1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy] carbonyl]hydrazine: An anticancer agent targeting hypoxic cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 26, 2005, Pages 9282-9287

  Seow, Helen A ^a   Penketh, Philip G ^a   Shyam, Krishnamurthy ^a   Rockwell, Sara ^a   Sartorelli, Alan C ^a,b  

^a YALE CANCER CENTER   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alkylation; Carbamylation; Cloretazine; VNP40101M

Indexed keywords

1,2 BIS(METHYLSULFONYL) 1 (2 CHLOROETHYL) 2 [[1 (4 NITROPHENYL)ETHOXY]CARBONYL]HYDRAZINE; ANTINEOPLASTIC AGENT; CLORETAZINE; DNA; EDETIC ACID; GLUTATHIONE; HYDRAZINE DERIVATIVE; KS 119; PRODRUG; UNCLASSIFIED DRUG; ZINC ION;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA CROSS LINKING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME PURIFICATION; GAMMA IRRADIATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOXIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SOLID TUMOR;

ANIMALS; ANOXIA; ANTINEOPLASTIC AGENTS; CELL SURVIVAL; CHO CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRICETINAE; CROSS-LINKING REAGENTS; CYTOCHROME-B(5) REDUCTASE; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; EDETIC ACID; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HYDRAZINES; MICE; MICE, INBRED BALB C; MODELS, CHEMICAL; NAD(P)H DEHYDROGENASE (QUINONE); NADPH-FERRIHEMOPROTEIN REDUCTASE; NEOPLASM TRANSPLANTATION; NEOPLASMS; NITROGEN; OXYGEN; SULFHYDRYL COMPOUNDS; SULFONAMIDES; TIME FACTORS; TREATMENT OUTCOME; XANTHINE OXIDASE; ZINC;

EID: 21544441743     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0409013102     Document Type: Article

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