Enhanced intracellular dissociation of major histocompatibility complex class I-associated peptides: A mechanism for optimizing the spectrum of cell surface-presented cytotoxic T lymphocyte epitopes

Journal of Experimental Medicine

Volumn 185, Issue 8, 1997, Pages 1403-1411

  Sijts, Alice J A M ^a   Pamer, Eric G ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BREFELDIN A; EPITOPE; H2 ANTIGEN; LYMPHOCYTE ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ANIMAL CELL; ANTIGEN BINDING; ANTIGEN PRESENTATION; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DISSOCIATION; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; LISTERIA MONOCYTOGENES; LYMPHOCYTE CLONE; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, BACTERIAL; BREFELDIN A; CELL LINE; CYCLOPENTANES; ENDOPLASMIC RETICULUM; EPITOPES; GOLGI APPARATUS; H-2 ANTIGENS; LISTERIA INFECTIONS; LISTERIA MONOCYTOGENES; MICE; PEPTIDES; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0030895911     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.185.8.1403     Document Type: Article

References (37)

1. Braciale, T.J., and V.L. Braciale. 1992. Viral antigen presentation and MHC assembly. Sem. Immunol. 4:81-84.
2. Germain, R.N. 1994. MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell. 76:287-299.
3. Yewdell, J.W., and J.R. Bennink. 1992. Cell biology of antigen processing and presentation to major histocompatibility complex class I molecule-restricted T lymphocytes. Adv. Immunol. 52:1-123.
4. Kaufmann, S.H.E. 1990. CD8+ T lymphocytes in intracellular microbial infections. Immunol. Today. 11:129-136.
5. Goettrup, M., A. Soza, U. Kuckelkorn, and P.-M. Kloetzel. 1996. Peptide antigen production by the proteasome: complexity provides efficiency. Immunol. Today. 17:429-435.
6. Yewdell, J.W., L.C. Anton, and J.R. Bennink. 1996. Defective ribosomal products (DRiPs): a major source of antigenic peptides for MHC class I molecules? J. Immunol. 157:1823-1826.
7. Androlewicz, M.J., and P. Cresswell. 1996. How selective is the transporter associated with antigen processing? Immunity. 5:1-5.
8. Sadasivan, B., P.J. Lehner, B. Ortmann, T. Spies, and P. Cresswell. 1996. Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP. Immunity. 5:103-114.
9. 2-microglobulin complexes associate with TAP transporters before peptide binding. Nature (Lond.). 368:864-867.
10. Lapham, C.K., I. Bacik, J.W. Yewdell, K.P. Kane, and J.R. Bennink. 1993. Class I molecules retained in the endoplasmic reticulum bind antigenic peptides. J. Exp. Med. 177:1633-1641.
11. Day, P.M., F. Esquivel, J. Lukszo, J.R. Bennink, and J.W. Yewdell. 1995. Effect of TAP on the generation and intracellular trafficking of peptide-receptive major histocompatibility complex class I molecules. Immunity. 2:137-147.
12. Rock, K.L., C. Gramm, L. Rothstein, K. Clark, R. Stein, L. Dick, D. Hwang, and A.L. Goldberg. 1994. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell. 78:761-771.
13. Gellin, B.G., and C.V. Broome. 1989. Listeriosis. JAMA (J. Am. Med. Assoc.). 261:1313-1320.
14. Bielecki, J., P. Youngman, P. Connelly, and D.A. Portnoy. 1990. Bacillus subtilis expressing a haemolysin gene from Listeria monocytogenes can grow in mammalian cells. Nature (Lond.). 345:175-176.
15. Pamer, E.G., J.T. Harty, and M.J. Bevan. 1991. Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes. Nature (Lond.). 353:852-855.
16. Pamer, E.G. 1994. Direct sequence identification and kinetic analysis of an MHC class I-restricted Listeria monocytogenes CTL epitope. J. Immunol. 152:686-694.
17. Sijts, A.J.A.M., A. Neisig, J. Neefjes, and E.G. Pamer. 1996. Two Listeria monocytogenes CTL epitopes are processed from the same antigen with different efficiencies. J. Immunol. 156: 685-692.
18. Sijts, A.J.A.M., M.S. Villanueva, and E.G. Pamer. 1996. CTL epitope generation is tightly linked to cellular proteolysis of a Listeria monocytogenes antigen. J. Immunol. 156:1497-1503.
19. Villanueva, M.S., P. Fisher, K. Feen, and E.G. Pamer. 1994. Efficiency of MHC class I antigen processing: a quantitative analysis. Immunity. 1:479-189.
20. Villanueva, M.S., A.J.A.M. Sijts, and E.G. Pamer. 1995. Listeriolysin is processed efficiently into an MHC class I-associated epitope in Listeria monocytogenes-infected cells. J. Immunol. 155:5227-5233.
21. Niedermann, G., S. Butz, H.G. Ihlenfeldt, R. Grimm, M. Lucchiari, H. Hoschützky, G. Jung, B. Maier, and K. Eichmann. 1995. Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules. Immunity. 2:289-299.
22. Ossendorp, F., M. Eggers, A. Neisig, T. Ruppert, M. Goettrup, A. Sijts, E. Mengedé, P.-M. Kloetzel, J. Neefjes, U. Koszinowski, and C. Melief. 1996. A single residue exchange within a viral CTL epitope alters proteasome-mediated degradation resulting in lack of antigen presentation. Immunity. 5: 115-124.
23. Gournier, H., S. Pascolo, C.A. Siegrist, J. Jehan, B. Perarnau, Z. Garcia, T. Rose, J. Neefjes, and T.A. Lemonnier. 1995. Restriction of self-antigen presentation to cytolytic T lymphocytes by mouse peptide pumps. Eur. J. Immunol. 25:2019-2026.
24. Chen, W., S. Khilko, J. Fecondo, D.H. Margulies, and J. McClukey. 1994. Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues. J. Exp. Med. 180:1471-1483.
25. Ljunggren, H.G., C. Öhlen, P. Höglund, L. Franksson, and K. Kärre. 1991. The RMA-S lymphoma mutant: consequences of a peptide loading defect on immunological recognition and graft rejection. Int. J. Cancer. (Suppl.)6:38-44.
26. Villanueva, M.S., C.J.M. Beckers, and E.G. Pamer. 1994. Infection with Listeria monocytogenes impairs sialic acid addition to host cell glycoproteins. J. Exp. Med. 180:2137-2145.
27. Klausner, R.D., J.G. Donaldson, and J. Lippincott-Schwartz. 1992. Brefeldin A: insights into the control of membrane traffic and organelle structure. J. Cell Biol. 116:1071-1080.
28. Wiertz, E.J.H.J., T.R. Jones, L. Sun, M. Bogyo, H.J. Geuze, and H.L. Ploegh. 1996. The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol. Cell. 84:769-779.
29. Nelson, C.A., S.J. Petzold, and E. Unanue. 1994. Peptides determine the lifespan of MHC class II molecules in the antigen-presenting cell. Nature (Lond.). 371:250-252.
30. Levitsky, V., Q.-J. Zhang, J. Levitskaya, and M.G. Masucci. 1996. The life span of major histocompatibility complex-peptide complexes influences the efficiency of presentation and immunogenicity of two class I-restricted cytotoxic T lymphocyte epitopes in the Epstein-Barr virus nuclear antigen 4. J. Exp. Med. 183:915-926.
31. Vijh, S., and E.G. Pamer. 1997. Immunodominant and subdominant CTL responses to Listeria monocytogenes infection. J. Immunol. In press.
32. van der Burg, S.H., M.J.W. Visseren, R.M.P. Brandt, W.M. Kast, and C.J.M. Melief. 1996. Immunogenicity of peptides bound to MHC class I molecules depends on the MHC-peptide complex stability. J. Immunol. 156: 3308-3314.
33. Denzin, L.K., and P. Cresswell. 1995. HLA-DM induces CLIP dissociation from MHC class II αβ dimers and facilitates peptide loading. Cell. 82:155-165.
34. Fung-Leung, W.-P., C.D. Surh, M. Liljedahl, J. Pang, D. Leturcq, P.A. Peterson, S.R. Webb, and L. Karlsson. 1996. Antigen presentation and T cell development in H-2-M-deficient mice. Science (Wash. DC). 271:1278-1281.
35. Sherman, M.A., D.A. Weber, and P.E. Jensen. 1995. DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide. Immunity. 3:197-205.
36. Sloan, V.S., P. Cameron, G. Porter, M. Gammon, M. Amaya, E. Mellins, and D.M. Zaller. 1995. Mediation by HLA-DM of dissociation of peptides from HLA-DR. Nature (Lond.). 375:802-806.
37. Weber, D.A., B.D. Evavold, and P.E. Jensen. 1996. Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM. Science (Wash. DC). 274:618-620.