Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT

European Journal of Pharmacology

Volumn 563, Issue 1-3, 2007, Pages 49-60

  Ou, Yen Chuan ^a   Yang, Chi Rei ^a   Cheng, Chen Li ^a   Raung, Shue Ling ^a   Hung, Yu Yeh ^a   Chen, Chun Jung ^a,b,c  

^a TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c TUNGHAI UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Endoplasmic reticulum stress; Indomethacin; MAPK; Oxidative stress; PPAR; Renal cell carcinoma

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ACTIVATING TRANSCRIPTION FACTOR 6; ANTIOXIDANT; CASPASE; CASPASE 3; CASPASE 6; CASPASE 9; CASPASE INHIBITOR; ENZYME INHIBITOR; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INDOMETACIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; TROLOX C;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROTECTION; CYTOTOXICITY; DRUG MECHANISM; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTIVATING TRANSCRIPTION FACTOR 6; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, RENAL CELL; CASPASES; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEAT-SHOCK PROTEINS; HUMANS; INDOMETHACIN; KIDNEY NEOPLASMS; MAP KINASE KINASE 4; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR CHAPERONES; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; TIME FACTORS; TRANSCRIPTION FACTOR CHOP; UP-REGULATION;

EID: 34247092489     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.01.071     Document Type: Article

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