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Volumn 94, Issue 4, 2006, Pages 678-691

Modeling human physiology: The IUPS/EMBS Physiome Project

Author keywords

Computational biology; Computational physiology; Mathematical modeling; Physiome project

Indexed keywords

CELL CULTURE; COMPUTATIONAL METHODS; DATABASE SYSTEMS; LIVING SYSTEMS STUDIES; MATHEMATICAL MODELS; MEDICAL EDUCATION; PROJECT MANAGEMENT; PROTEINS;

EID: 33947365954     PISSN: 00189219     EISSN: None     Source Type: Journal    
DOI: 10.1109/JPROC.2006.871767     Document Type: Review
Times cited : (34)

References (83)
  • 1
    • 0034352177 scopus 로고    scopus 로고
    • Strategies for the Physiome Project
    • J. B. Bassingthwaighte, "Strategies for the Physiome Project," Ann. Biomed. Eng., vol. 28, no. 8, pp. 1043-1058, 2000.
    • (2000) Ann. Biomed. Eng , vol.28 , Issue.8 , pp. 1043-1058
    • Bassingthwaighte, J.B.1
  • 2
    • 3042716105 scopus 로고    scopus 로고
    • The computational integrated myocyte: A view into the heart
    • J. B. Bassingthwaighte and K. C. Vinnakota, "The computational integrated myocyte: A view into the heart," Ann. NY Acad. Sci., vol. 1015, no. 1, pp. 391-404, 2004.
    • (2004) Ann. NY Acad. Sci , vol.1015 , Issue.1 , pp. 391-404
    • Bassingthwaighte, J.B.1    Vinnakota, K.C.2
  • 4
    • 0037212568 scopus 로고    scopus 로고
    • Understanding complex signaling networks through models and metaphors
    • U. S. Bhalla, "Understanding complex signaling networks through models and metaphors," Prog. Biophys. Mol. Biol., vol. 81, pp. 45-65, 2003.
    • (2003) Prog. Biophys. Mol. Biol , vol.81 , pp. 45-65
    • Bhalla, U.S.1
  • 6
    • 33947394255 scopus 로고    scopus 로고
    • G. Bock and J. A. Goode, Integrative Biological Modeling in Silica: In In Silica Simulation of Biological Processes, G. Bock and J. Goode, Eds. New York: Wiley, 2002.
    • G. Bock and J. A. Goode, Integrative Biological Modeling in Silica: In "In Silica" Simulation of Biological Processes, G. Bock and J. Goode, Eds. New York: Wiley, 2002.
  • 7
    • 0036901602 scopus 로고    scopus 로고
    • Modeling transcriptional regulatory networks
    • H. Bolouri and E. H. Davidson, "Modeling transcriptional regulatory networks," Bioessays, vol. 24, pp. 1118-1129, 2002.
    • (2002) Bioessays , vol.24 , pp. 1118-1129
    • Bolouri, H.1    Davidson, E.H.2
  • 8
    • 0036843965 scopus 로고    scopus 로고
    • Gene networks: How to put the function in genomics
    • P. Brazhnik, A. de la Fuente, and P. Mendes, "Gene networks: How to put the function in genomics," Trends Bioteclmol., vol. 20, pp. 467-172, 2002.
    • (2002) Trends Bioteclmol , vol.20 , pp. 467-172
    • Brazhnik, P.1    de la Fuente, A.2    Mendes, P.3
  • 9
    • 18344396568 scopus 로고    scopus 로고
    • Minimum information about a microarray experiment (MIAME) - toward standards for microarray data
    • A. Brazma et al., "Minimum information about a microarray experiment (MIAME) - toward standards for microarray data," Nature Genetics, vol. 29, pp. 365-371, 2001.
    • (2001) Nature Genetics , vol.29 , pp. 365-371
    • Brazma, A.1
  • 10
    • 0031603269 scopus 로고    scopus 로고
    • Biological computation
    • London, U.K, Wiley
    • S. Brenner, "Biological computation," in The Limits of Reductionism in Biology. London, U.K.: Wiley, 1998, vol. 213, pp. 106-116.
    • (1998) The Limits of Reductionism in Biology , vol.213 , pp. 106-116
    • Brenner, S.1
  • 11
    • 4344633832 scopus 로고    scopus 로고
    • An anatomical model of the gastric system for producing bioelectric and biomagnetic fields
    • M. Buist, L. Cheng, R. Yassi, L. Bradshaw, W. Richards, and A. Pullan, "An anatomical model of the gastric system for producing bioelectric and biomagnetic fields," Physiol. Meas., vol. 25, no. 4, pp. 849-861, 2004.
    • (2004) Physiol. Meas , vol.25 , Issue.4 , pp. 849-861
    • Buist, M.1    Cheng, L.2    Yassi, R.3    Bradshaw, L.4    Richards, W.5    Pullan, A.6
  • 12
    • 0036973236 scopus 로고    scopus 로고
    • Torso coupling techniques for the forward problem of electrocardiology
    • M. Buist and A. J. Pullan, "Torso coupling techniques for the forward problem of electrocardiology," Ann. Biomed. Eng., vol. 30, no. 10, pp. 1299-1312, 2002.
    • (2002) Ann. Biomed. Eng , vol.30 , Issue.10 , pp. 1299-1312
    • Buist, M.1    Pullan, A.J.2
  • 13
    • 2442520661 scopus 로고    scopus 로고
    • Modeling RBC and neutrophil distribution through an anatomically based pulmonary capillary network
    • K. S. Burrowes, M. H. Tawhai, and P. J. Hunter, "Modeling RBC and neutrophil distribution through an anatomically based pulmonary capillary network," Ann. Biomed. Eng., vol. 32, no. 4, pp. 585-595, 2004.
    • (2004) Ann. Biomed. Eng , vol.32 , Issue.4 , pp. 585-595
    • Burrowes, K.S.1    Tawhai, M.H.2    Hunter, P.J.3
  • 14
    • 0037007814 scopus 로고    scopus 로고
    • MD simulations of a K channel model - sensitivity to changes in ions, waters and membrane environment
    • C. E. Capener and M. S. P. Sansom, "MD simulations of a K channel model - sensitivity to changes in ions, waters and membrane environment," J. Phys. Chem. B., vol. 106, pp. 4543-1551, 2002.
    • (2002) J. Phys. Chem. B , vol.106 , pp. 4543-1551
    • Capener, C.E.1    Sansom, M.S.P.2
  • 15
    • 0034123344 scopus 로고    scopus 로고
    • Homology modeling and molecular dynamics simulation studies of an inward rectifier potassium channel
    • C. E. Capener, I. H. K. Shrivastava, M. L. Ranatunga, R. Forrest, G. R. Smith, and M. S. P. Sansom, "Homology modeling and molecular dynamics simulation studies of an inward rectifier potassium channel," Biophys. J., vol. 78, pp. 2929-2942, 2000.
    • (2000) Biophys. J , vol.78 , pp. 2929-2942
    • Capener, C.E.1    Shrivastava, I.H.K.2    Ranatunga, M.L.3    Forrest, R.4    Smith, G.R.5    Sansom, M.S.P.6
  • 16
    • 0033527032 scopus 로고    scopus 로고
    • Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia
    • C. E. Clancy and Y. Rudy, "Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia," Nature, vol. 400, pp. 566-569, 1999.
    • (1999) Nature , vol.400 , pp. 566-569
    • Clancy, C.E.1    Rudy, Y.2
  • 17
    • 0037066036 scopus 로고    scopus 로고
    • + channel mutation that causes both Brugada and long-QT syndrome phenotypes: A simulation study of mechanism
    • 12
    • + channel mutation that causes both Brugada and long-QT syndrome phenotypes: A simulation study of mechanism," Circulation, vol. 105, no. 10, pp. 1208-1213, 2002, 12.
    • (2002) Circulation , vol.105 , Issue.10 , pp. 1208-1213
    • Clancy, C.E.1    Rudy, Y.2
  • 18
    • 85044706215 scopus 로고    scopus 로고
    • Evolution of a foundational model of physiology: Symbolic representation for functional bioinformatics
    • D. L. Cook, J. V. L. Mejino, and C. Rosse, "Evolution of a foundational model of physiology: Symbolic representation for functional bioinformatics," in Proc. MEDINFO 2004 vol. 11, pp. 336-340.
    • Proc. MEDINFO 2004 , vol.11 , pp. 336-340
    • Cook, D.L.1    Mejino, J.V.L.2    Rosse, C.3
  • 20
    • 16644395233 scopus 로고    scopus 로고
    • Multi-scale modeling and the IUPS Physiome Project
    • E. Crampin, N. Smith, and P. Hunter, "Multi-scale modeling and the IUPS Physiome Project," J. Mol. Histol., vol. 35, no. 7, pp. 707-714, 2004.
    • (2004) J. Mol. Histol , vol.35 , Issue.7 , pp. 707-714
    • Crampin, E.1    Smith, N.2    Hunter, P.3
  • 22
    • 33947376741 scopus 로고    scopus 로고
    • ExperiBase - An object model implementation for biology
    • Online, Available
    • F. C. Dewey, Jr, A. Downes, H. Chou, and S. Zhang, "ExperiBase - An object model implementation for biology," in 8th Annu. Bio-Ontologies Meeting (Program Booklet) 2005, pp. 31-32 [Online]. Available: http://bio-ontologies.man.ac.uk/download/bio-ontologies-2005-programme-booklet. pdf
    • (2005) 8th Annu. Bio-Ontologies Meeting (Program Booklet) , pp. 31-32
    • Dewey Jr, F.C.1    Downes, A.2    Chou, H.3    Zhang, S.4
  • 23
  • 24
    • 6044257795 scopus 로고    scopus 로고
    • Anatomically based geometric modeling of the musculo-skeletal system and other organs
    • J. Fernandez, P. Mithraratne, S. Thrupp, M. H. Tawhai, and P. J. Hunter, "Anatomically based geometric modeling of the musculo-skeletal system and other organs," Biomechan. Model Mechanobiol., vol. 2, no. 3, pp. 139-155, 2004.
    • (2004) Biomechan. Model Mechanobiol , vol.2 , Issue.3 , pp. 139-155
    • Fernandez, J.1    Mithraratne, P.2    Thrupp, S.3    Tawhai, M.H.4    Hunter, P.J.5
  • 25
    • 0034688174 scopus 로고    scopus 로고
    • Construction of a genetic toggle switch in Escherichia coli
    • T. S. Gardner, C. R. Cantor, and J. J. Collins, "Construction of a genetic toggle switch in Escherichia coli," Nature, vol. 403, pp. 339-342/2000.
    • (2000) Nature , vol.403 , pp. 339-342
    • Gardner, T.S.1    Cantor, C.R.2    Collins, J.J.3
  • 26
    • 0037079012 scopus 로고    scopus 로고
    • Engineered gene circuits
    • J. Hasty, D. McMillan, and J. J. Collins, "Engineered gene circuits," Nature, vol. 420, pp. 224-230, 2002.
    • (2002) Nature , vol.420 , pp. 224-230
    • Hasty, J.1    McMillan, D.2    Collins, J.J.3
  • 28
    • 35649001607 scopus 로고
    • A quantitative description of membrane current and its application to conductance and excitation in nerve
    • A. L. Hodgkin and A. F. Huxley, "A quantitative description of membrane current and its application to conductance and excitation in nerve," J. Physiol., vol. 117, pp. 500-544, 1952.
    • (1952) J. Physiol , vol.117 , pp. 500-544
    • Hodgkin, A.L.1    Huxley, A.F.2
  • 29
  • 31
    • 0037342537 scopus 로고    scopus 로고
    • M. Hucka, H. Bolouri, A. Finney, H. M. Sauro, J. C. Doyle, H. Kitano, A. P. Arkin, B. J. Bornstein, D. Bray, A. Cuellar, S. Dronov, M. Ginkel, V. Gor, I. I. Goryanin, W. Hedley, T. C. Hodgman, P. J. Hunter, N. S. Juty, J. L. Kasberger, A. Kremling, U. Kummer, N. LeNovere, L. M. Loew, D. Lucio, P. Mendes, E. D. Mjolsness, Y. Nakayama, M. R. Nelson, P. Nielsen, T. Sakurada, J. C. Schaff, B. E. Shapiro, T. S. Shimizu, H. D. Spence, J. Stelling, K. Takahashi, M. Tomita, J. Wagner, and J. Wang, The Systems Biology Markup Language (SBML): A medium for representation and exchange of biochemical network models, Bioinformatics, 19, pp. 524-531, 2003.
    • M. Hucka, H. Bolouri, A. Finney, H. M. Sauro, J. C. Doyle, H. Kitano, A. P. Arkin, B. J. Bornstein, D. Bray, A. Cuellar, S. Dronov, M. Ginkel, V. Gor, I. I. Goryanin, W. Hedley, T. C. Hodgman, P. J. Hunter, N. S. Juty, J. L. Kasberger, A. Kremling, U. Kummer, N. LeNovere, L. M. Loew, D. Lucio, P. Mendes, E. D. Mjolsness, Y. Nakayama, M. R. Nelson, P. Nielsen, T. Sakurada, J. C. Schaff, B. E. Shapiro, T. S. Shimizu, H. D. Spence, J. Stelling, K. Takahashi, M. Tomita, J. Wagner, and J. Wang, "The Systems Biology Markup Language (SBML): A medium for representation and exchange of biochemical network models," Bioinformatics, vol. 19, pp. 524-531, 2003.
  • 32
    • 2442598065 scopus 로고    scopus 로고
    • The IUPS Physiome Project: A framework for computational physiology
    • P. J. Hunter, "The IUPS Physiome Project: A framework for computational physiology," Prog. Biophys. Mol. Biol. vol. 85, no. 2-3, pp. 551-569, 2004.
    • (2004) Prog. Biophys. Mol. Biol , vol.85 , Issue.2-3 , pp. 551-569
    • Hunter, P.J.1
  • 33
    • 0037336350 scopus 로고    scopus 로고
    • Integration from proteins to organs: The Physiome Project
    • P. J. Hunter and T. K. Borg, "Integration from proteins to organs: The Physiome Project," Nature Rev. Mol. Cell Biol., vol. 4, pp. 237-243, 2003.
    • (2003) Nature Rev. Mol. Cell Biol , vol.4 , pp. 237-243
    • Hunter, P.J.1    Borg, T.K.2
  • 35
    • 57249106528 scopus 로고    scopus 로고
    • Integrative models of the heart: Achievements and limitations
    • P. J. Hunter, P. Kohl, and D. Noble, "Integrative models of the heart: Achievements and limitations," Phil. Trans R. Soc. Lond. A, vol. 359, pp. 1049-1054, 2001.
    • (2001) Phil. Trans R. Soc. Lond. A , vol.359 , pp. 1049-1054
    • Hunter, P.J.1    Kohl, P.2    Noble, D.3
  • 37
    • 0036811480 scopus 로고    scopus 로고
    • The IUPS human Physiome Project
    • P. J. Hunter, P. Robbins, and D. Noble, "The IUPS human Physiome Project," Eur. J. Physiol., vol. 445, no. 1, pp. 1-9, 2002.
    • (2002) Eur. J. Physiol , vol.445 , Issue.1 , pp. 1-9
    • Hunter, P.J.1    Robbins, P.2    Noble, D.3
  • 38
    • 2042541227 scopus 로고    scopus 로고
    • Mechanoelectric feedback in cardiac cells
    • P. Kohl and F. Sachs, "Mechanoelectric feedback in cardiac cells," Phil. Trans. R. Soc. Lond. A, vol. 359, no. 1783, pp. 1173-1185, 2001.
    • (2001) Phil. Trans. R. Soc. Lond. A , vol.359 , Issue.1783 , pp. 1173-1185
    • Kohl, P.1    Sachs, F.2
  • 39
    • 0346041902 scopus 로고    scopus 로고
    • Computational modeling of biological system: Tools and visions
    • P. Kohl, D. Noble, R. L. Winslow, and P. J. Hunter, "Computational modeling of biological system: Tools and visions," Phil. Trans. R. Soc. Lond. A, vol. 358, no. 1766, pp. 579-610, 2000.
    • (2000) Phil. Trans. R. Soc. Lond. A , vol.358 , Issue.1766 , pp. 579-610
    • Kohl, P.1    Noble, D.2    Winslow, R.L.3    Hunter, P.J.4
  • 40
    • 36549024063 scopus 로고    scopus 로고
    • Laminar structure of the heart: A mathematical model
    • I. J. LeGrice, P. J. Hunter, and B. H. Smaill, "Laminar structure of the heart: A mathematical model," Amer. J. Physiol., vol. 272, pp. H2466-H2476, 1997.
    • (1997) Amer. J. Physiol , vol.272
    • LeGrice, I.J.1    Hunter, P.J.2    Smaill, B.H.3
  • 42
    • 0029151575 scopus 로고
    • Laminar structure of the heart: Ventricular myocyte arrangement and connective tissue architecture in the dog
    • I. J. LeGrice, B. H. Smaill, L. Z. Chai, S. G. Edgar, J. B. Gavin, and P. J. Hunter, "Laminar structure of the heart: Ventricular myocyte arrangement and connective tissue architecture in the dog," Amer. J. Physiol., vol. 269, pp. H571-H582, 1995.
    • (1995) Amer. J. Physiol , vol.269
    • LeGrice, I.J.1    Smaill, B.H.2    Chai, L.Z.3    Edgar, S.G.4    Gavin, J.B.5    Hunter, P.J.6
  • 43
    • 0346874502 scopus 로고    scopus 로고
    • CytometryML, an XML format based on DICOM for analytic cytology data
    • R. C. Leif, S. H. Leif, and S. B. Leif, "CytometryML, an XML format based on DICOM for analytic cytology data," Cytometry, vol. 54, pp. 56-65, 2003.
    • (2003) Cytometry , vol.54 , pp. 56-65
    • Leif, R.C.1    Leif, S.H.2    Leif, S.B.3
  • 44
    • 0031616241 scopus 로고    scopus 로고
    • REVEAL, a general reverse engineering algorithm for inference of genetic network architectures
    • S. Liang, S. Fuhrman, and R. Somogyi, "REVEAL, a general reverse engineering algorithm for inference of genetic network architectures," in Proc. Pacific Symp. Biocomputing 1998, vol. 3, pp. 18-29.
    • (1998) Proc. Pacific Symp. Biocomputing , vol.3 , pp. 18-29
    • Liang, S.1    Fuhrman, S.2    Somogyi, R.3
  • 45
    • 2442595958 scopus 로고    scopus 로고
    • CellML: Its future, present and past
    • Jun.-Jul
    • C. M. Lloyd, M. D. B. Halstead, and P. M. F. Nielsen, "CellML: Its future, present and past," Prog. Biophys. Mol. Biol., vol. 85, no. 2-3, pp. 433-450, Jun.-Jul. 2004.
    • (2004) Prog. Biophys. Mol. Biol , vol.85 , Issue.2-3 , pp. 433-450
    • Lloyd, C.M.1    Halstead, M.D.B.2    Nielsen, P.M.F.3
  • 46
    • 0033755968 scopus 로고    scopus 로고
    • Modeling the human cardiome in silico
    • A. McCulloch, "Modeling the human cardiome in silico," J. Nucl. Cardiol., vol. 7, no. 5, pp. 496-499, 2000.
    • (2000) J. Nucl. Cardiol , vol.7 , Issue.5 , pp. 496-499
    • McCulloch, A.1
  • 48
    • 0034435086 scopus 로고    scopus 로고
    • Computational mechanics of the heart. From tissue structure to ventricular function
    • M. P. Nash and P. J. Hunter, "Computational mechanics of the heart. From tissue structure to ventricular function," J. Elasticity, vol. 61, pp. 113-141, 2000.
    • (2000) J. Elasticity , vol.61 , pp. 113-141
    • Nash, M.P.1    Hunter, P.J.2
  • 50
    • 0025730285 scopus 로고
    • Mathematical model of geometry and fibrous structure of the heart
    • P. M. F. Nielsen, I. J. LeGrice, B. H. Smaill, and P. J. Hunter, "Mathematical model of geometry and fibrous structure of the heart," Amer. J. Physiol., vol. 260, pp. H1365-H1378, 1991.
    • (1991) Amer. J. Physiol , vol.260
    • Nielsen, P.M.F.1    LeGrice, I.J.2    Smaill, B.H.3    Hunter, P.J.4
  • 51
    • 73849164199 scopus 로고
    • Modification of the Hodgkin-Huxley equations applicable to Purkinje fiber action and pace-maker potentials
    • D. A. Noble, "Modification of the Hodgkin-Huxley equations applicable to Purkinje fiber action and pace-maker potentials," J. Physiol., vol. 160, pp. 317-352, 1962.
    • (1962) J. Physiol , vol.160 , pp. 317-352
    • Noble, D.A.1
  • 52
    • 0036082392 scopus 로고    scopus 로고
    • The rise of computational biology
    • D. Noble, "The rise of computational biology," Nature Rev. Mol. Cell Biol., vol. 3, pp. 460-463, 2002.
    • (2002) Nature Rev. Mol. Cell Biol , vol.3 , pp. 460-463
    • Noble, D.1
  • 53
    • 0036499997 scopus 로고    scopus 로고
    • Modeling the heart: From genes to cells to the whole organ
    • _, "Modeling the heart: From genes to cells to the whole organ," Science, vol. 295, pp. 1678-1682, 2002.
    • (2002) Science , vol.295 , pp. 1678-1682
    • Noble, D.1
  • 54
    • 0035136745 scopus 로고    scopus 로고
    • The G. L. Brown prize lecture. Nitric oxide and the autonomic regulation of cardiac excitability
    • D. J. Paterson, "The G. L. Brown prize lecture. Nitric oxide and the autonomic regulation of cardiac excitability," Exp. Physiol., vol. 86, no. 1, pp. 1-12, 2001.
    • (2001) Exp. Physiol , vol.86 , Issue.1 , pp. 1-12
    • Paterson, D.J.1
  • 55
    • 0034747382 scopus 로고    scopus 로고
    • Noninvasive electrical imaging of the heart: Theory and model development
    • A. J. Pullan, L. K. Cheng, M. P. Nash, C. P. Bradley, and D. J. Paterson, "Noninvasive electrical imaging of the heart: Theory and model development," Ann. Biomed. Eng., vol. 29, no. 10, pp. 817-836, 2001.
    • (2001) Ann. Biomed. Eng , vol.29 , Issue.10 , pp. 817-836
    • Pullan, A.J.1    Cheng, L.K.2    Nash, M.P.3    Bradley, C.P.4    Paterson, D.J.5
  • 56
    • 0842283371 scopus 로고    scopus 로고
    • A reference ontology for biomedical informatics: The foundational model of anatomy
    • C. Rosse and J. V. L. Mejino, "A reference ontology for biomedical informatics: The foundational model of anatomy," J. Biomed. Inf., vol. 36, no. 6, pp. 478-500, 2003.
    • (2003) J. Biomed. Inf , vol.36 , Issue.6 , pp. 478-500
    • Rosse, C.1    Mejino, J.V.L.2
  • 57
    • 0034352167 scopus 로고    scopus 로고
    • From genome to physiome: Integrative models of cardiac excitation
    • Y. Rudy, "From genome to physiome: Integrative models of cardiac excitation," Ann. Biomed. Eng., vol. 28, no. 8, pp. 945-950, 2000.
    • (2000) Ann. Biomed. Eng , vol.28 , Issue.8 , pp. 945-950
    • Rudy, Y.1
  • 59
    • 0346850834 scopus 로고    scopus 로고
    • J. J. Saucerman, L. L. Brunton, A. P. Michailova, and A. D. McCulloch, Modeling beta-adrenergic control of cardiac myocyte contractility in silico, J. Biol. Chem., 278, no. 48, pp. 47 997-48 003, 2003.
    • J. J. Saucerman, L. L. Brunton, A. P. Michailova, and A. D. McCulloch, "Modeling beta-adrenergic control of cardiac myocyte contractility in silico," J. Biol. Chem., vol. 278, no. 48, pp. 47 997-48 003, 2003.
  • 60
    • 2442587536 scopus 로고    scopus 로고
    • Mechanistic systems models of cell signaling networks: A case study of myocyte adrenergic regulation
    • J. J. Saucerman and A. D. McCulloch, "Mechanistic systems models of cell signaling networks: A case study of myocyte adrenergic regulation," Prog. Biophys. Mol. Biol., vol. 85, no. 2-3, pp. 261-278, 2004.
    • (2004) Prog. Biophys. Mol. Biol , vol.85 , Issue.2-3 , pp. 261-278
    • Saucerman, J.J.1    McCulloch, A.D.2
  • 61
    • 10644295566 scopus 로고    scopus 로고
    • Proarrhythmic consequences of a KCNQ1 AKAP-binding domain mutation: Computational models of whole cells and heterogeneous tissue
    • J. J. Saucerman, S. N. Healy, M. E. Belik, J. L. Puglisi, and A. D. McCulloch, "Proarrhythmic consequences of a KCNQ1 AKAP-binding domain mutation: Computational models of whole cells and heterogeneous tissue," Circulat. Res., vol. 95, no. 12, pp. 1216-1224, 2004.
    • (2004) Circulat. Res , vol.95 , Issue.12 , pp. 1216-1224
    • Saucerman, J.J.1    Healy, S.N.2    Belik, M.E.3    Puglisi, J.L.4    McCulloch, A.D.5
  • 62
    • 3042711556 scopus 로고    scopus 로고
    • 2+ management in cardiac myocytes
    • 2+ management in cardiac myocytes," Ann. NY Acad. Sci., vol. 1015, no. 1, pp. 28-38, 2004.
    • (2004) Ann. NY Acad. Sci , vol.1015 , Issue.1 , pp. 28-38
    • Shannon, T.R.1    Bers, D.M.2
  • 64
    • 0033621715 scopus 로고    scopus 로고
    • The generation of an anatomically accurate geometric coronary model
    • N. P. Smith, A. J. Pullan, and P. J. Hunter, "The generation of an anatomically accurate geometric coronary model," Ann. Biomed. Eng., vol. 28, pp. 14-25, 2000.
    • (2000) Ann. Biomed. Eng , vol.28 , pp. 14-25
    • Smith, N.P.1    Pullan, A.J.2    Hunter, P.J.3
  • 65
    • 0036302210 scopus 로고    scopus 로고
    • An anatomically based model of transient coronary blood flow in the heart
    • _, "An anatomically based model of transient coronary blood flow in the heart," SIAM J. Appl. Math., vol. 62, pp. 990-1018, 2002.
    • (2002) SIAM J. Appl. Math , vol.62 , pp. 990-1018
    • Smith, N.P.1    Pullan, A.J.2    Hunter, P.J.3
  • 66
    • 0033014826 scopus 로고    scopus 로고
    • Examination of the transverse tubular system in living cardiac rat myocytes by 2-photon microscopy and digital image-processing techniques
    • C. Soeller and M. B. Cannell, "Examination of the transverse tubular system in living cardiac rat myocytes by 2-photon microscopy and digital image-processing techniques," Circulat. Res., vol. 84, pp. 266-275, 1999.
    • (1999) Circulat. Res , vol.84 , pp. 266-275
    • Soeller, C.1    Cannell, M.B.2
  • 67
    • 0037547113 scopus 로고    scopus 로고
    • Sarcomere length changes in a 3-D mathematical model of the pig ventricles
    • C. Stevens and P. J. Hunter, "Sarcomere length changes in a 3-D mathematical model of the pig ventricles," Prog. Biophys. Mol. Biol., vol. 82, no. 1-3, pp. 229-241, 2003.
    • (2003) Prog. Biophys. Mol. Biol , vol.82 , Issue.1-3 , pp. 229-241
    • Stevens, C.1    Hunter, P.J.2
  • 69
    • 0037418911 scopus 로고    scopus 로고
    • Informatics and quantitative analysis in biological imaging
    • J. R. Swedlow, I. Goldberg, E. Brauner, and P. K. Sorger, "Informatics and quantitative analysis in biological imaging," Science, vol. 300, pp. 100-102, 2003.
    • (2003) Science , vol.300 , pp. 100-102
    • Swedlow, J.R.1    Goldberg, I.2    Brauner, E.3    Sorger, P.K.4
  • 71
    • 0034905956 scopus 로고    scopus 로고
    • Characterising respiratory airway gas mixing using a lumped parameter model of the pulmonary acinus
    • M. H. Tawhai and P. J. Hunter, "Characterising respiratory airway gas mixing using a lumped parameter model of the pulmonary acinus" Respirat. Physiol., vol. 127, pp. 241-248, 2001a.
    • (2001) Respirat. Physiol , vol.127 , pp. 241-248
    • Tawhai, M.H.1    Hunter, P.J.2
  • 72
    • 0034904007 scopus 로고    scopus 로고
    • Multibreath washout analysis: Modeling the influence of conducting airway asymmetry
    • _, "Multibreath washout analysis: Modeling the influence of conducting airway asymmetry," Respirat. Physiol., vol. 127, pp. 249-258, 2001b.
    • (2001) Respirat. Physiol , vol.127 , pp. 249-258
    • Tawhai, M.H.1    Hunter, P.J.2
  • 73
    • 9244243096 scopus 로고    scopus 로고
    • CT-based geometry analysis and finite element models of the human and ovine bronchial tree
    • M. H. Tawhai, P. J. Hunter, J. Tschirren, J. M. Reinhardt, G. McLennan, and E. A. Hoffman, "CT-based geometry analysis and finite element models of the human and ovine bronchial tree," J. Appl. Physiol., vol. 97, no. 6, pp. 2310-2321, 2004.
    • (2004) J. Appl. Physiol , vol.97 , Issue.6 , pp. 2310-2321
    • Tawhai, M.H.1    Hunter, P.J.2    Tschirren, J.3    Reinhardt, J.M.4    McLennan, G.5    Hoffman, E.A.6
  • 74
    • 0034231008 scopus 로고    scopus 로고
    • Generation of an anatomically based three-dimensional model of the conducting airways
    • M. H. Tawhai, A. J. Pullan, and P. J. Hunter, "Generation of an anatomically based three-dimensional model of the conducting airways," Ann. Biomed. Eng., vol. 28, pp. 793-802, 2000.
    • (2000) Ann. Biomed. Eng , vol.28 , pp. 793-802
    • Tawhai, M.H.1    Pullan, A.J.2    Hunter, P.J.3
  • 75
    • 0037337307 scopus 로고    scopus 로고
    • A systematic approach to modeling, capturing and disseminating proteomics experimental data
    • C. F. Taylor et al., "A systematic approach to modeling, capturing and disseminating proteomics experimental data," Nature Biotechnol., vol. 21, pp. 247-254, 2003.
    • (2003) Nature Biotechnol , vol.21 , pp. 247-254
    • Taylor, C.F.1
  • 76
    • 0037687416 scopus 로고    scopus 로고
    • Reverse engineering gene networks: Integrating genetic perturbations with dynamic modeling
    • J. Tegner, M. K. S. Yeung, J. Hasty, and J. J. Collins, "Reverse engineering gene networks: Integrating genetic perturbations with dynamic modeling," Proc. Nat. Acad. Sci., vol. 100, pp. 5944-5949, 2003.
    • (2003) Proc. Nat. Acad. Sci , vol.100 , pp. 5944-5949
    • Tegner, J.1    Yeung, M.K.S.2    Hasty, J.3    Collins, J.J.4
  • 77
    • 0036706241 scopus 로고    scopus 로고
    • A finite element method for an eikonal equation model of myocardial excitation wavefront propagation
    • K. A. Tomlinson, P. J. Hunter, and A. P. Pullan, "A finite element method for an eikonal equation model of myocardial excitation wavefront propagation," SIAM J. Appl. Math., vol. 63, no. 1, pp. 324-350, 2002.
    • (2002) SIAM J. Appl. Math , vol.63 , Issue.1 , pp. 324-350
    • Tomlinson, K.A.1    Hunter, P.J.2    Pullan, A.P.3
  • 78
    • 0037095891 scopus 로고    scopus 로고
    • + ion mobility in the mammalian ventricular myocyte, J. Physiol., 541.1, pp. 139-158, 2002.
    • + ion mobility in the mammalian ventricular myocyte," J. Physiol., vol. 541.1, pp. 139-158, 2002.
  • 79
    • 0036965605 scopus 로고    scopus 로고
    • Role of bicarbonate in the regulation of intracellular pH in the mammalian ventricular myocyte
    • R. D. Vaughan-Jones and K. W. Spitzer, "Role of bicarbonate in the regulation of intracellular pH in the mammalian ventricular myocyte," Biochem. Cell Biol., vol. 80, no. 5, pp. 579-596, 2002.
    • (2002) Biochem. Cell Biol , vol.80 , Issue.5 , pp. 579-596
    • Vaughan-Jones, R.D.1    Spitzer, K.W.2
  • 80
    • 0035895505 scopus 로고    scopus 로고
    • The sequence of the human genome
    • C. Venter et al., "The sequence of the human genome," Science, vol. 291, pp. 1304-1351, 2001.
    • (2001) Science , vol.291 , pp. 1304-1351
    • Venter, C.1
  • 81
    • 0038702346 scopus 로고    scopus 로고
    • Genome informatics - current status and future prospects
    • R. L. Winslow and M. S. Boguski, "Genome informatics - current status and future prospects," Circulat. Res., vol. 92, pp. 953-961, 2003.
    • (2003) Circulat. Res , vol.92 , pp. 953-961
    • Winslow, R.L.1    Boguski, M.S.2
  • 82
    • 0037197936 scopus 로고    scopus 로고
    • Reverse engineering gene networks using singular value decomposition and robust regression
    • M. K. S. Yeung, J. Tegner, and J. J. Collins, "Reverse engineering gene networks using singular value decomposition and robust regression," Proc. Nat. Acad. Sci., vol. 99, pp. 6163-6168, 2002.
    • (2002) Proc. Nat. Acad. Sci , vol.99 , pp. 6163-6168
    • Yeung, M.K.S.1    Tegner, J.2    Collins, J.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.