Cl - channel blockers NPPB and niflumic acid blunt Ca 2+ -induced erythrocyte "apoptosis"

Cellular Physiology and Biochemistry

Volumn 14, Issue 4-6, 2004, Pages 241-248

  Myssina, Svetlana ^a   Lang, Philipp A ^a   Kempe, Daniela S ^a   Kaiser, Stefanie ^a   Huber, Stephan M ^a   Wieder, Thomas ^a   Lang, Florian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Annexin; Cell volume; Osmolarity; Phosphatidylserine

Indexed keywords

ANNEXIN; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CHLORIDE; CHLORIDE CHANNEL; IONOMYCIN; NIFLUMIC ACID; PHOSPHATIDYLSERINE;

APOPTOSIS; ARTICLE; BLOOD SAMPLING; ERYTHROCYTE; FLUORESCENCE ACTIVATED CELL SORTING; HEMATOCRIT; HUMAN; NORMAL HUMAN; OXIDATIVE STRESS; POTASSIUM DEPLETION; PRIORITY JOURNAL;

EID: 4444374080     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000080333     Document Type: Article

References (50)

1. Berg CP, Engels IH, Rothbart A, Lauber K, Renz A, Schlosser SF, Schulze-Osthoff K, Wesselborg S: Human mature red blood cells express caspase-3 and caspase-8, but are devoid of mitochondrial regulators of apoptosis. Cell Death Differ 2001;8:1197-1206.
2. Bratosin D, Estaquier J, Petit F, Arnoult D, Quatannens B, Tissier JP, Slomianny C, Sartiaux C, Alonso C, Huart JJ, Montreuil J, Ameisen JC: Programmed cell death in mature erythrocytes: a model for investigating death effector pathways operating in the absence of mitochondria. Cell Death Differ 2001;8:1143-1156.
3. Daugas E, Cande C, Kroemer G: Erythrocytes: death of a mummy. Cell Death Differ 2001;8:1131-1133.
4. Lang KS, Duranton C, Poehlmann H, Myssina S, Bauer C, Lang F, Wieder T, Huber SM: Cation channels trigger apoptotic death of erythrocytes. Cell Death Differ 2003;10:249-256.
5. Lang KS, Myssina S, Brand V, Sandu C, Lang PA, Huber SM, Lang F, Wieder T: Involvement of ceramide in hyperosmotic shock-induced death of erythrocytes. Cell Death Differ 2004;11:231-243.
6. Green DR, Reed JC: Mitochondria and apoptosis. Science 1998;281:1309-1312.
7. Gulbins E, Jekle A, Ferlinz K, Grassme H, Lang F: Physiology of apoptosis. Am J Physiol Renal Physiol 2000;279:F605-F615.
8. Dekkers DW, Comfurius P, Bevers EM, Zwaal RF: Comparison between Ca2+-induced scrambling of various fluorescently labelled lipid analogues in red blood cells. Biochem J 2002;362:741-747.
9. Woon LA, Holland JW, Kable EP, Roufogalis BD: Ca2+ sensitivity of phospholipid scrambling in human red cell ghosts. Cell Calcium 1999;25:313-320.
10. Fadok VA, Bratton DL, Rose DM, Pearson A, Ezekewitz RA, Henson PM: A receptor for phosphatidylserinespecific clearance of apoptotic cells. Nature 2000;405:85-90.
11. Henson PM, Bratton DL, Fadok VA: The phosphatidylserine receptor: a crucial molecular switch? Nat Rev Mol Cell Biol 2001;2:627-633.
12. Boas FE, Forman L, Beutler E: Phosphatidylserine exposure and red cell viability in red cell aging and in hemolytic anemia. Proc Natl Acad Sci U S A 1998;95:3077-3081.
13. Eda S, Sherman IW: Cytoadherence of malaria-infected red blood cells involves exposure of phosphatidylserine. Cell Physiol Biochem 2002;12:373-384.
14. Duranton C, Huber SM, Lang F: Oxidation induces a Cl(-)-dependent cation conductance in human red blood cells. J Physiol 2002;539:847-855.
15. Huber SM, Gamper N, Lang F: Chloride conductance and volume-regulatory nonselective cation conductance in human red blood cell ghosts. Pflugers Arch 2001;441:551-558.
16. Bookchin RM, Ortiz OE, Lew VL: Activation of calcium-dependent potassium channels in deoxygenated sickled red cells. Prog Clin Biol Res 1987;240:193-200.
17. Brugnara C, de Franceschi L, Alper SL: Inhibition of Ca(2+)-dependent K+ transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives. J Clin Invest 1993;92:520-526.
18. Lang PA, Kaiser S, Myssina S, Wieder T, Lang F, Huber SM: Role of Ca2+ activated K+ channels in human erythrocyte apoptosis. Am J Physiol - Cell Physiol 2003;285:C1553-C1560.
19. Gekle M, Oberleithner H, Silbernagl S: Ochratoxin A impairs "postproximal" nephron function in vivo and blocks plasma membrane anion conductance in Madin-Darby canine kidney cells in vitro. Pflugers Arch 1993;425:401-408.
20. Stummann TC, Poulsen JH, Hay-Schmidt A, Grunnet M, Klaerke DA, Rasmussen HB, Olesen SP, Jorgensen NK: Pharmacological investigation of the role of ion channels in salivary secretion. Pflugers Arch 2003;446:78-87.
21. Ullrich S, Berchtold S, Boehmer C, Fillon S, Jendrossek V, Palmada M, Schroeder TH, Pier GB, Lang F: Pseudomonas aeruginosa activates Cl- channels in host epithelial cells. Pflugers Arch 2003;447:23-28.
22. Wu G, Hamill OP: NPPB block of Ca(++)-activated Cl- currents in Xenopus oocytes. Pflugers Arch 1992;420:227-229.
23. Chao AC, Mochizuki H: Niflumic and flufenamic acids are potent inhibitors of chloride secretion in mammalian airway. Life Sci 1992;51:1453-1457.
24. Fuller CM, Ji HL, Tousson A, Elble RC, Pauli BU, Benos DJ: Ca(2+)-activated Cl(-) channels: a newly emerging anion transport family. Pflugers Arch 2001;443 Suppl 1:S107-S110.
25. Papassotiriou J, Eggermont J, Droogmans G, Nilius B: Ca(2+)-activated Cl- channels in Ehrlich ascites tumor cells are distinct from mCLCA1, 2 and 3. Pflugers Arch 2001;442:273-279.
26. White MM, Aylwin M: Niflumic and flufenamic acids are potent reversible blockers of Ca2(+)-activated Cl- channels in Xenopus oocytes. Mol Pharmacol 1990;37:720-724.
27. Nilius B, Sehrer J, Viana F, De Greef C, Raeymaekers L, Eggermont J, Droogmans G: Volume-activated Cl-currents in different mammalian non-excitable cell types. Pflugers Arch 1994;428:364-371.
28. Valverde MA, Mintenig GM, Sepulveda FV: Differential effects of tamoxifen and I- on three distinguishable chloride currents activated in T84 intestinal cells. Pflugers Arch 1993;425:552-554.
29. Salhany JM, Schopfer LM: Kinetic mechanism of DIDS binding to band 3 (AE1) in human erythrocyte membranes. Blood Cells Mol Dis 2001;27:844-849.
30. Andree HA, Reutelingsperger CP, Hauptmann R, Hemker HC, Hermens WT, Willems GM: Binding of vascular anticoagulant alpha (VAC alpha) to planar phospholipid bilayers. J Biol Chem 1990;265:4923-4928.
31. Lang KS, Roll B, Myssina S, Schittenhelm M, Scheel-Walter HG, Kanz L, Fritz J, Lang F, Huber SM, Wieder T: Enhanced erythrocyte apoptosis in sickle cell anemia, thalassemia and glucose-6-phosphate dehydrogenase deficiency. Cell Physiol Biochem 2002;12:365-372.
32. Lang PA, Warskulat U, Heller-Stilb B, Huang DY, Duszenko M, Lang F, Häussinger D, Vallon V, Wieder T: Blunted apoptosis of erythrocytes from taurine transporter deficient mice. Cell Physiol Biochem 2003;13:337-346.
33. Eaton JW, Branda RF, Hadland C, Dreher K: Anion channel blockade: effects upon erythrocyte membrane calcium response. Am J Hematol 1980;9:391-399.
34. I. Bernhardt and C. Ellory, Red cell membrane transport in health and disease, Springer Verlag, Heidelberg 2003.
35. Szabo I, Lepple-Wienhues A, Kaba KN, Zoratti M, Gulbins E, Lang F: Tyrosine kinase-dependent activation of a chloride channel in CD95-induced apoptosis in T lymphocytes. Proc Natl Acad Sci U S A 1998;95:6169-74.
36. Maeno E, Ishizaki Y, Kanaseki T, Hazama A, Okada Y: Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis. Proc Natl Acad Sci U S A 2000;97:9487-92.
37. Rosette C, Karin M: Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science 1996;274:1194-7.
38. Bortner CD, Hughes FM, Jr., Cidlowski JA: A primary role for K+ and Na+ efflux in the activation of apoptosis. J Biol Chem 1997;272:32436-32442.
39. Bortner CD, Cidlowski JA: A necessary role for cell shrinkage in apoptosis. Biochem Pharmacol 1998;56:1549-59.
40. Gomez-Angelats M, Bortner CD, Cidlowski JA: Protein kinase C (PKC) inhibits fas receptor-induced apoptosis through modulation of the loss of K+ and cell shrinkage. A role for PKC upstream of caspases. J Biol Chem 2000;275:19609-19619.
41. Hughes FM, Jr., Bortner CD, Purdy GD, Cidlowski JA: Intracellular K+ suppresses the activation of apoptosis in lymphocytes. J Biol Chem 1997;272:30567-30576.
42. Hughes FM, Jr., Cidlowski JA: Potassium is a critical regulator of apoptotic enzymes in vitro and in vivo. Adv Enzyme Regul 1999;39:157-171.
43. Montague JW, Bortner CD, Hughes FM, Jr., Cidlowski JA: A necessary role for reduced intracellular potassium during the DNA degradation phase of apoptosis. Steroids 1999;64:563-569.
44. Perez GI, Maravei DV, Trbovich AM, Cidlowski JA, Tilly JL, Hughes FM, Jr.: Identification of potassium-dependent and -independent components of the apoptotic machinery in mouse ovarian germ cells and granulosa cells. Biol Reprod 2000;63:1358-1369.
45. Culliford S, Ellory C, Lang HJ, Englert H, Staines H, Wilkins R: Specificity of classical and putative Cl(-) transport inhibitors on membrane transport pathways in human erythrocytes. Cell Physiol Biochem 2003;13:181-188.
46. Assouline-Cohen M, Beitner R: Effects of Ca2+ on erythrocyte membrane skeleton-bound phosphofructokinase, ATP levels, and hemolysis. Mol Genet Metab 1999;66:56-61.
47. Birka C, Lang PA, Kempe DS, Hoefling L, Tanneur V, Duranton C, Nammi S, Henke G, Myssina S, Krikov M, Huber SM, Wieder T, Lang F: Enhanced susceptibility to erythrocyte "apoptosis" following phosphate depletion. Pflügers Arch 2004;448:471-477.
48. Duranton C, Huber S, Tanneur V, Lang K, Brand V, Sandu C, Lang F: Electrophysiological properties of the Plasmodium Falciparum-induced cation conductance of human erythrocytes. Cell Physiol Biochem 2003;13:189-198.
49. Huber SM, Uhlemann AC, Gamper NL, Duranton C, Kremsner PG, Lang F: Plasmodium falciparum activates endogenous Cl(-) channels of human erythrocytes by membrane oxidation. EMBO J 2002;21:22-30.
50. Brand VB, Sandu CD, Duranton C, Tanneur V, Lang KS, Huber SM, Lang F: Dependence of Plasmodium falciparum in vitro growth on the cation permeability of the human host erythrocyte. Cell Physiol Biochem 2003;13:347-356.