Intracellular delivery of nanometric DNA particles via the folate receptor

Bioconjugate Chemistry

Volumn 13, Issue 4, 2002, Pages 831-839

  Dauty, Emmanuel ^a   Remy, Jean Serge ^a   Zuber, Guy ^a   Behr, Jean Paul ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL CULTURE; CELLS; DNA; ELECTROPHORETIC MOBILITY; SULFUR COMPOUNDS;

CONDENSED DNA; DNA MOLECULES; FOLATE RECEPTOR; FOLATES; INTRACELLULAR DELIVERY; KEY DETERMINANTS; MONOMOLECULARS; NANOMETRICS; PLASMID DNA; TARGET CELLS;

BIOMOLECULES;

CARRIER PROTEIN; CELL SURFACE RECEPTOR; DETERGENT; DNA; DPPE PEG2000; DPPE-PEG2000; FOLATE BINDING PROTEIN; FOLATE-BINDING PROTEIN; FOLIC ACID; MACROGOL DERIVATIVE; PHOSPHATIDYLETHANOLAMINE;

ANIMAL; ARTICLE; CAVEOLA; CELL STRAIN 3T3; CHEMISTRY; DRUG DELIVERY SYSTEM; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSFECTION; METABOLISM; METHODOLOGY; MOUSE; NANOTECHNOLOGY; PARTICLE SIZE; STANDARD;

3T3 CELLS; ANIMALS; CARRIER PROTEINS; CAVEOLAE; DETERGENTS; DNA; DRUG DELIVERY SYSTEMS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FOLIC ACID; MICE; NANOTECHNOLOGY; PARTICLE SIZE; PHOSPHATIDYLETHANOLAMINES; POLYETHYLENE GLYCOLS; RECEPTORS, CELL SURFACE; TRANSFECTION;

EID: 0036071884     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc0255182     Document Type: Article

References (48)

1. Synthetic gene transier vectors
2. From genes to gene medicines: Recent advances in nonviral gene delivery
3. Nonviral vectors in the new millennium: Delivery barriers in gene transfer
4. The liver sieve: Considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse
5. Cystic fibrosis sputum: A barrier to the transport of nanospheres
6. Diffusion of macromolecules and virus-like particles in human cervical mucus
7. Folate-mediated targeting of therapeutic and imaging agents to cancers
8. Receptor-mediated particle uptake by liver macrophages. The galactose- particle receptor mediates uptake via coated and also noncoated structures
9. Lactosylated low-density lipoprotein: A potential carrier for the site- specific delivery of drugs to Kupffer cells
10. Determination of the upper size limit for uptake and processing of ligands by the asialoglycoprotein receptor on hepatocytes in vitro and in vivo
11. Size-dependent DNA mobility in cytoplasm and nucleus
12. Signal-mediated nuclear transport in proliferating and growth-arrested BALB/c 3T3 cells
13. Monomolecular collapse of plasmid DNA into stable virus-like particles
14. Template oligomerization of DNA-bound cations produces calibrated nanometric particles
15. Dimerizable cationic detergents with a low cmc condense plasmid DNA into nanometric particles and transfect cells in culture
16. Sterically stabilized liposomes
17. Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo
18. Impact of polymer tether length on multiple ligand-receptor bond formation
19. In vitro gene delivery to hepatocytes with galactosylated polyethylenimine
20. Conjugation of folate via gelonin carbohydrate residues retains ribosomal-inactivating properties of the toxin and permits targeting to folate receptor positive cells
21. Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA
22. Optimized galenics improve in vitro gene transfer with cationic molecules up to 1000-fold
23. Delivery of macromolecules into living cells: A method that exploits folate receptor endocytosis
24. DNA condensation by an oxidizable cationic detergent. Interactions with lipid vesicles
25. Gene transfer with a series of lipophilic DNA-binding molecules
26. An electron microscopy study into the mechanism of gene transfer with lipopolyamines
27. Evidence for the role of proteoglycans in cation-mediated gene transfer
28. Glutathione
29. Demonstration of nuclear compartmentalization of glutathione in hepatocytes
30. Reduction of disulfide bonds within lysosomes is a key step in antigen processing
31. A potent new class of reductively activated peptide gene delivery agents
32. Synthesis, activity, and structure - Activity relationship studies of novel cationic lipids for DNA transfer
33. Folate copolymer-mediated transfection of cultured cells
34. Water-soluble polyion complex associates of DNA and poly(ethylene glycol)-poly(L-lysine) block copolymer
35. Evaluation of polyether-polyethyleneimine graft copolymers as gene transfer agents
36. PEGylated DNA/transferrin-PEI complexes: Reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery
37. Delivery of liposomes into cultured KB cells via folate receptor- mediated endocytosis
38. Transfection and physical properties of various saccharide, poly(ethylene glycol), and antibody-derivatized polyethylenimines (PEI)
39. Poly(ethylene glycol)-modification of the phospholipid vesicles by using the spontaneous incorporation of poly(ethylene glycol)-lipid into the vesicles
40. The use of glycolipids and hydrophilic polymers in avoiding rapid uptake of liposomes by the mononuclear phagocyte system
41. Repulsive interactions and mechanical stability of polymer-grafted lipid membranes
42. Extracellular glycosaminoglycans modify cellular trafficking of lipoplexes and polyplexes
43. Cellular and molecular barriers to gene transfer by a cationic lipid
44. Towards synthetic viruses
45. Caveolae as potential macromolecule trafficking compartments within alveolar epithelium
46. Optimization of folate-conjugated liposomal vectors for folate receptor- mediated gene therapy