Polyethyleneimine grafted with pluronic P85 enhances Ku86 antisense delivery and the ionizing radiation treatment efficacy in vivo

Gene Therapy

Volumn 11, Issue 22, 2004, Pages 1665-1672

  Belenkov, A I ^a   Alakhov, V Y ^b   Kabanov, A V ^c   Vinogradov, S V ^c   Panasci, L C ^d   Monia, B P ^e   Chow, T Y K ^a,f  

^a MONTREAL GENERAL HOSPITAL   (Canada)

^b Supratek Pharma Inc   (Canada)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d MCGILL UNIVERSITY   (Canada)

^e ISIS PHARMACEUTICALS   (United States)

^f INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

Author keywords

Antisense; Block copolymer; DNA PK; Ionizing radiation; Ku86; Mouse xenografts; Poloxamer; Polyethyleneimine

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; DNA; DRUG CARRIER; MESSENGER RNA; NUCLEAR PROTEIN; POLOXAMER; POLYETHYLENEIMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER PATIENT; CARCINOGENESIS; CELL ADHESION; CELL DEATH; CELL LINE; CELL STRAIN HT29; CELL SUSPENSION; COLON ADENOCARCINOMA; CONTROLLED STUDY; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG FORMULATION; DRUG POTENTIATION; DRUG RESISTANCE; DRUG WITHDRAWAL; GENETIC TRANSFECTION; GROWTH INHIBITION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VIVO STUDY; IONIZING RADIATION; MORBIDITY; MORTALITY; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; TREATMENT OUTCOME; TUMOR XENOGRAFT;

ANIMALS; ANTIGENS, NUCLEAR; CELL LINE, TUMOR; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION; GENE THERAPY; HUMANS; MICE; MICE, INBRED BALB C; NEOPLASM TRANSPLANTATION; NEOPLASMS; OLIGONUCLEOTIDES, ANTISENSE; POLOXALENE; POLYETHYLENEIMINE; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS;

MUS MUSCULUS;

EID: 8844236162     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302355     Document Type: Article

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