Prevention of antibody-mediated elimination of ligand-targeted liposomes by using poly(ethylene glycol)-modified lipids

Journal of Pharmacology and Experimental Therapeutics

Volumn 300, Issue 3, 2002, Pages 976-983

  Li, Wai Ming ^a,b,c   Mayer, Lawrence D ^a,b   Bally, Marcel B ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b BRITISH COLUMBIA CANCER AGENCY   (Canada)

^c BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BOVINE SERUM ALBUMIN; DRUG CARRIER; HAPTEN; LIGAND; LIPID; LIPOSOME; MACROGOL; PHOSPHOETHANOLAMINE; PHOSPHOLIPID; POLYMER;

ANIMAL MODEL; ANTIBODY RESPONSE; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; DRUG TARGETING; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNIZATION; MEMBRANE VESICLE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES; ANTIGEN-ANTIBODY REACTIONS; BIOTIN; DRUG CARRIERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HAPTENS; LIGANDS; LIPIDS; LIPOSOMES; MICE; MICE, INBRED BALB C; POLYETHYLENE GLYCOLS;

EID: 0036182103     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.300.3.976     Document Type: Article

References (37)

1. Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo
2. Three-dimensional structure of antibodies
3. Three-dimensional structure of immunoglobulins
4. New sterically stabilized vesicles based on nonionic surfactant, cholesterol, and poly(ethylene glycol)-cholesterol conjugates
5. Inhibition of liposome-induced complement activation by incorporated poly(ethylene glycol)lipids
6. Selective protein interactions with phosphatidylserine containing liposomes alter the steric stabilization properties of poly(ethylene glycol)
7. Accelerated blood clearance and altered biodistribution of repeated injections of sterically stabilized liposomes
8. Grafted poly-(ethylene glycol) on lipid surfaces inhibits protein adsorption and cell adhesion
9. Targeting folate receptor with folate linked to extremities of poly(ethylene glycol)-grafted liposomes: In vitro studies
10. Dynamics of antibody- and lectin-mediated endocytosis of hapten-containing liposomes by murine macrophages
11. Immunogenicity and pharmacokinetic attributes of poly(ethylene glycol)-grafted immunoliposomes
12. Poly(ethylene glycol)-lipid conjugates regulate the calcium-induced fusion of liposomes composed of phosphatidylethanolamine and phosphatidylserine
13. Interactions of liposomes with the reticuloendothelial system. II: Nonspecific and receptor-mediated uptake of liposomes by mouse peritoneal macrophages
14. The characterisation of liposomes with covalently attached proteins
15. Surface-associated serum proteins inhibit the uptake of phosphatidylserine and poly(ethylene glycol) liposomes by mouse macrophages
16. Range and magnitude of the steric pressure between bilayers containing phospholipids with covalently attached poly(ethylene glycol)
17. Sterically stabilized anti-HER2 immunoliposomes: Design and targeting to human breast cancer cells in vitro
18. Enhanced immune response to T-independent antigen by using CpG oligodeoxynucleotides encapsulated in liposomes
19. Intermembrane transfer of poly-(ethylene glycol) modified phosphatidylethanolamine as a means to reveal surface associated binding ligands on liposomes
20. A two-step targeting approach for delivery of doxorubicin-loaded liposomes to tumour cells in vivo
21. Targetability of novel immunoliposomes modified with amphipathic poly(ethylene glycol)s conjugated at their distal terminals to monoclonal antibodies
22. Vesicles of variable sizes produced by a rapid extrusion procedure
23. Liposome-cell interactions in vitro: Effect of liposome surface charge on the binding and endocytosis of conventional and sterically stabilized liposomes
24. Surface chemistry of the sterically stabilized PEG-liposomes: General principles
25. Development of anti-p185HER2 immunoliposomes for cancer therapy
26. Accumulation of liposomal lipid and encapsulated doxorubicin in murine Lewis lung carcinoma: The lack of beneficial effects by coating liposomes with poly(ethylene glycol)
27. Interaction of antibodies with liposomes bearing fluorescent haptens
28. Immunogenicity of immunoliposomes: Reactivity against species-specific IgG and liposomal phospholipids
29. Immunogenicity of immunoliposomes
30. Immunoliposome targeting to murine CD4+ Leucocytes is dependent on immune status
31. Carrier-induced epitopic suppression is initiated through clonal dominance
32. Immune response mediated by liposome-associated protein antigens. III. Immunogenicity of bovine serum albumin covalently coupled to vesicle surface
33. An immune response to ovalbumin covalently coupled to liposomes is prevented when the liposomes used contain doxorubicin
34. Immunoliposomes in vivo
35. Sterically stabilized liposomes
36. Sterically stabilized liposomes: Physical and biological properties
37. Effect of sterical stabilization on macrophage uptake in vitro and on thickness of the fixed aqueous layer of liposomes made from alkylphosphocholines