Increased Tie2 expression, enhanced response to angiopoietin-1, and dysregulated angiopoietin-2 expression in hemangioma-derived endothelial cells

American Journal of Pathology

Volumn 159, Issue 6, 2001, Pages 2271-2280

  Yu, Ying ^a   Varughese, Joyce ^a   Brown, Lawrence F ^b   Mulliken, John B ^a   Bischoff, Joyce ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN 2; MESSENGER RNA; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ANGIOGENESIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; GENE EXPRESSION; HEMANGIOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REGULATORY MECHANISM; TUMOR REGRESSION;

EID: 0035180453     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63077-5     Document Type: Article

References (44)

1. Cutaneous hemangiomas in premature and mature infants
2. Cutaneous vascular anomalies
3. Interferon-alpha-2a therapy for life-threatening hemangioma of infancy
4. Successful treatment of infantile hemangioma with interferon-alpha-2b
5. Spastic diplegia is a complication of interferon-alpha 2a treatment of hemangiomas of infancy
6. An update on the treatment of hemangiomas in children with interferon alfa-2a
7. Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas
8. Infantile (juvenile) capillary hemangioma: A tumor of heterogenous cellular elements
9. Cellular markers that distinguish the phases of hemangioma during infancy and childhood
10. Proliferative hemangiomas: Analysis of cytokine gene expression and angiogenesis
11. Human endothelial cells express CCR2 and respond to MCP-1: Direct role of MCP-1 in angiogenesis and tumor progression
12. Monocyte chemoattractant protein-1 RNA expression in hemangiomas and vascular malformations
13. Expression of VE (vascular endothelial)-cadherin and other endothelial-specific markers in hemangiomas
14. E-selectin is present in proliferating endothelial cells in human hemangiomas
15. ICAM-3 and E-selectin endothelial expression differentiate two phases of angiogenesis in infantile hemangioma
16. Changes in matrix composition during the growth and regression of human hemangiomas
17. Cellular and extracellular markers of hemangioma
18. Progressive growth of infantile cutaneous hemangiomas is directly correlated with hyperplasia and angiogenesis of adjacent epidermis and inversely correlated with expression of endogenous angiogenesis inhibitor, IFN-beta
19. Clonality and altered behavior of endothelial cells from hemangiomas
20. Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins and ephrins in vascular development
21. A simplified method for growth of human microvascular endothelial cells results in decreased senescence and continued responsiveness to cytokines and growth factors
22. Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2
23. Hypoxia and vascular endothelial growth factor selectively up-regulate angiopoietin-2 in bovine microvascular endothelial cells
24. Genomic sequencing
25. Identification of Tek/Tie2 binding partners
26. Reappearance of an embryonic pattern of fibronectin splicing during wound healing in the adult rat
27. Vascular permeability factor RNA and protein expression in human kidney
28. Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract
29. Expression of Tie1, Tie2, and angiopoietins 1, 2, and 4 in Kaposi's sarcoma and cutaneous angiosarcoma
30. Regulation of angiopoietin-2 RNA levels in bovine microvascular endothelial cells by cytokines and hypoxia
31. Tek/Tie2 signaling: New and old partners
32. Tie2 receptor expression is stimulated by hypoxia and pro-inflammatory cytokines in human endothelial cells
33. Expression of angiopoietin-2 by human endometrial endothelial cells: Regulation by hypoxia and inflammation
34. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
35. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
36. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
37. Increased vascularization in overexpressing angiopoietin-1
38. Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth
39. Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2
40. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
41. Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3-kinase/Akt signal transduction pathway
42. Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis
43. Biologic significance of angiopoietin-2 expression in human hepatocellular carcinoma