CLAC binds to amyloid β peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils

Journal of Biological Chemistry

Volumn 280, Issue 9, 2005, Pages 8596-8605

  Osada, Yoshihide ^a   Hashimoto, Tadafumi ^a   Nishimura, Akiko ^a   Matsuo, Yuko ^a   Wakabayashi, Tomoko ^a   Iwatsubo, Takeshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOLOGICAL MEMBRANES; BRAIN; CELLS; DISEASES; PATIENT TREATMENT;

ALZHEIMER'S DISEASE; COLLAGENOUS ALZHEIMER AMYLOID PLAQUE COMPONENT (CLAC); MEMBRANE-BOUND COLLAGEN; SENILE PLAQUES;

COLLAGEN;

AMINO ACID; AMYLOID; AMYLOID BETA PROTEIN; COLLAGEN; COLLAGENOUS ALZHEIMER AMYLOID PLAQUE COMPONENT; PROTEIN PRECURSOR; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; ELECTROCHEMISTRY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; CELL LINE; COLLAGEN; CULTURE MEDIA, CONDITIONED; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROSTATICS; HEPARIN; HUMANS; IMMUNOBLOTTING; MICROSCOPY, ELECTRON; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; NON-FIBRILLAR COLLAGENS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM CHLORIDE; SPECTROMETRY, FLUORESCENCE; TEMPERATURE; THIAZOLES; TIME FACTORS; TRANSFECTION; TRYPSIN;

EID: 14844335677     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M413340200     Document Type: Article

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