Molecular markers in CNS stem cell research: Hitting a moving target

Nature Reviews Neuroscience

Volumn 2, Issue 11, 2001, Pages 843-846

  Kornblum, Harley I ^a   Geschwind, Daniel H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER;

ANIMAL; BIOLOGICAL MODEL; CELL LINEAGE; CENTRAL NERVOUS SYSTEM; CYTOLOGY; GENE EXPRESSION PROFILING; GROWTH, DEVELOPMENT AND AGING; HUMAN; IN SITU HYBRIDIZATION; NERVE CELL; PHYSIOLOGY; REVIEW; STEM CELL;

ANIMAL; BIOLOGICAL MARKERS; CELL LINEAGE; CENTRAL NERVOUS SYSTEM; GENE EXPRESSION PROFILING; HUMAN; IN SITU HYBRIDIZATION; MODELS, BIOLOGICAL; NEURONS; STEM CELLS; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0035511908     PISSN: 14710048     EISSN: None     Source Type: Journal    
DOI: 10.1038/35097597     Document Type: Review

References (34)

1. Raff, M. C. et al. Galactocerebroside is a specific cell-surface antigenic marker for oligodendrocytes in culture. Nature 274, 813-816 (1978).
2. Geisert, E. E., Jr. & Frankfurter, A. The neuronal response to injury as visualized by immunostaining of class III β-tubulin in the rat. Neurosci. Lett. 102, 137-141 (1989).
3. Zhang, S.-C. Defining glial cells during CNS development. Nature Rev. Neurosci. 2, 840-843 (2001).
4. Lendahl, U., Zimmerman, L. B. & McKay, R. D. CNS stem cells express a new class of intermediate filament protein. Cell 60, 585-595 (1990).
5. Clarke, S. R., Shetty, A. K., Bradley, J. L. & Turner, D. A. Reactive astrocytes express the embryonic intermediate neurofilament nestin. Neuroreport 5, 1885-1888 (1994).
6. Sejersen, T. & Lendahl, U. Transient expression of the intermediate filament nestin during skeletal muscle development. J. Cell Sci. 106, 1291-1300 (1993).
7. Reynolds, B. A. & Weiss, S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 255, 1707-1710 (1992).
8. Reynolds, B. A. & Weiss, S. Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell. Dev. Biol. 175, 1-13 (1996).
9. Vescovi, A. L., Reynolds, B. A., Fraser, D. D. & Weiss, S. bFGF regulates the proliferative fate of unipotent (neuronal) and bipotent (neuronal/astroglial) EGF-generated CNS progenitor cells. Neuron 11, 951-966 (1993).
10. Ciccolini, F. & Svendsen, C. N. Fibroblast growth factor 2 (FGF-2) promotes acquisition of epidermal growth factor (EGF) responsiveness in mouse striatal precursor cells: identification of neural precursors responding to both EGF and FGF-2. J. Neurosci. 18, 7869-7880 (1998).
11. Okabe, S., Forsberg-Nilsson, K., Spiro, A. C., Segal, M. & McKay, R. D. Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro. Mech. Dev. 59, 89-102 (1996).
12. Tropepe, V. et al. Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism. Neuron 30, 65-78 (2001).
13. Tropepe, V. et al. Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon. Dev. Biol. 208, 166-188 (1999).
14. Qian, X. et al. Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical stem cells. Neuron 28, 69-80 (2000).
15. Gage, F. H. et al. Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain. Proc. Natl Acad. Sci. USA 92, 11879-11883 (1995).
16. Parent, J. M. et al. Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. J. Neurosci. 17, 3727-3738 (1997).
17. Kempermann, G., Kuhn, H. G. & Gage, F. H. Experience-induced neurogenesis in the senescent dentate gyrus. J. Neurosci. 18, 3206-3212 (1998).
18. Laywell, E. D., Rakic, P., Kukekov, V. G., Holland, E. C. & Steindler, D. A. Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain. Proc. Natl Acad. Sci. USA 97, 13883-13883 (2000).
19. Doetsch, F., Caille, I., Lim, D. A., Garcia-Verdugo, J. M. & Alvarez-Buylla, A. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 97, 703-716 (1999).
20. Johansson, C. B. et al. Identification of a neural stem cell in the adult mammalian central nervous system. Cell 96, 25-34 (1999).
21. Kondo, T. & Raff, M. Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells. Science 289, 1754-1757 (2000).
22. Mezey, E., Chandross, K. J., Harta, G., Maki, R. A. & McKercher, S. R. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 290, 1779-1782 (2000).
23. Brazelton, T. R., Rossi, F. M., Keshet, G. I. & Blau, H. M. From marrow to brain: expression of neuronal phenotypes in adult mice. Science 290, 1775-1779 (2000).
24. Luo, Z. & Geschwind, D. H. Microarray applications in neuroscience. Neurobiol. Dis. 8, 183-193 (2001).
25. Luo, L. et al. Gene expression profiles of laser-captured adjacent neuronal subtypes. Nature Med. 5, 117-122 (1999).
26. Gall, C. M. Regulation of brain neurotrophin expression by physiological activity. Trends Pharmacol. Sci. 13, 401-403 (1992).
27. Vician, L. et al. Synaptotagmin IV is an immediate early gene induced by depolarization in PC12 cells and in brain. Proc. Natl Acad. Sci. USA 92, 2164-2168 (1995).
28. Vician, L., Basconcillo, R. & Herschman, H. R. Identification of genes preferentially induced by nerve growth factor versus epidermal growth factor in PC12 pheochromocytoma cells by means of representational difference analysis. J. Neurosci. Res. 50, 32-43 (1997).
29. Terskikh, A. V. et al. From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Proc. Natl Acad. Sci. USA 98, 7934-7939 (2001).
30. Geschwind, D. H. et al. A genetic analysis of neural progenitor differentiation. Neuron 29, 325-339 (2001).
31. Uchida, N. et al. Direct isolation of human central nervous system stem cells. Proc. Natl Acad. Sci. USA 97, 14720-14725 (2000).
32. Rietze, R. L. et al. Purification of a pluripotent neural stem cell from the adult mouse brain. Nature 412, 736-739 (2001).
33. Keyoung, H. M. et al. High-yield selection and extraction of two promoter-defined phenotypes of neural stem cells from the fetal human brain. Nature Biotechnol. 19, 843-850 (2001).
34. Tyagi, S. & Kramer, F. R. Molecular beacons: probes that fluoresce upon hybridization. Nature Biotechnol. 14, 303-308 (1996).