Non-linear enzymatic logic in natural product modular mega-synthases and -synthetases

Current Opinion in Drug Discovery and Development

Volumn 10, Issue 2, 2007, Pages 203-218

  Haynes, Stuart W ^a   Challis, Gregory L ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Biosynthesis; Co linearity; Mechanistic enzymology; Modular synthase; Modular synthetase; Non ribosomal peptide; Nonlinearity; Polyketide

Indexed keywords

6 DEOXYERYTHRONOLIDE B; AUREOTHAN; BORRELIDIN; CALICHEAMICIN; COELICHELIN; CYCLOSPORIN A; DAPTOMYCIN; DOXORUBICIN; ERYTHROMYCIN; ERYTHRONOLIDE DERIVATIVE; GRAMICIDIN S; LANKACIDIN; LEINAMYCIN; MACROLIDE; METHYMYCIN; MYXOCHELIN; MYXOCHROMIDE; NATURAL PRODUCT; PENICILLIN G; PIKROMYCIN; POLYKETIDE SYNTHASE; PROTEIN; STIGMATELLIN; SYNTHETASE; TACROLIMUS; UNCLASSIFIED DRUG; VANCOMYCIN; VIBRIOBACTIN;

CATALYSIS; ENZYME KINETICS; GENETIC ENGINEERING; MOLECULAR DYNAMICS; NONLINEAR SYSTEM; POLYMERIZATION; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN FUNCTION; REVIEW; SACCHAROPOLYSPORA; SACCHAROPOLYSPORA ERYTHREA;

ANIMALS; BIOLOGICAL PRODUCTS; HUMANS; LIGASES; NONLINEAR DYNAMICS;

EID: 33947303415     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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