Expression of a dominant negative form of Daxx In Vivo rescues motoneurons from Fas (CD95)-induced cell death

Journal of Neurobiology

Volumn 62, Issue 2, 2005, Pages 178-188

  Raoul, Cedric ^a,d   Barthelemy, Catherine ^a   Couzinet, Arnaud ^b   Hancock, David ^c   Pettmann, Brigitte ^a   Hueber, Anne Odile ^b  

^a CNRS   (France)

^b CENTRE ANTOINE LACASSAGNE   (France)

^c THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^d EPFL   (Switzerland)

Author keywords

Daxx dominant negative; Neuronal NOS; p38 kinase; Programmed cell death; Transgenic mice

Indexed keywords

DAXX PROTEIN; FAS ANTIGEN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; IN VIVO STUDY; MOTONEURON; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE; ULTRAVIOLET IRRADIATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, CD95; APOPTOSIS; CARRIER PROTEINS; CELL COUNT; EMBRYO; FAS LIGAND PROTEIN; FLUORESCENT ANTIBODY TECHNIQUE; GENES, DOMINANT; GREEN FLUORESCENT PROTEINS; IN SITU NICK-END LABELING; INDOLES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOTOR NEURONS; NERVE TISSUE PROTEINS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; NUCLEAR PROTEINS; PEPTIDES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPINAL CORD; TIME FACTORS;

EID: 11844306641     PISSN: 00223034     EISSN: None     Source Type: Journal    
DOI: 10.1002/neu.20086     Document Type: Article

References (33)

1. Arce V, Garces A, de Bovis B, Filippi P, Henderson C, Pettmann B, deLapeyriere O. 1999. Cardiotrophin-1 requires LIFRbeta to promote survival of mouse motoneurons purified by a novel technique. J Neurosci Res 55:119-126.
2. Barnhart BC, Alappat EC, Peter ME. 2003. The CD95 type I/type II model. Semin Immunol 15:185-193.
3. Burek MJ, Oppenheim RW. 1996. Programmed cell death in the developing nervous system. Brain Pathol 6:427-446.
4. Chang HY, Nishitoh H, Yang X, Ichijo H, Baltimore D. 1998. Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx. Science 281:1860-1863.
5. Charette SJ, Lavoie JN, Lambert H, Landry J. 2000. Inhibition of Daxx-mediated apoptosis by heat shock protein 27. Mol Cell Biol 20:7602-7612.
6. Chen LY, Chen JD. 2003. Daxx silencing sensitizes cells to multiple apoptotic pathways. Mol Cell Biol 23:7108-7121.
7. Colangelo V, Schurr J, Ball MJ, Pelaez RP, Bazan NG, Lukiw WJ. 2002. Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling. J Neurosci Res 70:462-473.
8. Dauer W, Przedborski S. 2003. Parkinson's disease: mechanisms and models. Neuron 39:889-909.
9. Dawson TM, Dawson VL. 2003. Molecular pathways of neurodegeneration in Parkinson's disease. Science 302:819-822.
10. Emelyanov AV, Kovac C, Sepulveda MA, Birshtein BK. 2002. The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells. JBC 277:11156-11164.
11. Heidenreich KA. 2003. Molecular mechanisms of neuronal cell death. Ann NY Acad Sci 991:237-250.
12. Hollenbach AD, Sublett JE, McPherson CJ, Grosveld G. 1999. The Pax3-FKHR oncoprotein is unresponsive to the Pax3-associated represser hDaxx. EMBO J 18:3702-3711.
13. Hurlin PJ, Queva C, Eisenman RN. 1997. Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites. Genes Dev 11:44-58.
14. Kim YY, Park BJ, Seo GJ, Lim JY, Lee SM, Kimm KC, Park C, Kim J, Park SI. 2003. Long form of cellular FLICE-inhibitory protein interacts with Daxx and prevents Fas-induced JNK activation. Biochem Biophys Res Commun 312:426-433.
15. Krammer PH. 2000. CD95's deadly mission in the immune system. Nature 407:789-795.
16. Le-Niculescu H, Bonfoco E, Kasuya Y, Claret FX, Green DR, Karin M. 1999. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death. Mol Cell Biol 19:751-763.
17. Li R, Pei H, Watson DK, Papas TS. 2000. EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes. Oncogene 19:745-753.
18. Michaelson JS, Bader D, Kuo F, Kozak C, Leder P. 1999. Loss of daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development. Genes Dev 13:1918-1923.
19. Michaelson JS, Leder P. 2003. RNAi reveals anti-apoptotic and transcriptionally repressive activities of DAXX. J Cell Sci 116:345-352.
20. Oppenheim RW. 1989. The neurotrophic theory and naturally occurring motoneuron death. Trends Neurosci 12:252-255.
21. Perlman R, Schiemann WP, Brooks MW, Lodish HF, Weinberg RA. 2001. TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation. Nat Cell Biol 3:708-714.
22. Peter ME, Krammer PH. 2003. The CD95(APO-1/Fas) DISC and beyond. Cell Death Differ 10:26-35.
23. Pettmann B, Henderson CE. 1998. Neuronal cell death. Neuron 20:633-647.
24. Raoul C, Estevez AG, Nishimune H, Cleveland DW, deLapeyriere O, Henderson CE, Haase G, Pettmann B. 2002. Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations. Neuron 35:1067-1083.
25. Raoul C, Henderson CE, Pettmann B. 1999. Programmed cell death of embryonic motoneurons triggered through the Fas death receptor. J Cell Biol 147:1049-1062.
26. Raoul C, Pettmann B, Henderson CE. 2000. Active killing of neurons during development and following stress: a role for p75(NTR) and Fas? Curr Opin Neurobiol 10:111-117.
27. Saitoh M, Nishitoh H, Fujii M, Takeda K, Tobiume K, Sawada Y, Kawabata M, Miyazono K, Ichijo H. 1998. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J 17:2596-2606.
28. Shinoda S, Skradski SL, Araki T, Schindler CK, Meller R, Lan JQ, Taki W, Simon RP, Henshall DC. 2003. Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death. Eur J Neurosci 17:2065-2076.
29. Ugolini G, Raoul C, Ferri A, Haenggeli C, Yamamoto Y, Salaun D, Henderson CE, Kato AC, Pettmann B, Hueber AO. 2003. Fas/tumor necrosis factor receptor death signaling is required for axotomy-induced death of motoneurons in vivo. J Neurosci 23:8526-8531.
30. Yaginuma H, Sato N, Homma S, Oppenheim RW. 2001. Roles of caspases in the programmed cell death of motoneurons in vivo. Arch Histol Cytol 64:461-474.
31. Yamamoto Y, Henderson CE. 1999. Patterns of programmed cell death in populations of developing spinal motoneurons in chicken, mouse, and rat. Dev Biol 214:60-71,
32. Yang X, Khosravi-Far R, Chang H, Baltimore D. 1997. Daxx, a novel Fas-binding protein that activates JNK and apoptosis. Cell 89:1067-1076.
33. Yuan J, Lipinski M, Degterev A. 2003. Diversity in the mechanisms of neuronal cell death. Neuron 40:401-413.