Cyclic nucleotide phosphodiesterase 3A-deficient mice as a model of female infertility

Journal of Clinical Investigation

Volumn 114, Issue 2, 2004, Pages 196-205

  Masciarelli, Silvia ^a   Horner, Kathleen ^b   Liu, Chengyu ^a   Park, Sun Hee ^a   Hinckley, Mary ^b   Hockman, Steven ^a   Nedachi, Taku ^b   Jin, Catherine ^b   Conti, Marco ^b   Manganiello, Vincent ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE 3',5' CYCLIC MONOPHOSPHOROTHIOATE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 3A; MATURATION PROMOTING FACTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOROTHIOIC ACID DERIVATIVE; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTRACEPTION; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME INHIBITION; FEMALE; FEMALE INFERTILITY; FERTILIZATION; GERMINAL VESICLE; HOMOLOGOUS RECOMBINATION; HYDROLYSIS; IN VITRO STUDY; MALE; MEIOSIS; MOUSE; MOUSE STRAIN; NONHUMAN; OOCYTE; OOCYTE DEVELOPMENT; OOCYTE MATURATION; OVULATION; POLAR BODY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 4043060912     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI21804     Document Type: Article

References (50)

1. Conti, M., et al. 2002. Role of cyclic nucleotide signaling in oocyte maturation. Mol. Cell. Endocrinol. 187:153-159.
2. Bornslaeger, A.E., and Schultz, R.M. 1985. Regulation of mouse oocyte maturation: effect of elevating cumulus cell cAMP on oocyte cAMP levels. Biol. Reprod. 33:698-704.
3. Nebreda, A.R., and Ferby, I. 2000. Regulation of the meiotic cell cycle in oocytes. Curr. Opin. Cell Biol. 12:666-675.
4. Downs, S.M., and Hunzicker-Dunn, M. 1995. Differential regulation of oocyte maturation and cumulus expansion of mouse oocyte-cumulus cell complex by site selective analogs of cAMP. Dev. Biol. 172:72-85.
5. Qian, Y.-W., Erikson, E., Taieb, F.E., and Maller, J.L. 2001. The Polo-like kinase Plx1 is required for activation of the phosphatase CDC 25C and cyclin B-CDC2 in Xenopus oocytes. Mol. Biol. Cell. 12:1791-1799.
6. Eppig, J.J. 1991. Intercommunication between mammalian oocytes and companion somatic cells. Bioessays. 13:569-574.
7. Aktas, H., Leibfried-Rutledge, M.L., and First, N. 2003. Meiotic state of bovine oocytes is regulated by interactions between cAMP, cumulus and granulosa. Mol. Reprod. Dev. 65:336-343.
8. Horner, K., et al. 2003. Rodent oocytes express an active adenylyl cyclase required for meiotic arrest. Dev. Biol. 258:385-396.
9. Mehlmann, L.M., Jones, T.L.Z., and Jaffe, L.A. 2002. Meiotic arrest in the mouse follicle maintained by a Gs protein in the oocyte. Science. 297:1343-1345.
10. Duckworth, B.C., Weaver, J.S., and Ruderman, J.V. 2002. G2 arrest in Xenopus oocytes depends on phosphorylation of CDC25 by protein kinase. Proc. Natl. Acad. Sci. U. S. A. 99:16794-16799.
11. Lincoln, A.J., et al. 2002. CDC25b phosphatase is required for resumption of meiosis during oocyte maturation. Nat. Genet. 30:446-449.
12. Francis, S.H., Turko, I.V., and Corbin, J.D. 2001. Cyclic nucleotide phosphodiesterases: relating structure and function. Prog. Nucleic Acid Res. Mol. Biol. 65:1-52.
13. Shakur, Y., et al. 2001. Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family. Prog. Nucleic Acid Res. Mol. Biol. 66:241-277.
14. Reinhardt, R.R., et al. 1995. Distinct anatomical patterns of gene expression for cGMP-inhibited cyclic nucleotide phosphodiesterases [erratum 1997, 99:551]. J. Clin. Invest. 95:1528-1538.
15. Tsafriri, A., Chun, S.Y., Zhang, R., Hsueh, J.W., and Conti, M. 1996. Oocyte maturation involves compartmentalization and opposing changes of cAMP levels in follicular somatic and germ cells: studies using selective phosphodiesterase inhibitors. Dev. Biol. 178:393-402.
16. Degerman, E., et al. 2004. Role for phosphodiesterase 3B in regulation of lipolysis and insulin secretion. In Diabetes Mellitus: A Fundamental and Clinical Text. 3rd edition. D. LeRoith, S.I. Taylor, and J.M. Olefsky, editors. Lippincott-Raven Publishers. Philadelphia, Pennsylvania, USA. 373-383.
17. Zhao, A., Zhao, H., Teague, J., Fujimoto, W., and Beavo, J.A. 1997. Attenuation of insulin secretion by IGF1 is mediated though activation of phosphodiesterase 3B. Proc. Natl. Acad. Sci. U. S. A. 93:14188-14192.
18. Zhao, A.Z., Bornfeldt, K.E., and Beavo, J.A. 1998. Leptin inhibits insulin secretion by activation of phosphodiesterase 3B. J. Clin. Invest. 102:869-873.
19. Zhao, A.Z., et al. 2000. Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes. J. Biol. Chem. 275:11348-11354.
20. Harndahl, L., et al. 2002. Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulin. J. Biol. Chem. 277:37446-37455.
21. Harndahl, L., et al. 2004. Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance and deranged islet morphology. J. Biol. Chem. 279:15214-15222.
22. Shitsukawa, K., et al. 2001. Cloning and characterization of the cyclic guanosine monophosphate-inhibited phosphodiesterase PDE3A expressed in mouse oocyte. Biol. Reprod. 65:188-196.
23. Richard, F.J., Tsafriri, A., and Conti, M. 2000. Role of phosphodiesterase type 3A in rat oocyte maturation. Biol. Reprod. 65:1444-1451.
24. Sadler, S.E. 1991. Type III phosphodiesterase plays necessary role in the growth-promoting actions of insulin, IGF1 and Ha-p21 ras in Xenopus laevis oocytes. Mol. Endocrinol. 5:1939-1946.
25. Jensen, J.T., et al. 2002. Phosphodiesterase 3 inhibitors selectively block resumption of meiosis by macaque oocytes in vitro. Hum. Reprod. 17:2079-2084.
26. Nogueira, D., Cortvrindt, R., DeMatos, D.G., Vanhourte, L., and Smitz, J. 2003. Human oocytes reversibly arrested in Prophase I by phosphodiesterase Type 3 inhibitor in vitro. Biol. Reprod. 69:2045-2052.
27. Wiersma, A., et al. 1998. Phosphodiesterase 3 inhibitors suppress oocyte maturation and consequent pregnancy without affecting ovulation and cyclicity in rodents. J. Clin. Invest. 102:532-537.
28. Schultz, R.M., Montgomery, R.R., and Belanoff, J.T. 1983. Regulation of mouse oocyte meiotic maturation: implication of a decrease in oocyte cAMP and protein dephosphorylation in commitment to resume meiosis. Dev. Biol. 97:264-273.
29. Aberdam, E., Hanski, E., and Dekel, N. 1987. Maintenance of meiotic arrest by the invasive adenylate cyclase of Bordetella pertussis. Biol. Reprod. 36:530-535.
30. Maller, J.L. 2001. The elusive progesterone receptor in Xenopus oocytes. Proc. Natl. Acad. Sci. U. S. A. 98:8-10.
31. Sadler, S.E., and Maller, J.L. 1989. A similar pool of cyclic AMP phosphodiesterase in Xenopus oocytes is stimulated by insulin, insulin-like growth factor 1 and (Val 12, Th 59) Ha-ras protein. J. Biol. Chem. 264:856-861.
32. Andersen, C.B., et al. 2003. Protein kinase B/Akt is essential for insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes. Biochem. J. 369:227-238.
33. Choi, Y.-H., et al. 2001. Identification of a novel isoform of the cyclic-nucleotide phosphodiesterase PDE3A expressed in vascular smooth muscle myocytes. Biochem. J. 353:41-50.
34. Wechsler, J., et al. 2002. Isoforms of cyclic nucleotide phosphodiesterase PDE3A in cardiac myocytes. J. Biol. Chem. 277:38072-38078.
35. Kincaid, R.L., and Manganiello, V.C. 1988. Assay of cyclic nucleotide phosphodiesterase using radiolabeled and fluorescent substrates. Methods Enzymol. 159:457-470.
36. Jin, S.-L., Richard, F.J., Kuo, W.P., D'Ercole, A.J., and Conti, M. 1999. Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice. Proc. Natl. Acad. Sci. U. S. A. 96:11998-12003.
37. Conti, M., et al. 2003. Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signalling. J. Biol. Chem. 278:5493-5496.
38. Houslay, M., and Adams, D.R. 2003. PDE4 cAMP Phosphodiesterases: modular enzymes that orchestrate signaling cross-talk, desensitization, and compartmentalization. Biochem. J. 370:1-18.
39. Jin, S.-L., and Conti, M. 2002. Induction of cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNFα response. Proc. Natl. Acad. Sci. U. S. A. 99:7628-7633.
40. Hansen, G., Jin, S.-L., Umetsu, D.T., and Conti, M. 2000. Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D. Proc. Natl. Acad. Sci. U. S. A. 97:6751-6756.
41. Robichaud, A., et al. 2002. Deletion of phosphodiesterase 4D in mice shortens α2-adrenoreceptor-mediated anesthesia, a behavioral correlate of emesis. J. Clin. Invest. 110:1045-1052. doi:/10.1172/JCI200215506.
42. Josefberg, L.B., and Dekel, N. 2002. Translational and post-translational modifications in meiosis of the mammalian oocyte. Mol. Cell. Endocrinol. 187:161-171.
43. Lazar, S., Galiana, D., and Dekel, N. 2002. cAMP-dependent PKA negatively regulates polyadenylation of c-mos mRNA in rat oocytes. Mol. Endocrinol. 16:331-341.
44. Brown, R.L., Ord, T., Moss, S.B., and Williams, C.J. 2002. A-Kinase Anchor Proteins as potential regulators of protein kinase A function in oocytes. Biol. Reprod. 67:981-987.
45. Kovo, M., et al. 2002. Expression and modification of PKA and AKAPs during meiosis in rat oocytes. Mol. Cell. Endocrinol. 192:105-113.
46. Rueh, M.L., et al. 2003. Targeting of protein kinase A by muscle A kinase-anchoring protein (mAKAP) regulates phosphorylation and function of the skeletal muscle ryanodine receptor. J. Biol. Chem. 278:24831-24836.
47. Perry, S.J., et al. 2002. Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins. Science. 278:834-836.
48. Schmitt, A., and Nebreda, A.K. 2002. Inhibitition of Xenopus oocyte maturation by catalytically inactive protein kinase A. Proc. Natl. Acad. Sci. U. S. A. 99:4361-4366.
49. Svoboda, P., Stein, P., Hayashi, H., and Schultz, R.M. 2000. Selective reduction of dormant maternal mRNAs in mouse oocytes by RNA interference development. Development. 127:4147-4158.
50. Beavo, J.A., Conti M., and Heaslip, R.J. 1994. Multiple cyclic nucleotide phosphodiesterases. Mol. Pharmacol. 46:399-405.