Role of bicarbonate in the regulation of intracellular pH in the mammalian ventricular myocyte

Biochemistry and Cell Biology

Volumn 80, Issue 5, 2002, Pages 579-596

  Vaughan Jones, Richard D ^a   Spitzer, Kenneth W ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

Bicarbonate transporter; Heart; pHi; Ventricular

Indexed keywords

CARDIOLOGY; ENZYMES; PH; SUBSTRATES;

MAMMALIAN VENTRICULAR MYOCYTES;

CELLS;

ACID; BICARBONATE; BICARBONATE CHLORIDE ANTIPORTER; BICARBONATE SODIUM COTRANSPORTER; BUFFER; CALCIUM ION; CARBONATE DEHYDRATASE; CARRIER PROTEINS AND BINDING PROTEINS; CHLORIDE HYDROXIDE EXCHANGE PROTEIN; SODIUM ION; SODIUM PROTON EXCHANGE PROTEIN; UNCLASSIFIED DRUG;

ACID BASE BALANCE; ACIDITY; ANION EXCHANGE; CELL PH; CYTOPLASM; ENZYME ACTIVITY; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART RHYTHM; HEART VENTRICLE; MEMBRANE TRANSPORT; NONHUMAN; PHENOMENOLOGY; REGULATORY MECHANISM; SARCOLEMMA; SHORT SURVEY; STEADY STATE;

ACID-BASE EQUILIBRIUM; ANIMALS; BICARBONATES; CHLORIDE-BICARBONATE ANTIPORTERS; HEART VENTRICLES; HYDROGEN-ION CONCENTRATION; MYOCYTES, CARDIAC; SODIUM-BICARBONATE SYMPORTERS;

MAMMALIA;

EID: 0036965605     PISSN: 08298211     EISSN: None     Source Type: Journal    
DOI: 10.1139/o02-157     Document Type: Short Survey

References (108)

1. Aickin, C.C. 1984. Direct measurement of intracellular pH and buffering power in smooth muscle cells of guinea-pig vas deferens. J. Physiol. 349: 571-585.
2. Aickin, C.C., and Thomas, R.C. 1977. Microelectrode measurement of the intracellular pH and buffering power of mouse soleus muscle fibres. J. Physiol. 267: 571-585.
3. 3 symport in rat cardiac myocytes. J. Physiol. 512: 137-148.
4. al-Baldawi, N.F., and Abercrombie, R.F. 1992. Cytoplasmic hydrogen ion diffusion coefficient. Biophys. J. 61: 1470-1479.
5. Alvarez, B.V., Fujinaga, J., and Casey, J.R. 2001. Molecular basis for angiotensin II-induced increase of chloride/bicarbonate exchange in the myocardium. Circ. Res. 89: 1246-1253.
6. 3 cotransporter. Proceedings, 45th annual meeting, Canadian Society of Biochemistry and Cellular Biology. (Abstr.)
7. + exchange inhibitors for cardioprotective therapy: progress, problems and prospects. J. Am. Coll. Cardiol. 39: 747-753.
8. 2+ sparks in rat ventricular myocytes. J. Physiol. 528: 25-37.
9. Barry, W.H., Matsui, H., Bridge, J.H.B., and Spitzer, K.W. 1995. Excitation-contraction coupling in ventricular myocytes: effects of angiotensin II. In Molecular and subcellular cardiology: effects of structure and function. Edited by S. Sideman and R. Beyar. Plenum Press, New York. pp. 31-39.
10. Bolton, T.B., and Vaughan-Jones, R.D. 1977. Continuous direct measurement of intracellular chloride and pH in frog skeletal muscle. J. Physiol. 270: 801-833.
11. Bountra, C., and Vaughan-Jones, R.D. 1989. Effect of intracellular and extracellular pH on contraction in isolated, mammalian cardiac muscle. J. Physiol. 418: 163-187.
12. 3 on intracellular pH in isolated type-I cells of the neonatal rat carotid body. J. Physiol. 444: 703-721.
13. i after an increase in heart rate. Circ. Res. 79: 698-704.
14. 3 exchange in ventricular myocardium. Circ. Res. 82: 473-481.
15. Cascio, W.E., Yan, G.-X., and Kléber, A.G. 1992. Early changes in extracellular potassium in ischemic rabbit myocardium. The role of extracellular carbon dioxide accumulation and diffusion. Circ. Res. 70: 409-422.
16. Chegwidden, W.R., and Carter, N.D. 2000. Introduction to the carbonic anhydrases. In The carbonic anhydrases. Edited by W.R. Chegwidden, N.D. Carter, and Y.H. Edwards. Birkhaser Verlag, Basel, Switzerland. pp. 13-28.
17. +. Biophys. J. 80: 74. (Abstr.)
18. 3 co-transport inhibitor, on intracellular pH regulation in the guinea pig ventricular myocyte. Proceedings of the 34th International Congress of Physiological Sciences a1495. (Abstr.) Available at http://www.IUPS.org.
19. Ch'en, F.F., Vaughan-Jones, R.D., Clarke, K., and Noble, D. 1998. Modelling myocardial ischaemia and reperfusion. Prog. Biophys. Mol. Biol. 69: 515-538.
20. Cheng, H., Lederer, W.J., and Cannell, M.B. 1993. Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle. Science (Washington, D.C.), 262: 740-744.
21. 2+ and sarcoplasmic reticulum calcium content in isolated rat ventricular myocytes. J. Physiol. 529: 661-668.
22. 3 cotransporter isoform (hhNBC). Am. J. Physiol. 276: C576-C584.
23. Choi, I., Aalkjaer, C., Boulpaep, E.L., and Boron, W.F. 2000. An electroneutral sodium/bicarbonate cotransporter NBCn1 and associated sodium channel. Nature (Lond.), 405: 571-575.
24. Cordeiro, J.M., Bridge, J.H., and Spitzer, K.W. 2001. Early and delayed afterdepolarizations in rabbit heart Purkinje cells viewed by confocal microscopy. Cell Calcium, 29: 289-297.
25. 3 symport in the sheep cardiac Purkinje fibre. J. Physiol. 451: 365-385.
26. de Hemptinne, A., Marrannes, R., and Vanheel, B. 1987. Surface pH and the control of intracellular pH in cardiac and skeletal muscle. Can. J. Physiol. Pharmacol. 65: 970-977.
27. Deitmer, J.W., and Ellis, D. 1980. Interactions between the regulation of the intracellular pH and sodium activity of sheep cardiac Purkinje fibres. J. Physiol. 304: 471-488.
28. Fabiato, A., and Fabiato, F. 1978. Effects of pH on the myofilaments and the sarcoplasmic reticulum of skinned cells from cardiac and skeletal muscles. J. Physiol. 276: 233-255.
29. + exchanger. Mol. Cell. Biochem. 125: 137-143.
30. Forster, R.E. 1991. Methods for the measurement of carbonic anhydrase activity. In The carbonic anhydrases: cellular physiology and molecular genetics. Edited by S.J. Dodgson, R.E. Tashian, G. Gros, and N.D. Carter. Plenum Press, London, U.K. pp. 79-97.
31. Gonda, T., Maouyo, D., Rees, S.E., and Montrose, M.H. 1999. Regulation of intracellular pH gradients by identified Na/H exchanger isoforms and a short-chain fatty acid. Am. J. Physiol. 276: G259-G270.
32. Grace, A.A., Metcalfe, J.C., Weissberg, P.L., Bethell, H.W., and Vandenberg, J.I. 1996. Angiotensin II stimulates sodium-dependent proton extrusion in perfused ferret heart. Am. J. Physiol. 270: C1687-C1694.
33. 2 receptors. Circ. Res. 85: 919-930.
34. + during acidosis in rat ventricular myocytes. Am. J. Physiol. 262: C348-C357.
35. Humphreys, B.D., Jiang, L., Chernova, M.N., and Alper, S.L. 1994. Functional characterization and regulation by pH of murine AE2 anion exchanger expressed in Xenopus oocytes. Am. J. Physiol. 267: C1295-C1307.
36. Irving, M., Maylie, J., Sizto, N.L., and Chandler, W.K. 1990. Intracellular diffusion in the presence of mobile buffers. Application to proton movement in muscle. Biophys. J. 57: 717-721.
37. Jennings, M.L. 1992. Cellular anion transport. In The kidney: physiology and pathophysiology. 2nd ed. Edited by D.W. Seldin and G. Giebisch. Raven Press, Ltd., New York. pp. 113-145.
38. Juel, C., and Halestrap, A.P. 1999. Lactate transport in skeletal muscle - role and regulation of the monocarboxylate transporter. J. Physiol. 517: 633-642.
39. Junge, W., and Mclaughlin, S. 1987. The role of fixed and mobile buffers in the kinetics of proton movement. Biochim. Biophys. Acta, 890: 1-5.
40. Kaila, K., and Vaughan-Jones, R.D. 1987. Influence of sodium-hydrogen exchange on intracellular pH, sodium and tension in sheep cardiac Purkinje fibres. J. Physiol. 390: 93-118.
41. + exchange in cardiac physiology and pathophysiology: mediation of myocardial reperfusion injury by the pH paradox. Cardiovasc. Res. 27: 915-924.
42. Kass, R.S., Lederer, W.J., Tsien, R.W., and Weingart, R. 1978. Role of calcium ions in transient inward currents and after-contractions induced by strophanthidin in cardiac Purkinje fibres. J. Physiol. 281: 187-208.
43. Khandoudi, N., Albadine, J., Robert, P., Krief, S., Berrebi-Bertrand, I., Martin, X., Bevensee, M.O., Boron, W.F., and Bril, A. 2001. Inhibition of the cardiac electrogenic sodium bicarbonate cotransporter reduces ischemic injury. Cardiovasc. Res. 52: 387-396.
44. Knuppel-Ruppert, A.S., Gros, G., Harringer, W., and Kubis, H.P. 2000. Immunochemical evidence for a unique GPI-anchored carbonic anhydrase isozyme in human cardiomyocytes. Am. J. Physiol. 278: H1335-H1344.
45. 2+ fluxes, and contraction in ventricular myocytes. Circ. Res. 66: 622-632.
46. 3 exchange in developing neonatal rat cardiac cells. Biochemical identification and immunolocalization of band 3-like proteins. Circ. Res. 77: 556-564.
47. 3 exchanger in cultured neonatal rat cardiac cells. J. Mol. Cell. Cardiol. 27: 2521-2528.
48. + exchanger. Circ. Res. 68: 269-279.
49. Lagadic-Gossmann, D., Buckler, K.J., and Vaughan-Jones, R.D. 1992a. Role of bicarbonate in pH recovery from intracellular acidosis in the guinea-pig ventricular myocyte. J. Physiol. 458: 361-384.
50. Lagadic-Gossmann, D., Vaughan-Jones, R.D., and Buckler, K.J. 1992b. Adrenaline and extracellular ATP switch between two modes of acid extrusion in the guinea-pig ventricular myocyte. J. Physiol. 458: 385-407.
51. 1- and β-adrenoceptors. J. Physiol. 464: 49-73.
52. i regulation mechanisms in isolated rat ventricular myocytes. J. Cardiovasc. Pharmacol. 28: 547-552.
53. Lazdunski, M., Frelin, C., and Vigne, P. 1985. The sodium/hydrogen exchange system in cardiac cells: its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH. J. Mol. Cell. Cardiol. 17: 1029-1042.
54. Lee, J.A., and Allen, D.G. 1992. Changes in intracellular free calcium concentration during long exposures to simulated ischemia in isolated mammalian ventricular muscle. Circ. Res. 71: 58-69.
55. Leem, C.H., and Vaughan-Jones, R.D. 1998a. Out-of-equilibrium pH transients in the guinea-pig ventricular myocyte. J. Physiol. 509: 471-485.
56. i recovery from alkalosis in the guinea-pig ventricular myocyte. J. Physiol. 509: 487-496.
57. Leem, C.H., Lagadic-Gossmann, D., and Vaughan-Jones, R.D. 1999. Characterization of intracellular pH regulation in the guinea-pig ventricular myocyte. J. Physiol. 517: 159-180.
58. 3 exchange. J. Gen. Physiol. 96: 1247-1269.
59. 3 exchange inhibitor, on intracellular pH regulation in guinea pig ventricular myocytes. J. Biomed. Sci. 8: 395-405.
60. Matsui, H., Barry, W.H., Livsey, C., and Spitzer, K.W. 1995. Angiotensin II stimulates sodium-hydrogen exchange in adult rabbit ventricular myocytes. Cardiovasc. Res. 29: 215-221.
61. Orchard, C.H., and Cingolani, H.E. 1994. Acidosis and arrhythmias in cardiac muscle. Cardiovasc. Res. 28: 1312-1319.
62. Orchard, C.H., and Kentish, J.C. 1990. Effects of changes of pH on the contractile function of cardiac muscle. Am. J. Physiol. 258: C967-C981.
63. Papageorgiou, P., Shmukler, B.E., Stuart-Tilley, A.K., Jiang, L., and Alper, S.L. 2001. AE anion exchangers in atrial tumor cells. Am. J. Physiol. 280: H937-H945.
64. 3 exchanger in single rat cardiac cells. J. Physiol. 444: 241-256.
65. Puceat, M., Clement-Chomienne, O., Terzic, A., and Vassort, G. 1993. Alpha 1-adrenoceptor and purinoceptor agonists modulate Na-H antiport in single cardiac cells. Am. J. Physiol. 264: H310-H119.
66. 3 exchange in isolated cardiomyocytes. J. Biol. Chem. 270: 1315-1322.
67. Pushkin, A., Abuladze, N., Newman, D., Lee, I., Xu, G., and Kurtz, I. 2000. Cloning, characterization and chromosomal assignment of NBC4, a new member of the sodium bicarbonate cotransporter family. Biochim. Biophys. Acta, 1493: 215-218.
68. Putnam, R.W. 1995. Intracellular pH regulation. In Cell physiology, source book. Edited by N. Sperelakis. Academic Press, New York. pp. 212-229.
69. Richards, S.M., Jaconi, M.E., Vassort, G., and Puceat, M. 1999. A spliced variant of AE1 gene encodes a truncated form of Band 3 in heart: the predominant anion exchanger in ventricular myocytes. J. Cell Sci. 112: 1519-1528.
70. Roos, A., and Boron, W.F. 1981. Intracellular pH. Physiol. Rev. 61: 296-434.
71. Scamps, F., and Vassort, G. 1990. Mechanism of extracellular ATP-induced depolarization in rat isolated ventricular cardiomyocytes. Pfluegers Arch. 417: 309-316.
72. Schafer, C., Ladilov, Y.V., Siegmund, B., and Piper, H.M. 2000. Importance of bicarbonate transport for protection of cardiomyocytes against reoxygenation injury. Am. J. Physiol. 278: H1457-H1463.
73. Scholz, W., Albus, U., Counillon, L., Gogelein, H., Lang, H.J., Linz, W., Weichert, A., and Scholkens, B.A. 1995. Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. Cardiovasc. Res. 29: 260-268.
74. Schwiening, C.J., and Willoughby, D. 2002. Depolarization-induced pH microdomains and their relationship to calcium transients in isolated snail neurons. J. Physiol. 538: 371-382.
75. Sender, S., Decker, B., Fenske, C.D., Sly, W.S., Carter, N.D., and Gros, G. 1998. Localization of carbonic anhydrase IV in rat and human heart muscle. J. Histochem. Cytochem. 46: 855-861.
76. Serrano, O.K., Jovanovic, A., and Terzic, A. 1999. Inhibition of both Na/H and bicarbonate-dependent exchange is required to prevent recovery of intracellular pH in single cardiomyocytes exposed to metabolic stress. Biosci. Rep. 19: 99-107.
77. i, and contraction in rabbit ventricular myocytes from infarcted hearts. Am. J. Physiol. 275: H1788-H1797.
78. Spitzer, K.W., Ershler, P.R., Skolnick, R.L., and Vaughan-Jones, R.D. 2000. Generation of intracellular pH gradients in single cardiac myocytes with a microperfusion system. Am. J. Physiol. 278: H1371-H1382.
79. 3 in rabbit ventricular myocytes is regulated by carbonic anhydrase. J. Physiol. 541: 159-167.
80. Sterling, D., and Casey, J.R. 1999. Transport activity of AE3 chloride/bicarbonate anion-exchange proteins and their regulation by intracellular pH. Biochem. J. 344: 221-229.
81. Sterling, D., Reithmeier, R.A., and Casey, J.R. 2001. A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers. J. Biol. Chem. 276: 47 886 - 47 894.
82. 3 exchanger binds carbonic anhydrase IV. J. Biol. Chem. 277: 25 239 - 25 246.
83. Stewart, A.K., Boyd, C.A., and Vaughan-Jones, R.D. 1999. A novel role for carbonic anhydrase: cytoplasmic pH gradient dissipation in mouse small intestinal enterocytes. J. Physiol. 516: 209-217.
84. 2-terminal cytoplasmic domain. Am. J. Physiol. 281: C1344-C1354.
85. Sun, B., Leem, C.H., and Vaughan-Jones, R.D. 1996. Novel chloride-dependent acid loader in the guinea-pig ventricular myocyte: part of a dual acid-loading mechanism. J. Physiol. 495: 65-82.
86. Swenson, E.R. 1997. Carbonic anhydrase and the heart. Cardiologia, 42: 453-462.
87. 2 transport at rest and during maximal exercise. Respir. Physiol. 35: 129-159.
88. Takamatsu, T., and Wier, W.G. 1990. Calcium waves in mammalian heart: quantification of origin, magnitude, waveform, and velocity. FASEB J. 4: 1519-1525.
89. + exchange is the major mechanism of pH regulation in cultured sympathetic neurons: measurements in single cell bodies and neurites using a fluorescent pH indicator. Neuroscience, 22: 1093-1102.
90. i recovery after global ischemia in the perfused heart. Circ. Res. 72: 993-1003.
91. Vandenberg, J.I., Carter, N.D., Bethell, H.W., Nogradi, A., Ridderstrale, Y., Metcalfe, J.C., and Grace, A.A. 1996. Carbonic anhydrase and cardiac pH regulation. Am. J. Physiol. 271: C1838-C1846.
92. Vaughan-Jones, R.D. 1979. Regulation of chloride in quiescent sheep-heart Purkinje fibres studied using intracellular chloride and pH-sensitive micro-electrodes. J. Physiol. 295: 111-137.
93. Vaughan-Jones, R.D. 1981. Chloride-bicarbonate exchange in the sheep cardiac Purkinje fibre. Kroc Found. Ser. 15: 239-252.
94. Vaughan-Jones, R.D. 1986. An investigation of chloride-bicarbonate exchange in the sheep cardiac Purkinje fibre. J. Physiol. 379: 377-406.
95. + exchange in the sheep cardiac Purkinje fibre. J. Physiol. 428: 441-466.
96. + ion mobility in the rabbit ventricular myocyte. J. Physiol. 541: 139-158.
97. 3 exchanger. J. Biol. Chem. 273: 28 430 - 28 437.
98. 3 cotransporter (NBCe2). Am. J. Physiol. 282: C1278-C1289.
99. Wilson, D.A., and Vaughan-Jones, R.D. 1998. Kinetic characterization of chloride-hydroxyl exchange in guinea-pig ventricular myocytes. J. Physiol. 511: 75P. (Abstr.)
100. Wit, A.L., and Rosen, M.R. 1992. Afterpolarizations and triggered activity: distinction from automaticity as an arrhythmogenic mechanism. In The heart and cardiovascular systerm. 2nd ed. Edited by H.A. Fozzard, R.B. Jennings, E. Haber, and A.M. Katz. Raven Press, Ltd., New York. pp. 2113-2163.
101. Woodbury, J.W. 1966. Regulation of pH. In Physiology and biophysics. Edited by T.C. Ruch and H.D. Patton. W.B. Saunders Co., Philadelphia, Pa. pp. 899-934.
102. + exchange in dog cardiac Purkinje fibres. J. Physiol. 471: 583-597.
103. + exchanger during ischemia and preconditioning in the isolated rat heart. Circ. Res. 85: 723-730.
104. i from alkalosis in guinea pig ventricular myocytes. Am. J. Physiol. 267: H85-H91.
105. Yannoukakos, D., Stuart-Tilley, A., Fernandez, H.A., Fey, P., Duyk, G., and Alper, S.L. 1994. Molecular cloning, expression, and chromosomal localization of two isoforms of the AE3 anion exchanger from human heart. Circ. Res. 75: 603-614.
106. + exchange and reperfusion arrhythmias: protection by intracoronary infusion of a novel inhibitor. Am. J. Physiol. 267: H2430-H2440.
107. + exchanger. Evidence for a receptor-mediated mechanism involving protein kinase C. Circ. Res. 79: 705-715.
108. + exchanger activity in rat ventricular myocytes: evidence for selective mediation by the alpha 1A-adrenoceptor subtype. Circ. Res. 82: 1078-1085.