Kinetic analysis of three activated phenylalanyl intermediates generated by the initiation module PheATE of gramicidin S synthetase

Biochemistry

Volumn 40, Issue 18, 2001, Pages 5329-5337

  Luo, Lusong ^a   Walsh, Christopher T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NONRIBOSOMAL PEPTIDE SYNTHETASE (NRPS);

ACTIVATION ANALYSIS; AMINO ACIDS; ANTIBIOTICS; CATALYSIS; CHEMICAL REACTIONS; ENZYMES; QUENCHING; SUBSTRATES;

BIOCHEMISTRY;

DEXTRO PHENYLALANYL S 4' PHOSPHOPANTETHEINE ACYL ENZYME; GRAMICIDIN S SYNTHETASE; PEPTIDE SYNTHASE; PHENYLALANINE DERIVATIVE; PHENYLALANYL ADENOSINE 5' PHOSPHATE DIESTER; PHENYLALANYL S 4' PHOSPHOPANTETHEINE; SULFUR DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID METABOLISM; ARTICLE; BREVIBACILLUS BREVIS; CATALYSIS; CHEMICAL ANALYSIS; CHEMICAL REACTION; CHEMICAL REACTION KINETICS; ENZYME ACTIVATION; PRIORITY JOURNAL; PROTEIN DOMAIN;

ADENOSINE MONOPHOSPHATE; ALANINE; AMINO ACID ISOMERASES; AMINO ACID MOTIFS; AMINOACYLATION; APOENZYMES; BACILLUS; CARBON RADIOISOTOPES; CATALYSIS; GRAMICIDIN; HISTIDINE; HOLOENZYMES; KINETICS; MUTAGENESIS, SITE-DIRECTED; PANTETHEINE; PEPTIDE CHAIN INITIATION, TRANSLATIONAL; PHENYLALANINE; PROTEIN STRUCTURE, TERTIARY;

BACTERIA (MICROORGANISMS); BREVIBACILLUS BREVIS;

EID: 0035826653     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi015518+     Document Type: Article

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