Bystander-induced differentiation: A major response to targeted irradiation of a urothelial explant model

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 597, Issue 1-2 SPEC. ISS., 2006, Pages 43-49

  Belyakov, Oleg V ^a,b   Folkard, Melvyn ^a   Mothersill, Carmel ^b   Prise, Kevin M ^a   Michael, Barry D ^a  

^a MOUNT VERNON HOSPITAL   (United Kingdom)

^b DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

Author keywords

Bystander effect; Differentiation; Microbeam; Urothelial explant model

Indexed keywords

HELIUM; PROTEIN ANTIBODY; UNCLASSIFIED DRUG; UROPLAKIN; UROPLAKIN 3;

ACCURACY; ANIMAL TISSUE; ARTICLE; BYSTANDER EFFECT; CELL DAMAGE; CELL DIFFERENTIATION; CELL FRACTIONATION; CONTROLLED STUDY; EXPLANT; INCUBATION TIME; IRRADIATION; LINEAR ENERGY TRANSFER; NONHUMAN; PRIORITY JOURNAL; SWINE; URETER; UROTHELIUM;

ANIMALS; CELL DIFFERENTIATION; MEMBRANE GLYCOPROTEINS; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION; SUS SCROFA; TISSUE CULTURE TECHNIQUES; UROTHELIUM;

ANIMALIA; SUIDAE; SUS SCROFA;

EID: 33646046779     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2005.08.012     Document Type: Article

References (56)

1. Prise K.M., Folkard M., and Michael B.D. A review of the bystander effect and its implications for low-dose exposure. Radiat. Prot. Dosimetry 104 (2003) 347-355
2. Morgan W.F. Non-targeted and delayed effects of exposure to ionizing radiation: II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects. Radiat. Res. 159 (2003) 581-596
3. Morgan W.F. Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro. Radiat. Res. 159 (2003) 567-580
4. Lorimore S.A., and Wright E.G. Radiation-induced genomic instability and bystander effects: related inflammatory-type responses to radiation-induced stress and injury? A review. Int. J. Radiat. Biol. 79 (2003) 15-25
5. Mothersill C., and Seymour C. Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. Int. J. Radiat. Biol. 71 (1997) 421-427
6. Nagasawa H., and Little J.B. Induction of sister chromatid exchanges by extremely low doses of alpha-particles. Cancer Res. 52 (1992) 6394-6396
7. Seymour C.B., and Mothersill C. Relative contribution of bystander and targeted cell killing to the low-dose region of the radiation dose-response curve. Radiat. Res. 153 (2000) 508-511
8. Azzam E.I., de Toledo S.M., Gooding T., and Little J.B. Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiat. Res. 150 (1998) 497-504
9. Azzam E.I., de Toledo S.M., and Little J.B. Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha -particle irradiated to nonirradiated cells. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 473-478
10. Mothersill C., and Seymour C.B. Cell-cell contact during gamma irradiation is not required to induce a bystander effect in normal human keratinocytes: evidence for release during irradiation of a signal controlling survival into the medium. Radiat. Res. 149 (1998) 256-262
11. Lewis D.A., Mayhugh B.M., Qin Y., Trott K., and Mendonca M.S. Production of delayed death and neoplastic transformation in CGL1 cells by radiation-induced bystander effects. Radiat. Res. 156 (2001) 251-258
12. Lorimore S.A., Kadhim M.A., Pocock D.A., Papworth D., Stevens D.L., Goodhead D.T., and Wright E.G. Chromosomal instability in the descendants of unirradiated surviving cells after alpha-particle irradiation. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 5730-5733
13. Watson G.E., Lorimore S.A., Macdonald D.A., and Wright E.G. Chromosomal instability in unirradiated cells induced in vivo by a bystander effect of ionizing radiation. Cancer Res. 60 (2000) 5608-5611
14. Zhou H., Randers-Pehrson G., Waldren C.A., Vannais D., Hall E.J., and Hei T.K. Induction of a bystander mutagenic effect of alpha particles in mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 2099-2104
15. Nagasawa H., and Little J.B. Unexpected sensitivity to the induction of mutations by very low doses of alpha-particle radiation: evidence for a bystander effect. Radiat. Res. 152 (1999) 552-557
16. Belyakov O.V., Malcolmson A.M., Folkard M., Prise K.M., and Michael B.D. Direct evidence for a bystander effect of ionizing radiation in primary human fibroblasts. Br. J. Cancer 84 (2001) 674-679
17. Belyakov O.V., Folkard M., Mothersill C., Prise K.M., and Michael B.D. A proliferation-dependent bystander effect in primary porcine and human urothelial explants in response to targeted irradiation. Br. J. Cancer 88 (2003) 767-774
18. Lehnert B.E., and Goodwin E.H. Extracellular factor(s) following exposure to alpha particles can cause sister chromatid exchanges in normal human cells. Cancer Res. 57 (1997) 2164-2171
19. Lehnert B.E., and Goodwin E.H. A new mechanism for DNA alterations induced by alpha particles such as those emitted by radon and radon progeny. Environ. Health Perspect. 105 (1997) 1095-1101
20. Deshpande A., Goodwin E.H., Bailey S.M., Marrone B.L., and Lehnert B.E. Alpha-particle-induced sister chromatid exchange in normal human lung fibroblasts: evidence for an extranuclear target. Radiat. Res. 145 (1996) 260-267
21. Hickman A., Jaramillo R., Lechner J., and Johnson N. Alpha-particle-induced p53 protein expression in a rat lung epithelial cell strain. Cancer Res. 54 (1994) 5797-5800
22. Azzam E.I., de Toledo S.M., Waker A.J., and Little J.B. High and low fluences of alpha-particles induce a G1 checkpoint in human diploid fibroblasts. Cancer Res. 60 (2000) 2623-2631
23. Iyer R., and Lehnert B.E. Factors underlying the cell growth-related bystander responses to alpha particles. Cancer Res. 60 (2000) 1290-1298
24. Baverstock K. Radiation-induced genomic instability: a paradigm-breaking phenomenon and its relevance to environmentally induced cancer. Mutat. Res./Fundam. Mol. Mech. Mutagen. 454 (2000) 89-109
25. Barcellos-Hoff M.H., and Brooks A.L. Extracellular signaling through the microenvironment: a hypothesis relating carcinogenesis, bystander effects, and genomic instability. Radiat. Res. 156 (2001) 618-627
26. Coates P.J., Lorimore S.A., and Wright E.G. Damaging and protective cell signalling in the untargeted effects of ionizing radiation. Mutat. Res. 568 (2004) 5-20
27. Shao C., Stewart V., Folkard M., Michael B.D., and Prise K.M. Nitric oxide-mediated signaling in the bystander response of individually targeted glioma cells. Cancer Res. 63 (2003) 8437-8442
28. Bishayee A., Rao D.V., and Howell R.W. Evidence for pronounced bystander effects caused by nonuniform distributions of radioactivity using a novel three-dimensional tissue culture model. Radiat. Res. 152 (1999) 88-97
29. Bishayee A., Rao D.V., Bouchet L.G., Bolch W.E., and Howell R.W. Protection by DMSO against cell death caused by intracellularly localized iodine-125, iodine-131 and polonium-210. Radiat. Res. 153 (2000) 416-427
30. Bishayee A., Hill H.Z., Stein D., Rao D.V., and Howell R.W. Free radical-initiated and gap junction-mediated bystander effect due to nonuniform distribution of incorporated radioactivity in a three-dimensional tissue culture model. Radiat. Res. 155 (2001) 335-344
31. Cummins R.J., Mothersill C., Seymour C.B., Johns H., and Joiner M.C. The effect of microcolony size, at time of irradiation, on colony forming ability. Int. J. Radiat. Biol. 75 (1999) 225-232
32. Jen Y., West C., and Hendry J. The lower radiosensitivity of mouse kidney cells irradiated in vivo than in vitro: a cell contact effect phenomenon. Int. J. Radiat. Oncol. Biol. Phys. 20 (1991) 1243-1248
33. Nobler M.P. The abscopal effect in malignant lymphoma and its relationship to lymphocyte circulation. Radiology 93 (1969) 410-412
34. Emerit I., Levy A., Cernjavski L., Arutyunyan R., Oganesyan N., Pogosian A., Mejlumian H., Sarkisian T., Gulkandanian M., and Quastel M. Transferable clastogenic activity in plasma from persons exposed as salvage personnel of the Chernobyl reactor. J. Cancer Res. Clin. Oncol. 120 (1994) 558-561
35. Hollowell Jr. J.G., and Littlefield L.G. Chromosome damage induced by plasma of X-rayed patients: an indirect effect of X-ray. Proc. Soc. Exp. Biol. Med. 129 (1968) 240-244
36. Mothersill C., Lyng F., Seymour C., Maguire P., Lorimore S., and Wright E. Genetic factors influencing bystander signaling in murine bladder epithelium after low-dose irradiation in vivo. Radiat. Res. 163 (2005) 391-399
37. Lorimore S.A., McIlrath J.M., Coates P.J., and Wright E.G. Chromosomal instability in unirradiated hemopoietic cells resulting from a delayed in vivo bystander effect of gamma radiation. Cancer Res. 65 (2005) 5668-5673
38. Xue L.Y., Butler N.J., Makrigiorgos G.M., Adelstein S.J., and Kassis A.I. Bystander effect produced by radiolabeled tumor cells in vivo. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 13765-13770
39. Belyakov O.V., Folkard M., Mothersill C., Prise K.M., and Michael B.D. Bystander-induced apoptosis and premature differentiation in primary urothelial explants after charged particle microbeam irradiation. Radiat. Prot. Dosimetry 99 (2002) 249-251
40. Southgate J., Kennedy W., Hutton K.A., and Trejdosiewicz L.K. Expression and in vitro regulation of integrins by normal human urothelial cells. Cell. Adhes. Commun. 3 (1995) 231-242
41. Stewart F., and Williams M. The urinary tract. In: Scherer E., Steffer C., and Trott K.-R. (Eds). Radiopathology of Organs and Tissues (1991), Springer-Verlag, Berlin 405-433
42. Mothersill C. Development of primary tissue culture techniques for use in radiobiology. Radiat. Res. 150 (1998) S121-S125
43. Folkard M., Vojnovic B., Hollis K.J., Bowey A.G., Watts S.J., Schettino G., Prise K.M., and Michael B.D. A charged-particle microbeam: II. A single-particle micro-collimation and detection system. Int. J. Radiat. Biol. 72 (1997) 387-395
44. Folkard M., Vojnovic B., Prise K.M., Bowey A.G., Locke R.J., Schettino G., and Michael B.D. A charged-particle microbeam: I. Development of an experimental system for targeting cells individually with counted particles. Int. J. Radiat. Biol. 72 (1997) 375-385
45. C.G. Loukas, P.R. Barber, G.D. Wilson, B. Vojnovic, A. Linney, An edge detection based approach for automated counting of cancer cell-nuclei in large-scale histological images, in: Proceedings of the Medical Image Understanding and Analysis, 2000. pp. 149-152.
46. Folkard M., Vojnovic B., Prise K.M., Gilchrist S., Schettino G., Belyakov O.V., Ozols A., and Michael B.D. The impact of microbeams in radiation biology. Nuclear Instrum. Methods Phys. Research, Sect. B, Beam Interact. Mater. Atoms (NIMB) 181 (2001) 426-430
47. Fujiyama C., Masaki Z., and Sugihara H. Reconstruction of the urinary bladder mucosa in three-dimensional collagen gel culture: fibroblast-extracellular matrix interactions on the differentiation of transitional epithelial cells. J. Urol. 153 (1995) 2060-2067
48. Vojnovic B. Advanced Technology Development Gray Laboratory Research Report (1996), Gray Laboratory, Northwood pp. 31-36
49. Fournier C., Kraft-Weyrather W., and Kraft G. Survival, differentiation and collagen secretion of human fibroblasts after irradiation with carbon ions and X-rays. Phys. Med. 14 Suppl. 1 (1998) 44-47
50. Fournier C., Scholz M., Weyrather W.K., Rodemann H.P., and Kraft G. Changes of fibrosis-related parameters after high- and low-LET irradiation of fibroblasts. Int. J. Radiat. Biol. 77 (2001) 713-722
51. Rodemann H.P., Binder A., Burger A., Guven N., Loffler H., and Bamberg M. The underlying cellular mechanism of fibrosis. Kidney Int. Suppl. 54 (1996) S32-S36
52. Wang B., Ohyama H., Shang Y., Fujita K., Tanaka K., Nakajima T., Aizawa S., Yukawa O., and Hayata I. Adaptive response in embryogenesis: IV. Protective and detrimental bystander effects induced by X-radiation in cultured limb bud cells of fetal mice. Radiat. Res. 161 (2004) 9-16
53. Dorr W., Eckhardt M., Ehme A., and Koi S. Pathogenesis of acute radiation effects in the urinary bladder. Exp. Res. Strahlenther. Onkol. 174 Suppl. 3 (1998) 93-95
54. Herskind C., Johansen J., Bentzen S.M., Overgaard M., Overgaard J., Bamberg M., and Rodemann H.P. Fibroblast differentiation in subcutaneous fibrosis after postmastectomy radiotherapy. Acta Oncol. 39 (2000) 383-388
55. Herskind C., and Rodemann H.P. Spontaneous and radiation-induced differentiationof fibroblasts. Exp. Gerontol. 35 (2000) 747-755
56. Prise K.M., Belyakov O.V., Folkard M., and Michael B.D. Studies of bystander effects in human fibroblasts using a charged particle microbeam. Int. J. Radiat. Biol. 74 (1998) 793-798