Regulation of NF-κB activation and nuclear translocation by exogenous nitric oxide (NO) donors in TNF-α activated vascular endothelial cells

Nitric Oxide - Biology and Chemistry

Volumn 16, Issue 3, 2007, Pages 379-391

  Rogers, Jennifer A ^a   Fuseler, John W ^b  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Human umbilical vein endothelial cells; Immunofluorescence image analysis; Interleukin 1 beta; Nitric oxide donors; Nuclear factor B; Tumor necrosis factor alpha

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA; NITRIC OXIDE DONOR; TRANSCRIPTION FACTOR RELA;

ARTICLE; CELL ACTIVATION; ENDOTHELIUM CELL; GENE TRANSLOCATION; HALF LIFE TIME; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; PHENOTYPE; PRIORITY JOURNAL; UMBILICAL VEIN; VASCULAR ENDOTHELIUM; ACTIVE TRANSPORT; CELL LINE; CELL NUCLEUS; CYTOLOGY; METABOLISM; OXIDATION REDUCTION REACTION; PHYSIOLOGY;

ACTIVE TRANSPORT, CELL NUCLEUS; CELL LINE; CELL NUCLEUS; ENDOTHELIAL CELLS; HUMANS; NITRIC OXIDE; NITRIC OXIDE DONORS; OXIDATION-REDUCTION; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34047100860     PISSN: 10898603     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.niox.2007.02.001     Document Type: Article

References (55)

1. Wink D.A., and Mitchell J.B. Chemical biology of nitric oxide: Insights into regulatory, cytotoxic and cytoprotective mechanisms of nitric oxide. Free Rad. Biol. Med. 25 (1998) 434-456
2. Moilanen E., Whittle B.J.R., and Moncada S. Nitric oxide as a factor in inflammation. In: Gallin J.I., and Snyderman R. (Eds). Inflammation: Principles and Clinical Correlations (1999), Lippincott Williams and Wilkins, Philadelphia, PA 787-800
3. Roerig S., Wolf R., and Grisham M.B. Nitric oxide, chronic joint inflammation, and pain. In: Ignarro L.J. (Ed). Nitric Oxide. Biology and Pathology (2000), Academic Press, San Diego 873-894
4. Nolan G.P., Ghosh S., Liou H.C., Tempst P., and Baltimore D. DNA binding I kappa B inhibition of the cloned p65 subunit of NF-kappa Ba rel-related polypeptide. Cell 64 (1991) 961-969
5. Kubes P., Suzuki M., and Granger D.N. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc. Natl. Acad. Sci. USA 88 (1991) 4651-4655
6. Wong J.M., and Billiar T.R. Regulation and function of inducible nitric oxide synthase during sepsis and acute inflammation. Adv. Pharmacol. 34 (1995) 155-170
7. Szabo C. Pathophysiological roles of nitric oxide in inflammation. In: Ignarro L.J. (Ed). Nitric Oxide. Biology and Pathology (2000), Academic Press, San Diego 841-872
8. Fuseler J.W., Merrill D.M., Rogers J.A., Grisham M.B., and Wolf R.E. Analysis and quantitation of NF-κB nuclear translocation in tumor necrosis factor alpha activated vascular endothelial cells. Microsc. Microanal. 12 (2006) 269-276
9. Ding G.J.F., Fischer P.A., Boltz R.C., Schmidt J.A., Colaianne J.J., Gough A., Rubin R.A., and Miller D.K. Characterization and quantitation of NF-kappaB nuclear translocation induced by interleukin-1 and tumor necrosis factor-alpha. Development and use of a high capacity fluorescence cytometric system. J. Biol. Chem. 273 (1998) 28897-28905
10. Carlotti F., Chapman R., Dower S.K., and Qwarnstrom E.E. Activation of nuclear factor κB in single living cells. Dependence of nuclear translocation and anti-apoptotic function on GFPRELA. J. Biol. Chem. 274 (1999) 37941-37949
11. Carlotti F., Chapman S.K., and Qwarnstrom E.E. Dynamic shuttling of nuclear factor κB between the nucleus and cytoplasm as a consequence of inhibitor dissociation. J. Biol. Chem. 275 (2000) 41028-41034
12. Tenjinbaru K., Furuno T., Hirashima N., and Nakanishi M. Nuclear translocation of green fluorescent protein-nuclear factor κB with distinct time lag in living cells. FEBS Lett. 444 (1999) 1-4
13. Nelson G., Paraoan L., Spiller D.G., Wilde G.J.C., Browne M.A., Djali P.K., Unitt J.F., Sullivan E., Floettmann E., and White M.R.H. Multi-parameter analysis of the kinetics of NF- kappaB signalling and transcription in single living cells. J. Cell Sci. 115 (2002) 1137-1148
14. De la Torre A., Schroeder R.A., and Kuo P.C. Alteration of NF-κB p50 DNA-binding kinetics by S-nitrosylation. Biochem. Biophys. Res. Commun. 238 (1997) 703-706
15. Wally K.R., McDonald T.E., Higashimoto Y., and Hayashi S. Modulation of proinflammatory cytokines by nitric oxide in immune lung injury. Am. J. Respir. Crit. Care Med. 160 (1999) 689-704
16. Peng H.B., Rajavashisth T.B., Libby P., and Liao J.K. Nitric oxide inhibits macrophage-colony stimulating factor gene transcription in vascular endothelial cells. J. Biol. Chem. 270 (1995) 17050-17055
17. Katsuyama K., Shichiri M., Marumo F., and Hirata Y. NO inhibits cytokine-induced iNOS expression and NF-kappaB activation by interfering with phosphorylation and degradation of IkappaB-alpha. Arterioscler. Thromb. Vasc. Biol. 18 (1998) 1796-1802
18. Regnier C.H., Song H.Y., Gao X., Goeddel D.V., Cao Z., and Rothe M. Identification and characterization of an IkappaB kinase. Cell 90 (1997) 373-383
19. DiDonato J.A., Hayakawa M., Rothwarf D.M., Zandi E., and Karin M. A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappa B. Nature 388 (1997) 548-554
20. Janssen-Heininger Y.M., Poynter M.E., and Baeuerle P.A. Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappa B. Free Radic. Biol. Med. 28 (2000) 1317-1327
21. Marshall H.E., Hess D.T., and Stamler J.S. S-nitrosylation: Physiological regulation of NF-κB. Proc. Natl. Acad. Sci. USA 101 (2004) 8841-8842
22. Katsuyama K., Shichiri M., Marumo F., and Hirata Y. NO inhibits cytokine-induced iNOS expression and NF-κB activation by interfering with phosphorylation and degradation of IκB-α. Atrerioscler. Thromb. Vasc. Biol. 18 (1998) 1796-1802
23. Reynaert N.L., Ckless K., Korn S.H., Vos N., Guala A.S., Wouters E.F., van der Vliet A., and Janssen-Heininger Y.M. Nitric oxide represses inhibitory kappaB kinase through S-nitrosylation. Proc. Natl. Acad. Sci. USA 101 (2004) 8945-8950
24. Matthews J.R., Botting C.H., Panico M., Morris H.R., and Hay R.T. Inhibition of NF-kappaB DNA binding by nitric oxide. Nucl. Acid. Res. 24 (1996) 2236-2242
25. Schroede R.A., Cai C., and Kuo P.C. Endotoxin-mediated nitric oxide synthesis inhibits IL-1beta gene transcription in ANA-1 murine macrophages. Am. J. Physiol. 277 (1999) C523-C530
26. de la Torre A., Schroeder R.A., Bartlett S.T., and Kuo P. Differential effects of nitric oxide-mediated S-nitrosylation on p50 and c-jun DNA binding. Surgery 124 (1998) 137-141
27. Park S.W., Huq M., Hu X., and Wei L.-N. Tyrosine nitration on p65. A novel mechanism to rapidly inactivate nuclear factor-κB. Mole. Cell. Proteomics 4 (2005) 300-309
28. J.A. Rogers, Nitric oxide inhibition of nuclear translocation of nuclear factor-kappa B in tumor necrosis factor-alpha activated human umbilical vein endothelial cells is dependent on nitric oxide donor half life, Master of Science thesis, LSU-health Science Center at Shreveport, Shreveport, LA, 2004.
29. Beckman J.S., and Koppenol W.H. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am. J. Physiol. 271 (1996) C1424-C1437
30. Stamler J.S., Jia L., Eu J.P., McMahon T.J., Demchenko I.T., Bonaventura J., Gernert K., and Piantadosi C.A. Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. Science 276 (1997) 2034-2037
31. Wolzt M., MacAllister R.J., Davis D., Feelisch M., Moncada S., Vallance P., and Hobbs A.J. Biochemical characterization of S-nitrosohemoglobin. Mechanisms underlying synthesis, no release, and biological activity. J. Biol. Chem. 274 (1999) 28983-28990
32. Pawloski J.R., and Stamler J.S. Nitric oxide in RBCs. Transfusion 42 (2002) 1603-1609
33. Gross S.S. Targeted delivery of nitric oxide. Nature 409 (2001) 577-578
34. Rothwarf D.M., and Karin M. The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus. Sci. STKE 5 (1999) RE1
35. Devin A., Coo A., Lin Y., Rodriguez Y., Kelliher M., and Liu Z. The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation. Immunity 4 (2000) 419-429
36. Li S., Strelow A., Fontana E.J., and Wesche H. IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc. Natl. Acad. Sci. USA 8 (2002) 5567-5572
37. Lye E., Mirtsos C., Suzuki N., Suzuki S., and Yeh W.C. The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling. J. Biol. Chem. 279 (2004) 40653-40658
38. Qian Y., Commane M., Ninomiya-Tsuji J., Matsumoto K., and Li X. IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B. J. Biol. Chem. 276 (2001) 41661-41667
39. Cao Z., Xiong J., Takeuchi M., Kurama T., and Goeddel D.V. TRAF6 is a signal transducer for interleukin-1. Nature 383 (1996) 443-446
40. Karin M., and Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu. Rev. Immunol. 18 (2000) 621-663
41. Woronicz J.D., Gao X., Cao Z., Rothe M., and Goeddel D.V. IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science 278 (1997) 866-869
42. Ghosh S., May M.J., and Kopp E.B. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16 (1998) 225-260
43. Ghosh S., and Karin M. Missing pieces in the NF-kappaB puzzle. Cell 109 Supplement (2002) S81-S96
44. Cook C.L., and Davidge S.T. Peroxynitrite increases iNOS through NF-kappaB and decreases prostacyclin synthesis in endothelial cells. Am. J. Physiol. Cell Physiol. 282 (2002) C395-C402
45. Zouki C., Jozsef L., Ouellet S., Paquette Y., and Filep J.G. Peroxynitrite mediates cytokine-induced IL-8 gene expression and production by human leukocytes. J. Leukoc. Biol. 69 (2001) 815-824
46. Clancy R.M., Gomez P.F., and Abramson S.B. Nitric oxide sustains nuclear factor kappaB activation in cytokine-stimulated chondrocytes. OsteoArthritis Cart. 12 (2004) 552-558
47. Simpson C.S., and Morris B.J. Activation of nuclear factor κB by nitric oxide in rat striatal neurons: Differential inhibition of the p50 and p65 subunits by dexamethasome. J. Neurochem. 73 (1999) 353-361
48. Pahan K., Liu X., McKinney M.J., Wood C., Sheikh F.G., and Raymond J.R. Expression of a dominant-negative mutant of p21(ras) inhibits induction of nitric oxide synthase and activation of nuclear factor-kappaB in primary astrocytes. J. Neurochem. 74 (2000) 2288-2295
49. Anrather J., Csizmadia V., Soares M.P., and Winkler H. Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells. J. Biol. Chem. 274 (1999) 13594-13603
50. Lander H.M., Hajjar D.P., Hempstead B.L., Mirza U.A., Chait B.T., Campbell S., and Quilliam L.A. A molecular redox switch on p21(ras). Structural basis for the nitric oxide-p21(ras) interaction. J. Biol. Chem. 272 (1997) 4323-4326
51. Connelly L., Palacios-Callende R.M., Ameixa C., Moncada S., and Hobbs A.J. Biphasic regulation of NF-kappa B activity underlies the pro- and anti-inflammatory actions of nitric oxide. J. Immunol. 166 (2001) 3873-3881
52. Filep J.G., Beauchamp M., Baron C., and Paquette Y. Peroxynitrite mediates IL-8 gene expression and production in lipopolysaccharide-stimulated human whole blood. J. Immunol. 161 (1998) 5656-5662
53. Matata B.M., and Galinanes M. Peroxynitrite is an essential component of cytokines production mechanism in human monocytes through modulation of nuclear factor-kappa B DNA binding activity. J. Biol. Chem. 277 (2002) 2330-2335
54. Singh S., Darnay B.G., and Aggarwal B.B. Site-specific tyrosine phosphorylation of IkappaBalpha negatively regulates its inducible phosphorylation and degradation. J. Biol. Chem. 271 (1996) 31049-31054
55. Gow A.J., Duran D., Malcolm S., and Ischiropoulos H. Effects of peroxynitrite-induced protein modifications on tyrosine phosphorylation and degradation. FEBS Lett. 385 (1996) 63-66