A systems biology approach to multicellular and multi-generational radiation responses

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 597, Issue 1-2 SPEC. ISS., 2006, Pages 32-38

  Barcellos Hoff, Mary Helen ^a   Costes, Sylvain V ^a  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

Extracellular matrix; Genomic instability; Ionizing radiation; Systems biology; TGF

Indexed keywords

PEPTIDE;

ARTICLE; BYSTANDER EFFECT; CELL DAMAGE; CELL FUNCTION; CYTOLOGY; EXTRACELLULAR MATRIX; GENOMIC INSTABILITY; IRRADIATION; MUTATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROGENY; RADIATION EXPOSURE; RADIATION INJURY; RADIATION RESPONSE; SIGNAL TRANSDUCTION; TISSUE STRUCTURE;

ANIMALS; DNA; DNA DAMAGE; EXTRACELLULAR MATRIX; GENOMIC INSTABILITY; HUMANS; MODELS, BIOLOGICAL; MUTATION; PHENOTYPE; RADIOBIOLOGY; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY; TRANSFORMING GROWTH FACTOR BETA;

EID: 33646030593     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2005.09.008     Document Type: Article

References (38)

1. Shiloh Y., and Lehmann A.R. Maintaining integrity. Nat. Cell Biol. 6 (2004) 923-928
2. Orosz C.G. An introduction to immuno-ecology and immuno-informatics. In: Segal L.A., and Cohen I.R. (Eds). Design Principles for Immune System and Other Distributed Autonomous Systems (2001), Oxford University Press, Oxford 125-149
3. Aggarwal K., and Lee K.H. Functional genomics and proteomics as a foundation for systems biology. Brief Funct. Genomic Proteomic 2 (2003) 175-184
4. Barcellos-Hoff M.H. How do tissues respond to damage at the cellular level? The role of cytokines in irradiated tissues. Radiat. Res. 150 (1998) S109-S120
5. Barcellos-Hoff M.H., and Brooks A.L. Extracellular signaling via the microenvironment: a hypothesis relating carcinogenesis, bystander effects and genomic instability. Radiat. Res. 156 (2001) 618-627
6. Trosko J.E. Hierarchical and cybernetic nature of biologic systems and their relevance to homeostatic adaptation to low-level exposures to oxidative stress-inducing agents. Environ. Health Perspect. 106 (1998) 331-339
7. Coates P.J., Lorimore S.A., and Wright E.G. Damaging and protective cell signalling in the untargeted effects of ionizing radiation. Mutat. Res./Fund. Mol. Mech. Mutagen. 568 (2004) 5-20
8. Maj J.G., Paris F., Haimovitz-Friedman A., Venkatraman E., Kolesnick R., and Fuks Z. Microvascular function regulates intestinal crypt response to radiation. Cancer Res. 63 (2003) 4338-4341
9. Barcellos-Hoff M.H., and Ravani S.A. Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells. Cancer Res. 60 (2000) 1254-1260
10. DeOme K.B., Faulkin L.J.J., Bern H.A., and Blair P.B. Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice. Cancer Res. 19 (1959) 515-520
11. Danielson K.G., Oborn C.J., Durban E.M., Buetel J.S., and Medina D. Epithelial mouse mammary cell line exhibiting normal morphogenesis in vivo and functional differentiation in vitro. Proc. Natl. Acad. Sci. U.S.A. 81 (1984) 3756-3760
12. Campbell S.M., Taha M.M., Medina D., and Rosen J.M. A clonal derivative of mammary epithelial cell line COMMA-D retains stem cell characteristics of unique morphological and functional heterogeneity. Exp. Cell Res. 177 (1988) 109-121
13. Jerry D.J., Medina D., and Butel J.S. p53 mutations in COMMA-D cells. In Vitro Cell. Dev. Biol. 30A (1994) 87-89
14. Coates P.J., Lorimore S.A., Lindsay K.J., and Wright E.G. Tissue-specific p53 responses to ionizing radiation and their genetic modification: the key to tissue-specific tumour susceptibility?. J. Pathol. 201 (2003) 377-388
15. Burns T.F., and El-Deiry W.S. Microarray analysis of p53 target gene expression patterns in the spleen and thymus in response to ionizing radiation. Cancer Biol. Ther. 2 (2003) 431-443
16. Ding L.-H., Shingyojia M., Chen F., Hwanga J.-J., Burma S., Cheng J.F., and Chen D.J. Gene expression profiles of normal human fibroblasts after ionizing radiation: a comparative study of low and high doses. Radiat. Res. 164 (2005) 17-26
17. Gudkov A.V., and Komarova E.A. The role of p53 in determining sensitivity to radiotherapy. Nat. Rev. Cancer 3 (2003) 117-129
18. Mott J.D., and Werb Z. Regulation of matrix biology by matrix metalloproteinases. Curr. Opin. Cell Biol. 16 (2004) 558-564
19. Barcellos-Hoff M.H. Radiation-induced transforming growth factor β and subsequent extracellular matrix reorganization in murine mammary gland. Cancer Res. 53 (1993) 3880-3886
20. Rosenkrans Jr. W.A., and Penney D.P. Cell-cell matrix interactions in induced lung injury. II. X-irradiation mediated changes in specific basal laminar glycosaminoglycans. Int. J. Rad. Oncol. Biol. Phys. 11 (1985) 1629-1637
21. Rosenkrans W.A., and Penney D.P. Cell-cell matrix interactions in induced lung injury. IV. Quantitative alterations in pulmonary fibronectin and laminin following X-irradiation. Radiat. Res. 109 (1987) 127-142
22. McBride W.H., Chiang C.-S., Olson J.L., Wang C.-C., Hong J.-H., Pajonk F., Dougherty G.J., Iwamoto K.S., Pervan M., and Liao Y.-P. A sense of danger from radiation. Radiat. Res. 162 (2004) 1-19
23. Stone H.B., Coleman C.N., Anscher M.S., and McBride W.H. Effects of radiation on normal tissue: consequences and mechanisms. Lancet Oncol. 4 (2003) 529-536
24. Naparstek E., FitzGerald J.J., Sakakeeny M.A., Klassen V., Pierce J.H., Woda B.A., Falco J., Fitzgerald S., Nizin P., and Greenberger J.S. Induction of malignant transformation of cocultivated hematopoietic stem cells by X-irradiation of murine bone marrow stromal cells in vitro. Cancer Res. 46 (1986) 4677-4684
25. Barcellos-Hoff M.H., Derynck R., Tsang M.L.-S., and Weatherbee J.A. Transforming growth factor-β activation in irradiated murine mammary gland. J. Clin. Invest. 93 (1994) 892-899
26. Derynck R., Ackhurst R.J., and Balmain A. TGF-β signaling in tumor suppression and cancer progression. Nat. Genet. 29 (2001) 117-129
27. Glick A.B., Kulkarni A.B., Tennenbaum T., Hennings H., Flanders K.C., O'Reilly M., Sporn M.B., Karlsson S., and Yuspa S.H. Loss of expression of transforming growth factor β in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 6076-6080
28. Tang B., Bottinger E.P., Jakowlew S.B., Bangall K.M., Mariano J., Anver M.R., Letterio J.J., and Wakefield L.M. Transforming growth factor-beta1 is a new form of tumor supressor with true haploid insufficiency. Nat. Med. 4 (1998) 802-807
29. Lawrence D.A., Pircher R., and Jullien P. Conversion of a high molecular weight latent beta-TGF from chicken embryo fibroblasts into a low molecular weight active beta-TGF under acidic conditions. Biochem. Biophys. Res. Comm. 133 (1985) 1026-1034
30. Annes J.P., Munger J.S., and Rifkin D.B. Making sense of latent TGF{beta} activation. J. Cell Sci. 116 (2003) 217-224
31. Barcellos-Hoff M.H., and Dix T.A. Redox-mediated activation of latent transforming growth factor-β1. Mol. Endocrinol. 10 (1996) 1077-1083
32. Ewan K.B., Henshall-Powell R.L., Ravani S.A., Pajares M.J., Arteaga C., Warters R., Akhurst R.J., and Barcellos-Hoff M.H. Transforming growth factor-{beta}1 mediates cellular response to DNA damage in situ. Cancer Res. 62 (2002) 5627-5631
33. Glick A.B., Weinberg W.C., Wu I.H., Quan W., and Yuspa S.H. Transforming growth factor beta 1 suppresses genomic instability independent of a G1 arrest, p53, and Rb. Cancer Res. 56 (1996) 3645-3650
34. Abraham R.T. Checkpoint signaling: epigenetic events sound the DNA strand-breaks alarm to the ATM protein kinase. Bioessays 25 (2003) 627-630
35. Kastan M.B., Lim D.S., Kim S.T., Xu B., and Canman C. Multiple signaling pathways involving ATM. Cold Spring Harb. Symp. Quant. Biol. 65 (2000) 521-526
36. Dunker N., and Krieglstein K. Targeted mutations of transforming growth factor-β genes reveal important roles in mouse development and adult homeostasis. Eur. J. Biochem. 267 (2000) 6982-6988
37. Massague J., Blain S.W., and Lo R.S. TGF-β signaling in growth control, cancer, and heritable disorders. Cell 103 (2000) 295-309
38. von Bertalanffy L. General system theory: a new approach to unity of science. 1. Problems of general system theory. Hum. Biol. 23 (1951) 302-312