메뉴 건너뛰기




Volumn 81, Issue 3, 1996, Pages 952-960

The insulin resistance in women with hyperandrogenism is partially reversed by antiandrogen treatment: Evidence that androgens impair insulin action in women

Author keywords

[No Author keywords available]

Indexed keywords

ANTIANDROGEN; BUSERELIN; FLUTAMIDE; GLUCOSE; GONADORELIN AGONIST; INSULIN; SPIRONOLACTONE;

EID: 0029863959     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.3.952     Document Type: Article
Times cited : (226)

References (76)
  • 1
    • 0026061628 scopus 로고
    • On the paradox of insulin-induced hyperandrogenism in insulin-resistant states
    • Poretsky L. 1991 On the paradox of insulin-induced hyperandrogenism in insulin-resistant states. Endocr Rev. 12:3-13.
    • (1991) Endocr Rev , vol.12 , pp. 3-13
    • Poretsky, L.1
  • 2
    • 0020454343 scopus 로고
    • Insulin resistance associated with androgen excess in women with autoantibodies to the insulin receptor
    • Taylor SI, Dons RF, Hernandez E, Roth J, Gorden P. 1982 Insulin resistance associated with androgen excess in women with autoantibodies to the insulin receptor. Ann Intern Med. 97:851-855.
    • (1982) Ann Intern Med , vol.97 , pp. 851-855
    • Taylor, S.I.1    Dons, R.F.2    Hernandez, E.3    Roth, J.4    Gorden, P.5
  • 3
    • 0022386164 scopus 로고
    • Obesity, acanthosis nigricans, insulin resistance, and hyperandrogenemia: Pediatric perspective and natural history
    • Richards GE, Cavallo A, Meyer III WJ, et al. 1985 Obesity, acanthosis nigricans, insulin resistance, and hyperandrogenemia: pediatric perspective and natural history. J Pediatr. 107:893-897.
    • (1985) J Pediatr , vol.107 , pp. 893-897
    • Richards, G.E.1    Cavallo, A.2    Meyer III, W.J.3
  • 4
    • 0022647650 scopus 로고
    • Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism
    • Barbieri RL, Makris A, Randall RW, Daniels G, Kistner RW, Ryan KJ. 1986 Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism. J Clin Endocrinol Metab. 62:904-910.
    • (1986) J Clin Endocrinol Metab , vol.62 , pp. 904-910
    • Barbieri, R.L.1    Makris, A.2    Randall, R.W.3    Daniels, G.4    Kistner, R.W.5    Ryan, K.J.6
  • 5
    • 0023876249 scopus 로고
    • Selective insulin action on skin, ovary, and heart in insulin-resistant states
    • Geffner ME, Golde DW. 1988 Selective insulin action on skin, ovary, and heart in insulin-resistant states. Diabetes Care. 11:500-505.
    • (1988) Diabetes Care , vol.11 , pp. 500-505
    • Geffner, M.E.1    Golde, D.W.2
  • 6
    • 0024381472 scopus 로고
    • Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome
    • Nestler JE, Barlascini CO, Matt DW, et al. 1989 Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome. J Clin Endocrinol Metab. 68:1027-1032.
    • (1989) J Clin Endocrinol Metab , vol.68 , pp. 1027-1032
    • Nestler, J.E.1    Barlascini, C.O.2    Matt, D.W.3
  • 7
    • 0025744602 scopus 로고
    • Insulin resistance and hyperinsulinemia induce hyperandrogenism in a young type B insulin-resistant female
    • DeClue TJ, Shah SC, Marchese M, Malone JI. 1991 Insulin resistance and hyperinsulinemia induce hyperandrogenism in a young type B insulin-resistant female. J Clin Endocrinol Metab. 72:1308-1311.
    • (1991) J Clin Endocrinol Metab , vol.72 , pp. 1308-1311
    • DeClue, T.J.1    Shah, S.C.2    Marchese, M.3    Malone, J.I.4
  • 8
    • 0028315971 scopus 로고
    • Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy
    • Velazquez EM, Mendoza S, Hamer T, Sosa F, Glueck CJ. 1994 Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy. Metabolism. 43:647-654.
    • (1994) Metabolism , vol.43 , pp. 647-654
    • Velazquez, E.M.1    Mendoza, S.2    Hamer, T.3    Sosa, F.4    Glueck, C.J.5
  • 10
    • 0019759028 scopus 로고
    • Glucose intolerance and insulin resistance in aplastic anemia treated with oxymetholone
    • Woodard TL, Burghen GA, Kitabchi AE, Wilimas JA. 1981 Glucose intolerance and insulin resistance in aplastic anemia treated with oxymetholone. J Clin Endocrinol Metab. 53:915-918.
    • (1981) J Clin Endocrinol Metab , vol.53 , pp. 915-918
    • Woodard, T.L.1    Burghen, G.A.2    Kitabchi, A.E.3    Wilimas, J.A.4
  • 11
    • 0023204170 scopus 로고
    • Insulin resistance and diminished glucose tolerance powerlifters ingesting anabolic steroids
    • Cohen JC, Hickman R. 1987 Insulin resistance and diminished glucose tolerance powerlifters ingesting anabolic steroids. J Clin Endocrinol Metab. 64: 960-963.
    • (1987) J Clin Endocrinol Metab , vol.64 , pp. 960-963
    • Cohen, J.C.1    Hickman, R.2
  • 12
    • 0025095874 scopus 로고
    • Effects of testosterone on muscle insulin sensitivity and morphology in female rats
    • Holmang A, Svedberg J, Jennische E, Bjorntorp P. 1990 Effects of testosterone on muscle insulin sensitivity and morphology in female rats. Am J Physiol. 259:E555-E560.
    • (1990) Am J Physiol , vol.259
    • Holmang, A.1    Svedberg, J.2    Jennische, E.3    Bjorntorp, P.4
  • 13
    • 0026337840 scopus 로고
    • The relative contribution of androgens and insulin in determining abdominal body fat distribution in premenopausal women
    • Pasquali R, Casimirri F, Balestra V, et al. 1991 The relative contribution of androgens and insulin in determining abdominal body fat distribution in premenopausal women. J Endocrinol Invest. 14:839-846.
    • (1991) J Endocrinol Invest , vol.14 , pp. 839-846
    • Pasquali, R.1    Casimirri, F.2    Balestra, V.3
  • 16
    • 0023189131 scopus 로고
    • Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia
    • Dunaif A, Graf M, Mandeli J, Laumas V, A. Dobrjansky. 1987 Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia. J Clin Endocrinol Metab. 65:499-507.
    • (1987) J Clin Endocrinol Metab , vol.65 , pp. 499-507
    • Dunaif, A.1    Graf, M.2    Mandeli, J.3    Laumas, V.4    Dobrjansky, A.5
  • 17
    • 0022625803 scopus 로고
    • Persistence of insulin resistance in polycystic ovarian disease after inhibition of ovarian steroid secretion
    • Geffner ME, Kaplan SA, Bersch N, Golde DW, Landaw EM, Chang RJ. 1986 Persistence of insulin resistance in polycystic ovarian disease after inhibition of ovarian steroid secretion. Fertil Steril. 45:327-333.
    • (1986) Fertil Steril , vol.45 , pp. 327-333
    • Geffner, M.E.1    Kaplan, S.A.2    Bersch, N.3    Golde, D.W.4    Landaw, E.M.5    Chang, R.J.6
  • 18
    • 0025359669 scopus 로고
    • Suppression of hyperandrogenism does not improve peripheral or hepatic insulin resistance in the polycystic ovary syndrome
    • Dunaif A, Green G, Futterweit W, Dobrjansky A. 1990 Suppression of hyperandrogenism does not improve peripheral or hepatic insulin resistance in the polycystic ovary syndrome. J Clin Endocrinol Metab. 70:699-704.
    • (1990) J Clin Endocrinol Metab , vol.70 , pp. 699-704
    • Dunaif, A.1    Green, G.2    Futterweit, W.3    Dobrjansky, A.4
  • 19
    • 0026537626 scopus 로고
    • Persistence of hyperinsulinemia in polycystic ovary syndrome after ovarian suppression by gonadotropin-releasing hormone agonist
    • Copenh
    • Dale PO, Tanbo T, Djoseland O, Jervell J, Abyholm T. 1992 Persistence of hyperinsulinemia in polycystic ovary syndrome after ovarian suppression by gonadotropin-releasing hormone agonist. Acta Endocrinol (Copenh). 126:132-136.
    • (1992) Acta Endocrinol , vol.126 , pp. 132-136
    • Dale, P.O.1    Tanbo, T.2    Djoseland, O.3    Jervell, J.4    Abyholm, T.5
  • 20
    • 0027364407 scopus 로고
    • Insulin resistance improves in hyperandrogenic women treated with Lupron
    • Elkind-Hirsch KE, Valdes CT, Malinak LR. 1993 Insulin resistance improves in hyperandrogenic women treated with Lupron. Fertil Steril. 60:634-641.
    • (1993) Fertil Steril , vol.60 , pp. 634-641
    • Elkind-Hirsch, K.E.1    Valdes, C.T.2    Malinak, L.R.3
  • 21
    • 0021227222 scopus 로고
    • The influence of androgens on insulin resistance
    • Shoupe D, Lobo RA. 1984 The influence of androgens on insulin resistance. Fertil Steril. 41:385-388.
    • (1984) Fertil Steril , vol.41 , pp. 385-388
    • Shoupe, D.1    Lobo, R.A.2
  • 22
    • 0025936065 scopus 로고
    • Hirsutism: Metabolic effects of two commonly used oral contraceptives and spironolactone
    • Wild RA, Demers LM, Applebaum-Bowden D, Lenker R. 1991 Hirsutism: metabolic effects of two commonly used oral contraceptives and spironolactone. Contraception. 44:113-124.
    • (1991) Contraception , vol.44 , pp. 113-124
    • Wild, R.A.1    Demers, L.M.2    Applebaum-Bowden, D.3    Lenker, R.4
  • 23
    • 0025046185 scopus 로고
    • The effects of oral dehydroepiandrosterone on endocrine-metabolic parameters in postmenopausal women
    • Mortola JF, Yen SSC. 1990 The effects of oral dehydroepiandrosterone on endocrine-metabolic parameters in postmenopausal women. J Clin Endocrinol Metab. 71:696-704.
    • (1990) J Clin Endocrinol Metab , vol.71 , pp. 696-704
    • Mortola, J.F.1    Yen, S.S.C.2
  • 25
    • 0018520840 scopus 로고
    • Glucose clamp technique: A method for quantifying insulin secretion and resistance
    • DeFronzo RA, Tobin JD, Andres R. 1979 Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 237:E214-E223.
    • (1979) Am J Physiol , vol.237
    • DeFronzo, R.A.1    Tobin, J.D.2    Andres, R.3
  • 26
    • 4243278503 scopus 로고
    • Diabetes mellitus and polycystic ovary syndrome
    • Dunaif A, Givens JR, Haseltine FP, Merriam GR, eds. Boston: Blackwell
    • Dunaif A. 1992 Diabetes mellitus and polycystic ovary syndrome. In: Dunaif A, Givens JR, Haseltine FP, Merriam GR, eds. Current issues in endocrinology and metabolism: polycystic ovary syndrome. Boston: Blackwell; 347-358.
    • (1992) Current Issues in Endocrinology and Metabolism: Polycystic Ovary Syndrome , pp. 347-358
    • Dunaif, A.1
  • 27
    • 0018602014 scopus 로고
    • Classification and diagnosis of diabetes mellitus and other diagnostic categories of glucose intolerance
    • National Diabetes Data Group. 1979 Classification and diagnosis of diabetes mellitus and other diagnostic categories of glucose intolerance. Diabetes. 28: 1039-1057.
    • (1979) Diabetes , vol.28 , pp. 1039-1057
  • 28
    • 85040846451 scopus 로고
    • Diabetes mellitus
    • WHO Study Group. 1985 Diabetes mellitus. WHO Tech Rep Ser. 727:1-113.
    • (1985) WHO Tech Rep Ser , vol.727 , pp. 1-113
  • 29
    • 0014082786 scopus 로고
    • Testosterone and androstenedione production rates in normal women and women in idiopathic hirsutism or polycystic ovaries
    • Bardin CW, Lipsett MB. 1967 Testosterone and androstenedione production rates in normal women and women in idiopathic hirsutism or polycystic ovaries. J Clin Invest. 46:891-902.
    • (1967) J Clin Invest , vol.46 , pp. 891-902
    • Bardin, C.W.1    Lipsett, M.B.2
  • 32
    • 0027305072 scopus 로고
    • Gonadotropin-releasing hormone agonist as a probe for the pathogenesis and diagnosis of ovarian hyperandrogenism
    • Rosenfield RL, Ehrmann DA, Barnes RB, Sheikh Z. 1993 Gonadotropin-releasing hormone agonist as a probe for the pathogenesis and diagnosis of ovarian hyperandrogenism. Ann NY Acad Sci 687:162-181.
    • (1993) Ann NY Acad Sci , vol.687 , pp. 162-181
    • Rosenfield, R.L.1    Ehrmann, D.A.2    Barnes, R.B.3    Sheikh, Z.4
  • 35
    • 0024600102 scopus 로고
    • Estimates of in vivo insulin action in man: Comparison of insulin tolerance tests with euglycemic and hyperglycemic glucose clamp studies
    • Bonora E, Moghetti P, Zancanaro C, et al. 1989 Estimates of in vivo insulin action in man: comparison of insulin tolerance tests with euglycemic and hyperglycemic glucose clamp studies. J Clin Endocrinol Metab. 68:374-378.
    • (1989) J Clin Endocrinol Metab , vol.68 , pp. 374-378
    • Bonora, E.1    Moghetti, P.2    Zancanaro, C.3
  • 36
    • 0023930822 scopus 로고
    • The theoretical bases of indirect calorimetry: A review
    • Ferrannini E. 1988 The theoretical bases of indirect calorimetry: a review. Metabolism. 37:287-301.
    • (1988) Metabolism , vol.37 , pp. 287-301
    • Ferrannini, E.1
  • 37
    • 0024026298 scopus 로고
    • The triumvirate: β-cell, muscle, liver: A collusion responsible for NIDDM
    • DeFronzo RA. 1988 The triumvirate: β-cell, muscle, liver: a collusion responsible for NIDDM. Diabetes. 37:667-687.
    • (1988) Diabetes , vol.37 , pp. 667-687
    • DeFronzo, R.A.1
  • 39
    • 0001960537 scopus 로고
    • Determination of blood sugar
    • Somogyi M. 1945 Determination of blood sugar. J Biol Chem. 160:69-73.
    • (1945) J Biol Chem , vol.160 , pp. 69-73
    • Somogyi, M.1
  • 40
    • 77049274176 scopus 로고
    • Measurement of size and turnover rate of body glucose pool by the isotope dilution method
    • Steele R, Wall JS, DeBodo RC, Altszuler N. 1956 Measurement of size and turnover rate of body glucose pool by the isotope dilution method. Am J Physiol. 187:15-25.
    • (1956) Am J Physiol , vol.187 , pp. 15-25
    • Steele, R.1    Wall, J.S.2    DeBodo, R.C.3    Altszuler, N.4
  • 41
    • 0019175765 scopus 로고
    • Androgen receptor in rat skeletal muscle: Characterization and physiological variations
    • Michel G, Baulieu EE. 1980 Androgen receptor in rat skeletal muscle: characterization and physiological variations. Endocrinology. 107:2088-2098.
    • (1980) Endocrinology , vol.107 , pp. 2088-2098
    • Michel, G.1    Baulieu, E.E.2
  • 42
    • 0019951922 scopus 로고
    • Induction of insulin-dependent diabetes by streptozotocin: Inhibition by estrogens and potentiation by androgens
    • Paik S-G, Michelis MA, Kim YT, Shin S. 1982 Induction of insulin-dependent diabetes by streptozotocin: inhibition by estrogens and potentiation by androgens. Diabetes. 31:724-729.
    • (1982) Diabetes , vol.31 , pp. 724-729
    • Paik, S.-G.1    Michelis, M.A.2    Kim, Y.T.3    Shin, S.4
  • 43
    • 0020563854 scopus 로고
    • Relationship of androgenic activity to body fat topography, fat cell morphology and metabolic aberrations in premenopausal women
    • Evans DJ, Hoffmann RG, Kalkhoff RK, Kissebah AH. 1983 Relationship of androgenic activity to body fat topography, fat cell morphology and metabolic aberrations in premenopausal women. J Clin Endocrinol Metab. 57:304-310.
    • (1983) J Clin Endocrinol Metab , vol.57 , pp. 304-310
    • Evans, D.J.1    Hoffmann, R.G.2    Kalkhoff, R.K.3    Kissebah, A.H.4
  • 44
    • 0021014504 scopus 로고
    • Impact of obesity on metabolism in men and women: Importance of regional adipose tissue distribution
    • Krotkiewski M, Bjorntorp P, Sjostrom L, Smith U. 1983 Impact of obesity on metabolism in men and women: importance of regional adipose tissue distribution. J Clin Invest. 72:1150-1162.
    • (1983) J Clin Invest , vol.72 , pp. 1150-1162
    • Krotkiewski, M.1    Bjorntorp, P.2    Sjostrom, L.3    Smith, U.4
  • 45
    • 0021723041 scopus 로고
    • Sex and insulin sensitivity
    • Yki-Jarvinen H. 1984 Sex and insulin sensitivity. Metabolism. 33:1011-1015.
    • (1984) Metabolism , vol.33 , pp. 1011-1015
    • Yki-Jarvinen, H.1
  • 46
    • 0025062622 scopus 로고
    • The effects of androgens on the regulation of lipolysis in adipose precursor cells
    • Xu X, De Pergola G, Bjorntorp P. 1990 The effects of androgens on the regulation of lipolysis in adipose precursor cells. Endocrinology. 126:1229-1234.
    • (1990) Endocrinology , vol.126 , pp. 1229-1234
    • Xu, X.1    De Pergola, G.2    Bjorntorp, P.3
  • 47
    • 0025748673 scopus 로고
    • Metabolic implications of body fat distribution
    • Bjorntorp P. 1991 Metabolic implications of body fat distribution. Diabetes Care. 14:1132-1143.
    • (1991) Diabetes Care , vol.14 , pp. 1132-1143
    • Bjorntorp, P.1
  • 48
    • 0026502231 scopus 로고
    • Sequence of changes in body composition induced by testosterone and reversal of changes after drug is stopped
    • Forbes GB, Porta CR, Herr BE, Griggs RC. 1992 Sequence of changes in body composition induced by testosterone and reversal of changes after drug is stopped. JAMA. 267:397-399.
    • (1992) JAMA , vol.267 , pp. 397-399
    • Forbes, G.B.1    Porta, C.R.2    Herr, B.E.3    Griggs, R.C.4
  • 49
    • 0027474155 scopus 로고
    • Female sex hormones, perinatal, and peripubertal androgenization on hepatocyte insulin dynamics in rats
    • Krakower GR, Meier DA, Kissebah AH. 1993 Female sex hormones, perinatal, and peripubertal androgenization on hepatocyte insulin dynamics in rats. Am J Physiol. 264:E342-E347.
    • (1993) Am J Physiol , vol.264
    • Krakower, G.R.1    Meier, D.A.2    Kissebah, A.H.3
  • 50
    • 0023838538 scopus 로고
    • Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensitivity in normal men
    • Nestler JE, Barlascini CO, Clore JN, Blackard WG. 1988 Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensitivity in normal men. J Clin Endocrinol Metab. 66:57-61.
    • (1988) J Clin Endocrinol Metab , vol.66 , pp. 57-61
    • Nestler, J.E.1    Barlascini, C.O.2    Clore, J.N.3    Blackard, W.G.4
  • 51
    • 0024584149 scopus 로고
    • The administration of pharmacological doses of testosterone or 19-nortestosterone to normal men is not associated with increased insulin secretion or impaired glucose tolerance
    • Friedl KE, Jones RE, Hannan CJ, Plymate SR. 1989 The administration of pharmacological doses of testosterone or 19-nortestosterone to normal men is not associated with increased insulin secretion or impaired glucose tolerance. J Clin Endocrinol Metab. 68:971-975.
    • (1989) J Clin Endocrinol Metab , vol.68 , pp. 971-975
    • Friedl, K.E.1    Jones, R.E.2    Hannan, C.J.3    Plymate, S.R.4
  • 52
    • 0022361971 scopus 로고
    • Assessment of insulin sensitivity in vivo
    • Bergman RN, Finegood DT, Ader M. 1985 Assessment of insulin sensitivity in vivo. Endocr Rev. 6:45-86.
    • (1985) Endocr Rev , vol.6 , pp. 45-86
    • Bergman, R.N.1    Finegood, D.T.2    Ader, M.3
  • 53
    • 0021824829 scopus 로고
    • Treatment of hirsutism with spironolactone
    • Givens JR. 1985 Treatment of hirsutism with spironolactone. Fertil Steril. 43:841-843.
    • (1985) Fertil Steril , vol.43 , pp. 841-843
    • Givens, J.R.1
  • 54
    • 0027725062 scopus 로고
    • Hirsutism and the effectiveness of spironolactone in its management
    • McMullen GR, Van Herle AJ. 1993 Hirsutism and the effectiveness of spironolactone in its management. J Endocrinol Invest. 16:925-932.
    • (1993) J Endocrinol Invest , vol.16 , pp. 925-932
    • McMullen, G.R.1    Van Herle, A.J.2
  • 55
    • 0028140279 scopus 로고
    • Comparison of flutamide and spironolactone in the treatment of hirsutism: A randomized controlled trial
    • Cusan L, Dupont A, Gomez JL, Tremblay RR, Labrie F. 1994 Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial. Fertil Steril. 61:281-287.
    • (1994) Fertil Steril , vol.61 , pp. 281-287
    • Cusan, L.1    Dupont, A.2    Gomez, J.L.3    Tremblay, R.R.4    Labrie, F.5
  • 56
    • 0023228346 scopus 로고
    • Inhibition of rat testicular 17α-hydroxylase and 17,20-lyase activities by anti-androgens (flutamide, hydroxyflutamide, RU23908, cyproterone acetate) in vitro
    • Ayub M, Levell MJ. 1987 Inhibition of rat testicular 17α-hydroxylase and 17,20-lyase activities by anti-androgens (flutamide, hydroxyflutamide, RU23908, cyproterone acetate) in vitro. J Steroid Biochem. 28:43-47.
    • (1987) J Steroid Biochem , vol.28 , pp. 43-47
    • Ayub, M.1    Levell, M.J.2
  • 57
    • 0023551136 scopus 로고
    • Effects of flutamide and aminoglutethimide on plasma 5α-reduced steroid glucuronide concentrations in castrated patients with cancer of the prostate
    • Brochu M, Belanger A, Dupont A, Cusan L, Labrie F. 1987 Effects of flutamide and aminoglutethimide on plasma 5α-reduced steroid glucuronide concentrations in castrated patients with cancer of the prostate. J Steroid Biochem. 28:619-622.
    • (1987) J Steroid Biochem , vol.28 , pp. 619-622
    • Brochu, M.1    Belanger, A.2    Dupont, A.3    Cusan, L.4    Labrie, F.5
  • 58
    • 0029088813 scopus 로고
    • Flutamide in the treatment of hirsutism: Long-term clinical effects, endocrine changes and androgen receptor behavior
    • Moghetti P, Castello R, Negri C, et al. 1995 Flutamide in the treatment of hirsutism: long-term clinical effects, endocrine changes and androgen receptor behavior. Fertil Steril. 64:511-517.
    • (1995) Fertil Steril , vol.64 , pp. 511-517
    • Moghetti, P.1    Castello, R.2    Negri, C.3
  • 59
    • 0027166066 scopus 로고
    • Use of gonadotropin-releasing hormone agonists in the treatment of hyperandrogenism
    • Rittmaster RS. 1993 Use of gonadotropin-releasing hormone agonists in the treatment of hyperandrogenism. Clin Obstet Gynecol. 36:679-689.
    • (1993) Clin Obstet Gynecol , vol.36 , pp. 679-689
    • Rittmaster, R.S.1
  • 60
    • 0023797278 scopus 로고
    • GnRH agonists and antagonists: A review of their current status
    • Filicori M, Flamigni C. 1988 GnRH agonists and antagonists: a review of their current status. Drugs. 35:63-82.
    • (1988) Drugs , vol.35 , pp. 63-82
    • Filicori, M.1    Flamigni, C.2
  • 61
    • 0024437305 scopus 로고
    • Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome
    • Dunaif A, Segal KR, Futterweit W, Dobrjansky A. 1989 Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes. 38:1165-1174.
    • (1989) Diabetes , vol.38 , pp. 1165-1174
    • Dunaif, A.1    Segal, K.R.2    Futterweit, W.3    Dobrjansky, A.4
  • 62
    • 0024516869 scopus 로고
    • The relative contributions of hepatic and peripheral tissues to insulin resistance in hyperandrogenic women
    • Peiris AN, Aiman EJ, Drucker WD, A. H. Kissebah. 1989 The relative contributions of hepatic and peripheral tissues to insulin resistance in hyperandrogenic women. J Clin Endocrinol Metab. 68:715-720.
    • (1989) J Clin Endocrinol Metab , vol.68 , pp. 715-720
    • Peiris, A.N.1    Aiman, E.J.2    Drucker, W.D.3    Kissebah, A.H.4
  • 65
    • 0026547429 scopus 로고
    • Interrelation between plasma testosterone and plasma insulin in healthy adult men: The Telecom study
    • Simon D, Preziosi P, Barret-Connor E, et al. 1992 Interrelation between plasma testosterone and plasma insulin in healthy adult men: the Telecom study. Diabetologia. 35:173-177.
    • (1992) Diabetologia , vol.35 , pp. 173-177
    • Simon, D.1    Preziosi, P.2    Barret-Connor, E.3
  • 66
    • 0028057563 scopus 로고
    • Insulin resistance, body fat distribution, and sex hormones in men
    • Haffner SM, Karhapaa P, Mykkanen L, M. Laakso. 1994 Insulin resistance, body fat distribution, and sex hormones in men. Diabetes. 43:212-219.
    • (1994) Diabetes , vol.43 , pp. 212-219
    • Haffner, S.M.1    Karhapaa, P.2    Mykkanen, L.3    Laakso, M.4
  • 67
    • 0026699302 scopus 로고
    • Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary sindrome
    • Dunaif A, Segal KR, Shelley DR, Green G, Dobrjansky A, Licholai T. 1992 Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary sindrome. Diabetes. 41:1257-1266.
    • (1992) Diabetes , vol.41 , pp. 1257-1266
    • Dunaif, A.1    Segal, K.R.2    Shelley, D.R.3    Green, G.4    Dobrjansky, A.5    Licholai, T.6
  • 68
    • 0023280188 scopus 로고
    • Evidence for insulin resistance in nonobese patients with polycystic ovarian disease
    • Jialal I, Naiker P, Reddi K, Moodley J, Joubert SM. 1987 Evidence for insulin resistance in nonobese patients with polycystic ovarian disease. J Clin Endocrinol Metab. 64:1066-1069.
    • (1987) J Clin Endocrinol Metab , vol.64 , pp. 1066-1069
    • Jialal, I.1    Naiker, P.2    Reddi, K.3    Moodley, J.4    Joubert, S.M.5
  • 69
    • 0027212609 scopus 로고
    • Roles of LH and insulin resistance in lean and obese polycystic ovary syndrome
    • Oxf
    • Grulet H, Hecart AC, Delemer B, et al. 1993 Roles of LH and insulin resistance in lean and obese polycystic ovary syndrome. Clin Endocrinol (Oxf). 38:621-626.
    • (1993) Clin Endocrinol , vol.38 , pp. 621-626
    • Grulet, H.1    Hecart, A.C.2    Delemer, B.3
  • 70
    • 0026647068 scopus 로고
    • Postprandial termogenesis is reduced in polycystic ovary syndrome and is associated with increased insulin resistance
    • Oxf
    • Robinson S, Chan S-P, Spacey S, Anyaoku V, Johnston DG, Franks S. 1992 Postprandial termogenesis is reduced in polycystic ovary syndrome and is associated with increased insulin resistance. Clin Endocrinol (Oxf). 36:537-543.
    • (1992) Clin Endocrinol , vol.36 , pp. 537-543
    • Robinson, S.1    Chan, S.-P.2    Spacey, S.3    Anyaoku, V.4    Johnston, D.G.5    Franks, S.6
  • 71
    • 0027301374 scopus 로고
    • The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries
    • Oxf
    • Robinson S, Kiddy D, Gelding SV, et al. 1993 The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries. Clin Endocrinol (Oxf). 39:351-355.
    • (1993) Clin Endocrinol , vol.39 , pp. 351-355
    • Robinson, S.1    Kiddy, D.2    Gelding, S.V.3
  • 72
    • 0027131201 scopus 로고
    • Normal basal and insulin-stimulated fuel metabolism in lean women with polycystic ovary syndrome
    • Ovesen P, Moller J, Ingerslev HJ, et al. 1993 Normal basal and insulin-stimulated fuel metabolism in lean women with polycystic ovary syndrome. J Clin Endocrinol Metab. 77:1636-1640.
    • (1993) J Clin Endocrinol Metab , vol.77 , pp. 1636-1640
    • Ovesen, P.1    Moller, J.2    Ingerslev, H.J.3
  • 73
    • 0028345924 scopus 로고
    • Enhanced early insulin response to glucose in relation to insulin resistance in women with polycystic ovary syndrome and normal glucose tolerance
    • Holte J, Bergh T, Berne C, Berglund L, Lithell H. 1994 Enhanced early insulin response to glucose in relation to insulin resistance in women with polycystic ovary syndrome and normal glucose tolerance. J Clin Endocrinol Metab. 78: 1052-1058.
    • (1994) J Clin Endocrinol Metab , vol.78 , pp. 1052-1058
    • Holte, J.1    Bergh, T.2    Berne, C.3    Berglund, L.4    Lithell, H.5
  • 74
    • 0025732777 scopus 로고
    • Clinical features and circulating gonadotropin, insulin, and androgen interactions in women with polycystic ovarian disease
    • Anttila L, Ying-Qing Ding MB, Ruutiainen K, Erkkola R, Irjala K, Huhtaniemi I. 1991 Clinical features and circulating gonadotropin, insulin, and androgen interactions in women with polycystic ovarian disease. Fertil Steril. 55:1057-1061.
    • (1991) Fertil Steril , vol.55 , pp. 1057-1061
    • Anttila, L.1    Ying-Qing Ding, M.B.2    Ruutiainen, K.3    Erkkola, R.4    Irjala, K.5    Huhtaniemi, I.6
  • 75
    • 0027274710 scopus 로고
    • Ethnicity and polycystic ovary syndrome are associated with independent and additive decreases in insulin action in Caribbean-Hispanic women
    • Dunaif A, Sorbara L, Delson R, Green G. 1993 Ethnicity and polycystic ovary syndrome are associated with independent and additive decreases in insulin action in Caribbean-Hispanic women. Diabetes. 42:1462-1468.
    • (1993) Diabetes , vol.42 , pp. 1462-1468
    • Dunaif, A.1    Sorbara, L.2    Delson, R.3    Green, G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.