The Final Touches Make Perfect the Peptide-MHC Class I Repertoire

Immunity

Volumn 26, Issue 4, 2007, Pages 397-406

  Hammer, Gianna Elena ^a   Kanaseki, Takayuki ^a   Shastri, Nilabh ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPEPTIDASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEIN DISULFIDE ISOMERASE; PROTEIN P57; PROTEIN PRECURSOR; TAPASIN;

ANTIGEN PRESENTATION; CARBOXY TERMINAL SEQUENCE; CD8+ T LYMPHOCYTE; COMPLEX FORMATION; CYTOPLASM; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME SUBSTRATE; HUMAN; IMMUNOSURVEILLANCE; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; REVIEW;

ANIMALS; CYTOPLASM; ENDOPLASMIC RETICULUM; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; LEUCYL AMINOPEPTIDASE; MEMBRANE TRANSPORT PROTEINS; OXIDATION-REDUCTION; PEPTIDES; PROTEIN DISULFIDE-ISOMERASE;

EID: 34247146913     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2007.04.003     Document Type: Review

References (63)

1. Brouwenstijn N., Serwold T., and Shastri N. MHC class I molecules can direct proteolytic cleavage of antigenic precursors in the endoplasmic reticulum. Immunity 15 (2001) 95-104
2. Cascio P., Hilton C., Kisselev A.F., Rock K.L., and Goldberg A.L. 26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide. EMBO J. V20 (2001) 2357-2366
3. Chang S.C., Momburg F., Bhutani N., and Goldberg A.L. The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism. Proc. Natl. Acad. Sci. USA 102 (2005) 17107-17112
4. Craiu A., Akopian T., Goldberg A., and Rock K.L. Two distinct proteolytic processes in the generation of a major histocompatibility complex class I-presented peptide. Proc. Natl. Acad. Sci. USA 94 (1997) 10850-10855
5. Cresswell P., Ackerman A.L., Giodini A., Peaper D.R., and Wearsch P.A. Mechanisms of MHC class I-restricted antigen processing and cross-presentation. Immunol. Rev. 207 (2005) 145-157
6. Dick T.P. Assembly of MHC class I peptide complexes from the perspective of disulfide bond formation. Cell. Mol. Life Sci. 61 (2004) 547-556
7. Dick T.P., Bangia N., Peaper D.R., and Cresswell P. Disulfide bond isomerization and the assembly of MHC class I-peptide complexes. Immunity 16 (2002) 87-98
8. Elliott T., and Williams A. The optimization of peptide cargo bound to MHC class I molecules by the peptide-loading complex. Immunol. Rev. 207 (2005) 89-99
9. Falk K., Rötzschke O., and Rammensee H.G. Cellular peptide composition governed by major histocompatibility complex class I molecules. Nature 348 (1990) 248-251
10. Falk K., Rotzschke O., Stevanovic S., Jung G., and Rammensee H.-G. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 351 (1991) 290-296
11. Firat E., Saveanu L., Aichele P., Staeheli P., Huai J., Gaedicke S., Nil A., Besin G., Kanzler B., van Endert P., and Niedermann G. The role of endoplasmic reticulum-associated aminopeptidase 1 in immunity to infection and in cross-presentation. J. Immunol. 178 (2007) 2241-2248
12. Fruci D., Niedermann G., Butler R.H., and van Endert P.M. Efficient MHC class I-independent amino-terminal trimming of epitope precursor peptides in the endoplasmic reticulum. Immunity 15 (2001) 467-476
13. Gao B., Adhikari R., Howarth M., Nakamura K., Gold M.C., Hill A.B., Knee R., Michalak M., and Elliott T. Assembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulin. Immunity 16 (2002) 99-109
14. Garbi N., Hammerling G., and Tanaka S. Interaction of ERp57 and tapasin in the generation of MHC class I-peptide complexes. Curr. Opin. Immunol. 19 (2007) 99-105
15. Garbi N., Tan P., Diehl A.D., Chambers B.J., Ljunggren H.-G., Momburg F., and Haemmerling G.J. Impaired immune responses and altered peptide repertoire in tapasin-deficient mice. Nat. Immunol. 1 (2000) 234-238
16. Garbi N., Tanaka S., Momburg F., and Hammerling G.J. Impaired assembly of the major histocompatibility complex class I peptide-loading complex in mice deficient in the oxidoreductase ERp57. Nat. Immunol. 7 (2006) 93-102
17. Grandea A.G., Golovina T.N., Hamilton S.E., Sriram V., Spies T., Brutkiewicz R.R., Harty J.T., Eisenlohr L.C., and Van Kaer L. Impaired assembly yet normal trafficking of MHC class I molecules in tapasin mutant mice. Immunity 13 (2000) 213-222
18. Green K.J., Miles J.J., Tellam J., van Zuylen W.J., Connolly G., and Burrows S.R. Potent T cell response to a class I-binding 13-mer viral epitope and the influence of HLA micropolymorphism in controlling epitope length. Eur. J. Immunol. 34 (2004) 2510-2519
19. Hammer G.E., Gonzalez F., Champsaur M., Cado D., and Shastri N. The aminopeptidase ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules. Nat. Immunol. 7 (2006) 103-112
20. Hammer G.E., Gonzalez F., James E., Nolla H., and Shastri N. In the absence of ERAAP the MHC class I molecules present many unstable and highly immunogenic peptides. Nat. Immunol. 8 (2007) 101-108
21. Howarth M., Williams A., Tolstrup A.B., and Elliott T. Tapasin enhances MHC class I peptide presentation according to peptide half-life. Proc. Natl. Acad. Sci. USA 101 (2004) 11737-11742
22. Hughes E.A., and Cresswell P. The thiol oxidoreductase ERp57 is a component of the MHC class I peptide-loading complex. Curr. Biol. 8 (1998) 709-712
23. Kanaseki T., Blanchard N., Hammer G.E., Gonzalez F., and Shastri N. ERAAP synergizes with MHC I to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum. Immunity 25 (2006) 795-806
24. Kloetzel P.M. Generation of major histocompatibility complex class I antigens: Functional interplay between proteasomes and TPPII. Nat. Immunol. 5 (2004) 661-669
25. Komlosh A., Momburg F., Weinschenk T., Emmerich N., Schild H., Nadav E., Shaked I., and Reiss Y. A role for a novel luminal endoplasmic reticulum aminopeptidase in final trimming of 26 S proteasome-generated major histocompatability complex class I antigenic peptides. J. Biol. Chem. V276 (2001) 30050-30056
26. Kunisawa J., and Shastri N. The group II chaperonin TRiC protects proteolytic intermediates from degradation in the MHC class I antigen processing pathway. Mol. Cell 12 (2003) 565-576
27. Lewis J.W., and Elliott T. Evidence for successive peptide binding and quality control stages during MHC class I assembly. Curr. Biol. 8 (1998) 717-720
28. Lindquist J.A., Jensen O.N., Mann M., and Hammerling G.J. ER-60, a chaperone with thiol-dependent reductase activity involved in MHC class I assembly. EMBO J. 17 (1998) 2186-2195
29. Morrice N.A., and Powis S.J. A role for the thiol-dependent reductase ERp57 in the assembly of MHC class I molecules. Curr. Biol. 8 (1998) 713-716
30. Neefjes J.J., Momburg F., and Hammerling G.J. Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter. Science 261 (1993) 769-771
31. Neisig A., Roelse J., Sijts A.J.A.M., Ossendorp F., Feltkamp M.C.W., Kast W.M., Melief C.J.M., and Neefjes J.J. Major differences in transporter associated with antigen presentation (TAP)-dependent translocation of MHC class I-presentable peptides and the effect of flanking sequences. J. Immunol. 154 (1995) 1273-1279
32. Ostrov D.A., Roden M.M., Shi W., Palmieri E., Christianson G.J., Mendoza L., Villaflor G., Tilley D., Shastri N., Grey H., et al. How H13 histocompatibility peptides differing by a single methyl group and lacking conventional MHC binding anchor motifs determine self- nonself discrimination. J. Immunol. 168 (2002) 283-289
33. Park B., Lee S., Kim E., Cho K., Riddell S.R., Cho S., and Ahn K. Redox regulation facilitates optimal peptide selection by MHC class I during antigen processing. Cell 127 (2006) 369-382
34. Paulsson K.M. Evolutionary and functional perspectives of the major histocompatibility complex class I antigen-processing machinery. Cell. Mol. Life Sci. 61 (2004) 2446-2460
35. Paz P., Brouwenstijn N., Perry R., and Shastri N. Discrete proteolytic intermediates in the MHC class I antigen processing pathway and MHC I-dependent peptide trimming in the ER. Immunity 11 (1999) 241-251
36. Peaper D.R., Wearsch P.A., and Cresswell P. Tapasin and ERp57 form a stable disulfide-linked dimer within the MHC class I peptide-loading complex. EMBO J. 24 (2005) 3613-3623
37. *3501. J. Immunol. 173 (2004) 5610-5616
38. Probst-Kepper M., Stroobant V., Kridel R., Gaugler B., Landry C., Brasseur F., Cosyns J.-P., Weynand B., Boon T., and Van den Eynde B.J. An alternative open reading frame of the human macrophage colony-stimulating factor gene is independently translated and codes for an antigenic peptide of 14 amino acids recognized by tumor-infiltrating CD8 T lymphocytes. J. Exp. Med. 193 (2001) 1189-1198
39. Purcell A.W., Gorman J.J., Garcia-Peydro M., Paradela A., Burrows S.R., Talbo G.H., Laham N., Peh C.A., Reynolds E.C., Lopez De Castro J.A., and McCluskey J. Quantitative and qualitative influences of tapasin on the class I peptide repertoire. J. Immunol. 166 (2001) 1016-1027
40. Rammensee H.G., Bachmann J., and Stevanovic S. MHC Ligands and Peptide Motifs (1997), Landes Bioscience, Austin, TX
41. Reits E., Griekspoor A., Neijssen J., Groothuis T., Jalink K., van Veelen P., Janssen H., Calafat J., Drijfhout J.W., and Neefjes J. Peptide diffusion, protection, and degradation in nuclear and cytoplasmic compartments before antigen presentation by MHC class I. Immunity 18 (2003) 97-108
42. Reits E.A.J., Vos J.C., Gromme M., and Neefjes J. The major substrates for TAP in vivo are derived from newly synthesized proteins. Nature 404 (2000) 774-778
43. Rock K.L., Gramm C., Rothstein L., Clark K., Stein R., Dick L., Hwang D., and Goldberg A.L. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78 (1994) 761-771
44. Saric T., Chang S.C., Hattori A., York I.A., Markant S., Rock K.L., Tsujimoto M., and Goldberg A.L. An IFN-g-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides. Nat. Immunol. 3 (2002) 1169-1176
45. Saveanu L., Carroll O., Lindo V., Del Val M., Lopez D., Lepelletier Y., Greer F., Schomburg L., Fruci D., Niedermann G., and van Endert P.M. Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum. Nat. Immunol. 6 (2005) 689-697
46. Serwold T., Gaw S., and Shastri N. ER aminopeptidases generate a unique pool of peptides for MHC class I molecules. Nat. Immunol. 2 (2001) 644-651
47. Serwold T., Gonzalez F., Kim J., Jacob R., and Shastri N. ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum. Nature 419 (2002) 480-483
48. Shastri N., Cardinaud S., Schwab S.R., Serwold T., and Kunisawa J. All the peptides that fit: The beginning, the middle, and the end of the MHC class I antigen-processing pathway. Immunol. Rev. 207 (2005) 31-41
49. Shastri N., Schwab S., and Serwold T. Producing nature's gene-chips. The generation of peptides for display by MHC class I molecules. Annu. Rev. Immunol. 20 (2002) 463-493
50. Sijts A.J.A.M., and Pamer E.G. Enhanced intracellular dissociation of major histocompatibility complex class I-associated peptides: A mechanism for optimizing the spectrum of cell surface-presented cytotoxic T lymphocyte epitopes. J. Exp. Med. 185 (1997) 1403-1411
51. Spee P., and Neefjes J. TAP-translocated peptides specifically bind proteins in the endoplasmic reticulum, including gp96, protein disulfide isomerase and calreticulin. Eur. J. Immunol. 27 (1997) 2441-2449
52. Srivastava P. Interaction of heat shock proteins with peptides and antigen presenting cells: Chaperoning of the innate and adaptive immune responses. Annu. Rev. Immunol. 20 (2002) 395-425
53. Tanioka T., Hattori A., Masuda S., Nomura Y., Nakayama H., Mizutani S., and Tsujimoto M. Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases. J. Biol. Chem. 278 (2003) 32275-32283
54. Tector M., Zhang Q., and Salter R.D. Beta 2-microglobulin and calnexin can independently promote folding and disulfide bond formation in class I histocompatibility proteins. Mol. Immunol. 34 (1997) 401-408
55. Tynan F.E., Elhassen D., Purcell A.W., Burrows J.M., Borg N.A., Miles J.J., Williamson N.A., Green K.J., Tellam J., Kjer-Nielsen L., et al. The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation. J. Exp. Med. 202 (2005) 1249-1260
56. Tynan F.E., Reid H.H., Kjer-Nielsen L., Miles J.J., Wilce M.C., Kostenko L., Borg N.A., Williamson N.A., Beddoe T., Purcell A.W., et al. A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule. Nat. Immunol. 8 (2007) 268-276
57. Van Endert P.M., Riganelli D., Greco G., Fleischhauer K., Sidney J., Sette A., and Bach J.F. The peptide-binding motif for the human transporter associated with antigen processing. J. Exp. Med. 182 (1995) 1883-1895
58. Vance R.E., Jamieson A.M., and Raulet D.H. Recognition of the class Ib molecule Qa-1(b) by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells. J. Exp. Med. 190 (1999) 1801-1812
59. Yan J., Parekh V.V., Mendez-Fernandez Y., Olivares-Villagomez D., Dragovic S., Hill T., Roopenian D.C., Joyce S., and Van Kaer L. In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules. J. Exp. Med. 203 (2006) 647-659
60. Yewdell J.W., Reits E., and Neefjes J. Making sense of mass destruction: Quantitating MHC class I antigen presentation. Nat. Rev. Immunol. 3 (2003) 952-961
61. York I.A., Brehm M.A., Zendzian S., Towne C.F., and Rock K.L. Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance. Proc. Natl. Acad. Sci. USA 103 (2006) 9202-9207
62. York I.A., Chang S.C., Saric T., Keys J.A., Favreau J.M., Goldberg A.L., and Rock K.L. The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues. Nat. Immunol. 3 (2002) 1177-1184
63. Zarling A.L., Luckey C.J., Marto J.A., White F.M., Brame C.J., Evans A.M., Lehner P.J., Cresswell P., Shabanowitz J., Hunt D.F., and Engelhard V.H. Tapasin is a facilitator, not an editor, of class I MHC peptide binding. J. Immunol. 171 (2003) 5287-5295