메뉴 건너뛰기




Volumn 261, Issue 3, 1999, Pages 618-628

Ectodomain cleavage and shedding of the type III transforming growth factor-β receptor in lung membranes. Effect of temperature, ligand binding and membrane solubilization

Author keywords

Ectodomain shedding; Lung membrane; Type III transforming growth factor (TGF) receptor

Indexed keywords

RECEPTOR SUBTYPE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

EID: 0033135695     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1999.00298.x     Document Type: Article
Times cited : (21)

References (48)
  • 1
  • 2
    • 0027503601 scopus 로고
    • Physiological actions and clinical applications of transforming growth factor-β (TGF-β)
    • 2. Roberts, A.B. & Sporn, M.B. (1993) Physiological actions and clinical applications of transforming growth factor-β (TGF-β). Growth Factors 8, 1-9.
    • (1993) Growth Factors , vol.8 , pp. 1-9
    • Roberts, A.B.1    Sporn, M.B.2
  • 3
    • 0026296976 scopus 로고
    • Expression of transforming growth factor-β1, -β2, and -β3 mRNA and protein in the murine lung
    • 3. Pelton, R.W., Johnson, M.D., Perkett, E.A., Gold, L.I. & Moses, H.L. (1991) Expression of transforming growth factor-β1, -β2, and -β3 mRNA and protein in the murine lung. Am. J. Respir. Cell. Mol. Biol. 5, 522-530.
    • (1991) Am. J. Respir. Cell. Mol. Biol. , vol.5 , pp. 522-530
    • Pelton, R.W.1    Johnson, M.D.2    Perkett, E.A.3    Gold, L.I.4    Moses, H.L.5
  • 4
    • 0025600873 scopus 로고
    • The β-type transforming growth factors: Mediators of cell regulation in the lung
    • 4. Pelton, R.W. & Moses, H.L. (1990) The β-type transforming growth factors: mediators of cell regulation in the lung. Am. Rev. Respir. Dis. 142, S31-S35.
    • (1990) Am. Rev. Respir. Dis. , vol.142
    • Pelton, R.W.1    Moses, H.L.2
  • 6
    • 0024307964 scopus 로고
    • Collagen synthesis by normal and fibrotic human lung fibroblasts and the effect of transforming growth factor-β
    • S.
    • 6. Raghu, G., Masta, S., Myera, D., Narayanan, A. & S. (1989) Collagen synthesis by normal and fibrotic human lung fibroblasts and the effect of transforming growth factor-β. Am. Rev. Respir. Dis. 140, 95-100.
    • (1989) Am. Rev. Respir. Dis. , vol.140 , pp. 95-100
    • Raghu, G.1    Masta, S.2    Myera, D.3    Narayanan, A.4
  • 7
    • 0029262749 scopus 로고
    • Retinoic acid inhibition of transforming growth factor-β induced collagen production by human lung fibroblasts
    • 7. Redlich, C.A., Delisser, H.M. & Elias, J.A. (1995). Retinoic acid inhibition of transforming growth factor-β induced collagen production by human lung fibroblasts. Am. J. Respir. Cell Mol. Biol. 12, 287-295.
    • (1995) Am. J. Respir. Cell Mol. Biol. , vol.12 , pp. 287-295
    • Redlich, C.A.1    Delisser, H.M.2    Elias, J.A.3
  • 8
    • 0023022613 scopus 로고
    • Regulation of proliferation and differentiation of respiratory tract epithelial cells by TGF-beta
    • 8. Jetten, A.M., Shirley, J.E. & Stoner, G. (1986). Regulation of proliferation and differentiation of respiratory tract epithelial cells by TGF-beta. Exp. Cell. Res. 167, 539-549.
    • (1986) Exp. Cell. Res. , vol.167 , pp. 539-549
    • Jetten, A.M.1    Shirley, J.E.2    Stoner, G.3
  • 9
    • 0024511220 scopus 로고
    • Control of growth and squamous differentiation in normal human bronchial epithelial cells by chemical and biological modifiers and transferred genes
    • 9. Pfeifer, A.M., Lechner, J.F., Masui, T., Reddel, R.R., Mark, G.E. & Harris, C.C. (1989) Control of growth and squamous differentiation in normal human bronchial epithelial cells by chemical and biological modifiers and transferred genes. Environ. Health Perspect. 80, 209-220.
    • (1989) Environ. Health Perspect. , vol.80 , pp. 209-220
    • Pfeifer, A.M.1    Lechner, J.F.2    Masui, T.3    Reddel, R.R.4    Mark, G.E.5    Harris, C.C.6
  • 10
    • 0027169155 scopus 로고
    • Cytokines and cytokine networking in interstitial and fibrotic lung disorders
    • 10. Rochester, C.L. & Elias, J.A. (1993) Cytokines and cytokine networking in interstitial and fibrotic lung disorders. Semin. Respir. Med. 14, 389-416.
    • (1993) Semin. Respir. Med. , vol.14 , pp. 389-416
    • Rochester, C.L.1    Elias, J.A.2
  • 11
    • 0031059572 scopus 로고    scopus 로고
    • Transforming growth factor-β1 and -β2 and -β3 stimulate fibroblast procollagen production in vitro but are differentially expressed during bleomycin-induced lung fibrosis
    • 11. Coker, R.K., Laurent, G.J., Shahzeidi, S., Lympany, P.A., du Bois, R.M., Jeffery, P.K. & McAnulty, R.J. (1997) Transforming growth factor-β1 and -β2 and -β3 stimulate fibroblast procollagen production in vitro but are differentially expressed during bleomycin-induced lung fibrosis. Am. J. Pathol. 150, 981-991.
    • (1997) Am. J. Pathol. , vol.150 , pp. 981-991
    • Coker, R.K.1    Laurent, G.J.2    Shahzeidi, S.3    Lympany, P.A.4    Du Bois, R.M.5    Jeffery, P.K.6    McAnulty, R.J.7
  • 13
    • 0028113563 scopus 로고
    • Transforming growth factor-β1 (TGF-β1), and β2-like activities in malignant pleural effusions caused by malignant mesothelioma or primary lung cancer
    • 13. Maeda, J., Ucki, N., Ohkawa, T., Iwahashi, N., Nakato, T., Hada, T. & Higashino, K. (1994) Transforming growth factor-β1 (TGF-β1), and β2-like activities in malignant pleural effusions caused by malignant mesothelioma or primary lung cancer. Clin. Exp. Immunol. 98, 319-322.
    • (1994) Clin. Exp. Immunol. , vol.98 , pp. 319-322
    • Maeda, J.1    Ucki, N.2    Ohkawa, T.3    Iwahashi, N.4    Nakato, T.5    Hada, T.6    Higashino, K.7
  • 14
    • 0023604578 scopus 로고
    • Distribution and modulation of the cellular receptors for transforming growth factor-β
    • 14. Wakefield, L.M., Smith, D.M., Masui, T., Harris, C.C. & Sporn, M.B. (1987) Distribution and modulation of the cellular receptors for transforming growth factor-β. J. Cell Biol. 105, 965-975.
    • (1987) J. Cell Biol. , vol.105 , pp. 965-975
    • Wakefield, L.M.1    Smith, D.M.2    Masui, T.3    Harris, C.C.4    Sporn, M.B.5
  • 16
    • 0027332995 scopus 로고
    • Cloning of TGF-β type I receptor that forms a heteromeric complex with the TGF-β type II receptor
    • 16. Franzen, P., ten Dijke, P., Ichijo, H., Yamashita, H., Schultz, P., Heldin, C.H. & Miyazono, K. (1993) Cloning of TGF-β type I receptor that forms a heteromeric complex with the TGF-β type II receptor. Cell 75, 681-692.
    • (1993) Cell , vol.75 , pp. 681-692
    • Franzen, P.1    Ten Dijke, P.2    Ichijo, H.3    Yamashita, H.4    Schultz, P.5    Heldin, C.H.6    Miyazono, K.7
  • 17
    • 0026537831 scopus 로고
    • Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase
    • 17. Lin, H.Y., Wang, X.-F., Ng-Eaton, E., Wainberg, R.A. & Lodish, H.F. (1992) Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase. Cell 68, 775-785.
    • (1992) Cell , vol.68 , pp. 775-785
    • Lin, H.Y.1    Wang, X.-F.2    Ng-Eaton, E.3    Wainberg, R.A.4    Lodish, H.F.5
  • 19
    • 0025989562 scopus 로고
    • Expression cloning and characterization of the TGF-β type III receptor
    • 19. Wang, X.F., Lin. H.Y., Ng-Eaton, E., Downward, J., Lodish, H.F. & Weinberg, R.A. (1992) Expression cloning and characterization of the TGF-β type III receptor. Cell 67, 797-805.
    • (1992) Cell , vol.67 , pp. 797-805
    • Wang, X.F.1    Lin, H.Y.2    Ng-Eaton, E.3    Downward, J.4    Lodish, H.F.5    Weinberg, R.A.6
  • 20
    • 0025987832 scopus 로고
    • Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-β receptor system
    • 20. Lopez-Casillas, F., Chieftez, S., Doody, J., Andres, J.L., Lane, W.S. & Massague, J. (1991) Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-β receptor system. Cell 67, 785-795.
    • (1991) Cell , vol.67 , pp. 785-795
    • Lopez-Casillas, F.1    Chieftez, S.2    Doody, J.3    Andres, J.L.4    Lane, W.S.5    Massague, J.6
  • 21
    • 0027276765 scopus 로고
    • Betaglycan presents ligand to the TGF-β signalling receptor
    • 21. Lopez-Casillas, F., Wrana, J.L. & Massague, J. (1993) Betaglycan presents ligand to the TGF-β signalling receptor. Cell 73, 1435-1444.
    • (1993) Cell , vol.73 , pp. 1435-1444
    • Lopez-Casillas, F.1    Wrana, J.L.2    Massague, J.3
  • 22
    • 0027490673 scopus 로고
    • The TGF-β receptors types I, II and III form hetero-oligomeric complexes in the presence of ligand
    • 22. Moustakas, A., Lin, H.Y., Henis, Y.I., Plamondon, J., O'Connor-McCourt, M.D. & Lodish, H.F. (1993) The TGF-β receptors types I, II and III form hetero-oligomeric complexes in the presence of ligand J. Biol. Chem. 268, 22215-22218.
    • (1993) J. Biol. Chem. , vol.268 , pp. 22215-22218
    • Moustakas, A.1    Lin, H.Y.2    Henis, Y.I.3    Plamondon, J.4    O'Connor-McCourt, M.D.5    Lodish, H.F.6
  • 23
    • 0023763397 scopus 로고
    • The transforming growth factor-β receptor type III is a membrane proteoglycan
    • 23. Cheifetz, S., Andres, J.L. & Massague, J. (1988). The transforming growth factor-β receptor type III is a membrane proteoglycan. J. Biol. Chem. 263, 16984-16991.
    • (1988) J. Biol. Chem. , vol.263 , pp. 16984-16991
    • Cheifetz, S.1    Andres, J.L.2    Massague, J.3
  • 24
    • 0024596861 scopus 로고
    • Binding of TGF-β to cell surface proteins varies with cell type
    • 24. Segarini, P.R., Rosen, D.M. & Seyedin, S.M. (1989). Binding of TGF-β to cell surface proteins varies with cell type. Mol. Endocrionol. 3, 261-272.
    • (1989) Mol. Endocrionol. , vol.3 , pp. 261-272
    • Segarini, P.R.1    Rosen, D.M.2    Seyedin, S.M.3
  • 25
    • 0025714554 scopus 로고
    • Distinct transforming growth factor-β receptor subsets as determinants of cellular responsiveness to three TGF-β isoforms
    • 25. Cheifetz, S., Hernandez, H., Laiho, M., ten Dijke, P., Iwata, K.K. & Massague, J. (1990) Distinct transforming growth factor-β receptor subsets as determinants of cellular responsiveness to three TGF-β isoforms. J. Biol. Chem. 265, 20533-20538.
    • (1990) J. Biol. Chem. , vol.265 , pp. 20533-20538
    • Cheifetz, S.1    Hernandez, H.2    Laiho, M.3    Ten Dijke, P.4    Iwata, K.K.5    Massague, J.6
  • 26
    • 0029066003 scopus 로고
    • Expression of transforming growth factor type III receptor in vascular endothelial cells increases their responsiveness to transforming growth factor-β2
    • 26. Sankar, S., Mahooti-Brooks, N., Centrella, M., McCarthy, T.L. & Madri, J.A. (1995) Expression of transforming growth factor type III receptor in vascular endothelial cells increases their responsiveness to transforming growth factor-β2. J. Biol. Chem. 270, 13567-13572.
    • (1995) J. Biol. Chem. , vol.270 , pp. 13567-13572
    • Sankar, S.1    Mahooti-Brooks, N.2    Centrella, M.3    McCarthy, T.L.4    Madri, J.A.5
  • 27
    • 0030774892 scopus 로고    scopus 로고
    • Expression of transforming growth factor beta type III receptor suppresses tumorigenicity of human breast cancer MDA-MB-231 cells
    • 27. Sun, L. & Chen, C. (1997) Expression of transforming growth factor beta type III receptor suppresses tumorigenicity of human breast cancer MDA-MB-231 cells. J. Biol. Chem. 272, 25367-25372.
    • (1997) J. Biol. Chem. , vol.272 , pp. 25367-25372
    • Sun, L.1    Chen, C.2
  • 28
    • 0024792629 scopus 로고
    • Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-β
    • 28. Andres, J.L., Stanley, K., Cheifetz, S. & Massague, J. (1989) Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-β. J. Cell Biol. 109, 3137-3145.
    • (1989) J. Cell Biol. , vol.109 , pp. 3137-3145
    • Andres, J.L.1    Stanley, K.2    Cheifetz, S.3    Massague, J.4
  • 29
    • 0027976511 scopus 로고
    • Betaglycan can act as a dual modulator of TGF-β access to signaling receptors: Mapping of ligand binding and GAG attachment sites
    • 29. Lopez-Casillas, F., Payne, H.M., Andres, J.L. & Massague, J. (1994) Betaglycan can act as a dual modulator of TGF-β access to signaling receptors: mapping of ligand binding and GAG attachment sites. J. Cell Biol. 124, 557-568.
    • (1994) J. Cell Biol. , vol.124 , pp. 557-568
    • Lopez-Casillas, F.1    Payne, H.M.2    Andres, J.L.3    Massague, J.4
  • 30
    • 0028361975 scopus 로고
    • Mapping of the ligand binding domain of the transforming growth factor-β receptor type III by deletion mutagenesis
    • 30. Pepin, M.C., Beauchemin, M., Plamondon, J. & O'Connor-McCourt, M.D. (1994) Mapping of the ligand binding domain of the transforming growth factor-β receptor type III by deletion mutagenesis. Proc. Natl Acad. Sci. USA 91, 6997-7001.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 6997-7001
    • Pepin, M.C.1    Beauchemin, M.2    Plamondon, J.3    O'Connor-McCourt, M.D.4
  • 31
    • 0027375819 scopus 로고
    • Localization of transforming growth factor-β binding site in betaglycan. Comparison with small extracellular matrix proteoglycans
    • 31. Fukushima, D., Butzow, R., Hildebrand, A. & Ruoslahti, E. (1993) Localization of transforming growth factor-β binding site in betaglycan. Comparison with small extracellular matrix proteoglycans. J. Biol. Chem. 268, 22710-22715.
    • (1993) J. Biol. Chem. , vol.268 , pp. 22710-22715
    • Fukushima, D.1    Butzow, R.2    Hildebrand, A.3    Ruoslahti, E.4
  • 32
    • 0029590097 scopus 로고
    • Mutagenesis analysis of the membrane proximal ligand binding site of the TGF-β receptor type III extracellular domain
    • 32. Pepin, M.C., Beauchemin, M., Collins, C., Plamondon, J. & O'Connor-McCourt, M.D. (1995) Mutagenesis analysis of the membrane proximal ligand binding site of the TGF-β receptor type III extracellular domain. FEBS Lett. 377, 368-372.
    • (1995) FEBS Lett. , vol.377 , pp. 368-372
    • Pepin, M.C.1    Beauchemin, M.2    Collins, C.3    Plamondon, J.4    O'Connor-McCourt, M.D.5
  • 33
    • 0029787215 scopus 로고    scopus 로고
    • Reconstitution of a pentameric complex of dimeric transforming growth factor beta ligand and a type I, II, III receptor in baculoviral-infected insect cells
    • 33. Matsuzaki, K., Kan, M. & McKeehan, W.L. (1996) Reconstitution of a pentameric complex of dimeric transforming growth factor beta ligand and a type I, II, III receptor in baculoviral-infected insect cells. In Vitro Cell. Devel. Biol. 32, 345-360.
    • (1996) In Vitro Cell. Devel. Biol. , vol.32 , pp. 345-360
    • Matsuzaki, K.1    Kan, M.2    McKeehan, W.L.3
  • 34
    • 0032452292 scopus 로고    scopus 로고
    • Ligand-dependent and -independent interactions with the transforming growth factor type II and type I receptor subunits reside in the aminoterminal portion of the ectodomain of the type III subunit
    • 34. Taniguchi, A., Matsuzaki, K., Nakano, K., Kan, M. & McKeehan, W.L. (1998) Ligand-dependent and -independent interactions with the transforming growth factor type II and type I receptor subunits reside in the aminoterminal portion of the ectodomain of the type III subunit. In Vitro Cell. Dev. Biol. Anim. 34, 232-238.
    • (1998) In Vitro Cell. Dev. Biol. Anim. , vol.34 , pp. 232-238
    • Taniguchi, A.1    Matsuzaki, K.2    Nakano, K.3    Kan, M.4    McKeehan, W.L.5
  • 35
    • 0028830903 scopus 로고
    • Expression of transforming growth factor type II receptor in rat lung is regulated during development
    • 35. Zhao, Y. & Young, S.L. (1995) Expression of transforming growth factor type II receptor in rat lung is regulated during development. Am. J. Physiol. 269, 419-426.
    • (1995) Am. J. Physiol. , vol.269 , pp. 419-426
    • Zhao, Y.1    Young, S.L.2
  • 36
    • 0030027895 scopus 로고
    • Requirement of transforming growth factor-β (TGF-β) type II receptor for TGF-β-induced proliferation and growth inhibition
    • 36. Zhao, Y. & Young, S.L. (1995) Requirement of transforming growth factor-β (TGF-β) type II receptor for TGF-β-induced proliferation and growth inhibition. J. Biol. Chem. 271, 2369-2372.
    • (1995) J. Biol. Chem. , vol.271 , pp. 2369-2372
    • Zhao, Y.1    Young, S.L.2
  • 37
    • 0025791977 scopus 로고
    • Interaction of transforming growth factor-β with α2-macroglobulin: Role in transforming growth factor-β clearance
    • 37. Philip, A. & O'Connor-McCourt, M.D. (1991) Interaction of transforming growth factor-β with α2-macroglobulin: role in transforming growth factor-β clearance. J. Biol. Chem. 266, 22290-22296.
    • (1991) J. Biol. Chem. , vol.266 , pp. 22290-22296
    • Philip, A.1    O'Connor-McCourt, M.D.2
  • 38
    • 0025356905 scopus 로고
    • Transforming growth factor receptors in liver regeneration following partial hepatectomy in the rat
    • 38. Gruppuso, P.A., Mead, J.E. & Fausto, N. (1990) Transforming growth factor receptors in liver regeneration following partial hepatectomy in the rat. Cancer Res. 50, 1464-1469.
    • (1990) Cancer Res. , vol.50 , pp. 1464-1469
    • Gruppuso, P.A.1    Mead, J.E.2    Fausto, N.3
  • 40
    • 0026513005 scopus 로고
    • Subtypes of betaglycan and of type I and type II transforming growth factor-β (TGF-β) receptors with different affinities for TGF-β1 and TGF-β2 are exhibited by human placental trophoblast cells
    • 40. Mitchell, E.J., Fitzgibbon, L. & O'Connor-McCourt, M.D. (1992) Subtypes of betaglycan and of type I and type II transforming growth factor-β (TGF-β) receptors with different affinities for TGF-β1 and TGF-β2 are exhibited by human placental trophoblast cells. J. Cell. Physiol. 150, 334-343.
    • (1992) J. Cell. Physiol. , vol.150 , pp. 334-343
    • Mitchell, E.J.1    Fitzgibbon, L.2    O'Connor-McCourt, M.D.3
  • 41
    • 0025370836 scopus 로고
    • Identification of disulfide-linked transforming growth factor-β1-specific binding proteins in rat glomeruli
    • 41. MacKay, K., Robbins, A.R., Bruce, M.D. & Danielpour, D. (1990) Identification of disulfide-linked transforming growth factor-β1-specific binding proteins in rat glomeruli. J. Biol. Chem. 265, 9351-9356.
    • (1990) J. Biol. Chem. , vol.265 , pp. 9351-9356
    • MacKay, K.1    Robbins, A.R.2    Bruce, M.D.3    Danielpour, D.4
  • 42
    • 0019887744 scopus 로고
    • Phase separation of integral membrane proteins in Triton X-114 solution
    • 42. Bordier, C. (1981) Phase separation of integral membrane proteins in Triton X-114 solution. J. Biol. Chem. 256, 1604-1607.
    • (1981) J. Biol. Chem. , vol.256 , pp. 1604-1607
    • Bordier, C.1
  • 43
    • 0028862086 scopus 로고
    • Characterization of transforming growth factor-β growth regulatory effects and receptors on bovine mammary cells
    • 43. Woodward, T.L., Dumont, N., O'Connor-McCourt, M., Turner, J.D. & Philip, A. (1995) Characterization of transforming growth factor-β growth regulatory effects and receptors on bovine mammary cells. J. Cell. Physiol. 165, 339-348.
    • (1995) J. Cell. Physiol. , vol.165 , pp. 339-348
    • Woodward, T.L.1    Dumont, N.2    O'Connor-McCourt, M.3    Turner, J.D.P.A.4
  • 45
    • 0028972972 scopus 로고
    • Transforming growth factor-β receptor expression on endothelial cells: Heterogeneity of type III receptor expression
    • 45. Morello, J.P., Plamondon, J., Meyrick, B., Hoover, R. & O'Connor-McCourt, M.D. (1995) Transforming growth factor-β receptor expression on endothelial cells: heterogeneity of type III receptor expression. J. Cell. Physiol. 165, 201-211.
    • (1995) J. Cell. Physiol. , vol.165 , pp. 201-211
    • Morello, J.P.1    Plamondon, J.2    Meyrick, B.3    Hoover, R.4    O'Connor-McCourt, M.D.5
  • 46
    • 1842375639 scopus 로고    scopus 로고
    • Role of the juxtamembrane domains of the transforming growth factor-α precusor and the β-amyloid precursor protein in regulated ectodomain shedding
    • 46. Arribas, J., Lopez-Casillas, F. & Massague, J. (1997) Role of the juxtamembrane domains of the transforming growth factor-α precusor and the β-amyloid precursor protein in regulated ectodomain shedding. J. Biol. Chem. 272, 17160-17165.
    • (1997) J. Biol. Chem. , vol.272 , pp. 17160-17165
    • Arribas, J.1    Lopez-Casillas, F.2    Massague, J.3
  • 47
    • 15844406752 scopus 로고    scopus 로고
    • Diverse cell surface ectodomains are shed by a system sensitive to metalloprotease inhibitiors
    • 47. Arribas, J., Coodly, L., Vollmer, P., Kishimoto, T.K., Rose-John, S. & Massague, J. (1996) Diverse cell surface ectodomains are shed by a system sensitive to metalloprotease inhibitiors. J. Biol. Chem. 271, 11376-11382.
    • (1996) J. Biol. Chem. , vol.271 , pp. 11376-11382
    • Arribas, J.1    Coodly, L.2    Vollmer, P.3    Kishimoto, T.K.4    Rose-John, S.5    Massague, J.6
  • 48
    • 0032515050 scopus 로고    scopus 로고
    • A cellular striptease act
    • 48. Werb, Z. & Yan, Y. (1998) A cellular striptease act. Science 282, 1279-1280.
    • (1998) Science , vol.282 , pp. 1279-1280
    • Werb, Z.1    Yan, Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.