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Volumn 36, Issue 1-3, 2006, Pages 83-89

Gene therapy for type 1 diabetes: Is it ready for the clinic?

Author keywords

Autoimmunity; Diabetes; Gene therapy; Immunotherapy

Indexed keywords

ADENOVIRUS VECTOR; INSULIN; PARVOVIRUS VECTOR;

EID: 33947188722     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1385/ir:36:1:83     Document Type: Review
Times cited : (5)

References (62)
  • 1
    • 0035516047 scopus 로고    scopus 로고
    • Projection of diabetes burden through 2050: Impact of changing demography and disease prevalence in the U.S
    • Boyle JP, Honeycutt AA, Narayan KM, et al: Projection of diabetes burden through 2050: impact of changing demography and disease prevalence in the U.S. Diabetes Care 2001;24:1936-1940.
    • (2001) Diabetes Care , vol.24 , pp. 1936-1940
    • Boyle, J.P.1    Honeycutt, A.A.2    Narayan, K.M.3
  • 2
    • 28444489240 scopus 로고    scopus 로고
    • Monitoring glycemic control: The cornerstone of diabetes care
    • LeRoith D, Smith DO: Monitoring glycemic control: the cornerstone of diabetes care. Clin Ther 2005;27:1489-1499.
    • (2005) Clin Ther , vol.27 , pp. 1489-1499
    • LeRoith, D.1    Smith, D.O.2
  • 4
    • 33644777683 scopus 로고    scopus 로고
    • Multifaceted therapeutic approaches for a multigenic disease
    • Bottino R, Trucco M: Multifaceted therapeutic approaches for a multigenic disease. Diabetes 2005;54:S79-S86.
    • (2005) Diabetes , vol.54
    • Bottino, R.1    Trucco, M.2
  • 5
    • 0036022663 scopus 로고    scopus 로고
    • Gene and cell therapies for diabetes mellitus: Strategies and clinical potential
    • Giannoukakis N, Robbins PD: Gene and cell therapies for diabetes mellitus: strategies and clinical potential. BioDrugs 2002;16:149-173.
    • (2002) BioDrugs , vol.16 , pp. 149-173
    • Giannoukakis, N.1    Robbins, P.D.2
  • 6
    • 0038621437 scopus 로고    scopus 로고
    • Gene- and cell-based therapeutics for type I diabetes mellitus
    • Bottino R, Lemarchand P, Trucco M, Giannoukakis N: Gene- and cell-based therapeutics for type I diabetes mellitus. Gene Ther 2003;10:875-889.
    • (2003) Gene Ther , vol.10 , pp. 875-889
    • Bottino, R.1    Lemarchand, P.2    Trucco, M.3    Giannoukakis, N.4
  • 7
    • 0038340194 scopus 로고    scopus 로고
    • Gene therapy technology applied to disorders of glucose metabolism: Promise, achievements, and prospects
    • Giannoukakis N, Trucco M: Gene therapy technology applied to disorders of glucose metabolism: promise, achievements, and prospects. Biotechniques 2003;35:122-145.
    • (2003) Biotechniques , vol.35 , pp. 122-145
    • Giannoukakis, N.1    Trucco, M.2
  • 8
    • 0344738831 scopus 로고    scopus 로고
    • Current status and prospects for gene and cell therapeutics for type 1 diabetes mellitus
    • Giannoukakis N, Trucco M: Current status and prospects for gene and cell therapeutics for type 1 diabetes mellitus. Rev Endocr Metab Disord 2003;4:369-380.
    • (2003) Rev Endocr Metab Disord , vol.4 , pp. 369-380
    • Giannoukakis, N.1    Trucco, M.2
  • 10
    • 0030752379 scopus 로고    scopus 로고
    • Advances in adenoviral vectors: From genetic engineering to their biology
    • Yeh P, Perricaudet M: Advances in adenoviral vectors: from genetic engineering to their biology. FASEB J 1997;11:615-623.
    • (1997) FASEB J , vol.11 , pp. 615-623
    • Yeh, P.1    Perricaudet, M.2
  • 11
    • 0032719482 scopus 로고    scopus 로고
    • Development of high-capacity adenoviral vectors for gene therapy
    • Kochanek S: Development of high-capacity adenoviral vectors for gene therapy. Thromb Haemost 1999;82:547-551.
    • (1999) Thromb Haemost , vol.82 , pp. 547-551
    • Kochanek, S.1
  • 12
    • 0033543992 scopus 로고    scopus 로고
    • High-capacity adenoviral vectors for gene transfer and somatic gene therapy
    • Kochanek S: High-capacity adenoviral vectors for gene transfer and somatic gene therapy. Hum Gene Ther 1999;10:2451-2459.
    • (1999) Hum Gene Ther , vol.10 , pp. 2451-2459
    • Kochanek, S.1
  • 13
    • 0034475066 scopus 로고    scopus 로고
    • Adenoviral vectors
    • Seth P: Adenoviral vectors. Adv Exp Med Biol 2000;465:13-22.
    • (2000) Adv Exp Med Biol , vol.465 , pp. 13-22
    • Seth, P.1
  • 14
    • 0041808932 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Adenoviral vectors
    • St George JA: Gene therapy progress and prospects: adenoviral vectors. Gene Ther 2003;10:1135-1141.
    • (2003) Gene Ther , vol.10 , pp. 1135-1141
    • St George, J.A.1
  • 15
    • 4544296841 scopus 로고    scopus 로고
    • Adenoviral vectors for gene replacement therapy
    • Cao H, Koehler DR, Hu J: Adenoviral vectors for gene replacement therapy. Viral Immunol 2004;17:327-333.
    • (2004) Viral Immunol , vol.17 , pp. 327-333
    • Cao, H.1    Koehler, D.R.2    Hu, J.3
  • 16
    • 4544344036 scopus 로고    scopus 로고
    • Immune responses against adenoviral vectors and their transgene products: A review of strategies for evasion
    • Schagen FH, Ossevoort M, Toes RE, Hoeben RC: Immune responses against adenoviral vectors and their transgene products: a review of strategies for evasion. Crit Rev Oncol Hematol 2004;50:51-70.
    • (2004) Crit Rev Oncol Hematol , vol.50 , pp. 51-70
    • Schagen, F.H.1    Ossevoort, M.2    Toes, R.E.3    Hoeben, R.C.4
  • 17
    • 4644258829 scopus 로고    scopus 로고
    • Adenoviral vectors for gene transfer and therapy
    • Volpers C, Kochanek S: Adenoviral vectors for gene transfer and therapy. J Gene Med 2004;6 Suppl 1:S164-171.
    • (2004) J Gene Med , vol.6 , Issue.SUPPL. 1
    • Volpers, C.1    Kochanek, S.2
  • 18
    • 0036968511 scopus 로고    scopus 로고
    • Adenovirus and adeno-associated virus vectors
    • Lai CM, Lai YK, Rakoczy PE: Adenovirus and adeno-associated virus vectors. DNA Cell Biol 2002;21:895-913.
    • (2002) DNA Cell Biol , vol.21 , pp. 895-913
    • Lai CM, L.Y.1    Rakoczy, P.E.2
  • 19
    • 1542369977 scopus 로고    scopus 로고
    • From virus evolution to vector revolution: Use of naturally occurring serotypes of adeno-associated virus (AAV) as novel vectors for human gene therapy
    • Grimm D, Kay MA: From virus evolution to vector revolution: use of naturally occurring serotypes of adeno-associated virus (AAV) as novel vectors for human gene therapy. Curr Gene Ther 2003;3:281-304.
    • (2003) Curr Gene Ther , vol.3 , pp. 281-304
    • Grimm, D.1    Kay, M.A.2
  • 20
    • 0037228848 scopus 로고    scopus 로고
    • Adeno-associated virus vectors for therapeutic gene transfer
    • passim
    • Stilwell JL, Samulski RJ: Adeno-associated virus vectors for therapeutic gene transfer. Biotechniques 2003;34:148-150, 152, 154 passim.
    • (2003) Biotechniques , vol.34
    • Stilwell, J.L.1    Samulski, R.J.2
  • 21
    • 0038805301 scopus 로고    scopus 로고
    • Immune responses to adeno-associated virus and its recombinant vectors
    • Sun JY, Anand-Jawa V, Chatterjee S,Wong KK: Immune responses to adeno-associated virus and its recombinant vectors. Gene Ther 2003;10:964-976.
    • (2003) Gene Ther , vol.10 , pp. 964-976
    • Sun, J.Y.1    Anand-Jawa, V.2    Chatterjee, S.3    Wong, K.K.4
  • 22
    • 4644273498 scopus 로고    scopus 로고
    • Progress in the use of adeno-associated viral vectors for gene therapy
    • Buning H, Braun-Falco M, Hallek M: Progress in the use of adeno-associated viral vectors for gene therapy. Cells Tissues Organs 2004;177:139-150.
    • (2004) Cells Tissues Organs , vol.177 , pp. 139-150
    • Buning, H.1    Braun-Falco, M.2    Hallek, M.3
  • 23
    • 10344230408 scopus 로고    scopus 로고
    • Adeno-associated virus and the development of adeno-associated virus vectors: A historical perspective
    • Carter BJ: Adeno-associated virus and the development of adeno-associated virus vectors: a historical perspective. Mol Ther 2004;10:981-989.
    • (2004) Mol Ther , vol.10 , pp. 981-989
    • Carter, B.J.1
  • 24
    • 3142699127 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus vectors for gene therapy
    • Conlon TJ, Flotte TR: Recombinant adeno-associated virus vectors for gene therapy. Expert Opin Biol Ther 2004;4:1093-1101.
    • (2004) Expert Opin Biol Ther , vol.4 , pp. 1093-1101
    • Conlon, T.J.1    Flotte, T.R.2
  • 25
    • 1542530051 scopus 로고    scopus 로고
    • Overview of adeno-associated viral vectors
    • Daly TM: Overview of adeno-associated viral vectors. Methods Mol Biol 2004;246:157-165.
    • (2004) Methods Mol Biol , vol.246 , pp. 157-165
    • Daly, T.M.1
  • 26
    • 2642539509 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Recombinant adeno-associated virus (rAAV) vectors
    • Flotte TR: Gene therapy progress and prospects: recombinant adeno-associated virus (rAAV) vectors. Gene Ther 2004;11:805-810.
    • (2004) Gene Ther , vol.11 , pp. 805-810
    • Flotte, T.R.1
  • 27
    • 10944269753 scopus 로고    scopus 로고
    • Integration of adeno-associated virus (AAV) and recombinant AAV vectors
    • McCarty DM,Young SM, Jr, Samulski RJ: Integration of adeno-associated virus (AAV) and recombinant AAV vectors. Annu Rev Genet 2004;38:819-845.
    • (2004) Annu Rev Genet , vol.38 , pp. 819-845
    • McCarty, D.M.1    Young Jr, S.M.2    Samulski, R.J.3
  • 28
    • 0842287787 scopus 로고    scopus 로고
    • Can genes transduced by adeno-associated virus vectors elicit or evade an immune response?
    • Wang CH, Liu DW, Tsao YP, Xiao X, Chen SL: Can genes transduced by adeno-associated virus vectors elicit or evade an immune response? Arch Virol 2004;149:1-15.
    • (2004) Arch Virol , vol.149 , pp. 1-15
    • Wang, C.H.1    Liu, D.W.2    Tsao, Y.P.3    Xiao, X.4    Chen, S.L.5
  • 29
    • 27144509758 scopus 로고    scopus 로고
    • Current development of adeno-associated viral vectors
    • Romano G: Current development of adeno-associated viral vectors. Drug News Perspect 2005;18:311-316.
    • (2005) Drug News Perspect , vol.18 , pp. 311-316
    • Romano, G.1
  • 30
    • 21244451129 scopus 로고    scopus 로고
    • Adeno-associated viral vectors for clinical gene transfer studies
    • Snyder RO, Francis J: Adeno-associated viral vectors for clinical gene transfer studies. Curr Gene Ther 2005;5:311-321.
    • (2005) Curr Gene Ther , vol.5 , pp. 311-321
    • Snyder, R.O.1    Francis, J.2
  • 31
    • 21244441929 scopus 로고    scopus 로고
    • Immune responses to adeno-associated virus vectors
    • Zaiss AK, Muruve DA: Immune responses to adeno-associated virus vectors. Curr Gene Ther 2005;5:323-331.
    • (2005) Curr Gene Ther , vol.5 , pp. 323-331
    • Zaiss, A.K.1    Muruve, D.A.2
  • 32
    • 0029933105 scopus 로고    scopus 로고
    • Adenovirus-mediated in vivo gene transfer and expression in normal rat pancreas
    • Raper SE, DeMatteo RP: Adenovirus-mediated in vivo gene transfer and expression in normal rat pancreas. Pancreas 1996;12:401-410.
    • (1996) Pancreas , vol.12 , pp. 401-410
    • Raper, S.E.1    DeMatteo, R.P.2
  • 33
    • 0035127574 scopus 로고    scopus 로고
    • Efficient ex vivo transduction of pancreatic islet cells with recombinant adeno-associated virus vectors
    • Flotte T, Agarwal A,Wang J, et al: Efficient ex vivo transduction of pancreatic islet cells with recombinant adeno-associated virus vectors. Diabetes 2001;50:515-520.
    • (2001) Diabetes , vol.50 , pp. 515-520
    • Flotte, T.1    Agarwal, A.2    Wang, J.3
  • 34
    • 23844508678 scopus 로고    scopus 로고
    • Localized gene expression following administration of adeno-associated viral vectors via pancreatic ducts
    • Loiler SA, Tang Q, Clarke T, et al: Localized gene expression following administration of adeno-associated viral vectors via pancreatic ducts. Mol Ther 2005;12:519-527.
    • (2005) Mol Ther , vol.12 , pp. 519-527
    • Loiler, S.A.1    Tang, Q.2    Clarke, T.3
  • 35
    • 33745322415 scopus 로고    scopus 로고
    • Widespread and stable pancreatic gene transfer by AAV vectors via different routes
    • Wang Z, Zhu T, Rehman KK, et al: Widespread and stable pancreatic gene transfer by AAV vectors via different routes. Diabetes 2006;55:875-884.
    • (2006) Diabetes , vol.55 , pp. 875-884
    • Wang, Z.1    Zhu, T.2    Rehman, K.K.3
  • 36
    • 33645522651 scopus 로고    scopus 로고
    • In vivo gene transfer to healthy and diabetic canine pancreas
    • Ayuso E, Chillon M, Garcia F, et al: In vivo gene transfer to healthy and diabetic canine pancreas. Mol Ther 2005;13:747-755.
    • (2005) Mol Ther , vol.13 , pp. 747-755
    • Ayuso, E.1    Chillon, M.2    Garcia, F.3
  • 37
    • 0031564327 scopus 로고    scopus 로고
    • Characterization of the immune response after local delivery of recombinant adenovirus in murine pancreas and successful strategies for readministration
    • McClane SJ, Chirmule N, Burke CV, Raper SE: Characterization of the immune response after local delivery of recombinant adenovirus in murine pancreas and successful strategies for readministration. Hum Gene Ther 1997;8:2207-2216.
    • (1997) Hum Gene Ther , vol.8 , pp. 2207-2216
    • McClane, S.J.1    Chirmule, N.2    Burke, C.V.3    Raper, S.E.4
  • 38
    • 0034778099 scopus 로고    scopus 로고
    • Adenoviral vector-mediated insulin gene transfer in the mouse pancreas corrects streptozotocin-induced hyperglycemia
    • Shifrin AL, Auricchio A, Yu QC, Wilson J, Raper SE: Adenoviral vector-mediated insulin gene transfer in the mouse pancreas corrects streptozotocin-induced hyperglycemia. Gene Ther 2001;8:1480-1489.
    • (2001) Gene Ther , vol.8 , pp. 1480-1489
    • Shifrin, A.L.1    Auricchio, A.2    Yu, Q.C.3    Wilson, J.4    Raper, S.E.5
  • 39
    • 13944278472 scopus 로고    scopus 로고
    • Gene therapy. As Gelsinger case ends, gene therapy suffers another blow
    • Couzin J, Kaiser J: Gene therapy. As Gelsinger case ends, gene therapy suffers another blow. Science 2005;307:1028.
    • (2005) Science , vol.307 , pp. 1028
    • Couzin, J.1    Kaiser, J.2
  • 40
    • 0034328925 scopus 로고    scopus 로고
    • Gene therapy: Trials and tribulations
    • Somia N, Verma IM: Gene therapy: trials and tribulations. Nat Rev Genet 2000;1:91-99.
    • (2000) Nat Rev Genet , vol.1 , pp. 91-99
    • Somia, N.1    Verma, I.M.2
  • 42
    • 2042435747 scopus 로고    scopus 로고
    • Tacrolimus impairment of insulin secretion in isolated rat islets occurs at multiple distal sites in stimulus-secretion coupling
    • Uchizono Y, Iwase M, Nakamura U, Sasaki N, Goto D, Iida M: Tacrolimus impairment of insulin secretion in isolated rat islets occurs at multiple distal sites in stimulus-secretion coupling. Endocrinology 2004;145:2264-2272.
    • (2004) Endocrinology , vol.145 , pp. 2264-2272
    • Uchizono, Y.1    Iwase, M.2    Nakamura, U.3    Sasaki, N.4    Goto, D.5    Iida, M.6
  • 43
    • 0037115212 scopus 로고    scopus 로고
    • Defining optimal immunosuppression for islet transplantation based on reduced diabetogenicity in canine islet autografts
    • Shapiro AM, Geng Hao E, Lakey JR, Finegood DT, Rajotte RV, Kneteman NM: Defining optimal immunosuppression for islet transplantation based on reduced diabetogenicity in canine islet autografts. Transplantation 2002;74:1522-1528.
    • (2002) Transplantation , vol.74 , pp. 1522-1528
    • Shapiro, A.M.1    Geng Hao, E.2    Lakey, J.R.3    Finegood, D.T.4    Rajotte, R.V.5    Kneteman, N.M.6
  • 44
    • 0036070177 scopus 로고    scopus 로고
    • Pancreatic stem cells
    • Bonner-Weir S, Sharma A: Pancreatic stem cells. J Pathol 2002;197:519-526.
    • (2002) J Pathol , vol.197 , pp. 519-526
    • Bonner-Weir, S.1    Sharma, A.2
  • 45
    • 4444320484 scopus 로고    scopus 로고
    • Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages
    • Seaberg RM, Smukler SR, Kieffer TJ, et al: Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages. Nat Biotechnol 2004;22:1115-1124.
    • (2004) Nat Biotechnol , vol.22 , pp. 1115-1124
    • Seaberg, R.M.1    Smukler, S.R.2    Kieffer, T.J.3
  • 46
    • 3242784831 scopus 로고    scopus 로고
    • Prospective isolation of multipotent pancreatic progenitors using flow-cytometric cell sorting
    • Suzuki A, Nakauchi H, Taniguchi H: Prospective isolation of multipotent pancreatic progenitors using flow-cytometric cell sorting. Diabetes 2004;53:2143-2152.
    • (2004) Diabetes , vol.53 , pp. 2143-2152
    • Suzuki, A.1    Nakauchi, H.2    Taniguchi, H.3
  • 47
    • 13744261497 scopus 로고    scopus 로고
    • Regeneration of the pancreatic beta cell
    • Trucco M: Regeneration of the pancreatic beta cell. J Clin Invest 2005;115:5-12.
    • (2005) J Clin Invest , vol.115 , pp. 5-12
    • Trucco, M.1
  • 48
    • 11444252141 scopus 로고    scopus 로고
    • The pancreatic ductal epithelium serves as a potential pool of progenitor cells
    • Bonner-Weir S, Toschi E, Inada A, et al: The pancreatic ductal epithelium serves as a potential pool of progenitor cells. Pediatr Diabetes 2004;5(Suppl 2):16-22.
    • (2004) Pediatr Diabetes , vol.5 , Issue.SUPPL. 2 , pp. 16-22
    • Bonner-Weir, S.1    Toschi, E.2    Inada, A.3
  • 49
    • 0038110577 scopus 로고    scopus 로고
    • Recovery of endogenous beta cell function in autoimmune diabetes
    • Zorina TD, Subbotin VM, Bertera S, et al: Recovery of endogenous beta cell function in autoimmune diabetes. Stem Cells 2003;21:377-388.
    • (2003) Stem Cells , vol.21 , pp. 377-388
    • Zorina, T.D.1    Subbotin, V.M.2    Bertera, S.3
  • 50
    • 0035987925 scopus 로고    scopus 로고
    • Distinct characteristics and features of allogeneic chimerism in the NOD mouse model of autoimmune diabetes
    • Zorina TD, Subbotin VM, Bertera S, et al: Distinct characteristics and features of allogeneic chimerism in the NOD mouse model of autoimmune diabetes. Cell Transplant 2002;11:113-123.
    • (2002) Cell Transplant , vol.11 , pp. 113-123
    • Zorina, T.D.1    Subbotin, V.M.2    Bertera, S.3
  • 51
    • 0029940504 scopus 로고    scopus 로고
    • ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules
    • Solimena M, Dirkx R, Jr, Hermel JM, et al: ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules. EMBO J 1996;15:2102-2114.
    • (1996) EMBO J , vol.15 , pp. 2102-2114
    • Solimena, M.1    Dirkx Jr, R.2    Hermel, J.M.3
  • 52
    • 0344338626 scopus 로고
    • Prevention of type I diabetes in nonobese diabetic mice by allogenic bone marrow transplantation
    • Ikehara S, Ohtsuki H, Good RA, et al.: Prevention of type I diabetes in nonobese diabetic mice by allogenic bone marrow transplantation. Proc Natl Acad Sci USA 1985;82:7743-7747.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 7743-7747
    • Ikehara, S.1    Ohtsuki, H.2    Good, R.A.3
  • 53
    • 11444250822 scopus 로고    scopus 로고
    • Islet regeneration needed for overcoming autoimmune destruction - considerations on the pathogenesis of type 1 diabetes
    • von Herrath M, Homann D: Islet regeneration needed for overcoming autoimmune destruction - considerations on the pathogenesis of type 1 diabetes. Pediatr Diabetes 2004;5(Suppl 2):23-28.
    • (2004) Pediatr Diabetes , vol.5 , Issue.SUPPL. 2 , pp. 23-28
    • von Herrath, M.1    Homann, D.2
  • 54
  • 55
    • 24144446405 scopus 로고    scopus 로고
    • Combination therapy with epidermal growth factor and gastrin increases {beta}-cell mass and reverses hyperglycemia in diabetic NOD mice
    • Suarez-Pinzon WL, Yan Y, Power R, Brand SJ, Rabinovitch A: Combination therapy with epidermal growth factor and gastrin increases {beta}-cell mass and reverses hyperglycemia in diabetic NOD mice. Diabetes 2005;54:2596-2601.
    • (2005) Diabetes , vol.54 , pp. 2596-2601
    • Suarez-Pinzon, W.L.1    Yan, Y.2    Power, R.3    Brand, S.J.4    Rabinovitch, A.5
  • 56
    • 12944327377 scopus 로고    scopus 로고
    • In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells
    • Baeyens L, De Breuck S, Lardon J, Mfopou JK, Rooman I, Bouwens L: In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells. Diabetologia 2005;48:49-57.
    • (2005) Diabetologia , vol.48 , pp. 49-57
    • Baeyens, L.1    De Breuck, S.2    Lardon, J.3    Mfopou, J.K.4    Rooman, I.5    Bouwens, L.6
  • 57
    • 0037191099 scopus 로고    scopus 로고
    • Heremans Y,Van De Casteele M, in't Veld P, et al: Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. J Cell Biol 2002;159:303-312.
    • Heremans Y,Van De Casteele M, in't Veld P, et al: Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. J Cell Biol 2002;159:303-312.
  • 58
    • 0033954474 scopus 로고    scopus 로고
    • Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia
    • Garcia-Ocana A, Takane KK, Syed MA, Philbrick WM, Vasavada RC, Stewart AF: Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia. J Biol Chem 2000;275:1226-1232.
    • (2000) J Biol Chem , vol.275 , pp. 1226-1232
    • Garcia-Ocana, A.1    Takane, K.K.2    Syed, M.A.3    Philbrick, W.M.4    Vasavada, R.C.5    Stewart, A.F.6
  • 60
    • 18944407852 scopus 로고    scopus 로고
    • Pancreatic islet-specific expression of an insulin-like growth factor-I transgene compensates islet cell growth in growth hormone receptor gene-deficient mice
    • Guo Y, Lu Y, Houle D, et al: Pancreatic islet-specific expression of an insulin-like growth factor-I transgene compensates islet cell growth in growth hormone receptor gene-deficient mice. Endocrinology 2005;146:2602-2609.
    • (2005) Endocrinology , vol.146 , pp. 2602-2609
    • Guo, Y.1    Lu, Y.2    Houle, D.3
  • 61
    • 0036828227 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats
    • Farilla L, Hui H, Bertolotto C, et al: Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats. Endocrinology 2002;143:4397-4408.
    • (2002) Endocrinology , vol.143 , pp. 4397-4408
    • Farilla, L.1    Hui, H.2    Bertolotto, C.3
  • 62
    • 30644470444 scopus 로고    scopus 로고
    • Efficient gene delivery to human and rodent islets with double-stranded (ds) AAV-based vectors
    • Rehman KK, Wang Z, Bottino R, et al: Efficient gene delivery to human and rodent islets with double-stranded (ds) AAV-based vectors. Gene Ther 2005;12:1313-1323.
    • (2005) Gene Ther , vol.12 , pp. 1313-1323
    • Rehman, K.K.1    Wang, Z.2    Bottino, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.