Proliferation-stimulating effects of icaritin and desmethylicaritin in MCF-7 cells

European Journal of Pharmacology

Volumn 504, Issue 3, 2004, Pages 147-153

  Wang, Zhi Qiang ^a   Lou, Yi Jia ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Cell cycle analysis; Desmethylicaritin; Estrogenic activity; Icariin; Icaritin; Phytoestrogen; Reverse transcriptase polymerase chain reaction (RT PCR); S phase

Indexed keywords

ANTIESTROGEN; ESTRADIOL; ESTROGEN RECEPTOR; FULVESTRANT; ICARIIN; ICARITIN; MESSENGER RNA; NORICARITIN; PHYTOESTROGEN; PROGESTERONE RECEPTOR; PROTEIN PS2; UNCLASSIFIED DRUG;

ARTICLE; BREAST ADENOCARCINOMA; CARCINOMA CELL; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CHARCOAL; DEXTRANS; ESTRADIOL; ESTROGEN ANTAGONISTS; ESTROGENS, NON-STEROIDAL; FEMALE; FLAVONOIDS; HUMANS; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STIMULATION, CHEMICAL;

EID: 8444230563     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.10.002     Document Type: Article

References (29)

1. S.A. Bingham, C. Atkinson, J. Liggins, L. Bluck, and A. Coward Phyto-oestrogens: where are we now? Br. J. Nutr. 79 1998 393 406
2. V. Breinholt, and J.C. Larsen Detection of weak estrogenic flavonoids using a recombinant yeast strain and a modified MCF7 cell proliferation assay Chem. Res. Toxicol. 11 1998 622 629
3. C.A. Calliste, J.C. Le Bail, P. Trouillas, C. Pouget, G. Habrioux, A.J. Chulia, and J.L. Duroux Chalcones: structural requirements for antioxidant, estrogenic and antiproliferative activities Anticancer Res. 21 2001 3949 3956
4. G. Castoria, M.V. Barone, M. Di Domenico, A. Bilancio, D. Ametrano, A. Migliaccio, and F. Auricchio Non-transcriptional action of oestradiol and progestin triggers DNA synthesis EMBO J. 18 1999 2500 2510
5. B.M. Collins-Burow, M.E. Burow, B.N. Duong, and J.A. McLachlan Estrogenic and antiestrogenic activities of flavonoid phytochemicals through estrogen receptor binding-dependent and -independent mechanisms Nutr. Cancer 38 2000 229 244
6. P. Cos, T. De Bruyne, S. Apers, D. Vanden Berghe, L. Pieters, and A.J. Vlietinck Phytoestrogens: recent developments Planta Med. 69 2003 589 599
7. S. Dauvois, P.S. Danielian, R. White, and M.G. Parker Antiestrogen ICI 164,384 reduces cellular estrogen receptor content by increasing its turnover Proc. Natl. Acad. Sci. U. S. A. 89 9 1992 4037 4041
8. J. Frasor, J.M. Danes, B. Komm, K.C. Chang, C.R. Lyttle, and B.S. Katzenellenbogen Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype Endocrinology 144 2003 4562 4574
9. M.K. Gibson, L.A. Nemmers, W.C. Beckman Jr., V.L. Davis, S.W. Curtis, and K.S. Korach The mechanism of ICI 164,384 antiestrogenicity involves rapid loss of estrogen receptor in uterine tissue Endocrinology 129 1991 2000 2010
10. J.M. Hall, J.F. Couse, and K.S. Korach The multifaceted mechanisms of estradiol and estrogen receptor signaling J. Biol. Chem. 276 2001 36869 36872
11. W. He, H. Sun, B. Yang, D. Zhang, and D. Kabelitz Immunoregulatory effects of the herb Epimedia glycoside icariin Arzneimittel-Forschung 45 1995 910 913
12. S.P. Hiremath, S. Badami, S.K. Hunasagatta, and S.B. Patil Antifertility and hormonal properties of flavones of Striga orobanchioides Eur. J. Pharmacol. 391 2000 193 197
13. A. Howell, C.K. Osborne, C. Morris, and A.E. Wakeling ICI 182,780 (Faslodex): development of a novel, "pure" antiestrogen Cancer 89 2000 817 825
14. M. Kitaoka, H. Kadokawa, M. Sugano, K. Ichikawa, M. Taki, S. Takaishi, Y. Iijima, S. Tsutsumi, M. Boriboon, and T. Akiyama Prenylflavonoids: a new class of non-steroidal phytoestrogen (Part 1). Isolation of 8-isopentenylnaringenin and an initial study on its structure-activity relationship Planta Med. 64 1998 511 515
15. G.G.E.E. Kuiper, M. Pelto-Huikko, S. Nilsson, and J.A. Gustafsson Cloning of a novel receptor expressed in rat prostate and ovary Proc. Natl. Acad. Sci. 93 1996 5925 5930
16. M.K. Lee, Y.J. Choi, S.H. Sung, D.I. Shin, J.W. Kim, and Y.C. Kim Antihepatotoxic activity of icariin, a major constituent of Epimedium koreanum Planta Med. 61 1995 523 526
17. F. Li, E. Li, Z. Lu, S. Song, X. Wang, and X. Tong Effects of icariin on secretive function of cultured granulosa and adrenal cortical cells of rats Zhongguo Zhongyao Zazhi 22 1997 499 500
18. J. Liggins, L.J. Bluck, S. Runswick, C. Atkinson, W.A. Coward, and S.A. Bingham Daidzein and genistein contents of vegetables Br. J. Nutr. 84 2000 717 725
19. H. Mao, L. Zhang, Y. Wang, and X. Li Experimental studies of icariin on anticancer mechanism Zhong Yao Cai 23 2000 554 556
20. J.F.W. Mcomie, M.L. Watts, and D.E. West Demethylation of aryl methyl ethers by boron tribromide Tetrahedron 24 1968 2289 2292
21. R.J. Miksicek Estrogenic flavonoids: structural requirements for biological activity Proc. Soc. Exp. Biol. Med. 208 1995 44 50
22. C.A. Oliveira, R. Nie, K. Carnes, L.R. Franca, G.S. Prins, P.T. Saunders, and R.A. Hess The antiestrogen ICI 182,780 decreases the expression of estrogen receptor-alpha but has no effect on estrogen receptor-beta and androgen receptor in rat efferent ductules Reprod. Biol. Endocrinol. 1 2003 75
23. T. Otsuki, O. Yamada, J. Kurebayashi, T. Moriya, H. Sakaguchi, H. Kunisue, K. Yata, M. Uno, Y. Yawata, and A. Ueki Estrogen receptors in human myeloma cells Cancer Res. 60 2000 1434 1441
24. J. Payne, C. Jones, S. Lakhani, and A. Kortenkamp Improving the reproducibility of the MCF-7 cell proliferation assay for the detection of xenoestrogens Sci. Total Environ. 248 2000 51 62
25. J.C. Reese, and B.S. Katzenellenbogen Examination of the DNA-binding ability of estrogen receptor in whole cells: implications for hormone-dependent transactivation and the actions of antiestrogens Mol. Cell. Biol. 12 1992 4531 4538
26. A.M. Soto, C. Sonnenschein, K.L. Chung, M.F. Fernandez, N. Olea, and F.O. Serrano The E-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants Environ. Health Perspect. 103 Suppl 7 1995 113 122
27. M.J. Tsai, and B.W. O'Malley Molecular mechanisms of action of steroid/thyroid receptor superfamily members Annu. Rev. Biochem. 63 1994 451 486
28. H. Wu, E.J. Lien, and L.L. Lien Chemical and pharmacological investigations of Epimedium species: a survey Prog. Drug Res. 60 2003 1 57
29. Y.W. Zhang, I. Morita, G. Shao, X.S. Yao, and S. Murota Screening of anti-hypoxia/reoxygenation agents by an in vitro model: Part 1. Natural inhibitors for protein tyrosine kinase activated by hypoxia/reoxygenation in cultured human umbilical vein endothelial cells Planta Med. 66 2000 114 118