MHC class I molecules can direct proteolytic cleavage of antigenic precursors in the endoplasmic reticulum

Immunity

Volumn 15, Issue 1, 2001, Pages 95-104

  Brouwenstijn, Nathalie ^a   Serwold, Thomas ^a   Shastri, Nilabh ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPEPTIDASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEIN HYDROLYSATE;

AMINO TERMINAL SEQUENCE; ANTIGEN PRESENTATION; ARTICLE; CYTOPLASM; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MICROSOME; PRECURSOR; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION;

EID: 0034907526     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(01)00174-1     Document Type: Article

References (39)

1. Evidence that multiple residues on both the α helices of the class I MHC molecule are simultaneoulsy recognized by the T cell receptor
2. How selective is the transporter associated with antigen processing?
3. Presentation without processing of endogenous precursors in the MHC class I presentation pathway
4. Two distinct proteolytic processes in the generation of a major histocompatibility complex class I-presented peptide
5. The nature of the MHC class I peptide loading complex
6. Cellular peptide composition governed by major histocompatibility complex class I molecules
7. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules
8. BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation
9. Generation, translocation, and presentation of MHC class I-restricted peptides
10. Cooperative interaction of B lymphocytes and antigen-specific helper T lymphocytes is MHC restricted
11. Detection of rare antigen presenting cells by the lacZ T-cell activation assay suggests an expression cloning strategy for T-cell antigens
12. Export of antigenic peptides from the endoplasmic reticulum intersects with retrograde protein translocation through the Sec61p channel
13. Human transporters associated with antigen processing (TAPs) select epitope precursor peptides for processing in the endoplasmic reticulum and presentation to T cells
14. The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation
15. The role of MHC class I molecules in the generation of endogenous peptide/MHC complexes
16. Novel peptide-binding proteins and peptide transport in normal and TAP-deficient microsomes
17. Selectivity of MHC-encoded peptide transporters from human, mouse and rat
18. Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter
19. Analysis of the fine specificity of rat, mouse and human TAP peptide transporters
20. Discrete proteolytic intermediates in the MHC class I antigen processing pathway and MHC I-dependent peptide trimming in the ER
21. The rat cim effect: TAP allele-dependent changes in a class I MHC anchor motif and evidence against C-terminal trimming of peptides in the ER
22. MHC ligands and peptide motifs: First listing
23. The major substrates for TAP in vivo are derived from newly synthesized proteins
24. Degradation of cell proteins and the generation of MHC class I-presented peptides
25. Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
26. Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator
27. Specific proteolytic cleavages limit the diversity of the pool of peptides available to MHC class I molecules in living cells
28. b complex to T-cells
29. TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective
30. b mutants
31. In vivo regulation of the assembly and intracellular transport of class I major histocompatibility complex molecules
32. TAP-translocated peptides specifically bind proteins in the endoplasmic reticulum, including gp96, protein disulfide isomerase and calreticulin
33. Heat shock proteins come of age: Primitive functions acquire new roles in an adaptive world
34. Two new proteases in the MHC class I processing pathway
35. Low-molecular-weight enzyme inhibitors of microbial origin
36. A sequential model for peptide binding and transport by the transporters associated with antigen processing
37. The peptide-binding motif for the human transporter associated with antigen processing
38. Preparation of microsomal membranes for cotranslational protein translocation
39. Murine transporter associated with antigen presentation (TAP) preferences influence class I-restricted T cell responses