Chronic testosterone treatment induces selective insulin resistance in subcutaneous adipocytes of women

Journal of Endocrinology

Volumn 192, Issue 3, 2007, Pages 585-594

  Corbould, Anne ^a  

^a MONASH MEDICAL CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; CYPROTERONE ACETATE; FLUTAMIDE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE C ZETA; TESTOSTERONE;

ADIPOSE TISSUE CELL; ADULT; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; HYPERANDROGENISM; IN VITRO STUDY; INSULIN RESISTANCE; METABOLIC PARAMETERS; NORMAL HUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SUBCUTANEOUS FAT;

ADIPOCYTES; ADULT; ANALYSIS OF VARIANCE; BIOLOGICAL TRANSPORT; CELL DIFFERENTIATION; CELLS, CULTURED; CYPROTERONE ACETATE; FEMALE; FLUTAMIDE; GLUCOSE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; PHOSPHOPROTEINS; PHOSPHORYLATION; POLYCYSTIC OVARY SYNDROME; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SUBCUTANEOUS FAT; TESTOSTERONE;

EID: 33947416676     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.1.07070     Document Type: Article

References (52)

1. Abel ED, Peroni O, Kim JK, Kim Y-B, Boss O, Hadro E, Minnemann T, Shulman GI & Kahn BB 2001 Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature 409 729-733.
2. Anderson LA, McTernan PG, Harte AL, Barnett AH & Kumar S 2002 The regulation of HSL and LPL expression by DHT and flutamide in human subcutaneous adipose tissue. Diabetes, Obesity and Metabolism 4 209-213.
3. Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert ML, Quon MJ, Lea-Currie R, Sen A & Farese RV 2002 PKC-ζ mediated insulin effects on glucose transport in cultured preadipocyte-derived human adipocytes. Journal of Clinical Endocrinology and Metabolism 87 716-723.
4. 3 is defective in muscle in type 2 diabetes and impaired glucose tolerance. Amelioration by rosiglitazone and exercise. Diabetes 52 1926-1934.
5. Chen CH, Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert M, Farese RV Jr & Farese RV 2002 Activation of the ERK pathway and atypical protein kinase C isoforms in exercise and aminoimidazole-4-carboxaniide-1-β-D- riboside (AICAR,)-stimulated glucose transport. Journal of Biological Chemisty 277 23554-23562.
6. Ciaraldi TP el-Roeiy A, Madar Z, Reichart D, Olefsky JM & Yen SS 1992 Cellular mechanisms of insulin resistance in polycystic ovarian syndrome. Journal of Clinical Endocrinology and Metabolism 75 577-583.
7. Ciaraldi TP, Abrams L, Nikoulina S, Mudaliar S & Henry RR 1995 Glucose transport in cultured human skeletal muscle cells. Regulation by insulin and glucose in nondiabetic and non-insulin-dependent diabetes mellitus subjects. Journal of Clinical Investigation 96 2820-2827.
8. Clyne CD, Speed CJ, Zhou J & Simpson ER 2002 Liver receptor homologue-1 (LRH-1) regulated expression of aromatase in preadipocytes. Journal of Biological Chemistry 277 20591-20597.
9. Cobb MH 1999 MAP kinase pathways. Progress in Biophysics and Molecular Biology 71 479-500.
10. Corbould A, Kim Y-B, Youngren JF, Pender C, Kahn BB, Lee A & Dunaif A 2005 Insulin resistance in the skeletal muscle of women with polycystic ovary syndrome involves both intrinsic and acquired defects in insulin signaling. American Journal of Physiology, Endocrinology and Metabolism 288 1047-1054.
11. Corbould A, Zhao H, Mirzoeva S, Aird F & Dunaif A 2006 Enhanced mitogenic signaling in skeletal muscle of women with polycystic ovary syndrome. Diabetes 55 751-759.
12. Coviello AD, Legro RS & Dunaif A 2006 Adolescent girls with polycystic ovary syndrome have an increased risk of the metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance. Journal of Clinical Endocrinology and Metabolism 91 492-497.
13. Dahlgren E, Landin K, Krotkiewski M, Holm G & Janson PO 1998 Effects of two anti-androgen treatments on hirsutism and insulin sensitivity on women with polycystic ovary syndrome. Human Reproduction 13 2706-2711.
14. Deslypere JP, Verdonck L & Vermeulen A 1985 Fat tissue: a steroid reservoir and site ofsteroid metabohsm.journal ofClinical Endocrinology and Metabolism 61 564-570.
15. Dicker A, Rydén M, Näslund E, Muehlen IE, Wirén M, Lafontan M & Artier P 2004 Effect of testosterone on lipolysis in human pre-adipocytes from different fat depots. Diabetologia 47 420-428.
16. Dieudonné MN, Pecquery R, Boumediene A, Leneveu MC & Giudicells Y 1998 Androgen receptors in human preadipocytes and adipocytes: regional specificities and regulation by sex steroids. American Journal of Physiology 274 C1645-C1652.
17. Dieudonné MN, Pecquery R, Leneveu MC & Giudicelli Y 2000 Opposite effects of androgens and estrogens on adipogenesis in rat preadipocytes: evidence for sex and site-related specificities and possible involvement of insulin-like growth factor 1 receptor and peroxisome, proliferator-activated receptor γ2. Endocrinology 141 649-656.
18. Dunaif A 1997 Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocrine Reviews 18 774-800.
19. Dunaif A, Green G, Futterweit W & Dobrjansky A 1990 Suppression of hyperandrogenism does not improve peripheral or hepatic insulin resistance in the polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 70 699-704.
20. Dunaif A, Segal KR, Shelley DR, Green G, Dobdansky A & Licholai T 1992 Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome. Diabetes 41 1257-1266.
21. Dunaif A, Wu X, Lee A & Diamanti-Kandarakis E 2001 Defects in insulin receptor signaling in vivo in the polycystic ovary syndrome (PCOS). American Journal of Physiology, Endocrinology and Metabolism 281 E392-E399.
22. Eisner JR, Durnesic DA, Kemnitz JW, Colman RJ & Abbott DH 2003 Increased adiposity in female rhesus monkeys exposed to androgen excess during early gestation. Obesity Research 11 279-286.
23. 632 in a human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells. Endocrinology 142 2833-2840.
24. Farese RV Sajan MP & Standaert ML 2005 Atypical protein kinase C in insulin action and insulin resistance. Biochemistry Society Transactions 33 350-353.
25. Goodyear LJ, Giorgio F, Sherman LA, Carey J, Smith JR & Dohm GL 1995 Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact muscle strips from obese subjects. Journal of Clinical Investigation 95 2195-2204.
26. Hauner H, Rohrig K, Spelleken M, Lui LS & Eckel J 1998 Development of insulin-responsive glucose uptake and GLUT4 expression in differentiating human adipocyte precursor cells. International Journal of Obesity 22 448-453.
27. Holmäng A, Larsson BM, Brzezinska Z & Bjorntorp P 1992 Effects of short-term testosterone exposure on insulin sensitivity of muscles in female rats. American Journal of Physiology 262 E851-E855.
28. Ishike M & Khp A 2005 Minireview: recent developments in the regulation of glucose transporter-4 traffic: new signals, locations, and partners. Endocrinology 146 5071-5078.
29. Korytkowski MT, Krug EI, Daly MA, DePiso L, Wilson JW & Winters SJ 2005 Does androgen excess contribute to the cardiovascular risk profile in postmenopausal women with type 2 diabetes? Metabolism 54 1626-1631.
30. Lasco A, Cucinotta D, Gigante A, Denuzzo G, Pedulla M, Trifiletti A & Frisina N 1995 No changes in peripheral insulin resistance in polycystic ovary syndrome after long-term reduction of endogenous androgens with leuprolide. European Journal of Endocrinology 133 718-722.
31. Luna V Casauban L, Sagan MP, Gomez-Daspet J, Powe JL, Miara A, Rivas J, Standaert ML & Farese RV 2006 Metformin improves atypical protein kinase C activation by insulin and phosphatidylinolistol-3,4,5-(PO4)3 in muscle of diabetic subjects. Diabetologia 49 375-382.
32. Marsden PJ, Murdoch A & Taylor R 1994 Severe impairment of insulin action in adipocytes from amenorrheic subjects with polycystic ovary syndrome. Metabolism 43 1536-1542.
33. Martel C, Melner MH, Gagne D, Simard J & Labrie F 1994 Widespread tissue distribution of steroid sulfitase, 3 beta-hydroxysteroid dehydrogenase/ delta 5-delta 4 isomerase (3 beta-HSD), 17 beta-HSD, 5 alpha-reductase and aromatase activities in the rhesus monkey. Molecular and Cellular Endocrinology 104 103-111.
34. Minokoshi Y, Kahn CR & Kahn BB 2003 Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis. Journal of Biological Chemistry 278 33609-33612.
35. Moghetti P, Tosi F, Castello R, Magnam CM, Negir C, Brun E, Furlani L, Caputo M & Muggeo M 1996 The insulin resistance in women with hyperandrogenism is partially reversed by antiandrogen treatment. Journal of Clinical Endocrinology and Metabolism 81 952-960.
36. Nelson VL, Legro RS, Strauss JF III & McAllister JM 1999 Augmented androgen production is a stable stemidogenic phenotype of propagated theca cells from polycystic ovaries. Molecular Endocrinology 13 946-957.
37. Nesder JE, Jakubowicz DJ, Falcon de Vargas A, Brik C, Quintero N & Medina F 1998 Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system. Journal of Clinical Endocrinology and Metabolism 83 2001-2005.
38. Oh JY, Barrett-Connor E, Wedick NM & Wingard DL 2W2 Endogenous sex hormones and the development of type 2 diabetes in older men and women: the Rancho Bernardo study. Diabetes Care 25 55-60.
39. Pedersen SB, Fuglsig S, Sjogren P & Richelsen B 1996 Identification of steroid receptors in human adipose tissue. European Journal of Clinical Investigation 26 1051-1056.
40. Reiling BA, Drackley JK, Grum LR & Berger LL 1997 Effects of prenatal androgenization and lactation on adipose metabolism in finishing single-calf heifers. Journal of Animal Science 75 1504-1513.
41. Reinecke H, Bogdanski J, Woltering A, Breithardt G, Assmann G, Kerber S & von Eckardstein A 2002 Relation of serum levels of sex hormone binding globulin to coronary heart disease in postmenopausal women. American Journal of Cardiology 90 364-368.
42. Rodbell NMJ 1964 Metabolism of isolated fat cells. Journal of Biological Chemistry 239 375-380.
43. Ruderman NB, Saba AK & Kraegen EW 2003 Minireview: malonyl CoA, AMP-activated protein kinase and adiposity Endocrinology 144 5166-5171.
44. Saygili F, Oge A & Yilmaz C 2005 Hyperinsulinemia and insulin insensitivity in women with nonclassical congenital adrenal hyperplasia due to 21-hydroxylase deficiency: the relationship between serum leptin levels and chronic hyperinsulenemia. Hormone Research 63 270-274.
45. Simioncini T & Genazzani AR. 2003 Non-genomic actions of sex steroids. European Journal of Endocrinology 148 281-292.
46. Singh R., Artaza JN, Taylor WE, Braga M, Yuan X, Gonzalez-Cadavid NF & Bhasin S 2006 Testosterone inhibits adipagenic dif[erentiation in 3T3-LI cells: nuclear translocation of androgen receptor complex with β-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors. Endocrinology 147 141-154.
47. Smith PJ, Wise LS, Berkowitz R, Wan C & Rubin CS 1988 Insulin-like growth factor-1 is an essential regulator of the differentiation of 3T3-L1 adipocytes. Journal of Biological Chemistry 263 9402-9408.
48. Smith U, Axelsen M, Carvalho E, Eliasson B, Jansson PA & Wesslau C 1999 Insulin signalling and action in fat cells: associations with insulin resistance and type 2 diabetes. Annals of the New York Academy of Sciences 892 119-126.
49. Speiser PW, Serrat J, New MI & Gertner JM 1992 Insulin insensitivity in adrenal hyperplasia due to nonclassic steroid 21-hydroxylase deficiency. Journal of Clinical Endocrinology and Metabolism 75 1421-1424.
50. Stolic M, Russell A, Hutley L, Fielding G, Hay J, MacDonald G, Whitehead J & Prins J 2002 Glucose uptake and insulin action in human adipose tissue - influence of BMI, anatomical depot and body fat distribution. International Journal of Obesity 26 17-23.
51. White MF & Yenush L 1998 The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action. Current Topics in Microbiology and Immunology 228 179-208.
52. Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L & Kahn BB 2005 Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 436 356-362.