Murine EMT-6 carcinoma: High therapeutic efficacy of microbeam radiation therapy

Radiation Research

Volumn 159, Issue 5, 2003, Pages 632-641

  Dilmanian, F Avraham ^a   Morris, Gerard M ^b   Zhong, Nan ^a,f   Bacarian, Tigran ^a   Hainfeld, James F ^a   Kalef Ezra, John ^c   Brewington, Laura J ^d   Tammama, Jennifer ^a,g   Rosen, Eliot M ^e  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b CHURCHILL HOSPITAL   (United Kingdom)

^c UNIVERSITY OF IOANNINA   (Greece)

^d PHARMACYCLICS INC   (United States)

^e LONG ISLAND JEWISH MEDICAL CENTER   (United States)

^f STONY BROOK UNIVERSITY   (United States)

^g MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; BREAST CANCER; CANCER RADIOTHERAPY; CONTROLLED STUDY; DATA ANALYSIS; DESQUAMATION; DISEASE SEVERITY; DRUG EFFICACY; DRUG MEGADOSE; FEMALE; HAIR GROWTH; LEG DISEASE; MICROBEAM RADIATION THERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INJURY; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; SYNCHROTRON RADIATION; X RAY ANALYSIS;

ANIMALS; FEMALE; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; RADIATION TOLERANCE; RADIOTHERAPY DOSAGE; SYNCHROTRONS; X-RAY THERAPY;

MURINAE;

EID: 0037625956     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/0033-7587(2003)159[0632:MECHTE]2.0.CO;2     Document Type: Article

References (40)

1. D. N. Slatkin, P. O. Spanne, F. A. Dilmanian, J-O. Gebbers and J. A. Laissue, Subacute neuropathological effects on rats of microplanar beams of x rays from a synchrotron wiggler. Proc. Natl. Acad. Sci. USA 92, 8783-8787 (1995).
2. D. N. Slatkin, F. A. Dilmanian, M. M. Nawrocky, P. Spanne, J-O. Gebbers, D. W. Archer and J. A. Laissue, Design of a multislit, variable width collimator for microplanar beam radiotherapy. Rev. Sci. Instrum. 65, 1495-1460 (1995).
3. J. A. Laissue, G. Geiser, P. O. Spanne, F. A. Dilmanian, J. O. Gebbers, M. Geiser, X. Y. Wu, M. S. Makar, P. L. Micca and D. N. Slatkin, Neuropathology of ablation of rat gliosarcoma and contiguous brain tissues using a microplanar beam of synchrotron-wiggler-generated x ray. Int. J. Cancer 78, 654-660 (1988).
4. F. A. Dilmanian, T M. Button, G. Le Duc, N. Zhong, L. A. Peña, J. A. L. Smith, S. R. Martinez, T Bacarian, J. Tammam and E. M. Rosen, Response of rat intracranial 9L gliosarcoma to microbeam radiation therapy. Neuro-Oncology 4, 26-38 (2002).
5. J. A. Laissue, N. Lyubimova, H-P. Wagner, D. W. Archer, D. N. Slatkin, M. Di Michiel, C. Nemoz, M. Renier, E. Brauer and H. Blattmann, Microbeam radiation therapy. In Medical Applications of Penetrating Radiation (H. B. Barber and H. Roehrig, Eds.), SPIE Conference Proceedings Vol. 3770, pp. 38-45. SPIE, Bellingham, WA, 1999.
6. F. A. Dilmanian, G. M. Morris, G. Le Duc, X. Huang, B. Ren, T Bacarian, J. C. Allen, J. Kalef-Ezra, I. Orion and H. L. Shivaprasad, Response of avian embryonic brain to spatially segmented x-ray microbeams. Cell. Mol. Biol. 47, 485-494 (2001).
7. J. A. Laissue, H. Blattmann, M. Di Michiel, D. N. Slatkin, N. Lyubimova, R. Guzman, W. Zimmermann, S. Birrer, T. Bley and H. P. Wagner, The weanling piglet cerebellum: α surrogate for tolerance to MRT (microbeam radiation therapy) in pediatric neuro-oncology. In Penetrating Radiation Systems and Applications III (H. B. Barber, H. Roehrig, F. P. Doty, R. C. Schirato and E. J. Morton, Eds.), SPIE Conference Proceedings Vol. 4508, pp. 65-73. SPIE, Bellingham, WA, 2001.
8. H. J. Curtis, The use of a deuteron microbeam for simulating the biological effects of heavy cosmic-ray particles. Radiat. Res. Suppl. 7, 250-257 (1967).
9. H. J. Curtis, The interpretation of microbeam experiments for manned space flight. Radiat. Res. Suppl. 7, 258-264 (1967).
10. D. D. Joel, R. G. Fairchild, J. A. Laissue, S. K. Saraf, J. A. Kalef-Ezra and D. N. Slatkin, Boron neutron capture therapy of intracerebral rat gliosarcomas. Proc. Natl. Acad. Sci. USA 87, 9808-9812 (1990).
11. J. Coderre, P. Rubin, A. Freedman, J. Hansen, T. S. Wooding, D. Joel and D. Gash, Selective ablation of rat brain tumors by boron neutron capture therapy. Int. J. Radiat. Oncol. Biol. Phys. 28, 1067-1077 (1994).
12. S. C. Rockwell, R. F. Kallman and L. F. Fajardo, Characteristics of a serially transplanted mouse mammary tumor and its tissue-culture-adapted derivative. J. Natl. Cancer Inst. 49, 735-749 (1972).
13. M. M. Morris, R. Schmidt-Ullrich and C. R. Johnson, Advances in radiotherapy for carcinoma of the head and neck. Surg. Oncol. Clin. N. Am. 9, 563-575 (2000).
14. F. A. Dilmanian, G. M. Morris, N. Zhong, T Bacarian, J. Tammam, M. Miura, P. L. Micca, L. Rigon, B. Scharf and E. M. Rosen, Response of subcutaneous murine mammary carcinoma EMT-6 to synchrotron-generated segmented X-ray microbeams, In Proceedings of the Joint Symposium on Bio-Sensing and Bio-Imaging, August 2-4, 2001, Yamagata, Japan (A. Akatsuka, Ed.), pp. 118-122. The Japan Society for Analytical Chemistry, Tokyo, 2002. [Available on CD ROM]
15. H. Winick, Properties of synchrotron radiation. In Synchrotron Radiation Research (H. Winick and S. Doniach Eds.), pp. 11-25. Plenum Press, New York, 1982.
16. J. Kalef-Ezra, A. Boziari, J. Litsas, P. Tsekeris and T. Koligliatis, Thermoluminescent dosimetry for quality assurance in radiation therapy. Radiat. Prot. Dosim. 101, 403-405 (2002).
17. M. Bazioglou and J. Kalef-Ezra, Dosimetry with radiochromic films: A document scanner technique, neutron response, applications. Appl. Radiat. Isot. 55, 339-345 (2001).
18. D. L. Chapman, N. F. Gmür, N. Lazarz and W. Thomlinson, Photon: A program for synchrotron radiation dose calculations. Nuclear Instrum. Methods Phys. Res. A266, 191-194 (1988).
19. W. R. Nelson, H. Hirayama and D. W. O. Rogers, The EGS4 Code System. SLAC-265, Stanford Linear Accelerator Center, Stanford, CA, 1985.
20. Y. Namito, S. Ban and H. Hirayama, Implementation of linearlypolarized photon scattering into the EGS code. Nuclear Instrum. Methods Phys. Res. A332, 277-283 (1993).
21. Y. Namito, S. Ban and H. Hirayama, Compton scattering of 20- to 40-keV photons. Phys. Rev. A 51, 3036-043 (1995).
22. Y. Namito, S. Ban and H. Hirayama, LSCAT: Low-energy photonscattering expansion for the EGS4 Code. KEK Internal Document 95-10, KEK National Laboratory for High Energy Physics, Tsukuba, Japan, 1995.
23. D. N. Slatkin, P. Spanne, F. A. Dilmanian and M, Sandborg, Microbeam radiation therapy. Med. Phys. 19, 1395-1400 (1992).
24. I. Orion, A. B. Rosenfeld, F. A. Dilmanian, F. Telang, B. Ren and Y. Namito, Monte Carlo simulation of dose distributions from a synchrotron-produced microplanar beam array using the EGS4 code system. Phys. Med. Biol. 45, 2497-2508 (2000).
25. M. Miura, G. M. Morris, P. L. Micca, D. T. Lombardo, K. M. Youngs, J. A. Kalef-Ezra, D. A. Hoch, D. N. Slatkin, R. Ma and J. A. Coderre, Boron neutron capture therapy of a murine mammary carcinoma using a lipophilic carboranyltetraphenylporphyrin. Radiat. Res. 155, 603-610 (2001).
26. K. K. Ang, Fractionation effects in clinical practice. In Textbook of Radiation Oncology (S. A. Leibel and T. L. Phillips, Eds.), pp. 26-41. W. B. Saunders, Philadelphia, 1988.
27. J. S. Rasey, E. E., Carpenter, N. J. Nelson and R. G. Packer, Cure of EMT-6 tumors by x rays of neutrons: Effect of mixed-fractionation schemes. Radiology 123, 207-212 (1977).
28. S, Greer, J. Schwade and H. S. Marison, Five-chlorodeoxycytidine and biomodulators of its metabolism result in fifty to eighty percent cures of advanced EMT-6 tumors when used with fractionated radiation. Int. J. Radiat. Oncol. Biol. Phys. 32, 1059-1069 (1995).
29. B. A. Teicher, S. A. Holden, N. P. Dupuis, Y. Kakeji, M. Ikebe, Y. Emi and D. Goff, Potentiation of cytotoxic therapies by TNP-470 and minocycline in mice bearing EMT-6 mammary carcinoma. Breast Cancer Res. Treat. 36, 227-236 (1995).
30. J. Denekamp, Vascular endothelium as the vulnerable element in tumors. Acta Radiol. Oncol. 23, 217-225 (1984).
31. R. K. Jain, Determinants of tumor blood flow: A review. Cancer Res. 48, 2641-2658 (1988).
32. A. J. van der Kogel, B. J. Kleiboer, I. Verhagen, G. M. Morris, J. W. Hopewell and J. A. Coderre, White matter necrosis of the spinal cord: Studies on glial progenitor survival and selective vascular irradiation. In Radiation Research, Vol. 2 (U. Hagen, D. Harder, H. Jung and C. Streffer, Eds.), pp. 769-772. Universitätsdruckerei H. Stürtz AG, Würzburg, 1995.
33. G. M. Morris, J. A. Coderre, A. Bywaters, E. Whitehouse and J. W. Hopewell, Boron neutron capture irradiation of the rat spinal cord: Histopathological evidence of a vascular mediated pathogenesis. Radiat. Res. 146, 313-320 (1996).
34. D. G. Baker and R. J. Krochak, The response of the microvascular system to radiation: A review. Cancer Invest. 7, 287-294 (1989).
35. K. K. Richter, L. M. Fink, B. M. Hughes, H. M. Shmaysani, C. C. Sung and M. Hauer-Jensen, Differential effect of radiation on endothelial cell function in rectal cancer and normal rectum. Am. J. Surg. 176, 642-647 (1998).
36. F. Paris, Z. Fuks, A. Kang, P. Capodieci, G. Juan, D. Ehleiter, A. Haimovitz-Friedman, C. Cordon-Cardo and R. Kolesnick, Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice. Science 293, 293-297 (2001).
37. H. R. Withers, J. M. G. Taylor and B. Maciejewski, Treatment volume and tissue tolerance. Int. J. Radiat. Oncol. Biol. Phys. 14, 751-759 (1988).
38. K. Tiver, Treatment of CNS tumours with conventional radiotherapy: The importance of dose & volume factors in tumour control & CNS radiation tolerance. Australasian Radiol. 33, 15-22 (1989).
39. J. Debus, E. B. Hug, N. J. Liebsch, D. O'Farrel, D. Finkelstein, J. Efird and J. E. Munzenrider, Brainstem tolerance to conformal radiotherapy of skull base tumors. Int. J. Radiat. Oncol. Biol. Phys. 39, 967-975 (1997).
40. M. Mohiuddin, M. Fujita, W. F. Regine, A. S. Megooni, G. S. Ibbott and M. M. Ahmed, High-dose spatially-fractionated radiation (GRID): A new paradigm in the management of advanced cancers. Int. J. Radiat. Oncol. Biol. Phys. 45, 721-727 (1999).