CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; MEMORY CELL; PRIORITY JOURNAL; TH1 CELL;

EID: 34247149460     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.178.8.5010     Document Type: Article
Times cited : (42)

References (50)
  • 1
    • 0028807328 scopus 로고
    • In situ studies of the germinal center reaction
    • Kelsoe, G. 1995. In situ studies of the germinal center reaction. Adv. Immunol. 60: 267-288.
    • (1995) Adv. Immunol , vol.60 , pp. 267-288
    • Kelsoe, G.1
  • 3
    • 0030938144 scopus 로고    scopus 로고
    • Germinal center development
    • Liu, Y. J., and C. Arpin. 1997. Germinal center development. Immunol. Rev. 156: 111-126.
    • (1997) Immunol. Rev , vol.156 , pp. 111-126
    • Liu, Y.J.1    Arpin, C.2
  • 4
    • 0016274718 scopus 로고    scopus 로고
    • Jacobson, E. B., L. H. Corporate, and G. J. Thorbeck. 1974. Effect of thymus cell injection on germinal center formation in lymphoid tissues of nude mice. Cell. Immunol. 13: 416-430.
    • Jacobson, E. B., L. H. Corporate, and G. J. Thorbeck. 1974. Effect of thymus cell injection on germinal center formation in lymphoid tissues of nude mice. Cell. Immunol. 13: 416-430.
  • 5
    • 0028330986 scopus 로고
    • Distinct pathways of B cell differentiation, I: Residual T cells in athymic mice support the development of splenic germinal centers and B cell memory without an induction of antibody
    • Stedra, J., and S. Cerny. 1994. Distinct pathways of B cell differentiation, I: residual T cells in athymic mice support the development of splenic germinal centers and B cell memory without an induction of antibody. J. Immunol. 152: 1718-1726.
    • (1994) J. Immunol , vol.152 , pp. 1718-1726
    • Stedra, J.1    Cerny, S.2
  • 6
    • 0035399920 scopus 로고    scopus 로고
    • Cutting edge: Germinal centers can be induced in the absence of T cells
    • Lentz, V. M., and T. Manser. 2001. Cutting edge: germinal centers can be induced in the absence of T cells. J. Immunol. 167: 15-20.
    • (2001) J. Immunol , vol.167 , pp. 15-20
    • Lentz, V.M.1    Manser, T.2
  • 7
    • 0037017391 scopus 로고    scopus 로고
    • Low-level hypermutation in T cell-independent germinal centers compared with high mutation rates associated with T cell-dependent germinal centers
    • Toellner, K. M., W. E. Jenkinson, D. R. Taylor, M. Khan, D. M. Sze, D. M. Sansom, C. G. Vinuesa, and I. C. MacLennan. 2002. Low-level hypermutation in T cell-independent germinal centers compared with high mutation rates associated with T cell-dependent germinal centers. J. Exp. Med. 195: 383-389.
    • (2002) J. Exp. Med , vol.195 , pp. 383-389
    • Toellner, K.M.1    Jenkinson, W.E.2    Taylor, D.R.3    Khan, M.4    Sze, D.M.5    Sansom, D.M.6    Vinuesa, C.G.7    MacLennan, I.C.8
  • 8
    • 0025951891 scopus 로고
    • Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens
    • Liu, Y. J., J. Zhang, P. J. Lane, E. Y. Chan, and I. C. MacLennan. 1991. Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens. Eur. J. Immunol. 21: 2951-2962.
    • (1991) Eur. J. Immunol , vol.21 , pp. 2951-2962
    • Liu, Y.J.1    Zhang, J.2    Lane, P.J.3    Chan, E.Y.4    MacLennan, I.C.5
  • 9
    • 0025726702 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)-acetyl: I. The architecture and dynamics of responding cell populations
    • Jacob, J., R. Kassir, and G. Kelsoe. 1991. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)-acetyl: I. The architecture and dynamics of responding cell populations. J. Exp. Med. 173: 1165-1175.
    • (1991) J. Exp. Med , vol.173 , pp. 1165-1175
    • Jacob, J.1    Kassir, R.2    Kelsoe, G.3
  • 10
    • 0027373275 scopus 로고
    • In vivo CD40-gp-39 interactions are essential for thymus-dependent humoral immunity, I: In vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate T-B cell interactions
    • van den Eertwegh, A. J., R. J. Noelle, M. Roy, D. M. Shepherd, A. Aruffo, J. A. Ledbetter, W. J. Boersma, and E. Claassen. 1993. In vivo CD40-gp-39 interactions are essential for thymus-dependent humoral immunity, I: in vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate T-B cell interactions. J. Exp. Med. 178: 1555-1565.
    • (1993) J. Exp. Med , vol.178 , pp. 1555-1565
    • van den Eertwegh, A.J.1    Noelle, R.J.2    Roy, M.3    Shepherd, D.M.4    Aruffo, A.5    Ledbetter, J.A.6    Boersma, W.J.7    Claassen, E.8
  • 12
    • 0027433123 scopus 로고
    • T cells within germinal centers are specific for the immunizing antigen
    • Fuller, K. A., O. Kanagawa, and M. H. Nahm. 1993. T cells within germinal centers are specific for the immunizing antigen. J. Immunol. 151: 4505-4512.
    • (1993) J. Immunol , vol.151 , pp. 4505-4512
    • Fuller, K.A.1    Kanagawa, O.2    Nahm, M.H.3
  • 13
    • 0029813549 scopus 로고    scopus 로고
    • Sequential antigen-specific growth of T cells in the T zones and follicles in response to pigeon cytochrome c
    • Gulbranson-Judge, A., and I. C. MacLennan. 1996. Sequential antigen-specific growth of T cells in the T zones and follicles in response to pigeon cytochrome c. Eur. J. Immunol. 26: 1830-1837.
    • (1996) Eur. J. Immunol , vol.26 , pp. 1830-1837
    • Gulbranson-Judge, A.1    MacLennan, I.C.2
  • 15
    • 0029840392 scopus 로고    scopus 로고
    • T helper cells in the murine germinal centers are antigen-specific emigrants that downregulate Thy-1
    • Zheng, B., S. Man, and G. Kelsoe. 1996. T helper cells in the murine germinal centers are antigen-specific emigrants that downregulate Thy-1. J. Exp. Med. 184: 1083-1091.
    • (1996) J. Exp. Med , vol.184 , pp. 1083-1091
    • Zheng, B.1    Man, S.2    Kelsoe, G.3
  • 16
    • 0029989925 scopus 로고    scopus 로고
    • Alternative pathways for the selection of antigen-specific peripheral T cells
    • Zheng, B., S. Han, Q. Zhu, R. Goldsby, and G. Kelsoe. 1996. Alternative pathways for the selection of antigen-specific peripheral T cells. Nature 384: 263-266.
    • (1996) Nature , vol.384 , pp. 263-266
    • Zheng, B.1    Han, S.2    Zhu, Q.3    Goldsby, R.4    Kelsoe, G.5
  • 17
    • 0028283841 scopus 로고
    • Expression of the G-protein-coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells
    • Forster, R., T. Emrich, E. Kremmer, and M. Lipp. 1994. Expression of the G-protein-coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells. Blood 84: 830-840.
    • (1994) Blood , vol.84 , pp. 830-840
    • Forster, R.1    Emrich, T.2    Kremmer, E.3    Lipp, M.4
  • 18
    • 0030582773 scopus 로고    scopus 로고
    • A putative chemokine receptor, BLR, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen
    • Forster, R., A. Mattis, E. Kremmer, E. Wolf, G. Brem, and M. Lipp. 1996. A putative chemokine receptor, BLR, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 87: 1037-1047.
    • (1996) Cell , vol.87 , pp. 1037-1047
    • Forster, R.1    Mattis, A.2    Kremmer, E.3    Wolf, E.4    Brem, G.5    Lipp, M.6
  • 21
    • 0032701695 scopus 로고    scopus 로고
    • In vivo activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines
    • Ansel, K. M., L. J. McHeyzer-Williams, V. N. Ngo, M. G. McHeyzer-Williams, and J. G. Cyster. 1999. In vivo activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J. Exp. Med. 190: 1123-1134.
    • (1999) J. Exp. Med , vol.190 , pp. 1123-1134
    • Ansel, K.M.1    McHeyzer-Williams, L.J.2    Ngo, V.N.3    McHeyzer-Williams, M.G.4    Cyster, J.G.5
  • 22
    • 17644365138 scopus 로고    scopus 로고
    • Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs
    • Cyster, J. G. 2005. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu. Rev. Immunol. 23: 127-159.
    • (2005) Annu. Rev. Immunol , vol.23 , pp. 127-159
    • Cyster, J.G.1
  • 23
    • 0034606359 scopus 로고    scopus 로고
    • Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
    • Breitfeld, D., L. Ohl, E. Kremmer, J. Ellwart, F. Sallusto, M. Lipp, and R. Forster. 2000. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J. Exp. Med. 192: 1545-1552.
    • (2000) J. Exp. Med , vol.192 , pp. 1545-1552
    • Breitfeld, D.1    Ohl, L.2    Kremmer, E.3    Ellwart, J.4    Sallusto, F.5    Lipp, M.6    Forster, R.7
  • 24
    • 0034606348 scopus 로고    scopus 로고
    • CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    • Schaerli, P., K. Willimann, A. B. Lang, M. Lipp, P. Loetscher, and B. Moser. 2000. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J. Exp. Med. 192: 1553-1562.
    • (2000) J. Exp. Med , vol.192 , pp. 1553-1562
    • Schaerli, P.1    Willimann, K.2    Lang, A.B.3    Lipp, M.4    Loetscher, P.5    Moser, B.6
  • 26
    • 33748465307 scopus 로고    scopus 로고
    • Human germinal center T cells are unique Th cells with high propensity for apoptosis induction
    • Marinova, E., S. Han, and B. Zheng. 2006. Human germinal center T cells are unique Th cells with high propensity for apoptosis induction. Int. Immunol. 18: 1337-1345.
    • (2006) Int. Immunol , vol.18 , pp. 1337-1345
    • Marinova, E.1    Han, S.2    Zheng, B.3
  • 28
    • 0036773188 scopus 로고    scopus 로고
    • Continued expression of recombination-activating genes and TCR gene recombination in human peripheral T cells
    • Li, T. T., S. Han, M. Cubbage, and B. Zheng. 2002. Continued expression of recombination-activating genes and TCR gene recombination in human peripheral T cells. Eur. J. Immunol. 32: 2792-2799.
    • (2002) Eur. J. Immunol , vol.32 , pp. 2792-2799
    • Li, T.T.1    Han, S.2    Cubbage, M.3    Zheng, B.4
  • 30
    • 22544440345 scopus 로고    scopus 로고
    • + germinal center-T cells are the major helpers for GC-B cells and induce class switch recombination
    • + germinal center-T cells are the major helpers for GC-B cells and induce class switch recombination. BMC Immunol. 6: 3.
    • (2005) BMC Immunol , vol.6 , pp. 3
    • Kim, J.R.1    Lim, H.W.2    Kang, S.G.3    Hillsamer, P.4    Kim, C.H.5
  • 33
    • 0036597371 scopus 로고    scopus 로고
    • + suppressor T cells: More questions than answers
    • + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2: 389-400.
    • (2002) Nat. Rev. Immunol , vol.2 , pp. 389-400
    • Shevach, E.M.1
  • 34
    • 16844362608 scopus 로고    scopus 로고
    • Mechanisms of suppression by suppressor T cells
    • von Boehmer, H. 2005. Mechanisms of suppression by suppressor T cells. Nat. Immunol. 4: 338-344.
    • (2005) Nat. Immunol , vol.4 , pp. 338-344
    • von Boehmer, H.1
  • 35
    • 0347994958 scopus 로고    scopus 로고
    • B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions
    • Taylor, P. A., C. J. Lees, S. Fournier, J. Allison, A. H. Sharpe, and B. R. Blazar. 2004. B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions. J. Immunol. 172: 34-39.
    • (2004) J. Immunol , vol.172 , pp. 34-39
    • Taylor, P.A.1    Lees, C.J.2    Fournier, S.3    Allison, J.4    Sharpe, A.H.5    Blazar, B.R.6
  • 36
    • 3142708571 scopus 로고    scopus 로고
    • Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease
    • Paust, S., L. Lu, N. McCarty, and H. Cantor. 2004. Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease. Proc. Natl. Acad. Sci. USA 101: 10398-10403.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 10398-10403
    • Paust, S.1    Lu, L.2    McCarty, N.3    Cantor, H.4
  • 38
    • 5644302161 scopus 로고    scopus 로고
    • Human T regulatory cells can use the perform pathway to cause autologous target cell death
    • Grossman, W. J., J. W. Verbsky, W. Barchet, M. Colonna, J. P, Atkinson, and T. J. Ley. 2004. Human T regulatory cells can use the perform pathway to cause autologous target cell death. Immunity 21: 589-601.
    • (2004) Immunity , vol.21 , pp. 589-601
    • Grossman, W.J.1    Verbsky, J.W.2    Barchet, W.3    Colonna, M.4    Atkinson, J.P.5    Ley, T.J.6
  • 41
    • 0033523607 scopus 로고    scopus 로고
    • An essential role for IL-10 in the function of regulatory T cells that inhibit intestinal inflammation
    • Asseman, C., S. Mauze, M. W. Leach, R. L. Coffman, and F. Powrie. 1999. An essential role for IL-10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190: 995-1004.
    • (1999) J. Exp. Med , vol.190 , pp. 995-1004
    • Asseman, C.1    Mauze, S.2    Leach, M.W.3    Coffman, R.L.4    Powrie, F.5
  • 42
    • 0035801335 scopus 로고    scopus 로고
    • + regulatory T cells is mediated by cell surface-bound transforming growth factor β
    • + regulatory T cells is mediated by cell surface-bound transforming growth factor β. J. Exp. Med. 194: 629-644.
    • (2001) J. Exp. Med , vol.194 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 44
    • 0037099733 scopus 로고    scopus 로고
    • + regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells (corrected)
    • + regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells (corrected). J. Exp. Med. 196: 247-253.
    • (2002) J. Exp. Med , vol.196 , pp. 247-253
    • Dieckmann, D.1    Bruett, C.H.2    Ploettner, H.3    Lutz, M.B.4    Schuler, G.5
  • 47
    • 0035186416 scopus 로고    scopus 로고
    • Induction and mechanism of action of transforming growth factor-β-secreting Th3 regulatory cells
    • Weiner, H. L. 2001. Induction and mechanism of action of transforming growth factor-β-secreting Th3 regulatory cells. Immunol. Rev. 182: 207-214.
    • (2001) Immunol. Rev , vol.182 , pp. 207-214
    • Weiner, H.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.