Role of P-glycoprotein in colchicine and vinblastine cellular kinetics in an immortalized rat brain microvessel endothelial cell line

Biochemical Pharmacology

Volumn 53, Issue 11, 1997, Pages 1735-1742

  El Hafny, Bouchra ^a   Cano, Nathalie ^a   Piciotti, Michèle ^a   Regina, Anthony ^a   Scherrmann, Jean Michel ^a   Roux, Françoise ^a  

^a HÔPITAL FERNAND WIDAL   (France)

Author keywords

Blood brain barrier; Colchicine; Endothelial cells; P glycoprotein; Tubulin; Vinblastine

Indexed keywords

COLCHICINE; GLYCOPROTEIN P; VINBLASTINE;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; CELL IMMORTALIZATION; CELL KINETICS; CYTOSOL; DRUG RECEPTOR BINDING; DRUG UPTAKE; ENDOTHELIUM CELL; LIPID SOLUBILITY; MULTIDRUG RESISTANCE; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; RAT;

ANIMALS; BLOOD-BRAIN BARRIER; CELL LINE; COLCHICINE; CYCLOSPORINE; ENDOTHELIUM, VASCULAR; P-GLYCOPROTEIN; RATS; TIME FACTORS; TUBULIN; VINBLASTINE;

EID: 0030738230     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00093-2     Document Type: Article

References (28)

1. Roberts W, Liang M and Stern S, Colchicine in acute gout. Reassessment of risks and benefits. J Am Med Ass 257: 1920-1922, 1987.
2. Levy M and Eliakim M, Long-term colchicine prophylaxis in familial Mediterranean fever. Br Med J 1977: 808-809, 1990.
3. Malawista SE, Colchicine: A common mechanism for its anti-inflammatory and anti-mitotic effects. Arthritis Rheum 11: 191-197, 1968.
4. Hastie SB, Interactions of colchicine with tubulin. Pharmac Ther 51: 377-401, 1991.
5. Wilson L and Jordan MA, Pharmacological probes of microtubule function. In: Microtubules (Eds. Hyams JS and Lloyd CW), 13 pp. 59-83. Wiley-Liss, New York, 1994.
6. Dhamodharan R, Jordan MA, Thrower D, Wilson L and Wadsworth P, Vinblastine suppresses dynamics of individual microtubules in living interphase cells. Mol Biol Cell 6: 1215-1229, 1995.
7. Mundy WR and Tilson HA, Neurotoxic effects of colchicine. Neurotoxicology 11: 539-548, 1990.
8. Cordon-Cardo C, O'Brien JP, Casals D, Rittman-Grauer L, Biedler JL, Melamed MR and Bertino JR, Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood brain-barrier sites. Proc Natl Acad Sci USA 86: 695-698, 1989.
9. Jetté L, Têtu B and Béliveau R, High levels of P-glycoprotein detected in isolated brain capillaries. Biochim Biophys Acta 1150: 147-154, 1993.
10. Gros P, Ben-Neriah Y, Croop JM and Housman DE, Isolation and expression of a complementary DNA that confers multidrug resistance. Nature 323: 728-731, 1986.
11. Gottesman MM and Pastan I, Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62: 385-427, 1993.
12. Doige CA and Sharom FJ, Transport properties of P-glycoprotein in plasma membrane vesicles from multidrug-resistant Chinese hamster ovary cells. Biochim Biophys Acta 1109: 161-171, 1992.
13. Schinkel AH, Smit JJM, van Tellingen O, Beijnen JH, Wagenaar E, van Deemter L, Mol CAAM, van der Valk MA, Robanus-Maandag EC, te Riele HPJ, Berns AJM and Borst P, Disruption of the mouse mdrla P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77: 491-502, 1994.
14. Liu RH and Sharom FJ, Site-directed fluorescence labeling of P-glycoprotein on cysteine residues in the nucleotide binding domains. Biochemistry 35(36): 11865-11873, 1996.
15. Roux F, Durieu-Trautmann O, Chaverot N, Claire M, Mailly P, Bourre J-M, Strosberg AD and Couraud PO, Regulation of gamma-glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells. J Cell Physiol 159: 101-113, 1994.
16. El Hafny B, Bourre J-M and Roux F, Synergistic stimulation of gamma-glutamyl transpeptidase and alkaline phosphatase activities by retinoic acid and astroglial factors in immortalized rat brain microvessel endothelial cells. J Cell Physiol 167: 451-460, 1996.
17. Sabouraud AE, Urtizberea M, Cano NJ, Grandgeorge M, Rouzioux JM and Scherrmann J-M, Colchicine-specific Fab fragments alter colchicine disposition in rabbits. J Pharmacol Exp Ther 260: 1214-1219, 1992.
18. Tatsuta T, Naito M, Oh-hara T, Sugawara I and Tsuruo T, Functional involvement of P-glycoprotein in blood-brain barrier. J Biol Chem 267: 20383-20391, 1992.
19. Lowry OH, Rosebrough NJ, Farr AL and Randall RJ, Protein measurement with Folin phenol reagent. J Biol Chem 193: 265-275, 1951.
20. Chappey ON, Niel E, Debray M, Wautier J-L and Scherrmann J-MG, Efflux of intracellular colchicine in lymphocytes with colchicine-specific Fab fragments. J Pharmacol Exp Ther 274: 1072-1076, 1995.
21. Begley DJ, Lechardeur D, Chen Z-D, Rollinson C, Bardoul M, Roux F, Scherman D and Abbott NJ, Functional expression of P-glycoprotein in an immortalised cell line of rat brain endothelial cells, RBE4. J Neurochem 67: 988-995, 1996.
22. Barrand MA, Rhodes T, Center MS and Twentyman PR, Chemosensitisation and drug accumulation effects of cyclosporin A, PSC-833 and verapamil in human MDR large cell lung cancer cells expressing a 190k membrane protein distinct from P-glycoprotein. Eur J Cancer 29A(3): 408-415, 1993.
23. Safa AR, Stern RK, Choi K, Agresti M, Tamai I, Mehta ND and Roninson IB, Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185 → Val-185 substitution in P-glycoprotein. Proc Natl Acad Sci USA 87: 7225-7229, 1990.
24. Diaz JF and Andreu JM, Kinetics of dissociation of the tubulin-colchicine complex. J Biol Chem 266: 2890-2896, 1991.
25. Greig NH, Soncrant TT, Shetty HU, Momma S, Smith QR and Rapoport SI, Brain uptakes and anticancer activities of vincristine and vinblastine are restricted by their low cerebrovascular permeability and binding to plasma constituents in rat. Cancer Chemother Pharmacol 26: 263-268, 1990.
26. Reichel A, Reeve-Chen ZD, Begley DJ and Abbott NJ, A method to assess functional activity of P-glycoprotein in vitro based on the energy requirements of the transporter. In: Biology and Physiology of the Blood-Brain Barrier: Transport, Cellular Interactions and Brain Pathologies (Eds. Couraud PO and Scherman D), pp. 183-187, Plenum Press, New York, 1997.
27. McClure WO and Paulson JC, The interaction of colchicine and some related alkaloids with rat brain tubulin. Mol Pharmacol 13: 560-575, 1977.
28. Seidel A, Hasmann M, Löser R, Bunge A, Schaefer B, Herzig I, Steidtmann K and Dietel M, Intracellular localization, vesicular accumulation and kinetics of daunorubicin in sensitive and multidrug-resistant gastric carcinoma EPG85-257 cells. Virchows Archiv 426: 249-256, 1995.