TIM-3 is expressed in melanoma cells and is upregulated in TGF-beta stimulated mast cells

Journal of Investigative Dermatology

Volumn 127, Issue 4, 2007, Pages 906-914

  Wiener, Zoltan ^a   Kohalmi, Barbara ^b   Pocza, Peter ^a   Jeager, Judit ^b   Tolgyesi, Gergely ^a   Toth, Sara ^a   Gorbe, Eva ^b   Papp, Zoltan ^b   Falus, Andras ^a,c  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; DNA; T LYMPHOCYTE IMMUNOGLOBULIN AND MUCIN DOMAIN CONTAINING PROTEIN 3; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ARTICLE; AUTOCRINE EFFECT; CANCER CELL CULTURE; CARCINOGENICITY; CELL ADHESION; CELL STIMULATION; CONTROLLED STUDY; DNA MICROARRAY; EPIDERMIS CELL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; HUMAN; HUMAN CELL; MAST CELL; MELANOCYTE; MELANOMA CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SKIN CARCINOGENESIS; UPREGULATION;

CELLS, CULTURED; EPIDERMIS; GALECTINS; HUMANS; LIGANDS; MAST CELLS; MELANOCYTES; MELANOMA; MEMBRANE PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, VIRUS; REPRODUCIBILITY OF RESULTS; SKIN NEOPLASMS; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 33947224207     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5700616     Document Type: Article

References (41)

1. Ahn K, Takai S, Pawankar R, Kuramasu A, Ohtsu H, Kempuraj D et al. (2000) Regulation of chymase production in human mast cell progenitors. J Allergy Clin Immunol 106:321-8
2. Akhurst RJ, Derynck R (2001) TGF-β signaling in cancer: a double-edged sword. Trends Cell Biol 11:S44-51
3. Baek SJ, Kim KS, Nixon JB, Wilson LC, Eling TE (2001) Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities. Mol Pharmacol 59:901-8
4. Bagga S, Price KS, Lin DA, Friend DS, Austen KF, Boyce JA (2004) Lysophosphatidic acid accelerates the development of human mast cells. Blood 104:4080-7
5. Beil WJ, Fureder W, Wiener H, Grossschmidt K, Maier U, Schedle A et al. (1998) Phenotypic and functional characterization of mast cells derived from renal tumor tissues. Exp Hematol 26:158-69
6. Ch'ng S,Wallis RA, Yuan L, Davis PF, Tan ST (2006) Mast cells and cutaneous malignancies. Review. Mod Pathol 19:149-59
7. Chabot S, Kashio Y, Seki M, Shirato Y, Nakamura K, Nishi N et al. (2002) Regulation of galectin-9 expression and release in Jurkat T cell line cells. Glycobiology 12:111-8
8. Derynck R, Akhurst RJ, Balmain A (2001) TGF-β signaling in tumor suppression and cancer progression. Nat Genet 29:117-29
9. Frisancho-Kiss S, Nyland JF, Davis SE, Barrett MA, Gatewood SJ, Njoku DB et al. (2006) Cutting edge: T cell Ig mucin-3 reduces inflammatory heart disease by increasing CTLA-4 during innate immunity. J Immunol 176:6411-5
10. Fukui M, Whittlesey K, Metcalfe DD, Dastych J (2000) Human mast cells express the hyaluronic-acid-binding isoform of CD44 and adhere to hyaluronic acid. Clin Immunol 94:173-8
11. Gebhardt T, Lorentz A, Detmer F, Trautwein C, Bektas H, Manns MP et al. (2005) Growth, phenotype, and function of human intestinal mast cells are tightly regulated by transforming growth factor beta1. Gut 54:928-34
12. Geng H, Zhang GM, Li D, Zhang H, Yuan Y, Zhu HG et al. (2006) Soluble form of T cell Ig mucin 3 is an inhibitory molecule in T cell-mediated immune response. J Immunol 176:1411-20
13. Ghannadan M, Baghestanian M, Wimazal F, Eisenmenger M, Latal D, Kargul G et al. (1998) Phenotypic characterization of human skin mast cells by combined staining with toluidine blue and CD antibodies. J Invest Dermatol 111:689-95
14. Gielen AW, Lobell A, Lidman O, Khademi M, Olsson T, Piehl F (2005) Expression of T cell immunoglobulin- and mucin-domain-containing molecules-1 and -3 (TIM-1 and -3) in the rat nervous and immune systems. J Neuroimmunol 164:93-104
15. Gomez G, Ramirez CD, Rivera J, Patel M, Norozian F, Wright HV et al. (2005) TGF-beta 1 inhibits mast cell Fc epsilon RI expression. J Immunol 174:5987-93
16. Grimbaldeston MA, Pearce AL, Robertson BO, Coventry BJ, Marshman G, Finlay-Jones JJ et al. (2004) Association between melanoma and dermal mast cell prevalence in sun-unexposed skin. Br J Dermatol 150:895-903
17. Hegyesi H, Somlai B, Varga VL, Toth G, Kovacs P, Molnar EL et al. (2001) Suppression of melanoma cell proliferation by histidine decarboxylase specific antisense oligonucleotides. J Invest Dermatol 117:151-3
18. Ibaraki T, Muramatsu M, Takai S, Jin D, Maruyama H, Orino T et al. (2005) The relationship of tryptase- and chymase-positive mast cells to angiogenesis in stage I non-small cell lung cancer. Eur J Cardiothorac Surg 28:617-21
19. Irie A, Yamauchi A, Kontani K, Kihara M, Liu D, Shirato Y et al. (2005) Galectin-9 as a prognostic factor with antimetastatic potential in breast cancer. Clin Cancer Res 11:2962-8
20. Kageshita T, Kashio Y, Yamauchi A, Seki M, Abedin MJ, Nishi N et al. (2002) Possible role of galectin-9 in cell aggregation and apoptosis of human melanoma cell lines and its clinical significance. Int J Cancer 99:809-16
21. Khademi M, Illes Z, Gielen AW, Marta M, Takazawa N, Baecher-Allan C et al. (2004) T cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis. J Immunol 172:7169-76
22. Kirshenbaum AS, Goff JP, Semere T, Foster B, Scott LM, Metcalfe DD (1999) Demonstration that human mast cells arise from a progenitor cell population that is CD34(+), c-kit(+), and expresses aminopeptidase N (CD13). Blood 94:2333-42
23. Kruger-Krasagakes S, Grutzkau A, Baghramian R, Henz BM (1996) Interactions of immature human mast cells with extracellular matrix: expression of specific adhesion receptors and their role in cell binding to matrix proteins. J Invest Dermatol 106:538-43
24. Li MO, Wan YY, Sanjabi S, Robertson AKL, Flavell RA (2006) Transforming growth factor-β regulation of immune responses. Annu Rev Immunol 24:99-146
25. Li PX, Wong J, Ayed A, Ngo D, Brade AM, Arrowsmith C et al. (2000) Placental transforming growth factor-beta is a downstream mediator of the growth arrest and apoptotic response of tumor cells to DNA damage and p53 overexpression. J Biol Chem 275:20127-35
26. Markowitz SD, Roberts AB (1996) Tumor suppressor activity of the TGF-β pathway in human cancers. Cytokine Growth Factor Rev 7:93-102
27. Medrano EE (2003) Repression of TGF-beta signaling by the oncogenic protein SKI in human melanomas: consequences for proliferation, survival, and metastasis. Oncogene 22:3123-9
28. Meyers JH, Sabatos CA, Chakravarti S, Kuchroo VK (2005) The TIM gene family regulates autoimmune and allergic diseases. Trends Mol Med 11:362-9
29. Miller HR, Wright SH, Knight PA, Thornton EM (1999) A novel function for transforming growth factor-beta1: upregulation of the expression and the IgE-independent extracellular release of a mucosal mast cell granule-specific beta-chymase, mouse mast cell protease-1. Blood 93:3473-86
30. Monney L, Sabatos CA, Gaglia JL, Ryu A, Waldner H, Chernova T et al. (2002) Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415: 536-41
31. Moretti S, Pinzi C, Berti E, Spallanzani A, Chiarugi A, Boddi V et al. (1997) In situ expression of transforming growth factor beta is associated with melanoma progression and correlates with Ki67, HLA-DR and beta 3 integrin expression. Melanoma Res 7:313-21
32. Nagata M, Shijubo N, Walls AF, Ichimiya S, Abe S, Sato N (2003) Chymase-positive mast cells in small sized adenocarcinoma of the lung. Virchows Arch 443:565-73
33. Norozian F, Kashyap M, Ramirez CD, Patel N, Kepley CL, Barnstein BO et al. (2006) TGFbeta1 induces mast cell apoptosis. Exp Hematol 34:579-87
34. Olsson N, Piek E, ten Dijke P, Nilsson G (2000) Human mast cell migration in response to members of the transforming growth factor-beta family. J Leukoc Biol. 67:350-6
35. Rojas IG, Spencer ML, Martinez A, Maurelia MA, Rudolph MI (2005) Characterization of mast cell subpopulations in lip cancer. J Oral Pathol Med 34:268-73
36. Sabatos CA, Chakravarti S, Cha E, Schubart A, Sanchez-Fueyo A, Zheng XX et al. (2003) Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol 4:1102-10
37. Sanchez-Fueyo A, Tian J, Picarella D, Domenig C, Zheng XX, Sabatos CA et al. (2003) Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat Immunol 4:1093-101
38. Tan M, Wang Y, Guan K, Sun Y (2000) PTGF-beta, a type beta transforming growth factor (TGF-beta) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway. Proc Natl Acad Sci USA 97:109-14
39. Wakefield LM, Roberts AB (2002) TGF-β signaling: positive and negative effects on tumorigenesis. Curr Opin Genet Dev 12:22-9
40. Zheng Y, Manzotti CN, Liu M, Burke F, Med KI, Sansom DM (2004) CD86 and CD80 differentially modulate the suppressive function of human regulatory T cells. J Immunol 172:2778-84
41. Zhu C, Anderson AC, Schubart A, Xiong H, Imitola J, Khoury SJ et al. (2005) The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol 6:1245-52