Functional genomics of the β-cell: Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents

Molecular Endocrinology

Volumn 21, Issue 3, 2007, Pages 765-773

  Hardy, Olga T ^a   Hohmeier, Hans E ^b   Becker, Thomas C ^b   Manduchi, Elisabetta ^c   Doliba, Nicolai M ^a   Gupta, Rana K ^a   White, Peter ^a   Stoeckert Jr , Christian J ^c   Matschinsky, Franz M ^a   Newgard, Christopher B ^b   Kaestner, Klaus H ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BUTYRYL COENZYME A DEHYDROGENASE; GLUCOSE; INSULIN; POTASSIUM; POTASSIUM CHANNEL; RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME REGULATION; FATTY ACID OXIDATION; FEMALE; FUNCTIONAL GENOMICS; GENE CONTROL; GENE IDENTIFICATION; GENE REPRESSION; GLUCOSE BLOOD LEVEL; HYPERINSULINISM; INSULIN RELEASE; INSULINOMA; MITOCHONDRION; NONHUMAN; PANCREAS ISLET BETA CELL; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE;

ANIMALS; BUTYRYL-COA DEHYDROGENASE; CELLS, CULTURED; GENE EXPRESSION PROFILING; GENOMICS; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; POTASSIUM CHANNELS; RATS; RNA INTERFERENCE;

RODENTIA;

EID: 33847196062     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2006-0411     Document Type: Article

References (42)

1. McGarry JD, Dobbins RL 1999 Fatty acids, lipotoxicity and insulin secretion. Diabetologia 42:128-138
2. Nenquin M, Szollosi A, Aguilar-Bryan L, Bryan J, Henquin JC 2004 Both triggering and amplifying pathways contribute to fuel-induced insulin secretion in the absence of sulfonylurea receptor-1 in pancreatic β-cells. J Biol Chem 279:32316-32324
3. Baeg GH, Zhou R, Perrimon N 2005 Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. Genes Dev 19:1861-1870
4. Boutros M, Kiger AA, Armknecht S, Kerr K, Hild M, Koch B, Haas SA, Paro R, Perrimon N 2004 Genome-wide RNAi analysis of growth and viability in Drosophila cells. Science 303:832-835
5. Kamath RS, Fraser AG, Dong Y, Poulin G, Durbin R, Gotta M, Kanapin A, Le Bot N, Moreno S, Sohrmann M, Welchman DP, Zipperlen P, Ahringer J 2003 Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421:231-237
6. Kim YO, Park SJ, Balaban RS, Nirenberg M, Kim Y 2004 A functional genomic screen for cardiogenic genes using RNA interference in developing Drosophila embryos. Proc Natl Acad Sci USA 101:159-164
7. Nybakken K, Vokes SA, Lin TY, McMahon AP, Perrimon N 2005 A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. Nat Genet 37:1323-1332
8. Gupta RK, Vatamaniuk MZ, Lee CS, Flaschen RC, Fulmer JT, Matschinsky FM, Duncan SA, Kaestner KH 2005 The MODY1 gene HNF-4α regulates selected genes involved in insulin secretion. J Clin Invest 115:1006-1015
9. Lantz KA, Vatamaniuk MZ, Brestelli JE, Friedman JR, Matschinsky FM, Kaestner KH 2004 Foxa2 regulates multiple pathways of insulin secretion. J Clin Invest 114:512-520
10. Corkey BE, Deeney JT, Yaney GC, Tornheim K, Prentki M 2000 The role of long-chain fatty acyl-CoA esters in β-cell signal transduction. J Nutr 130:299S-304S
11. Kaestner KH, Katz J, Liu Y, Drucker DJ, Schutz G 1999 Inactivation of the winged helix transcription factor HNF3α affects glucose homeostasis and islet glucagon gene expression in vivo. Genes Dev 13:495-504
12. Miura A, Yamagata K, Kakei M, Hatakeyama H, Takahashi N, Fukui K, Nammo T, Yoneda K, Inoue Y, Sladek FM, Magnuson MA, Kasai H, Miyagawa J, Gonzalez FJ, Shimomura I 2006 Hepatocyte nuclear factor-4α is essential for glucose-stimulated insulin secretion by pancreatic β-cells. J Biol Chem 281:5246-5257
13. Shih DQ, Navas MA, Kuwajima S, Duncan SA, Stoffel M 1999 Impaired glucose homeostasis and neonatal mortality in hepatocyte nuclear factor 3α-deficient mice. Proc Natl Acad Sci USA 96:10152-10157
14. Sund NJ, Vatamaniuk MZ, Casey M, Ang SL, Magnuson MA, Stoffers DA, Matschinsky FM, Kaestner KH 2001 Tissue-specific deletion of Foxa2 in pancreatic β cells results in hyperinsulinemic hypoglycemia. Genes Dev 15:1706-1715
15. Vatamaniuk MZ, Gupta RK, Lantz KA, Doliba NM, Matschinsky FM, Kaestner KH 2006 Foxa1-deficient mice exhibit impaired insulin secretion due to uncoupled oxidative phosphorylation. Diabetes 55:2730-2736
16. Chen G, Hohmeier HE, Gasa R, Tran VV, Newgard CB 2000 Selection of insulinoma cell lines with resistance to interleukin-1β- and γ-interferon-induced cytotoxicity. Diabetes 49:562-570
17. Hohmeier HE, Mulder H, Chen G, Henkel-Rieger R, Prentki M, Newgard CB 2000 Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion. Diabetes 49:424-430
18. Boucher A, Lu D, Burgess SC, Telemaque-Potts S, Jensen MV, Mulder H, Wang MY, Unger RH, Sherry AD, Newgard CB 2004 Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue. J Biol Chem 279:27263-27271
19. Clayton PT, Eaton S, Aynsley-Green A, Edginton M, Hussain K, Krywawych S, Datta V, Malingre HE, Berger R, van den Berg IE 2001 Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of β-oxidation in insulin secretion. J Clin Invest 108:457-465
20. Eaton S, Chatziandreou I, Krywawych S, Pen S, Clayton PT, Hussain K 2003 Short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency associated with hyperinsulinism: a novel glucose-fatty acid cycle? Biochem Soc Trans 31:1137-1139
21. Hussain K, Clayton PT, Krywawych S, Chatziandreou I, Mills P, Ginbey DW, Geboers AJ, Berger R, van den Berg IE, Eaton S 2005 Hyperinsulinism of infancy associated with a novel splice site mutation in the SCHAD gene. J Pediatr 146:706-708
22. Molven A, Matre GE, Duran M, Wanders RJ, Rishaug U, Njolstad PR, Jellum E, Sovik O 2004 Familial hyperinsulinemic hypoglycemia caused by a defect in the SCHAD enzyme of mitochondrial fatty acid oxidation. Diabetes 53:221-227
23. Bain JR, Schisler JC, Takeuchi K, Newgard CB, Becker TC 2004 An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of langerhans. Diabetes 53:2190-2194
24. Schisler JC, Jensen PB, Taylor DG, Becker TC, Knop FK, Takekawa S, German M, Weir GC, Lu D, Mirmira RG, Newgard CB 2005 The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet β cells. Proc Natl Acad Sci USA 102:7297-302
25. Iype T, Francis J, Garmey JC, Schisler JC, Nesher R, Weir GC, Becker TC, Newgard CB, Griffen SC, Mirmira RG 2005 Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes. J Biol Chem 280:16798-16807
26. Husson A, Brasse-Lagnel C, Fairand A, Renouf S, Lavoinne A 2003 Argininosuccinate synthetase from the urea cycle to the citrulline-NO cycle. Eur J Biochem 270:1887-1899
27. Schmidt HH, Warner TD, Ishii K, Sheng H, Murad F 1992 Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides. Science 255:721-723
28. Thams P, Capito K 1999 L-arginine stimulation of glucose-induced insulin secretion through membrane depolarization and independent of nitric oxide. Eur J Endocrinol 140:87-93
29. Emamaullee J, Liston P, Korneluk RG, Shapiro AM, Elliott JF 2005 XIAP overexpression in islet β-cells enhances engraftment and minimizes hypoxia-reperfusion injury. Am J Transplant 5:1297-1305
30. Hui H, Khoury N, Zhao X, Balkir L, D'Amico E, Bullotta A, Nguyen ED, Gambotto A, Perfetti R 2005 Adenovirus-mediated XIAP gene transfer reverses the negative effects of immunosuppressive drugs on insulin secretion and cell viability of isolated human islets. Diabetes 54:424-433
31. Ou D, Wang X, Metzger DL, James RF, Pozzilli P, Plesner A, Korneluk RG, Verchere CB, Tingle AJ 2005 Synergistic inhibition of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human pancreatic β cells by Bcl-2 and X-linked inhibitor of apoptosis. Hum Immunol 66:274-284
32. Steiner P, Kulangara K, Sarria JC, Glauser L, Regazzi R, Hirling H 2004 Reticulon 1-C/neuroendocrine-specific protein-C interacts with SNARE proteins. J Neurochem 89:569-580
33. Briscoe CP, Tadayyon M, Andrews JL, Benson WG, Chambers JK, Eilert MM, Ellis C, Elshourbagy NA, Goetz AS, Minnick DT, Murdock PR, Sauls HR, Jr., Shabon U, Spinage LD, Strum JC, Szekeres PG, Tan KB, Way JM, Ignar DM, Wilson S, Muir AI 2003 The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J Biol Chem 278:11303-11311
34. Olofsson CS, Salehi A, Holm C, Rorsman P 2004 Palmitate increases L-type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic β-cells. J Physiol 557:935-948
35. Kaestner KH, Lee CS, Scearce LM, Brestelli JE, Arsenlis A, Le PP, Lantz KA, Crabtree J, Pizarro A, Mazzarelli J, Pinney D, Fischer S, Manduchi E, Stoeckert Jr CJ, Gradwohl G, Clifton SW, Brown JR, Inoue H, Cras-Meneur C, Permutt MA 2003 Transcriptional program of the endocrine pancreas in mice and humans. Diabetes 52:1604-1610
36. Manduchi E, Grant GR, He H, Liu J, Mailman MD, Pizarro AD, Whetzel PL, Stoeckert Jr CJ 2004 RAD and the RAD Study-Annotator: an approach to collection, organization and exchange of all relevant information for high-throughput gene expression studies. Bioinformatics 20:452-459
37. Yang YH, Buckley MJ, Dudoit S, Speed TP 2002 Comparison of methods for image analysis on cDNA microarray data. J Comput Graph Stat 11:108-136
38. Yang YH, Dudoit S, Luu P, Lin DM, Peng V, Ngai J, Speed TP 2002 Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res 30:e15
39. Lonnstedt I, Speed T 2002 Replicated microarray data. Statistica Sinica 12:31-46
40. Brummelkamp TR, Bernards R, Agami R 2002 A system for stable expression of short interfering RNAs in mammalian cells. Science 296:550-553
41. Scharp DW, Kemp CB, Knight MJ, Ballinger WF, Lacy PE 1973 The use of ficoll in the preparation of viable islets of langerhans from the rat pancreas. Transplantation 16:686-689
42. Jensen MV, Joseph JW, Ilkayeva O, Burgess S, Lu D, Ronnebaum SM, Odegaard M, Becker TC, Sherry AD, Newgard CB 2006 Compensatory responses to pyruvate carboxylase suppression in islet β-cells. Preservation of glucose-stimulated insulin secretion. J Biol Chem 281:22342-22351