Determination of rat urinary metabolites of icariin in vivo and estrogenic activities of its metabolites on MCF-7 cells

Pharmazie

Volumn 60, Issue 2, 2005, Pages 120-125

  Jian, Liu ^a   Haiyong, Ye ^a   Yijia, Lou ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHANIN A; DAIDZEIN; ESTRADIOL; FORMONONETIN; GENISTEIN; ICARIIN; ICARISIDE; ICARITIN; KAEMPFEROL; NORICARITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPILLARY ZONE ELECTROPHORESIS; CELL PROLIFERATION; CONTROLLED STUDY; DRUG BINDING; DRUG DETERMINATION; DRUG METABOLISM; DRUG URINE LEVEL; ELECTROSPRAY MASS SPECTROMETRY; ESTROGEN ACTIVITY; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MALE; METABOLITE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; BIOTRANSFORMATION; CELL LINE, TUMOR; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CULTURE MEDIA; FLAVONOIDS; MALE; PHYTOESTROGENS; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 14244268901     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Bail LJC, Varnat F, Nicoals JC, Habrioux G (1998) Estrogenic and antiproliferative activities on MCF-7 human breast cancer cells by flavonoids. Cancer Lett 130: 209-216.
2. Berthois Y, Katzenellenbogen J, Katzenellenbogen B (1986) Phenol red in tissue culture media is a weak oestrogen: implications concerning the study of oestrogen-responsive cells in culture. Proc Natl Acad Sci USA 83: 2496-2500.
3. Bingham SA, Atkinson C, Liggins J, Bluck L, Coward A (1998) Phytooestrogens: where are we now? Br J Nutr 79: 393-406.
4. Boone CM, Franke JP, Zeeuw RA, Ensing K (1999) Evaluation of capillary electrophoretic techniques towards systematic toxicological analysis. J Chromatogr A 838: 259-272.
5. Breinholt V, Larsen JC (1998) Detection of weak estrogenic flavonoids using a recombinant yeast strain and a modified MCF-7 cell proliferation assay. Chem Res Toxicol 11: 622-629.
6. Carmichael J, DeGraff WG, Gazadar AF, Minna JD, Mitchell JB (1987) Evaluation of a tetrazolium-based semiautomated colormetric assay: assessment of chemosensitivity testing. Cancer Research 47: 943-946.
7. China Pharmacopa 7th Ed. 2000: 267-268.
8. Darbre PD, Daly RJ (1989) Effects of oestrogen on human breast cancer cells in culture. Proc R Soc Edinburgh 95B: 119-132.
9. Grace PB, Taylor JI, Botting NP, Fryatt T, Oldfield MF, AI-Maharik N, Bingham SA (2003) Quantification of isoflavones and lignans in serum using isotope dilution liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 17: 1350-1357.
10. Guo T, Shi GB, Song HT, Gao SC, Chi WG, Mu P, Ma Y, Jin BF, Yang S (1996) Development of Huichunzhibao oral preparation. China J Chin Materia Med (Zhongguo Zhong Yao Za Zhi) 21: 219-222.
11. Huang HY, Kuo KL, Hsieh YZ (1997) Determination of cinnamaldehyde, cinnamic acid, paeoniflorin, glycyrrhizin and [6]-gingerol in the traditional Chinese medicinal preparation Kuei-chih-tang by cyclodextrin-modified micellar electrokinetic chromatography. J Chromatogr A 771: 267-274.
12. Huang SSC, Komatsu KI, Ren SSJ, Lien LL, Lien EJ (2001) Phytohormones and antioxidants in Chinese herbs and natural food. Int J Oriental Med 26: 66-86.
13. Ji H, Liu K, Li SP, Gong XJ (2000), Effect of HEF on osteoporosis induced by retinoic acid in male rats. J Chin Pharma University (Zhong-guo Yao Ke Da Xue Xue Bao) 31: 222-225.
14. Jiang YN, Mo HY, Chen JM (2002) Effects of Epimedium total flavonoids phytosomes on preventing and treating bone-loss of ovariectomized rats. China J Chin Materia Med (Zhongguo Zhong Yao Za Zhi) 27: 221-224.
15. Kavlock RJ, Daston GP, DeRosa C, Fenner-Crisp P, Gray LE, Kaatari S, Lucier G, Luster M, Mac MJ, Maczka C, Miller R, Moore J, Rolland R, Scott G, Sheehan DM, Sinks T, Tilson HA (1996) Research needs for risk assessment of health and environmental effects of endocrine disrupters: A report of U.S. EPA-sponsored workshop. Environ Health Perspect 104: 715-740.
16. Kelly GE, Nelson C, Waring MA, Joannou GE, Reeder AY (1993) Metabolites of dietary (soya) isoflavones in human urine. Clin Chim Acta 223: 9-22.
17. Kuiper GGJM, Lemmen JG, Carlsson B, Corton JC, Safe SH, Saag PTVD, Burg BVD, Gustafsson JA (1998) Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology 139: 4252-4263.
18. Lenoble R, Richheimer SL, Bailey DT, Mannila CG, Nichol RL: PCT Int. Appl. 2002, 45 PP. Application: WO 2001-US22700 20010719. Priority: US 2000-63836720000815.
19. Mauri PL, Basilico F, Pietta PG, Pasini E, Monti D, Sauerwein W (2003) New approach for the detection of BSH and its metabolites using capillary electrophoresis and electrospray ionization mass spectrometry. J Chromatogr B 788: 9-16.
20. Miksicek RJ (1995) Estrogenic flavonoids: structural requirements for biological activity. Proc Soc Exp Biol Med 208: 44-50.
21. Mohsen MMAE, Kuhnle G, Rechner AR, Schroeter H, Rose S, Jenner P, Rice-Evans CA (2002) Uptake and metabolism of epicatechin and its access to the brain after oral ingestion. Free Radic Biol Med 33: 1639-1702.
22. Nemutlu E, Kir S (2003) Method development and validation for the analysis of meloxicam in tablets by CZE. J Pharm Biomed Anal 31: 393-400.
23. O'Leary KA, Day AJ, Needs PW, Mellon FA, O'Brien NM, Williamson G (2003) Metabolism of quercetin-7-and quercetin-3-glucuronides by an in vivo hepatic model: the role of human β-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (BRP2) in flavonoid metabolism. Biochem Pharma 65: 479-491.
24. Payne J, Jones C, Lakhani S, and Kortenkamp A (2000) Improving the reproducibility of the MCF-7 cell proliferation assay for the detection of xenoestrogens. Sci Tot Environ 248: 51-62.
25. Qiu F, Chen YJ, Kano YH, Yao XS (1999) Metabolism of orally administered icariin in rats. Acta Pharm Sin (Yao Xue Xue Bao) 34: 222-226.
26. Soto A, Sonnenschein C (1985) The role of estrogens on the proliferation of human breast tumor cells (MCF-7). J Steroid Biochem 23: 87-94.
27. Soto AM, Sonnenschein C, Chung KL, Fernandez MF, Olean N, Serrano FO (1995) The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants. Environ Health Perspect 103: 113-122.
28. Soto AM, Fernandez MF, Luizzi MF, Oles Karasko AS, and Sonnenschein C (1997) Developing a marker of exposure to xenoestrogen mixtures in human serum. Environ Health Perspect 105: 647-654.
29. Tagliaro F, Smith FP, Turrina S, Equisetto V, Mango M (1996) Complementary use of capillary zone electrophoresis and micellar electrokinetic capillary chromatography for mutual confirmation of results in forensic drug analysis. J Chromatogr A 735: 227-235.
30. Thomas JA, Keenam EJ (1986) Estrogens and anti-estrogenic drugs. In: Principles of Endocrine Pharmacology. Plenum, New York, p. 135-165.
31. Vibeke B, John CL (1998) Detection of weak estrogenic flavonoids using a recombinant yeast strain and a modified MCF-7 cell proliferation assay. Chem Res Toxicol 11: 622-629.
32. Wang BL, Quan JX, Guo SY, Jia WH, Qiu MC (2000) Effects of Epimedium on the expression of interleukin-6 messenger ribonucleic acid in bone of ovariectomized rat. Chin J Obstet Gynecol (Zhonghua Fu Chan Ke Za Zhi) 35: 724-726.
33. Wu H, Lien EJ, Lien LL (2003) Chemical and pharmaceutical investigations of Epimedium species: a survey. Prog Drug Res 60: 1-57.
34. Xin ZC: PCT Int. Appl. 2000, 20 PP. Application: WO 2000-CN161 20000616. Priority: KR 99-2266519990617.
35. Zhang RZ, Xu XH, Chen TB, Long L, Rao PF (2000) An assay for angiotensin-converting enzyme using capillary zone electrophoresis. Anal Biochem 280: 286-290.
36. Zhou TS, Yu H, Hu Q, Fang YZ (2002) Determination of codeine and its metabolite in human urine by CE with amperometric detection. J Pharm Biomed Anal 30: 13-19.