Role of potassium channels in the antinociception induced by agonists of α2-adrenoceptors

British Journal of Pharmacology

Volumn 126, Issue 5, 1999, Pages 1214-1220

  Galeotti, Nicoletta ^a   Ghelardini, Carla ^a   Vinci, Maria Cristina ^a   Bartolini, Alessandro ^a  

^a Dept Preclin and Clin Pharmacol ^*  (Italy)

Author keywords

Antinociception; Apamin; Clonidine; Diazoxide; Gliquidone; Guanabenz; K+ channel; Kvl.1; Minoxidil; Pinacidil

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ANTISENSE OLIGONUCLEOTIDE; APAMIN; CLONIDINE; DIAZOXIDE; GLIQUIDONE; GUANABENZ; MINOXIDIL; PERTUSSIS TOXIN; PINACIDIL; POTASSIUM CHANNEL;

ANALGESIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG POTENTIATION; HOT PLATE TEST; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; MOTOR COORDINATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0032976334     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702395     Document Type: Article

References (42)

1. 2-agonists in locus coeruleus neurones. Brain Res., 371, 390-394.
2. + channels. Science, 247, 852-854.
3. 2-adrenoceptor-induced hyperpolarization of locus coeruleus neurones in brain slices: Reversal by cyclic adenosine 3′ : 5′-monophosphate analogues. J. Neurosci., 5, 2359-2364.
4. ARONSON, J.K. (1992). Potassium channels in nervous tissue. Biochem. Pharmacol., 43, 11-14.
5. BOSMA, M.M., ALLEN, M.L., MARTIN, T.M. & TEMPEL, B.L. (1993). PKA-dependent regulation of mKv1.1, a mouse Shaker-like potassium channel gene, when expressed in CHO cells. J. Neurosci., 13, 5242-5250.
6. CHANDY, K.G., WILLIAMS, C.B., SPENCER, R.H., AGUILAR, B.A., GHANSHANI, S., TEMPEL, B.L. & GUTMAN, G.A. (1990). A family of three mouse potassium channel genes with intronless coding regions. Science, 247, 973-975.
7. CHERUBINI, E. & NORTH, R.A. (1985). μ and κ opioids inhibit transmitter release by different mechanisms. Proc. Natl. Acad. Sci. U.S.A., 82, 1860-1863.
8. COOK, N.S. (1988). The pharmacology of potassium channels and their therapeutic potential. Trend Pharmacol. Sci., 9, 21-28.
9. COOK, N.S. & QUAST, U. (1990). Potassium channel pharmacology. In Potassium Channels: Structure, Classification, Function and Therapeutic Potential. ed. Cook, N.S. pp. 181-255. Chichester: Ellis Horwood Limited.
10. + on the responses to levcromakalim and P1060 in the isolated human myometrium. Eur. J. Pharmacol., 272, 293-296.
11. EDWARDS, G. & WESTON, A.H. (1993). The pharmacology of ATP-sensitive potassium channels. Annu. Rev. Pharmacol. Toxicol., 33, 597-637.
12. FIELDING, S. & LAL, H. (1981). Clonidine: new research in psychotropic drugs pharmacology. Med. Res. Rev., 1, 97-123.
13. FIELDING, S., WILKER, J., HYNES, J., SZEWCZAK, M., NOVIC, W.J. & LAL, M. (1978). A comparison of clonidine with morphine for antinociceptive and antiwithdrawal actions. J. Pharmacol. Exp. Ther., 270, 899-905.
14. GALEOTTI, N., GHELARDINI, C., PAPUCCI, L., QUATTRONE, A., CAPACCIOLI, S. & BARTOLINI, A. (1997). An antisense oligonucleotide to the mouse Shaker-like potassium channel Kv1.1 gene prevents the antinociception induced by morphine and baclofen. J. Pharmacol. Exp. Ther., 281, 941-949.
15. GHELARDINI, C., GALEOTTI, N. & BARTOLINI, A. (1998). Potassium channel modulators influence cognitive processes in mice. Br. J. Pharmacol., 123, 1079-1084.
16. GHELARDINI, C., GALEOTTI, N., PECORI VETTORI, A., CAPACCIOLI, S., QUATTRONE, A. & BARTOLINI, A. (1997). Effect of potassium channels modulation on mouse feeding behaviour. Eur. J. Pharmacol., 329, 1-8.
17. + current by isoprenaline in bull-frog atrial myocytes. J. Physiol., 415, 233-249.
18. HALEY, T.J. & MCCORMICK, W.G. (1957). Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse. Br. J. Pharmacol. Chemother., 12, 12-15.
19. + channels in the central nervous system. In Potassium Channels: Structure, Classification, Function and Therapeutic Potential. ed. Cook, N.S. pp. 348-381. Chichester: Ellis Horwood Limited.
20. HILLE, B. (1994). Modulation of ion-channel function by G-protein-coupled receptors. Trends Neurosci., 17, 531-536.
21. HOLZ, G.G., RANE, S.G. & DUNLAP, K. (1986). GTP-binding proteins mediate transmitter inhibition of voltage-dependent calcium channels. Nature, 319, 670-672.
22. HOPKINS, W.F. & TEMPEL, B.L. (1992). Members of a mouse subfamily of genes encoding voltage-gated potassium channel subunits form heteromultimers when coexpressed in Xenopus oocytes. Soc. Neurosci. Abstr., 18, 1093.
23. LONGMAN, S.D. & HAMILTON, T.C. (1992). Potassium channel activator drugs: mechanism of action, pharmacological properties, and therapeutic potential. Med. Res. Rev., 12, 73-148.
24. 2-adrenoceptor-subtype function. Trends Pharmacol. Sci., 18, 211-219.
25. + channels in the modulation of cholinergic neural responses in guinea-pig and human airways. J. Physiol., 455, 1-15.
26. MORITA, K. & NORTH, R.A. (1981). Clonidine activates membrane potassium conductance in myenteric neurones. Br. J. Pharmacol., 74, 419-428.
27. O'CALLAGHAN, J.P. & HOLTZMAN, S.G. (1975). Quantification of the analgesic activity of narcotic antagonists by a modified hotplate procedure. J. Pharmacol. Exp. Ther., 192, 497-505.
28. B and κ-opioid receptor agonists. Br. J. Pharmacol., 110, 1049-1054.
29. B, mu and kappa opioid receptors. J. Pharmacol. Exp. Ther., 276, 1136-1142.
30. QUAYLE, J.M., STANDEN, N.B. & STANFIELD, P.R. (1988). The voltage-dependent block of ATP-sensitive potassium channels of frog skeletal muscle by caesium and barium ions. J. Physiol., 405, 677-697.
31. RAFFA, R.B. & MARTINEZ, R.P. (1995). The glibenclamide shift of centrally-acting antinociceptive agents in mice. Brain Res., 677, 277-282.
32. RUDY, B. (1988). Diversity and ubiquity of K channels. Neuroscience, 25, 729-749.
33. 2-mediated supraspinal analgesia in mice. Life Sci., 48, 1721-1727.
34. SKINGLE, M., HAYES, A.G. & TYERS, M.B. (1982). Antinociceptive activity of clonidine in the mouse, rat and dog. Life Sci., 31, 1123-1132.
35. + current in human T lymphocytes. J. Membr. Biol., 117, 263-274.
36. STRETTON, D., MIURA, M., BELVISI, M.G. & BARNES, P.J. (1992). Calcium-activated potassium channels mediate prejunctional inhibition of peripheral sensory nerves. Proc. Natl. Acad. Sci. U.S.A., 89, 1325-1329.
37. TATSUMI, H., COSTA, M., SCHIMERLIK, M. & NORTH, R.A. (1990). Potassium conductance increased by noradrenaline, opioids, somatostatin, and G-proteins: whole-cell recording from guinea-pig submucous neurons. J. Neurosci., 10, 1675-1682.
38. VAUGHT, J., PELLEY, K., COSTA, L.G., SETHER, P. & ENNA, S.J. (1985). A comparison of the antinociceptive responses to GABA-receptor agonists THIP and baclofen. Neuropharmacology, 24, 211-216.
39. WANG, H., KUNKEL, D.D., SCHWARTZKROIN, P.A. & TEMPEL, B.L. (1994). Localization of Kv1.1 and Kv1.2, two K channel proteins, to synaptic terminals, somata, and dendrites in the mouse brain. J. Neurosci., 14, 4588-4599.
40. WELCH, S.P. & DUNLOW, L.D. (1993). Antinociceptive activity of intrathecally administered potassium channel openers and opioid agonists: a common mechanism of action? J. Pharmacol. Exp. Ther., 267, 390-399.
41. WILLIAMS, J.T. & NORTH, R.A. (1985). Catecholamine inhibition of calcium action potentials in rat locus coeruleus neurones. Neuroscience, 14, 103-109.
42. WILLIAMS, J.T., NORTH, R.A. & TOKIMASA, T. (1988). Inward rectification of resting and opiate-activated potassium currents in rat locus coeruleus neurones. J. Neurosci., 8, 4299-4306.