Intrathecal clonidine reduces hypersensitivity after nerve injury by a mechanism involving spinal m4 muscarinic receptors

Anesthesia and Analgesia

Volumn 96, Issue 5, 2003, Pages 1403-1408

  Kang, Yoo Jin ^a   Eisenach, James C ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CLONIDINE; MUSCARINIC M1 RECEPTOR PROTEIN; MUSCARINIC M4 RECEPTOR PROTEIN; MUSCARINIC RECEPTOR; RECEPTOR PROTEIN; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ADRENERGIC SYSTEM; ANIMAL BEHAVIOR; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; IMMUNOBLOTTING; MALE; NERVE INJURY; NEUROPATHIC PAIN; NONHUMAN; PAIN; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL CORD;

EID: 0037406189     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ANE.0000060450.80157.FF     Document Type: Article

References (33)

1. Arner S, Meyerson BA. Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain. Pain 1988;33:11-23.
2. Yaksh TL, Pogrel JW, Lee YW, Chaplan SR. Reversal of nerve ligation-induced allodynia by spinal alpha-2 adrenoceptor agonists. J Pharmacol Exp Ther 1995;272:207-14.
3. Eisenach JC, DuPen S, Dubois M, et al. Epidural clonidine analgesia for intractable cancer pain. Pain 1995;61:391-9.
4. Detweiler DJ, Eisenach JC, Tong C, Jackson C. A cholinergic interaction in alpha2 adrenoceptor-mediated antinociception in sheep. J Pharmacol Exp Ther 1993;265:536-42.
5. Yaksh TL, Dirksen R, Harty GJ. Antinociceptive effects of intrathecally injected cholinomimetic drugs in the rat and cat. Eur J Pharmacol 1985;117:81-8.
6. Pan HL, Chen SR, Eisenach JC. Intrathecal clonidine alleviates allodynia in neuropathic rats: interaction with spinal muscarinic and nicotinic receptors. Anesthesiology 1999;90:509-14.
7. Iwamoto ET, Marion L. Characterization of the antinociception produced by intrathecally administered muscarinic agonists in rats. J Pharmacol Exp Ther 1993;266:329-38.
8. Naguib M, Yaksh TL. Characterization of muscarinic receptor subtypes that mediate antinociception in the rat spinal cord. Anesth Analg 1997;85:847-53.
9. 1 receptor agonist activity is not a requirement for muscarinic antinociception. J Pharmacol Exp Ther 1997;281:868-75.
10. 1 activity - SAR of alkylthio-TZTP's and related 1,2,5-thiadiazole analogs. Life Sci 1995;56:807-14.
11. Höglund AU, Baghdoyan HA. M2, M3 and M4, but not M1, muscarinic receptor subtypes are present in rat spinal cord. J Pharmacol Exp Ther 1997;281:470-7.
12. Ellis JL, Harman D, Gonzalez J, et al. Development of muscarinic analgesics derived from epibatidine: role of the M4 receptor subtype. J Pharmacol Exp Ther 1999;288:1143-50.
13. , Adem A, Karlsson E. Muscarinic receptor subtype selective toxins. Life Sci 1997;60:1069-76.
14. Kim SH, Chung JM. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 1992;50:355-63.
15. Storkson RV, Kjorsvik A, Tjolsen A, Hole K. Lumbar catheterization of the spinal subarachnoid space in the rat. J Neurosci Methods 1996;65:167-172.
16. Chaplan SR, Bach FW, Pogrel JW, et al. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 1994;53: 55-63.
17. Ndoye A, Buchli R, Greenberg B, et al. Identification and mapping of keratinocyte muscarinic acetylcholine receptor subtypes in human epidermis. J Invest Dermatol 1998;111:410-6.
18. 2-adrenoceptor agonists clonidine and dexmedetomidine on the prevention and treatment of experimental neuropathic pain. Anesth Analg 1993;77:104-9.
19. Stevens CW, Kajander KC, Bennett GJ, Seybold VS. Bilateral and differential changes in spinal mu, delta and kappa opioid binding in rats with a painful, unilateral neuropathy. Pain 1991;46: 315-26.
20. Xu Z, Chen SR, Eisenach JC, Pan HL. Role of spinal muscarinic and nicotinic receptors in clonidine-induced nitric oxide release in a rat model of neuropathic pain. Brain Res 2000;861:390-8.
21. Klamt JG, Dos Reis MP, Neto JB, Prado WA. Analgesic effect of subarachnoid neostigmine in two patients with cancer pain. Pain 1996;66:389-91.
22. Bonner TI, Buckley NJ, Young AC, Brann MR. Identification of a family of muscarinic acetylcholine receptor genes. Science 1987;237:527-32.
23. Kubo T, Fukuda K, Mikami A, et al. Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor. Nature 1986;323:411-6.
24. Levey AI. Immunological localization of m1-m5 muscarinic acetylcholine receptors in peripheral tissues and brain. Life Sci 1993;52:441-8.
25. Caulfield MP, Muscarinic receptors: characterization, coupling and function. Pharmacol Ther 1993;58:319-79.
26. Gillberg PG, Nordberg A, Aquilonius SM. Muscarinic binding sites in small homogenates and in autoradiographic sections from rat and human spinal cord. Brain Res 1984;300:327-33.
27. Kayaalp SO, Neff NH. Regional distribution of cholinergic muscarinic receptors in spinal cord. Brain Res 1980;196:429-36.
28. Hood DD, Mallak KA, Eisenach JC, Tong CY. Interaction between intrathecal neostigmine and epidural clonidine in human volunteers. Anesthesiology 1996;85:315-25.
29. Bartolini A, Ghelardini C, Fantetti L, et al. Role of muscarinic receptor subtypes in central antinociception. Br J Pharmacol 1992;105:77-82.
30. 3 muscarinic receptors of the spinal cord in formalin-induced nociception in mice. Brain Res 2000;859:38-44.
31. 1 receptors. Br J Pharmacol 2000;129:1633-40.
32. Gomeza J, Shannon H, Kostems E, et al. Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knock-out mice. Proc Natl Acad Sci USA 1999;96:1692-7.
33. Gomeza J, Zhang L, Kostenis E, et al. Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice. Proc Natl Acad Sci USA 1999;96:10483-8.