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Volumn 10, Issue 12 II, 2004, Pages

Pemetrexed (ALIMTA), a novel multitargeted antineoplastic agent

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOPLATIN; CISPLATIN; DOCETAXEL; FLUOROURACIL; FOLIC ACID; FOLINIC ACID; GEMCITABINE; HOMOCYSTEINE; NAVELBINE; OXALIPLATIN; PEMETREXED; PLATINUM DERIVATIVE;

EID: 3042575322     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-040010     Document Type: Conference Paper
Times cited : (158)

References (28)
  • 2
    • 0031852056 scopus 로고    scopus 로고
    • Multiple folate enzyme inhibition: Mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA)
    • Shih C, Mendelsohn LG, Chen VJ, Schultz RM. Multiple folate enzyme inhibition: mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA). Adv Enzyme Regul 1998;38:135-52.
    • (1998) Adv Enzyme Regul , vol.38 , pp. 135-152
    • Shih, C.1    Mendelsohn, L.G.2    Chen, V.J.3    Schultz, R.M.4
  • 3
    • 0033817515 scopus 로고    scopus 로고
    • The mechanism of transport of the multitargeted antifolate. MTA-LY231514, and its cross-resistance pattern in cell with impaired transport of methotrexate
    • Zhao R, Babani S, Gao F, Liu L, Goldman ID. The mechanism of transport of the multitargeted antifolate. MTA-LY231514, and its cross-resistance pattern in cell with impaired transport of methotrexate. Clin Cancer Res 2000;6:3687-95.
    • (2000) Clin Cancer Res , vol.6 , pp. 3687-3695
    • Zhao, R.1    Babani, S.2    Gao, F.3    Liu, L.4    Goldman, I.D.5
  • 4
    • 0011565973 scopus 로고    scopus 로고
    • Multidrug resistance proteins (MRP) 2 and 5 transport and confer resistance to Alimta
    • Pratt SE, Emerick RM, Horwit L, et al. Multidrug resistance proteins (MRP) 2 and 5 transport and confer resistance to Alimta. Proc Am Assoc Cancer Res 2002;43:782.
    • (2002) Proc Am Assoc Cancer Res , vol.43 , pp. 782
    • Pratt, S.E.1    Emerick, R.M.2    Horwit, L.3
  • 5
    • 0036987083 scopus 로고    scopus 로고
    • Molecular, biochemical, and cellular pharmacology of pemetrexed
    • Goldman ID, Zhao R. Molecular, biochemical, and cellular pharmacology of pemetrexed. Semin Oncol 2002;29(6 Suppl 18):3-17.
    • (2002) Semin Oncol , vol.29 , Issue.6 SUPPL. 18 , pp. 3-17
    • Goldman, I.D.1    Zhao, R.2
  • 6
    • 0003125962 scopus 로고    scopus 로고
    • LY231514 and its polyglutamates exhibit potent inhibition against both human dihydrofolate reductase (DHFR) and thymidylate synthase (TS): Multiple folate enzyme inhibition
    • Shih C, Gosset L, Gates S, et al. LY231514 and its polyglutamates exhibit potent inhibition against both human dihydrofolate reductase (DHFR) and thymidylate synthase (TS): multiple folate enzyme inhibition. Ann Oncol 1996;7:85.
    • (1996) Ann Oncol , vol.7 , pp. 85
    • Shih, C.1    Gosset, L.2    Gates, S.3
  • 7
    • 0032898580 scopus 로고    scopus 로고
    • Role of thymidylate synthase in the antitumor activity of the multitargeted antifolate, LY231514
    • Schultz RM, Patel VF, Worzalla JF, Shih CA. Role of thymidylate synthase in the antitumor activity of the multitargeted antifolate, LY231514. Anticancer Res 1999;19:437-43.
    • (1999) Anticancer Res , vol.19 , pp. 437-443
    • Schultz, R.M.1    Patel, V.F.2    Worzalla, J.F.3    Shih, C.A.4
  • 8
    • 0003075420 scopus 로고
    • Antimetabolites
    • Perry MC, editor. Baltimore: Williams & Wilkins
    • Schilsky RL. Antimetabolites. In: Perry MC, editor. The chemotherapy source book. Baltimore: Williams & Wilkins; 1992. p. 301-15.
    • (1992) The Chemotherapy Source Book , pp. 301-315
    • Schilsky, R.L.1
  • 9
    • 0002685062 scopus 로고
    • Fluorinated pyrimidines
    • Chabner BA, Collins JM, editors. Philadelphia: Lippincott
    • Grem JL. Fluorinated pyrimidines. In: Chabner BA, Collins JM, editors. Cancer chemotherapy: principles and practice. Philadelphia: Lippincott; 1990. p. 180-224.
    • (1990) Cancer Chemotherapy: Principles and Practice , pp. 180-224
    • Grem, J.L.1
  • 10
    • 0030891198 scopus 로고    scopus 로고
    • LY231514, a pyrrolo(2,3-d)pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes
    • Shih C, Chen VJ, Gossett LS, et al. LY231514, a pyrrolo(2,3-d)pyrimidine- based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res 1997;57:1116-2011.
    • (1997) Cancer Res , vol.57 , pp. 1116-2011
    • Shih, C.1    Chen, V.J.2    Gossett, L.S.3
  • 11
    • 0002454641 scopus 로고    scopus 로고
    • Preclinical pharmacology studies and the clinical development of a novel multitargeted antifolate, MTA (LY231514)
    • Jackman AL, editor. Totowa, NJ: Humana Press
    • Shih C, Thornton DE. Preclinical pharmacology studies and the clinical development of a novel multitargeted antifolate, MTA (LY231514). In: Jackman AL, editor, Antifolate drugs in cancer therapy. Totowa, NJ: Humana Press, 1999. p. 183-201
    • (1999) Antifolate Drugs in Cancer Therapy , pp. 183-201
    • Shih, C.1    Thornton, D.E.2
  • 12
    • 85047688457 scopus 로고    scopus 로고
    • Pemetrexed (Alimta): A novel multitargeted antifolate agent
    • Adjei AA. Pemetrexed (Alimta): A novel multitargeted antifolate agent. Expert Rev Anticancer Ther 2003;3:89-100.
    • (2003) Expert Rev Anticancer Ther , vol.3 , pp. 89-100
    • Adjei, A.A.1
  • 13
    • 0027423427 scopus 로고
    • Metabolic abnormalities in cobalamin (vitamin B12) and folate deficiency
    • Allen RH, Stabler SP, Savage DG, Lindenbaum J. Metabolic abnormalities in cobalamin (vitamin B12) and folate deficiency. FASEB J Rev 1993;7:1344-53.
    • (1993) FASEB J Rev , vol.7 , pp. 1344-1353
    • Allen, R.H.1    Stabler, S.P.2    Savage, D.G.3    Lindenbaum, J.4
  • 14
    • 0036562507 scopus 로고    scopus 로고
    • Homocysteine and methylmalonic acid: Markers to predict and avoid toxicity from pemetrexed therapy
    • Niyikiza C, Baker SD, Seitz DE, et al. Homocysteine and methylmalonic acid: markers to predict and avoid toxicity from pemetrexed therapy. Mol Cancer Ther 2002;1:545-52.
    • (2002) Mol Cancer Ther , vol.1 , pp. 545-552
    • Niyikiza, C.1    Baker, S.D.2    Seitz, D.E.3
  • 15
    • 0003238993 scopus 로고    scopus 로고
    • Efficacy and toxicity of pemetrexed disodium (ALIMTA) with folic acid (FA) in gastric cancer
    • Celio L, Bajetta E, Buzzoni R, et al. Efficacy and toxicity of pemetrexed disodium (ALIMTA) with folic acid (FA) in gastric cancer (abstract 660). Proc Am Soc Clin Oncol 2001;166a.
    • (2001) Proc Am Soc Clin Oncol
    • Celio, L.1    Bajetta, E.2    Buzzoni, R.3
  • 16
    • 0345061338 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic (PK) study of the multitargeted antifol (MTA) LY231514 with folic acid
    • Hammond L, Villalona-Calero M, Eckhardt SG, et al. A phase I and pharmacokinetic (PK) study of the multitargeted antifol (MTA) LY231514 with folic acid (abstract 866). Proc Am Soc Clin Oncol 1998;17:255.
    • (1998) Proc Am Soc Clin Oncol , vol.17 , pp. 255
    • Hammond, L.1    Villalona-Calero, M.2    Eckhardt, S.G.3
  • 17
    • 0032908148 scopus 로고    scopus 로고
    • Multitargeted antifolate LY231514 as first line chemotherapy for patients with advanced non-small cell lung cancer: A phase II study
    • Rusthoven J, Eisenhauer E, Butts C, et al. Multitargeted antifolate LY231514 as first line chemotherapy for patients with advanced non-small cell lung cancer: a phase II study. J Clin Oncol 1999;17:1194-9.
    • (1999) J Clin Oncol , vol.17 , pp. 1194-1199
    • Rusthoven, J.1    Eisenhauer, E.2    Butts, C.3
  • 18
    • 0035985288 scopus 로고    scopus 로고
    • Phase II trial of pemetrexed disodium in chemotherapy-naïve patients with advanced non-small-cell lung cancer
    • Clarke SJ, Abratt R, Goedhals L, Boyer MJ, Millward MJ, Ackland SP. Phase II trial of pemetrexed disodium in chemotherapy-naïve patients with advanced non-small-cell lung cancer. Ann Oncol 2002;13:737-41.
    • (2002) Ann Oncol , vol.13 , pp. 737-741
    • Clarke, S.J.1    Abratt, R.2    Goedhals, L.3    Boyer, M.J.4    Millward, M.J.5    Ackland, S.P.6
  • 19
    • 0000112979 scopus 로고    scopus 로고
    • Phase II trial of MTA (LY231514) in patients (PTS) with non-small cell lung cancer (NSCLC) who relapsed after previous platinum or non-platinum chemotherapy
    • Postmus P, Mattson K, von Pawel J, et al. Phase II trial of MTA (LY231514) in patients (PTS) with non-small cell lung cancer (NSCLC) who relapsed after previous platinum or non-platinum chemotherapy. Eur J Cancer 1999;35(Suppl 4):249.
    • (1999) Eur J Cancer , vol.35 , Issue.SUPPL. 4 , pp. 249
    • Postmus, P.1    Mattson, K.2    Von Pawel, J.3
  • 20
    • 0042676766 scopus 로고    scopus 로고
    • A phase III study of pemetrexed in patients with recurrent non-small cell lung cancer (NSCLC) who were previously treated with chemotherapy (abstract 2503)
    • Hanna NH, Shepherd FA, Rosell R, et al. A phase III study of pemetrexed in patients with recurrent non-small cell lung cancer (NSCLC) who were previously treated with chemotherapy (abstract 2503). Proc Am Soc Clin Oncol 2003;23.
    • (2003) Proc Am Soc Clin Oncol , pp. 23
    • Hanna, N.H.1    Shepherd, F.A.2    Rosell, R.3
  • 21
    • 0034029995 scopus 로고    scopus 로고
    • Front-line treatment of advanced non-small cell lung cancer with MTA and cisplatin: A multicenter phase II trial
    • Manegold C, Von Pawel J, Pirker R, Malayeri R, Blatter J, Krejcy K. Front-line treatment of advanced non-small cell lung cancer with MTA and cisplatin: a multicenter phase II trial. Ann Oncol 2000;11:435-40.
    • (2000) Ann Oncol , vol.11 , pp. 435-440
    • Manegold, C.1    Von Pawel, J.2    Pirker, R.3    Malayeri, R.4    Blatter, J.5    Krejcy, K.6
  • 22
    • 0035423962 scopus 로고    scopus 로고
    • Phase II study of pemetrexed disodium, a multitargeted antifolate, and cisplatin as first-line therapy in patients with advanced nonsmall cell lung carcinoma
    • Shepherd FA, Dancey J, Arnold A, Neville A, Rusthoven J, Johnson RD, Fisher B, Eisenhauer E. Phase II study of pemetrexed disodium, a multitargeted antifolate, and cisplatin as first-line therapy in patients with advanced nonsmall cell lung carcinoma. Cancer (Phila) 2001;92:595-600.
    • (2001) Cancer (Phila) , vol.92 , pp. 595-600
    • Shepherd, F.A.1    Dancey, J.2    Arnold, A.3    Neville, A.4    Rusthoven, J.5    Johnson, R.D.6    Fisher, B.7    Eisenhauer, E.8
  • 23
    • 0041296381 scopus 로고    scopus 로고
    • Phase II randomized study of pemetrexed plus carboplatin or oxaliplatin as front-line chemotherapy in patients with locally advanced or metastatic non-small cell lung cancer
    • Scaglioti G, Kortsik C, Castellano D, et al. Phase II randomized study of pemetrexed plus carboplatin or oxaliplatin as front-line chemotherapy in patients with locally advanced or metastatic non-small cell lung cancer (abstract 2513). Proc Am Soc Clin Oncol 2003;23.
    • (2003) Proc Am Soc Clin Oncol , pp. 23
    • Scaglioti, G.1    Kortsik, C.2    Castellano, D.3
  • 24
    • 0042298020 scopus 로고    scopus 로고
    • Phase II study of pemetrexed and vinorelbine in patients with locally advanced or metastatic non-small cell lung cancer
    • Clarke S, Underhill C, White S, et al. Phase II study of pemetrexed and vinorelbine in patients with locally advanced or metastatic non-small cell lung cancer. Ann Oncol 2002;13(Suppl. 5):149.
    • (2002) Ann Oncol , vol.13 , Issue.SUPPL. 5 , pp. 149
    • Clarke, S.1    Underhill, C.2    White, S.3
  • 25
    • 0033993714 scopus 로고    scopus 로고
    • A phase I and pharmacologic study of sequences of gemcitabine and the multitargeted antifolate agent (MTA) in patients with advanced solid tumors
    • Adjei AA, Erlichman E, Sloan JA, et al. A phase I and pharmacologic study of sequences of gemcitabine and the multitargeted antifolate agent (MTA) in patients with advanced solid tumors. J Clin Oncol 2000;18:1748-57.
    • (2000) J Clin Oncol , vol.18 , pp. 1748-1757
    • Adjei, A.A.1    Erlichman, E.2    Sloan, J.A.3
  • 26
    • 0001413611 scopus 로고    scopus 로고
    • Phase II trial of pemetrexed + gemcitabine in patients with advanced non-small cell lung cancer: Importance of survival over response
    • Ettinger DS, Monnerat C, Kelly K, et al. Phase II trial of pemetrexed + gemcitabine in patients with advanced non-small cell lung cancer: importance of survival over response (abstract 1243). Proc Am Assoc Clin Oncol 2002;21.
    • (2002) Proc Am Assoc Clin Oncol , pp. 21
    • Ettinger, D.S.1    Monnerat, C.2    Kelly, K.3
  • 27
    • 0013109748 scopus 로고    scopus 로고
    • Synergistic cytotoxicity of MTA (LY231514) and gemcitabine in vitro and in vivo
    • 10th NCI-EORTC Symposium on New Drugs in Cancer Therapy; 1998 June 16-19. Amsterdam, the Netherlands
    • Adjei AA, Erlichman C, Thornton D, et al. Synergistic cytotoxicity of MTA (LY231514) and gemcitabine in vitro and in vivo [abstract]. 10th NCI-EORTC Symposium on New Drugs in Cancer Therapy; 1998 June 16-19. Amsterdam, the Netherlands. Ann Oncol, 1998;644.
    • (1998) Ann Oncol , pp. 644
    • Adjei, A.A.1    Erlichman, C.2    Thornton, D.3
  • 28
    • 0033179374 scopus 로고    scopus 로고
    • Cell cycle modulation by a multitargeted antifolate, LY231514, increases the cytotoxicity and antitumor activity of gemcitabine in HT29 colon carcinoma
    • Tonkinson JL, Worzalla JF, Teng CH, Mendelsohn LG. Cell cycle modulation by a multitargeted antifolate, LY231514, increases the cytotoxicity and antitumor activity of gemcitabine in HT29 colon carcinoma. Cancer Res 1999;59:3671-6.
    • (1999) Cancer Res , vol.59 , pp. 3671-3676
    • Tonkinson, J.L.1    Worzalla, J.F.2    Teng, C.H.3    Mendelsohn, L.G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.