Tissue-sparing effect of x-ray microplanar beams particularly in the CNS: Is a bystander effect involved?

Experimental Hematology

Volumn 35, Issue 4 SUPPL., 2007, Pages 69-77

  Dilmanian, F Avraham ^a   Qu, Yun ^b   Feinendegen, Ludwig E ^a,c   Peña, Louis A ^a   Bacarian, Tigran ^a   Henn, Fritz A ^a   Kalef Ezra, John ^d   Liu, Su ^b   Zhong, Zhong ^a   McDonald, John W ^b  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d UNIVERSITY OF IOANNINA   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

MYELIN;

ANIMAL CELL; ANIMAL CELL CULTURE; AORTA; APOPTOSIS; ARTICLE; ASTROCYTE; BYSTANDER EFFECT; CELL DEATH; CELL LOSS; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DOSIMETRY; ENDOTHELIUM CELL; IRRADIATION; MONTE CARLO METHOD; NONHUMAN; OLIGODENDROGLIA; POPULATION RECOVERY; PRIORITY JOURNAL; RADIATION BEAM; RADIATION DOSE; RADIATION DOSE DISTRIBUTION; REMYELINIZATION; SPINAL CORD; SYNCHROTRON RADIATION; TISSUE REPAIR;

ANIMALS; ASTROCYTES; BYSTANDER EFFECT; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; DOSE-RESPONSE RELATIONSHIP, RADIATION; MONTE CARLO METHOD; MYELIN SHEATH; NEOVASCULARIZATION, PHYSIOLOGIC; OLIGODENDROGLIA; RADIATION DOSAGE; RATS; RATS, INBRED F344; REGENERATION; SPINAL CORD INJURIES; X-RAYS;

BOVINAE; RATTUS;

EID: 33947260704     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2007.01.014     Document Type: Article

References (69)

1. Slatkin D.N., Spanne P., Dilmanian F.A., Gebbers J.-O., and Laissue J.A. Subacute neuropathological effects on rats of microplanar beams of x-rays from a synchrotron wiggler. Proc Natl Acad Sci U S A 92 (1995) 8783-8787
2. Laissue J.A., Geiser G., Spanne P.O., et al. Neuropathology of ablation of rat gliosarcomas and contiguous brain tissues using a microplanar beam of synchrotron-wiggler-generated x rays. Int J Cancer 78 (1998) 654-660
3. Laissue J.A., Lyubimova N., Wagner H.P., et al. Microbeam radiation therapy. In: Barber H.B., and Roehrig H. (Eds). Medical Applications of Penetrating Radiation (SPIE Conference Proceedings Vol. 3770) (1999), SPIE, Bellingham, WA 38-45
4. Laissue J.A., Blattmann H., Di Michiel M., et al. The weanling piglet cerebellum:a surrogate for tolerance to MRT (microbeam radiation therapy) in pediatric neuro-oncology. In: Barber H.B., Roehrig H., Doty F.P., Schirato R.C., and Morton E.J. (Eds). Penetrating Radiation Systems and Applications III (SPIE Conference Proceedings Vol. 4508) (2001), SPIE, Bellingham, WA 65-73
5. Dilmanian F.A., Morris G.M., Le Duc G., et al. Response of avian embryonic brain to spatially segmented x-ray microbeams. Cell Mol Biol 47 (2001) 485-494
6. Blattmann H, Burkard W, Michiel M, et al. Microbeam irradiation of the chorio-allantoic membrane (CAM) of the chicken embryo. In: Jaussi R, Gschwend B, eds. Paul Scherrer Institute (PSI) Scientific Report 2001/ Volume II (Life Sciences), ISSN 1423-7318, 2002, Villigen, Switzerland. p. 73.
7. Dilmanian F.A., Button T.M., Le Duc G., et al. Response of the rat intracranial 9L gliosarcoma to Microbeam Radiation Therapy (MRT). Neuro-Oncol 4 (2002) 26-38
8. Dilmanian F.A., Morris G.M., Zhong N., et al. Murine EMT-6 carcinoma: high therapeutic efficacy of microbeam radiation therapy. Radiat Res 159 (2003) 632-641
9. Dilmanian F.A., Kalef-Ezra J., Petersen M.J., et al. Could x-ray microbeams inhibit angioplasty-induced restenosis in the rat carotid artery?. Cardiovasc Radiat Med 4 (2003) 139-145
10. Zhong N., Morris G.M., Bacarian T., Rosen E.M., and Dilmanian F.A. Response of rat skin to high-dose unidirectional X-ray microbeams: a histological study. Radiat Res 160 (2003) 133-142
11. Blattmann H., Gebbers J.-O., Bräuer-Krisch E., et al. Applications of synchrotron X-rays to radiotherapy. Nucl Instrum Methods Phys Res A 548 (2005) 17-22
12. Dilmanian F.A., Qu Y., Liu S., et al. X-ray microbeams: tumor therapy and central nervous system research. Nucl Instrum Methods Phys Res A 548 (2005) 30-37
13. Brauer-Krisch E., Requardt H., Regnard P., et al. New irradiation geometry for microbeam radiation therapy. Phys Med Biol 50 (2005) 3103-3111
14. Miura M., Blattmann H., Brauer-Krisch E., et al. Radiosurgical palliation of aggressive murine SCCVII squamous cell carcinomas using synchrotron-generated X-ray microbeams. Br J Radiol 79 (2006) 71-75
15. Serduc R., Verant P., Vial J.C., et al. In vivo two-photon microscopy study of short-term effects of microbeam irradiation on normal mouse brain microvasculature. Int J Radiat Oncol Biol Phys 64 (2006) 1519-1527
16. Smilowitz H.M., Blattmann H., Brauer-Krisch E., et al. Synergy of gene-mediated immunoprophylaxis and microbeam radiation therapy for advanced intracerebral rat 9L gliosarcomas. J Neurooncol 78 (2006) 135-143
17. Dilmanian F.A., Zhong Z., Bacarian T., et al. Interlaced X-ray microplanar beams: a radiosurgery approach with clinical potential. Proc Natl Acad Sci U S A 103 (2006) 9709-9714
18. Anschel DJ, Romanelli P, Benveniste H, et al. Evolution of a focal brain lesion produced by interlaced microplanar x-rays. Minim Invas Neurosurg. (in press).
19. Nagasawa H., and Little J.B. Induction of sister chromatid exchanges by extremely low doses of alpha-particles. Cancer Res 52 (1992) 6394-6396
20. Prise K.M., Belyakov O.V., Folkard M., et al. Investigating the cellular effects of isolated radiation tracks using microbeam techniques. Adv Space Res 30 (2002) 871-876
21. Belyakov O.V., Folkard M., Mothersill C., Prise K.M., and Michael B.D. Bystander-induced differentiation: a major response to targeted irradiation of a urothelial explant model. Mutat Res 597 (2006) 43-49
22. Shao C., Furusawa Y., Aoki M., and Ando K. Role of gap junctional intercellular communication in radiation-induced bystander effects in human fibroblasts. Radiat Res 160 (2003) 318-323
23. Iyer R., and Lehnert B.E. Low dose, low-LET ionizing radiation-induced radioadaptation and associated early responses in unirradiated cells. Mutat Res 503 (2002) 1-9
24. Prise K.M., Folkard M., and Michael B.D. Bystander responses induced by low LET radiation. Oncogene 22 (2003) 7043-7049
25. Yang H., Asaad N., and Held K.D. Medium-mediated intercellular communication is involved in bystander responses of X-ray-irradiated normal human fibroblasts. Oncogene 24 (2005 Mar 17) 2096-2103
26. Schettino G., Folkard M., Michael B.D., and Prise K.M. Low-dose binary behavior of bystander cell killing after microbeam irradiation of a single cell with focused c(k) x rays. Radiat 163 (2005) 332-336
27. Snyder A.R. Review of radiation-induced bystander effects. Hum Exp Toxicol 23 (2004) 87-89
28. Barcellos-Hoff M.H., and Costes S.V. A systems biology approach to multicellular and multi-generational radiation responses. Mutat Res 597 (2006) 32-38
29. Albanese J., and Dainiak N. Ionizing radiation alters Fas antigen ligand at the cell surface and on exfoliated plasma membrane-derived vesicles: implications for apoptosis and intercellular signaling. Radiat Res 153 (2000) 49-61
30. Mothersill C., and Seymour C. Radiation-induced bystander effects: past history and future directions. Radiat Res 155 (2001) 759-767
31. Goldberg Z., and Lehnert B.E. Radiation-induced effects in unirradiated cells: a review and implications in cancer. Int J Oncol 21 (2002) 337-349
32. Mothersill C., and Seymour C. Radiation-induced bystander effects: are they good, bad or both?. Med Confl Surviv 21 (2005) 101-110
33. Feinendegen L.E., Pollycove M., and Sondhaus C.A. Response to low doses of ionizing radiation in biological systems. Nonlinearity Biol Toxicol Med 2 (2004) 143-171
34. Feinendegen L.E. Relative implications of protective responses versus damage induction at low-dose and low-dose rate exposures, using the microdose approach. Radiat Prot Dosimetry 104 (2003) 337-346
35. Zhou H., Randers-Pehrson G., Waldren C.A., and Hei T.K. Radiation-induced bystander effect and adaptive response in mammalian cells. Adv Space Res 34 (2004) 1368-1372
36. Wang B., Ohyama H., Shang Y., et al. Adaptive response in embryogenesis: IV. Protective and detrimental bystander effects induced by X radiation in cultured limb bud cells of fetal mice. Radiat Res 161 (2004) 9-16
37. Scott B.R. A biological-based model that links genomic instability, bystander effects, and adaptive response. Mutat Res 568 (2004) 129-143
38. Feinendegen L.E., and Neumann R.D. Physics must join with biology in better assessing risk from low-dose irradiation. Radiat Prot Dosimetry 117 (2005) 346-356
39. Kamath A.T., Sheasby C.E., and Tough D.F. Dendritic cells and NK cells stimulate bystander T cell activation in response to TLR agonists through secretion of IFN-αβ and IFN-γ. J Immunol 174 (2005) 767-776
40. Belyakov O.V., Malcolmson A.M., Folkard M., Prise K.M., and Michael B.D. Direct evidence for a bystander effect of ionizing radiation in primary human fibroblasts. Br J Cancer 84 (2001) 674-679
41. Belyakov O.V., Folkard M., Mothersill C., Prise K.M., and Michael B.D. A proliferation-dependent bystander effect in primary porcine and human urothelial explants in response to targeted irradiation. Br J Cancer 88 (2003) 767-774
42. Belyakov O.V., Mitchell S.A., Parikh D., et al. Biological effects in unirradiated human tissue induced by radiation damage up to 1 mm away. Proc Natl Acad Sci U S A 102 (2005) 14203-14208
43. Landthaler M., Hagspiel H.J., and Braun-Falco O. Late irradiation damage to the skin caused by soft X-ray radiation therapy of cutaneous tumors. Arch Dermatol 131 (1995 Feb) 182-186
44. Peña LA, Dilmanian FA, Zhong N, Recksiek FP, Bacarian T. Adaptation of endothelium to microlesions created by x-ray microbeam irradiation. In: Corwin M.A., Ehrlich S.N, eds. National Synchrotron Light Source Annual Activity Report 2002. Abstract Peña0595, 2003 (available at http://www.nsls.bnl.gov/newsroom/publications/activityreport/2002/Abstracts/pena0595.pdf).
45. Nelson WR, Hirayama H, Rogers DWO. The EGS4 Code System, Stanford Linear Accelerator (SLAC) 265, Stanford, CA: SLAC. 1985.
46. Namito Y., Ban S., and Hirayama H. Compton scattering of 20- to 40-keV photons. Phys Rev A 51 (1995) 3036-3043
47. Orion I., Rozenfeld A., Dilmanian F.A., Telang F., Ren B., and Namito Y. Monte Carlo simulation of dose distributions from synchrotron-produced micro-planar beam array using the EGS4 code system. Phys Med Biol 45 (2000) 2497-2508
48. De Felici M., Felici R., Sanchez del Rio M., Ferrero C., Bacarian T., and Dilmanian F.A. Dose distribution from x-ray microbeam arrays applied to radiation therapy: an EGS4 Monte Carlo study. Med Phys 32 (2005) 2455-2463
49. Withers H.R., Taylor J.M., and Maciejewski B. Treatment volume and tissue tolerance. Int J Radiat Oncol Biol Phys 14 (1988) 751-759
50. Mohiuddin M., Stevens J.H., Reiff J.E., Saiful Huq M., and Suntharalingam N. Spatially fractionated (grid) radiation for palliative treatment of advanced cancer. Radiat Oncol Invest 4 (1996) 41-47
51. Leksell L. The stereotaxic method and radiosurgery of the brain. Acta Chir Scand 102 (1951) 316-319
52. Curtis H.L. The use of a deuteron microbeam for simulating the biological effects of heavy cosmic-ray particles. Radiat Res Suppl 7 (1967) 250-257
53. Gabbiani G., Gabbiani F., Heimark R.L., and Schwartz S.M. Organization of actin cytoskeleton during early endothelial regeneration in vitro. J Cell Sci 66 (1984) 39-50
54. Giancotti F.G., and Rouslahti E. Integrin signaling. Science 285 (1999 August 13) 1028-1032
55. Fukuhra S., Sakurai A., Yamagishi A., Sako K., and Mochizuki N. Vascular endothelial cadherin-mediated cell-cell adhesion regulated by a small GTPase, Rap1. J Biochem Mol Biol 39 (2006) 132-139
56. Jeffery N.D., and Blakemore W.F. Locomotor deficits induced by experimental spinal cord demyelination are abolished by spontaneous remyelination. Brain 120 (1997) 27-37
57. Ong W.Y., and Levine J.M. A light and electron microscopic study of NG2 chondroitin sulfate proteoglycan-positive oligodendrocyte precursor cells in the normal and kainate-lesioned rat hippocampus. Neuroscience 92 (1999) 83-95
58. Dawson M.R., Polito A., Levine J.M., and Reynolds R. NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS. Mol Cell Neurosci 24 (2003) 476-488
59. Keirstead H.S., and Blakemore W.F. The role of oligodendrocytes and oligodendrocyte progenitors in CNS remyelination. Adv Exp Med Biol 468 (1999) 183-197
60. van der Maazen R.W., Verhagen I., Kleiboer B.J., and van der Kogel A.J. Radiosensitivity of glial progenitor cells of the perinatal and adult rat optic nerve studied by an in vitro clonogenic assay. Radiother Oncol 20 (1991) 258-264
61. Philippo H., Winter E.A., van der Kogel A.J., and Huiskamp R. Recovery capacity of glial progenitors after in vivo fission-neutron or X irradiation: age dependence, fractionation and low-dose-rate irradiations. Radiat Res 163 (2005) 636-643
62. Li Y.Q., and Wong C.S. Radiation-induced apoptosis in the neonatal and adult rat spinal cord. Radiat Res 154 (2000) 268-276
63. Franklin R.J., Gilson J.M., and Blakemore W.F. Local recruitment of remyelinating cells in the repair of demyelination in the central nervous system. J Neurosci Res 50 (1997) 337-344
64. Miller R.H. Contact with central nervous system myelin inhibits oligodendrocyte progenitor maturation. Dev Biol 216 (1999) 359-368
65. Osterhout D.J., Wolven A., Wolf R.M., Resh M.D., and Chao M.V. Morphological differentiation of oligodendrocytes requires activation of Fyn tyrosine kinase. J Cell Biol 145 (1999) 1209-1218
66. Kim J.H., Chung Y.G., Kim C.Y., Kim H.K., and Lee H.K. Upregulation of VEGF and FGF2 in normal rat brain after experimental intraoperative radiation therapy. J Korean Med Sci 19 (2004) 879-886
67. Hovinga K.E., Stalpers L.J., van Bree C., et al. Radiation-enhanced vascular endothelial growth factor (VEGF) secretion in glioblastoma multiforme cell lines-a clue to radioresistance?. J Neurooncol 74 (2005) 99-103
68. Bartholdi D., Rubin B.P., and Schwab M.E. VEGF mRNA induction correlates with changes in the vascular architecture upon spinal cord damage in the rat. Eur J Neurosci 9 (1997) 2549-2560
69. Skold M., Cullheim S., Hammarberg H., et al. Induction of VEGF and VEGF receptors in the spinal cord after mechanical spinal injury and prostaglandin administration. Eur J Neurosci 12 (2000) 3675-3686