Correlating transfection barriers and biophysical properties of cationic polymethacrylates

Biomacromolecules

Volumn 8, Issue 2, 2007, Pages 448-454

  Tan, J F ^a   Hatton, T A ^a,b   Tam, K C ^a,c   Too, H P ^a,d  

^a SINGAPORE MIT ALLIANCE   (Singapore)

^b Massachusetts Institute of Technology Cambridge   (United States)

^c NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

POLYMERASE CHAIN REACTION; TRANSFECTION EFFICIENCIES;

CYTOTOXICITY; DNA; MOLECULAR STRUCTURE; RNA;

GENETIC ENGINEERING;

CATION; COPOLYMER; MACROGOL B POLY(DIETHYLAMINO)ETHYL METHACRYLATE; MACROGOL B POLY(DIMETHYLAMINO)ETHYL METHACRYLATE; MESSENGER RNA; PLASMID DNA; POLY(DIMETHYLAMINO)ETHYL METHACRYLATE; POLYMER; POLYMETHACRYLIC ACID; POLYMETHACRYLIC ACID DERIVATIVE; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOPHYSICS; CELLULAR DISTRIBUTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOTOXICITY; DNA BINDING; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; STRUCTURE ANALYSIS;

ACRYLAMIDES; CATIONS; CELL LINE; CELL SURVIVAL; HUMANS; PLASMIDS; POLYETHYLENE GLYCOLS; POLYMERASE CHAIN REACTION; POLYMETHACRYLIC ACIDS; RNA, MESSENGER; TRANSFECTION;

EID: 33847299592     PISSN: 15257797     EISSN: None     Source Type: Journal    
DOI: 10.1021/bm060502q     Document Type: Article

References (40)

1. Mahato, R. I.; Henry, J.; Narang, A. S.; Sabek, O.; Fraga, D.; Kotb, M.; Gaber, A. O. Cationic lipid and polymer-based gene delivery to human pancreatic islets. Mol. Ther. 2003, 7, 89-100.
2. Pinthus, J. H.; Waks, T.; Kaufman-Francis, K.; Schindler, D. G.; Harmelin, A.; Kanety, H.; Ramon, J.; Eshhar, Z. Immuno-gene therapy of established prostate tumors using chimeric receptor-redirected human lymphocytes. Cancer Res. 2003, 63, 2470-2476.
3. Roth, C. M.; Sundaram, S. Engineering synthetic vectors for improved DNA delivery: Insights from intracellular pathways. Annu. Rev. Biomed. Eng. 2004, 6, 397-426.
4. Pannier, A. K.; Shea, L. D. Controlled release systems for DNA delivery. Mol. Ther. 2004, 10, 19-26.
5. Niidome, T.; Huang, L. Gene therapy progress and prospects: Nonviral vectors. Gene Ther. 2002, 9, 1647-1652.
6. Pack, D. W.; Hoffman, A. S.; Pun, S.; Stayton, P. S. Design, and Development of polymers for gene delivery. Nat. Rev. 2005, 4, 581-593.
7. Belenkov, A. I.; Alakhov, V. Y.; Kabanov, A. V.; Vinogradov, S. V.; Panasci, L. C.; Monia, B. P.; Chow, T. Y. K. Polyethyleneimine grafted with pluronic P85 enhances Ku86 antisense delivery and the ionizing radiation treatment efficacy in vivo. Gene Ther. 2004, 11, 1665-1672.
8. Putnam, D.; Gentry, C. A.; Pack, D. W.; Langer, R. Polymer-based gene delivery with low cytotoxicity by a unique balance of sidechain termini. Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 1200-1205.
9. Azzam, T.; Eliyahu, H.; Makovitzki, A.; Linial, M.; Domb, A. J. Hydrophobized dextran-spermine conjugate as potential vector for in vitro gene transfection. J. Controlled Release 2004, 96, 309-323.
10. Mastrobattista, E.; Kapel, R. H. G.; Eggenhuisen, M. H.; Roholl, P. J. M.; Crommelin, D. J. A.; Hennink, W. E.; Storm, G. Lipid-coated polyplexes for targeted gene delivery to ovarian carcinoma cells. Cancer Gene Ther. 2001, 8, 405-413.
11. van Dijk-Wolthuis; van de Wetering; Hinrichs, W.; Hofmeyer, L.; Liskamp, R.; Crommelin, D.; Hennink, W. A versatile method for the conjugation of proteins and peptides to poly [2-(dimethylamino)-ethyl methacrylatel. Bioconjugate Chem. 1999, 10, 687-692.
12. Megeed, Z.; Haider, M.; Li, D. Q.; O'Malley, B. W.; Cappello, J.; Ghandehari, H. In vitro and in vivo evaluation of recombinant silkelastinlike hydrogels for cancer gene therapy. J. Controlled Release 2004, 94, 433-445.
13. Varga, C.; Tedford, N.; Thomas, M.; Klibanov, A.; Griffith, L.; Lauffenburger, D. Quantitative comparison of polyethylenimine formulations and adenoviral vectors in terms of intracellular gene delivery processes. Gene Ther. 2005, 1-10.
14. Chesnoy, S.; Huang, L. Structure and function of lipid-DNA complexes for gene delivery. Annu. Rev. Biophys. Biomol. Struct. 2000, 29, 27-47.
15. Wang, K. C.; Wu, J. C.; Chung, Y. C.; Ho, Y. C.; Chang, D. T.; Hu, Y. C. Baculovirus as a highly efficient gene delivery vector for the expression of hepatitis delta virus antigens in mammalian cells. Biotechnol. Bioeng. 2004, 89, 464-473.
16. Ouahabia, A.; Thiryb, M.; Schiffmannc, S.; Fuksd, R.; Nguyen, H.; Ruysschaerta, J. M.; Vandenbrandena, M. Intracellular visualization of BrdU-labeled plasmid DNA/cationic liposome complexes. J. Histochem. Cytochem. 1999, 47, 1159-1166.
17. Kinoshita, A.; Fukumoto, H.; Shah, T.; Whelan, C. M.; Irizarry, M.; Hyman, B. Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes. J. Cell Sci. 2003, 116, 3339-3346.
18. Wong, M. L.; Medrano, J. F. Real-time PCR for mRNA quantitation. BioTechniques 2005, 39, 75-85.
19. Too, H. P. Real time PCR quantification of GFR alpha-2 alternatively spliced isoforms in murine brain and peripheral tissues. Mol. Brain Res. 2003, 114, 146-153.
20. Gygi, S. P.; Rochon, Y.; Franza, B. R.; Aebersold, R. Correlation between protein and mRNA abundance in yeast. Mol. Cell. Proteomics 1999, 19, 1720-1730.
21. Chen, G. A.; Gharib, T. G.; Huang, C. C.; Taylor, J. M. G.; Misek, D. E.; Kardia, S. L. R.; Giordano, T. J.; Iannettoni, M. D.; Orringer, M. B.; Hanash, S. M.; Beer, D. G. Discordant protein and mRNA expression in lung adenocarcinomas. Mol. Cell. Proteomics 2002, 1, 304-313.
22. Zabner, J.; Fasbender, A.; Moninger, T.; Poellinger, K.; Welsh, M. Cellular and molecular barriers to gene transfer by a cationic lipid. J. Biol. Chem. 1995, 270, 18997-19004.
23. Bromberg, L.; Deshmukh, S.; Temchenko, M.; Iourtchenko, L.; Alakbov, V.; Alvarez-Lorenzo, C.; Barreiro-Iglesias, R.; Concheiro, A.; Hatton, T. A. Polycationic block copolymers of poly(ethylene oxide) and poly(propylene oxide) for cell transfection. Bioconjugate Chem. 2005, 16, 626-633.
24. Tan, J. F.; Ravi, P.; Too, H. P.; Hatton, T. A.; Tam, K. C. Association behavior of biotinylated and non-biotinylated PEO-b-PDEAEMA. Biomacromolecules 2005, 6, 498-506.
25. Tan, J. F.; Too, H. P.; Hatton, T. A.; Tam, K. C. Aggregation behavior and thermodynamics of binding between PEO-PDEAEMA and plasmid DNA. Langmuir 2006, 22, 3744-3750.
26. Moghimi, S. M.; Symonds, P.; Murray, J. C.; Hunter, A. C.; Debska, G.; Szewczyk, A. A two-Stage poly(ethylenimine)-mediated cytotoxicity: Implications for gene transfer/therapy. Mol. Ther. 2005, 11, 990-995.
27. Vihola, H.; Laukkanen, A.; Valtola, L.; Tenhu, H.; Hirvonen, J. Cytotoxicity of thermosensitive polymers poly(N-isopropylacrylamide), poly(N-vinylcaprolactam) and amphiphilically modified poly(N-vinylcaprolactam). Biomaterials 2005, 26, 3055-3064.
28. Noria, A.; Kopecek, J. Intracellular targeting of polymer-bound drugs for cancer chemotherapy. Adv. Drug Delivery Rev. 2005, 57, 609-636.
29. Fischer, D.; Dautzenberg, H.; Kunath, K.; Kissel, T. Poly(diallyldimethylammonium chlorides) and their N-methyl-N-vinylacetamide, copolymer-based DNA-polyplexes: role of molecular weight and charge density in complex formation, stability, and in vitro activity. Int. J. Pharm. 2004, 280, 253-269.
30. Kunath, K.; von Harpe, A.; Fischer, D.; Kissel, T. Galactose-PEI-DNA complexes for targeted gene delivery: degree of substitution affects complex size and transfection efficiency. J. Controlled Release 2003, 88, 159-172.
31. Fischer, D.; Li, Y. X.; Ahlemeyer, B.; Krieglstein, J.; Kissel, T. In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis. Biomaterials 2003, 24, 1121-1131.
32. Dailey, L. A.; Kleemann, E.; Merdan, T.; Petersen, H.; Schmehl, T.; Gessler, T.; Hanze, J.; Seeger, W.; Kissel, T. Modified polyethylenimines as non viral gene delivery systems for aerosol therapy: effects of nebulization on cellular uptake and transfection efficiency. J. Controlled Release 2004, 100, 425-436.
33. Christiaens, B.; Dubruel, P.; Grooten, J.; Goethals, M.; Vandekerckhove, J.; Schacht, E.; Rosseneu, M. Enhancement of polymethacry-late-mediated gene delivery by Penetratin. Eur. J. Pharm. Sci. 2005, 24, 525-537.
34. Mounkes, L. C.; Zhong, W.; Cipres-Palacin, G.; Heath, T. D.; Debs, R. J. Proteoglycans mediate cationic liposome-DNA complex based gene delivery in vitro and in vivo. J. Biol. Chem. 1998, 40, 26164-70.
35. Ryhanen, S. J.; Saily, M. J.; Paukku, T.; Borocci, S.; Mancini, G.; Holopainen, J. M.; Kinnunen, P. K. J. Surface charge density determines the efficiency of cationic gemini surfactant based lipofection. Biophys. J. 2003, 84, 578-587.
36. de la Maza, A.; Coderch, L.; Gonzalez, P.; Parra, J. L. Subsolubilizing alterations caused by alkyl glucosides in phosphatidylcholine liposomes. J. Controlled Release 1998, 52, 159-168.
37. Vial, F.; Rabhi, S.; Tribet, C. Association of octyl-modified, poly(acrylic acid) onto unilamellar vesicles of lipids and kinetics of vesicle disruption. Langmuir 2005, 21, 853-862.
38. Warisnoicharoen, W.; Lansley, A. B.; Lawrence, M. J. Toxicological evaluation of mixtures of nonionic surfactants, alone and in combination with oil. J. Pharm. Sci. 2003, 92, 859-868.
39. Funhoff, A. M.; van Nostrum, C. F.; Koning, G. A.; Schuurmans, N. M. E.; Crommelin, D. J. A.; Hennink, W. E. Endosomal escape of polymeric gene delivery complexes is not always enhanced by polymers buffering at low pH. Biomacromolecules 2004, 5, 32-39.
40. Dauty, E.; Remy, J. S.; Zuber, G.; Behr, J. P. Intracellular delivery of nanometric DNA particles via the folate receptor. Bioconjugate Chem. 2002, 13, 831-839.