Endotoxin-mediated nitric oxide synthesis inhibits IL-1β gene transcription in ANA-1 murine macrophages

American Journal of Physiology - Cell Physiology

Volumn 277, Issue 3 46-3, 1999, Pages

  Schroeder, Rebecca A ^a   Cai, Charles ^a   Kuo, Paul C ^a  

^a GEORGETOWN UNIVERSITY   (United States)

Author keywords

Cytokine; Inducible nitric oxide synthase; Interleukin 1 ; Lipopolysaccharide; Nuclear factor B; S nitrosation

Indexed keywords

ENDOTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ARTICLE; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INDUCTION; GENETIC TRANSFECTION; MACROPHAGE; MOUSE; NITROSATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN SYNTHESIS; SEPSIS; TRANSCRIPTION REGULATION;

EID: 0032883235     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1999.277.3.c523     Document Type: Article

References (10)

1. Akira, S., and T. Kishimoto. NF-IL6 and NF-κB in cytokine gene regulation. Adv. Immunol. 65: 1-45, 1997.
2. Blackwell, T. S., and J. W. Christman. The role of nuclear factor κB in cytokine gene regulation. Am. J. Respir. Cell Mol. Biol. 17: 3-9, 1997.
3. Calmels, S., P. Hainaut, and H. Ohshima. Nitric oxide induces conformational and functional modifications of wild-type p53 tumor suppressor protein. Cancer Res. 57: 3365-3369, 1997.
4. Chujors, C. S., L. Klein, and C. Lam. Selective inhibition of interleukin-1 beta gene expression in activated RAW 264.7 macrophages by interferon-gamma. Eur. J. Immunol. 26: 1253-1259, 1996.
5. Cogswell, J. P., M. M. Godlevski, G. B. Wisely, W. C. Clay, L. M. Leesnitzer, J. P. Ways, and J. G. Gray. NF-κB regulates IL-1β transcription through a consensus NF-κB binding site and a consensus CRE-like site. J. Immunol. 153: 712-723, 1994.
6. DelaTorre, A., R. A. Schroeder, and P. C. Kuo. Alteration of NF-κB p50 binding kinetics by S-nitrosylation. Biochem. Biophys. Res. Commun. 238: 703-706, 1997.
7. DelaTorre, A., R. A. Schroeder, C. Punzalan, and P. C. Kuo. Endotoxin-mediated S-nitrosylation of p50 alters NF-κB-dependent gene transcription in ANA-1 murine macrophages. J. Immunol. 162: 4101-4108, 1999.
8. Dinarello, C. A. Biologic basis for interleukin-1 in disease. Blood 87: 2095-2147, 1996.
9. Godambe, S. A., D. D. Chaplin, T. Takova, and C. J. Bellone. Upstream NF-IL-6-like site located within a DNase 1 hypersensitivity region mediates LPS-induced transcription of the murine interleukin-1β gene. J. Immunol. 153: 143-152, 1994.
10. Hiscott, J., J. Marois, J. Garoufalis, M. D'Addario, A. Roulston, I. Kwan, N. Pepin, J. Lacoste, H. Nguyen, G. Bensi, and M. Fenton. Characterization of a functional NF-κB site in the human interleukin 1β promoter: evidence for a positive autoregulatory loop. Mol. Cell. Biol. 13: 6231-6240, 1993.