Evidence that a novel thioesterase is responsible for polyketide chain release during biosynthesis of the polyether ionophore monensin

ChemBioChem

Volumn 7, Issue 9, 2006, Pages 1435-1442

  Harvey, Barbara M ^a   Hong, Hui ^a   Jones, Michelle A ^a,b   Hughes Thomas, Zoë A ^a,c   Goss, Rebecca M ^a,d   Heathcote, Michelle L ^a,e   Bolanos Garcia, Victor M ^a   Kroutil, Wolfgang ^a,f   Staunton, James ^a   Leadlay, Peter F ^a   Spencer, Jonathan B ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ASTEX PHARMACEUTICALS   (United Kingdom)

^c Dowpharma Chirotech Technology Ltd   (United Kingdom)

^d UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^e GLAXOSMITHKLINE   (United Kingdom)

^f UNIVERSITY OF GRAZ   (Austria)

Author keywords

Antibiotics; Biosynthesis; Monensin; Polyketides; Thioesterase

Indexed keywords

BENZYLSULFONYL FLUORIDE; EPOXIDE HYDROLASE; IONOPHORE; MONENSIN; POLYETHER DERIVATIVE; POLYKETIDE SYNTHASE; THIOL ESTER HYDROLASE;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL CELL; BIOSYNTHESIS; CATALYSIS; CYCLIZATION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; ENZYME SYNTHESIS; GENE CLUSTER; GENE EXPRESSION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; STREPTOMYCES;

AMINO ACID SEQUENCE; CATALYSIS; CATALYTIC DOMAIN; DITHIONITROBENZOIC ACID; ESCHERICHIA COLI; GENE DELETION; MACROLIDES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; MONENSIN; PHENYLMETHYLSULFONYL FLUORIDE; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; STREPTOMYCES; THIOLESTER HYDROLASES;

STREPTOMYCES CINNAMONENSIS;

EID: 33748550675     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200500474     Document Type: Article

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