Development of novel poly(ethylene glycol)-based vehicles for gene delivery

Biotechnology and Bioengineering

Volumn 96, Issue 5, 2007, Pages 967-976

  Schmieder, Anne H ^a   Grabski, Lauren E ^a   Moore, Nicole M ^a   Dempsey, Leslie A ^a   Sakiyama Elbert, Shelly E ^a  

^a WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

Author keywords

Cytotoxicity; Gene therapy; Non viral

Indexed keywords

AMINO ACIDS; CYTOTOXICITY; DNA; GENES; POLYETHYLENE GLYCOLS; ZETA POTENTIAL;

CHARGE RATIOS; GENE THERAPY; TRANSFECTION EFFICIENCY;

GENETIC ENGINEERING;

BETA GALACTOSIDASE; DNA BINDING PROTEIN; DRUG VEHICLE; GREEN FLUORESCENT PROTEIN; MACROGOL; PLASMID DNA; POLYETHYLENEIMINE;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CHO CELL; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DRUG SYNTHESIS; GENE DELIVERY SYSTEM; GENETIC TRANSFECTION; LIGHT SCATTERING; LYSOSOME; NONHUMAN; PARTICLE SIZE; ZETA POTENTIAL;

GENE TRANSFER TECHNIQUES; POLYETHYLENE GLYCOLS; TRANSFECTION; VEHICLES;

CRICETULUS GRISEUS;

EID: 33947583305     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.21199     Document Type: Article

References (32)

1. Benns JM, Maheshwari A, Furgeson DY, Mahato RI, Kim SW. 2001. Folate-PEG-folate-graft-polyethylenimine-based gene delivery. J Drug Target 9(2):123-139.
2. Bradley AJ, Devine DV. 1998. The complement system in liposome clearance: Can complement deposition be inhibited? Adv Drug Deliv Rev 32(1-2):19-29.
3. Cheung CY, Murthy N, Stayton PS, Hoffman AS. 2001. A pH-sensitive polymer that enhances cationic lipid-mediated gene transfer. Bioconjug Chem 12(6):906-910.
4. Chonn A, Semple SC, Cullis PR. 1992. Association of blood proteins with large unilamellar liposomes in vivo. Relation to circulation lifetimes. J Biol Chem 267(26):18759-18765.
5. Dash PR, Read ML, Barrett LB, Wolfert MA, Seymour LW. 1999a. Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery. Gene Ther 6(4):643-650.
6. Dash PR, Read ML, Barrett LB, Wolfert MA, Seymour LW. 1999b. Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery. Gene Ther 6(4):643-650.
7. Elbert DL, Hubbell JA. 2001. Conjugate addition reactions combined with free-radical cross-linking for the design of materials for tissue engineering. Biomacromolecules 2(2):430-441.
8. Finsinger D, Remy JS, Erbacher P, Koch C, Plank C. 2000. Protective copolymers for nonviral gene vectors: Synthesis, vector characterization and application in gene delivery. Gene Ther 7(14):1183-1192.
9. Gonzalez H, Hwang SJ, Davis ME. 1999. New class of polymers for the delivery of macromolecular therapeutics. Bioconjug Chem 10(6):1068-1074.
10. Harvie P, Wong FM, Bally MB. 2000. Use of poly(ethylene glycol)-lipid conjugates to regulate the surface attributes and transfection activity of lipid-DNA particles. J Pharm Sci 89(5):652-663.
11. Huang L, Hung M-C, Wagner E, editors. 1999. Nonviral vectors for gene therapy. San Diego: Academic Press.
12. Ishida T, Maeda R, Ichihara M, Irimura K, Kiwada H. 2003. Accelerated clearance of PEGylated liposomes in rats after repeated injections. J Control Release 88(1):35-42.
13. Ishida T, Ichihara M, Wang X, Yamamoto K, Kimura J, Majima E, Kiwada H. 2006. Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes. J Control Release 112(1):15-25.
14. Kichler A. 2004. Gene transfer with modified polyethylenimines. J Gene Med 6(Suppl 1):S3-S10.
15. Kichler A, Leborgne C, Coeytaux E, Danos O. 2001. Polyethylenimine- mediated gene delivery: A mechanistic study. J Gene Med 3(2):135-144.
16. Klemm AR, Young D, Lloyd JB. 1998. Effects of polyethyleneimine on endocytosis and lysosome stability. Biochem Pharmacol 56(1):41-46.
17. Kunath K, Merdan T, Hegener O, Haberlein H, Kissel T. 2003. Integrin targeting using RGD-PEI conjugates for in vitro gene transfer. J Gene Med 5(7):588-599.
18. Lee H, Jeong JH, Park TG. 2002. PEG grafted polylysine with fusogenic peptide for gene delivery: High transfection efficiency with low cytotoxicity. J Control Release 79(1-3):283-291.
19. Li Y, Pei Y, Zhang X, Gu Z, Zhou Z, Yuan W, Zhou J, Zhu J, Gao X. 2001. PEGylated PLGA nanoparticles as protein carriers: Synthesis, preparation and biodistribution in rats. J Control Release 71(2):203-211.
20. Li WM, Mayer LD, Bally MB. 2002. Prevention of antibody-mediated elimination of ligand-targeted liposomes by using poly(ethylene glycol)-modified lipids. J Pharmacol Exp Ther 300(3):976-983.
21. Metallo SJ, Paolella DN, Schepartz A. 1997. The role of a basic amino acid cluster in target site selection and non-specific binding of bZIP peptides to DNA. Nucleic Acids Res 25(15):2967-2972.
22. Mishra S, Webster P, Davis ME. 2004. PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles. Eur J Cell Biol 83(3):97-111.
23. Ogris M, Brunner S, Schuller S, Kircheis R, Wagner E. 1999a. PEGylated DNA/transferrin-PEI complexes: Reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Ther 6(4):595-605.
24. Ogris M, Brunner S, Schuller S, Kircheis R, Wagner E. 1999b. PEGylated DNA/transferrin-PEI complexes: Reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Ther 6(4):595-605.
25. Oupicky D, Konak C, Ulbrich K, Wolfert MA, Seymour LW. 2000. DNA delivery systems based on complexes of DNA with synthetic polycations and their copolymers. J Control Release 65(1-2):149-171.
26. Putnam D, Gentry CA, Pack DW, Langer R. 2001. Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain termini. Proc Natl Acad Sci USA 98(3):1200-1205.
27. Putnam D, Zelikin AN, Izumrudov VA, Langer R. 2003. Polyhistidine-PEG:DNA nanocomposites for gene delivery. Biomaterials 24(24): 4425-4433.
28. Sawhney A, Pathak C, Hubbell JA. 1993. Bioerodible hydrogels based on photopolymerized poly(ethylene glycol)-co-poly(alpha-hydroxy acid) diacrylate macromers. Macromolecules 26:581-587.
29. Semple SC, Harasym TO, Clow KA, Ansell SM, Klimuk SK, Hope MJ. 2005. Immunogenicity and rapid blood clearance of liposomes containing polyethylene glycol-lipid conjugates and nucleic Acid. J Pharmacol Exp Ther 312(3):1020-1026.
30. Sung SJ, Min SH, Cho KY, Lee S, Min YJ, Yeom YI, Park JK. 2003. Effect of polyethylene glycol on gene delivery of polyethylenimine. Biol Pharm Bull 26(4):492-500.
31. Varga CM, Tedford NC, Thomas M, Klibanov AM, Griffith LG, Lauffenburger DA. 2005. Quantitative comparison of polyethylenimine formulations and adenoviral vectors in terms of intracellular gene delivery processes. Gene Ther 12(13):1023-1032.
32. Wiethoff CM, Middaugh CR. 2003. Barriers to nonviral gene delivery. J Pharm Sci 92(2):203-217.