Cartilage link protein interacts with neurocan, which shows hyaluronan binding characteristics different from CD44 and TSG-6

Matrix Biology

Volumn 22, Issue 8, 2004, Pages 629-639

  Rauch, Uwe ^a   Hirakawa, Satoshi ^b   Oohashi, Toshitaka ^b   Kappler, Joachim ^c   Roos, Gunnel ^a  

^a LUND UNIVERSITY   (Sweden)

^b OKAYAMA UNIVERSITY   (Japan)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

Hyaluronan; Link module; Link protein; Neurocan

Indexed keywords

ALKALINE PHOSPHATASE; CHONDROITIN SULFATE; HERMES ANTIGEN; HYALURONIC ACID; HYBRID PROTEIN; HYPERTONIC SOLUTION; IMMUNOGLOBULIN; MUTANT PROTEIN; NEUROCAN; PROTEIN; PROTEIN DERIVATIVE; TUMOR SUSCEPTIBILITY GENE 6 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BLOTTING; BRAIN DEVELOPMENT; CARTILAGE; CONTROLLED STUDY; CROSS LINKING; ENZYME IMMOBILIZATION; GENE MUTATION; INCUBATION TIME; MOLECULAR BIOLOGY; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT;

ALANINE; ALKALINE PHOSPHATASE; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD44; CELL ADHESION MOLECULES; CELL LINE; CULTURE MEDIA, CONDITIONED; EXTRACELLULAR MATRIX PROTEINS; HUMANS; HYALURONIC ACID; LECTINS, C-TYPE; MICE; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; POINT MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEOCHONDROITIN SULFATES; PROTEOGLYCANS; RATS; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT;

MAMMALIA;

EID: 1942451831     PISSN: 0945053X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.matbio.2003.11.007     Document Type: Article

References (34)

1. Aspberg A., Miura R., Bourdoulous S., Shimonaka M., Heinegard D., Schachner M., et al. The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety. Proc. Natl. Acad. Sci. USA. 94:1997;10 116-10 121.
2. Bajorath J., Greenfield B., Munro S.B., Day A.J., Aruffo A. Identification of CD44 residues important for hyaluronan binding and delineation of the binding site. J. Biol. Chem. 273:1998;338-343.
3. Bekku Y., Su W.-D., Hirakawa S., Fassler R., Ohtsuka A., Kang J.S., et al. Molecular cloning of Bral2, a novel brain-specific link protein and immunohistochemical colocalization with brevican in perineuronal nets. Mol. Cell Neurosci. 24:2003;148-159.
4. Brakebusch C., Seidenbecher C.I., Asztely F., Rauch U., Matthies H., Meyer H., et al. Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory. Mol. Cell Biol. 22:2002;7417-7427.
5. Day A.J., Prestwich G.D. Hyaluronan-binding proteins: tying up the giant. J. Biol. Chem. 277:2002;4585-4588.
6. Flanagan J.G., Leder P. The kit ligand: a cell surface molecule altered in steel mutant fibroblasts. Cell. 63:1990;185-194.
7. Grover J., Roughley P.J. The expression of functional link protein in a baculovirus system: analysis of mutants lacking the A, B and B′ domains. Biochem. J. 300:1994;317-324.
8. Hardingham T.E., Fosang A.J. Proteoglycans: many forms and many functions. Faseb J. 6:1992;861-870.
9. Hirakawa S., Oohashi T., Su W.D., Yoshioka H., Murakami T., Arata J., et al. The brain link protein-1 (BRAL1): cDNA cloning, genomic structure and characterization as a novel link protein expressed in adult brain. Biochem. Biophys. Res. Commun. 276:2000;982-989.
10. Iozzo R.V., Murdoch A.D. Proteoglycans of the extracellular environment: clues from the gene and protein side offer novel perspectives in molecular diversity and function. Faseb J. 10:1996;598-614.
11. Kiani C., Chen L., Wu Y.J., Yee A.J., Yang B.B. Structure and function of aggrecan. Cell Res. 12:2002;19-32.
12. Knudson C.B. Hyaluronan receptor-directed assembly of chondrocyte pericellular matrix. J. Cell Biol. 120:1993;825-834.
13. Kohfeldt E., Gohring W., Mayer U., Zweckstetter M., Holak T.A., Chu M.L., et al. Conversion of the Kunitz-type module of collagen VI into a highly active trypsin inhibitor by site-directed mutagenesis. Eur. J. Biochem. 238:1996;333-340.
14. Koprunner M., Mullegger J., Lepperdinger G. Synthesis of hyaluronan of distinctly different chain length is regulated by differential expression of Xhas1 and 2 during early development of Xenopus laevis. Mech. Dev. 90:2000;275-278.
15. Mahoney D.J., Blundell C.D., Day A.J. Mapping the hyaluronan-binding site on the link module from human tumor necrosis factor-stimulated gene-6 by site-directed mutagenesis. J. Biol. Chem. 276:2001;22 764-22 771.
16. Matsumoto K., Shionyu M., Go M., Shimizu K., Shinomura T., Kimata K., et al. Distinct interaction of versican/PG-M with hyaluronan and link protein. J. Biol. Chem. 278:2003;41 205-41 212.
17. Morgelin M., Heinegard D., Engel J., Paulsson M. The cartilage proteoglycan aggregate: assembly through combined protein-carbohydrate and protein-protein interactions. Biophys. Chem. 50:1994;113-128.
18. Morgelin M., Paulsson M., Heinegard D., Aebi U., Engel J. Evidence of a defined spatial arrangement of hyaluronate in the central filament of cartilage proteoglycan aggregates. Biochem. J. 307:1995;595-601.
19. Nomoto H., Oohashi T., Hirakawa S., Ueki Y., Ohtsuki H., Ninomiya Y. Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23. Acta Med. Okayama. 56:2002;25-29.
20. Oohashi T., Hirakawa S., Bekku Y., Rauch U., Zimmermann D.R., Su W.D., et al. Bral1, a brain-specific link protein, colocalizing with the versican V2 isoform at the nodes of Ranvier in developing and adult mouse central nervous systems. Mol. Cell Neurosci. 19:2002;43-57.
21. Perin J.P., Bonnet F., Thurieau C., Jolles P. Link protein interactions with hyaluronate and proteoglycans. Characterization of two distinct domains in bovine cartilage link proteins. J. Biol. Chem. 262:1987;13 269-13 272.
22. Rauch U. Modeling an extracellular environment for axonal pathfinding and fasciculation in the central nervous system. Cell Tissue Res. 290:1997;349-356.
23. Rauch U., Clement A., Retzler C., Frohlich L., Fassler R., Gohring W., et al. Mapping of a defined neurocan binding site to distinct domains of tenascin-C. J. Biol. Chem. 272:1997;26 905-26 912.
24. Rauch U., Feng K., Zhou X.H. Neurocan: a brain chondroitin sulfate proteoglycan. Cell Mol. Life Sci. 58:2001;1842-1856.
25. Rauch U., Gao P., Janetzko A., Flaccus A., Hilgenberg L., Tekotte H., et al. Isolation and characterization of developmentally regulated chondroitin sulfate and chondroitin/keratan sulfate proteoglycans of brain identified with monoclonal antibodies. J. Biol. Chem. 266:1991;14 785-14 801.
26. Rauch U., Karthikeyan L., Maurel P., Margolis R.U., Margolis R.K. Cloning and primary structure of neurocan, a developmentally regulated, aggregating chondroitin sulfate proteoglycan of brain. J. Biol. Chem. 267:1992;19 536-19 547.
27. Retzler C., Wiedemann H., Kulbe G., Rauch U. Structural and electron microscopic analysis of neurocan and recombinant neurocan fragments. J. Biol. Chem. 271:1996;17 107-17 113.
28. Ruoslahti E. Brain extracellular matrix. Glycobiology. 6:1996;489-492.
29. Spicer A.P., Joo A., Bowling R.A. jr. The missing links: a hyaluronan binding link protein gene family whose members are physically linked adjacent to chrondroitin sulfate proteoglycan core protein genes. J. Biol. Chem. 278:2003;21 083-21 091.
30. Talts U., Kuhn U., Roos G., Rauch U. Modulation of extracellular matrix adhesiveness by neurocan and identification of its molecular basis. Exp. Cell Res. 259:2000;378-388.
31. Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., et al. The sequence of the human genome. Science. 291:2001;1304-1351.
32. Watanabe H., Yamada Y. Mice lacking link protein develop dwarfism and craniofacial abnormalities. Nat. Genet. 21:1999;225-229.
33. Yamaguchi Y. Lecticans: organizers of the brain extracellular matrix. Cell Mol. Life Sci. 57:2000;276-289.
34. Yang B.L., Cao L., Kiani C., Lee V., Zhang Y., Adams M.E., et al. Tandem repeats are involved in G1 domain inhibition of versican expression and secretion and the G3 domain enhances glycosaminoglycan modification and product secretion via the complement-binding protein- like motif. J. Biol. Chem. 275:2000;21 255-21 261.