Adrenergic and cholinergic compounds

Handbook of Experimental Pharmacology

Volumn 177, Issue , 2007, Pages 251-264

  Sanders, R D ^a   Maze, M ^a  

^a CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

Author keywords

Adrenergic; Antinociception; Cholinergic; Clonidine; Dexmedetomidine; Muscarinic; Nicotinic; Pain

Indexed keywords

ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; CHOLINERGIC RECEPTOR STIMULATING AGENT;

ANIMAL; DRUG EFFECT; GENETICS; HUMAN; PAIN; PATHOPHYSIOLOGY; REVIEW;

ADRENERGIC AGENTS; ADRENERGIC ALPHA-AGONISTS; ANIMALS; CHOLINERGIC AGENTS; HUMANS; PAIN; RECEPTORS, ADRENERGIC, ALPHA-2;

EID: 33947329693     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-540-33823-9_9     Document Type: Article

References (82)

1. Adamson P, Xiang JZ, Mantzourides T, BrammerMJ, Campbell IC (1989) Presynaptic alpha 2-adrenoceptor and kappa-opiate receptor occupancy promotes closure of neuronal (N-type) calcium channels. Eur J Pharmacol 174:63-70
2. Arain SR, Ruehlow RM, Uhrich TD, Ebert TJ, Arain SR, Ruehlow RM, Uhrich TD, Ebert TJ (2004) The efficacy of dexmedetomidine versus morphine for postoperative analgesia after major inpatient surgery. Anesth Analg 98:153-158
3. Arner S, Meyerson BA (1988) Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain. Pain 33:11-23
4. Bannon AW, Decker MW, Holladay MW, Curzon P, Donnelly-Roberts D, Puttfarcken PS, Bitner RS, Diaz A, Dickenson AH, Porsolt RD, Williams M, Arneric SP (1998) Broadspectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors. Science 279:77-81
5. Bernard JM, Macaire P (1997) Dose-range effects of clonidine added to lidocaine for brachial plexus block. Anesthesiology 87:277-284
6. Bernard JM, Kick O, Bonnet F (1995) Comparison of intravenous and epidural clonidine for postoperative patient-controlled analgesia. Anesth Analg 81:706-712
7. Bernardini N, Roza C, Sauer SK, Gomeza J, Wess J, ReehPW (2002) Muscarinic M2 receptors on peripheral nerve endings: a molecular target of antinociception. J Neurosci 22:RC229
8. Bitner RS, Nikkel AL, Curzon P, Arneric SP, Bannon AW, Decker MW (1998) Role of the nucleus raphe magnus in antinociception produced by ABT-594: immediate early gene responses possibly linked to neuronal nicotinic acetylcholine receptors on serotonergic neurons. J Neurosci 18:5426-5432
9. Blednov YA, Stoffel M, Alva H, Harris RA (2003) A pervasive mechanism for analgesia: activation of GIRK2 channels. Proc Natl Acad Sci U S A 100:277-282
10. Bonnet F, Diallo A, Saada M, BelonM, GuilbaudM, Boico O (1989) Prevention of tourniquet pain by spinal isobaric bupivacaine with clonidine. Br J Anaesth 63:93-96
11. Byas-Smith MG, Max MB, Muir J, Kingman A (1995) Transdermal clonidine compared to placebo in painful diabetic neuropathy using a two-stage "enriched enrollment" design. Pain 60:267-274
12. Caulfield MP, Birdsall NJ (1998) International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev 50:279-290
13. Celleno P, Capogna G, Costantino P (1995) Comparison of fentanyl with clonidine as adjuvants for epidural analgesia with 0.125% bupivacaine in the first stage of labor. Int J Obstet Anesth 4:26-29
14. Chen SR, Pan HL (2001) Spinal endogenous acetylcholine contributes to the analgesic effect of systemic morphine in rats. Anesthesiology 95:525-530
15. Chen SR, Wess J, PanHL (2005) Functional activity of them2 andm4receptor subtypes in the spinal cord studied withmuscarinic acetylcholine receptor knockoutmice. J Pharmacol Exp Ther 313:765-770
16. Cordero-Erausquin M, Changeux JP (2001) Tonic nicotinic modulation of serotoninergic transmission in the spinal cord. Proc Natl Acad Sci U S A 98:2803-2807
17. Cortinez LI, Hsu YW, Sum-Ping ST, Young C, Keifer JC, Macleod D, Robertson KM, Wright DR, Moretti EW, Somma J (2004) Dexmedetomidine pharmacodynamics. Part II. Crossover comparison of the analgesic effect of dexmedetomidine and remifentanil in healthy volunteers. Anesthesiology 101:1077-1083
18. Coursin DB, Coursin DB, Maccioli GA (2001) Dexmedetomidine. Curr Opin Crit Care 7:221-226
19. Decker MW, Meyer MD (1999) Therapeutic potential of neuronal nicotinic acetylcholine receptor agonists as novel analgesics. Biochem Pharmacol 58:917-923
20. Detweiler DJ, Eisenach JC, Tong C, Jackson C (1993) A cholinergic interaction in alpha2 adrenoreceptor-mediated antinociception in sheep. J Pharmacol Exp Ther 265:536-542
21. Duttaroy A, Gomeza J, Gan JW, Basile AS, Harman WD, Smith PL, Felder CC, Wess J (2000) Analysis of muscarinic agonist-induced analgesia by the use of receptor knockout mice (abstract) . Neurosci Abstr 26:616-618
22. Duttaroy A, Gomeza J, Gan JW, Siddiqui N, Basile AS, Harman WD, Smith PL, Felder CC, Levey AI, Wess J (2002) Evaluationofmuscarinic agonist- inducedanalgesia inmuscarinic acetylcholine receptor knockout mice. Mol Pharmacol 62:1084-1093
23. Eisenach J, Rauck RLR, Buzzanell C, Lysak SZ (1989) Epidural clonidine analgesia for intractable cancer pain: phase I. Anesthesiology 71:647-652
24. Eisenach JC (1999) Muscarinic-mediated analgesia. Life Sci 64:549-554
25. Eisenach JC, DuPen S, Dubois M, Miguel R, Allin D (1995) Epidural clonidine analgesia for intractable cancer pain. The Epidural Clonidine Study Group. Pain 61:391-399
26. Eisenach JC, Detweiler DJ, Tong C, DAngelo R, Hood DD (1996) Cerebrospinal fluid norepinephrine and acetylcholine concentrations during acute pain. Anesth Analg 82: 621-626
27. Eisenach JC, Hood DD, Curry R (1998) Intrathecal, but not intravenous, clonidine reduces experimental thermal or capsaicin-induced pain and hyperalgesia in normal volunteers. Anesth Analg 87:591-596
28. Fernandez-Fernandez JM, Wanaverbecq N, Halley P, Caulfield MP, Brown D.A.(1999) Selective activation of heterologously expressed G protein-gated K+ channels by M2 muscarinic receptors in rat sympathetic neurones. J Physiol 515:631-637
29. Flood P, Daniel D (2004) Intranasal nicotine for postoperative pain treatment. Anesthesiology 101:1417-1421
30. Galeotti N, Ghelardini C, Vinci MC, Bartolini A (1999) Role of potassium channels in the antinociception induced by agonists of alpha2-adrenoceptors. Br J Pharmacol 126: 1214-1220
31. Glynn C, Dawson D, Sanders R (1988) A double-blind comparison between epidural morphine and epidural clonidine, in patients with chronic non-cancer pain. Pain 34:123-128
32. Glynn CJ, Jamous MA, Teddy PJ, Moore RA, Lloyd JW (1986) Role of spinal noradrenergic system in transmission of pain in patients with spinal cord injury. Lancet 2:1249-1250
33. Gotti C, Clementi F (2004) Neuronal nicotinic receptors: from structure to pathology. Prog Neurobiol 74:363-396
34. GraceD, Bunting H, Milligan KR, Fee JP (1995) Postoperative analgesia after co-administration of clonidine and morphine by the intrathecal route in patients undergoing hip replacement. Anesth Analg 80:86-91
35. Guo TZ, Jiang JY, Buttermann AE, MazeM (1996) Dexmedetomidine injection into the locus ceruleus produces antinociception. Anesthesiology 84:873-881
36. Harada Y, Nishioka K, Kitahata LM, Kishikawa K, Collins JG (1995) Visceral antinociceptive effects of spinal clonidine combined with morphine, [D-Pen2, D-Pen5] enkephalin, or U50, 488H. Anesthesiology 83:344-352
37. Hoeger-Bement MK, Sluka KA (2003) Phosphorylation of CREB and mechanical hyperalgesia is reversed by blockade of the cAMP pathway in a time-dependent manner after repeated intramuscular acid injections. J Neurosci 23:5437-5445
38. Hood DD, Mallak KA, James RL, Tuttle R, Eisenach JC (1997) Enhancement of analgesia from systemic opioid in humans by spinal cholinesterase inhibition. J Pharmacol Exp Ther 282:86-92
39. Ishibashi H, Akaike N (1995) Norepinephrine modulates high voltage-activated calcium channels in freshly dissociated rat nucleus tractus solitarii neurons. Neuroscience 68: 1139-1146
40. Iwasaki H, Collins JG, Saito Y, Uchida H, Kerman-Hinds A (1991) Low dose clonidine enhances pregnancy-induced analgesia to visceral but not somatic stimuli in rats.Anesth Analg 72:325-329
41. Jones SL, Gebhart GF (1986) Characterization of coerulospinal inhibition of the nociceptive tail-flick reflex in the rat:mediation by spinal a2-adrenoreceptors. Brain Res 364:315-330
42. Kang YJ, Eisenach JC (2003) Intrathecal clonidine reduces hypersensitivity after nerve injury by a mechanism involving spinal m4 muscarinic receptors. Anesth Analg 96:1403-1408
43. Lakhlani PP, MacMillan LB, Guo TZ, McCool BA, Lovinger DM, MazeM, Limbird LE (1997) Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo. Proc Natl Acad Sci U S A 94:9950-9955
44. Lauretti GR, Hood DD, Eisenach JC, Pfeifer BL (1998) A multi-center study of intrathecal neostigmine for analgesia following vaginal hysterectomy. Anesthesiology 89:913-918
45. Lee JJ, Rubin AP (1994) Comparison of a bupivacaine-clonidine mixture with plain bupivacaine for caudal analgesia in children. Br J Anaesth 72:258-262
46. Li DP, Chen SR, Pan YZ, Levey AI, Pan HL (2002) Role of presynaptic muscarinic and GABA (B) receptors in spinal glutamate release and cholinergic analgesia in rats. J Physiol 543:807-818
47. Li P, ZhuoM (2001) Cholinergic, noradrenergic, and serotonergic inhibition of fast synaptic transmission in spinal lumbar dorsal horn of rat. Brain Res Bull 54:639-647
48. Li X, Eisenach JC (2001) alpha2A-adrenoceptor stimulation reduces capsaicin-induced glutamate release from spinal cord synaptosomes. J Pharmacol Exp Ther 299:939-944
49. Marubio LM, del Mar Arroyo-Jimenez M, Cordero-Erausquin M, Lena C, Le Novere N, de Kerchove dExaerde A, Huchet M, DamajMI, Changeux JP (1999) Reduced antinociception in mice lacking neuronal nicotinic receptor subunits. Nature 398:805-810
50. Maze M, Angst MS (2004) Dexmedetomidine and opioid interactions: defining the role of dexmedetomidine for intensive care unit sedation. Anesthesiology 101:1059-1061
51. Millar J, OBrien FE, Williams GV, Wood J (1993) The effect of iontophoretic clonidine on neurones in the rat superficial dorsal horn. Pain 53:137-145
52. Mitrovic I, Margeta-Mitrovic M, Bader S, Stoffel M, Jan LY, BasbaumAI (2003) Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences. Proc Natl Acad Sci U S A 100:271-276
53. Nakamura M, Ferreira SH (1998) Peripheral analgesic action of clonidine: mediation by enkephalin-like substances. Eur J Pharmacol 146:223-228
54. North RA, Williams JT, Surprenant A, Christie MJ (1997) Mu and delta opioid receptors belong to a family of receptors that are coupled to potassium channels. Proc Natl Acad Sci U S A 84:5487-5491
55. Ohashi Y, Stowell JM, Nelson LE, Hashimoto T, Maze M, Fujinaga M (2002) Nitrous oxide exerts age-dependent antinociceptive effects in Fischer rats. Pain 100:7-18
56. Owen H, McMillan V, Rogowski D (1990) Postoperative pain therapy: a survey of patients expectations and their experiences. Pain 41:303-307
57. Pan HL, Chen SR, Eisenach JC (1999) Intrathecal clonidine alleviates allodynia in neuropathic rats: interaction with spinal muscarinic and nicotinic receptors. Anesthesiology 90:509-514
58. Pan PM, Huang CT, Wei TT, Mok MS (1998) Enhancement of analgesic effect of intrathecal neostigmine, clonidine on bupivacaine spinal anesthesia. RegAnesth PainMed 23:49-56
59. Paqueron X, Li X, Bantel C, Tobin JR, Voytko ML, Eisenach JC (2001) An obligatory role for spinal cholinergic neurons in the antiallodynic effects of clonidine after peripheral nerve injury. Anesthesiology 94:1074-1081
60. Poree LR, Guo TZ, KingeryWS, MazeM (1998) The analgesic potency of dexmedetomidine is enhanced after nerve injury: a possible role for peripheral a2-adrenoreceptors. Anesth Analg 87:941-948
61. Puke MJ, Wiesenfeld-Hallin Z (1993) The differential effects of morphine and the [alpha]2- adrenoceptor agonists clonidine and dexmedetomidine on the prevention and treatment of experimental neuropathic pain. Anesth Analg 77:104-109
62. Remy-NerisO, BarbeauH, DanielO, BoiteauF, BusselB (1999) Effectsof intrathecal clonidine injection on spinal reflexes and human locomotion in incomplete paraplegic subjects. Exp Brain Res 129:433-440
63. Roelants F, Lavandhomme PM (2004) Epidural neostigmine combined with sufentanil provides balanced and selective analgesia in early labor. Anesthesiology 101:439-444
64. Rogers DT, Iwamoto ET (1993) Multiple spinal mediators in parenteral nicotine-induced antinociception. J Pharmacol Exp Ther 267:341-349
65. Rueter LE, Meyer MD, DeckerMW (2000) Spinal mechanisms underlying A-85380-induced effects on acute thermal pain. Brain Res 872:93-101
66. Ryan JS, Tao QP, Kelly ME (1998) Adrenergic regulation of calcium-activated potassium current in cultured rabbit pigmented ciliary epithelial cells. J Physiol 511:145-157
67. SabbeMB, Penning JP, Ozaki GT, Yaksh TL (1994) Spinal and systemic action of the alpha 2 receptor agonist dexmedetomidine in dogs. Anesthesiology 80:1057-1072
68. Sanders RD, Giombini M, Ma D, Ohashi Y, Hossain M, Fujinaga M, Maze M (2005) Dexmedetomidine exerts dose-dependent age-independent antinociception but agedependent hypnosis in Fischer rats. Anesth Analg 100:1295-1302
69. Shannon HE, Sheardown MJ, Bymaster FP, Calligaro DO, Delapp NW, Gidda J, Mitch CH, Sawyer BD, Stengel PW, Ward JS, Wong DT, Olesen PH, Suzdak PD, Sauerberg P, Swedberg MD (1997) Pharmacology of butylthio[2. 2 2] (LY297802/NNC11-1053) : a novel analgesic with mixed muscarinic receptor agonist and antagonist activity. J Pharmacol Exp Ther 281:884-894
70. Shannon HE, Jones CK, Li DL, Peters SC, Simmons RM, Iyengar S (2001) Antihyperalgesic effects of the muscarinic receptor ligand vedaclidine in models involving central sensitization in rats. Pain 93:221-227
71. SheardownMJ, ShannonHE, SwedbergMD, Suzdak PD, Bymaster FP, Olesen PH, Mitch CH, Ward JS, Sauerberg P (1997) M1 receptor agonist activity is not a requirement for muscarinic antinociception. J Pharmacol Exp Ther 281:868-875
72. Svensson I, Sjostrom B, Haljamae H (2000) Assessment of pain experiences after elective surgery. J Pain Symptom Manage 20:193-201
73. SwedbergMD, SheardownMJ, Sauerberg P, Olesen PH, SuzdakPD, HansenKT, Bymaster FP, Ward JS, Mitch CH, CalligaroDO, DelappNW, ShannonHE (1997) Butylthio[2. 2 2] (NNC 11-1053/LY297802) : an orally activemuscarinic agonist analgesic. J Pharmacol Exp Ther 281:876-883
74. Takano Y, Yaksh TL (1998) Release of calcitonin gene-related peptide (CGRP) , substance P (SP) , and vasoactive intestinal polypeptide (VIP) from rat spinal cord: modulation by alpha 2 agonists. Peptides 14:371-378
75. Tassonyi E, Charpantier E, Muller D, Dumont L, Bertrand D (2002) The role of nicotinic acetylcholine receptors in the mechanisms of anesthesia. Brain Res Bull 57:133-150
76. Thomas T, Robinson C, Champion D, McKell M, PellM (1998) Prediction and assessment of the severity of postoperative pain and of satisfaction with management. Pain 75:177-185
77. Tjolsen A, Lund A, Hole K (1990) The role of descending noradrenergic systems in regulation of nociception: the effects of intrathecally administered alpha-adrenoreceptor antagonists and clonidine. Pain 43:113-120
78. Traynor JR (1998) Epibatidine and pain. Br J Anaesth 81:69-76
79. Wess J, Duttaroy A, Gomeza J, Zhang W, Yamada M, Felder CC, Bernardini N, Reeh PW (2003) Muscarinic receptor subtypes mediating central and peripheral antinociception studied with muscarinic receptor knockout mice: a review. Life Sci 72:2047-2054
80. Wilcox GL, Carlsson KH, Jochim A, Jurna I (1987) Mutual potentiation of antinociceptive effects of morphine and clonidine on motor and sensory responses in rat spinal cord. Brain Res 405:84-93
81. Wilson SG, Smith SB, Chesler EJ, Melton KA, Haas JJ, Mitton B, Strasburg K, Hubert L, Rodriguez-Zas SL, Mogil JS (2003) The heritability of antinociception: common pharmacogenetic mediation of five neurochemically distinct analgesics. J Pharmacol Exp Ther 304:547-559
82. Zhang HM, Li DP, Chen SR, Pan HL (2005) M2, m3, andm4 receptor subtypes contribute to muscarinic potentiation ofGABAergic inputs to spinal dorsal horn neurons. J Pharmacol Exp Ther 313:697-704