ACTX-8, a cytotoxic l-amino acid oxidase isolated from Agkistrodon acutus snake venom, induces apoptosis in Hela cervical cancer cells

Life Sciences

Volumn 80, Issue 13, 2007, Pages 1189-1197

  Zhang, Liang ^a   Wei, Li Jun ^b  

^a SOOCHOW UNIVERSITY   (China)

^b Changzhou Qianhong Biopharm Co   (China)

Author keywords

ACTX 8; Apoptosis; Bcl 2 family; Cytotoxin; l amino acid oxidase (LAO); Mitochondria

Indexed keywords

ACTX 8; ALANYLASPARTYLASPARTYLARGINYLASPARAGINYLPROLYLLEUCYL GLUTAMYLGLUTAMYLPHENYLALANYLARGINYLGLUTAMYLASPARAGINYL ASPARAGINYLTYROSYLGLUTAMYLGLUTAMYLPHENYLALANYLLEUCINE; ANTINEOPLASTIC AGENT; CASPASE; CASPASE INHIBITOR; CYTOCHROME C; DNA FRAGMENT; PHOSPHATIDYLSERINE; PROTEIN; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SNAKE VENOM; UNCLASSIFIED DRUG;

AGKISTRODON; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL DEATH; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY TEST; DISSOCIATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME SYNTHESIS; FEMALE; HELA CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PROTEIN BINDING; SIGNAL TRANSDUCTION;

AGKISTRODON; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASE 9; CELL FRACTIONATION; CELL SURVIVAL; CROTALID VENOMS; CYTOCHROMES C; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMALE; HELA CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PHOSPHATIDYLSERINES; PROTO-ONCOGENE PROTEINS C-BCL-2; UTERINE CERVICAL NEOPLASMS;

DEINAGKISTRODON ACUTUS;

EID: 33847299416     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2006.12.024     Document Type: Article

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