Protective effects of kakkalide from Flos Puerariae on ethanol-induced lethality and hepatic injury are dependent on its biotransformation by human intestinal microflora

Journal of Pharmacological Sciences

Volumn 93, Issue 3, 2003, Pages 331-336

  Han, Yeo Ok ^a   Han, Myung Joo ^a   Park, Sung Hwan ^a   Kim, Dong Hyun ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Ethanol induced lethality; Hepatic injury; Intestinal bacteria; Irisolidone; Kakkalide

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ASPARTATE AMINOTRANSFERASE; FLOS PUERARIAE EXTRACT; HESPERETIN; IRISOLIDONE; KAKKALIDE; KAKKALIDONE; PLANT EXTRACT; PRODRUG; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL BLOOD LEVEL; ALCOHOL INTOXICATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG EFFECT; DRUG ISOLATION; DRUG METABOLISM; DRUG TRANSFORMATION; ENZYME ACTIVITY; FATALITY; FLOS PUERARIAE; HUMAN; INTESTINE FLORA; LIVER INJURY; LIVER PROTECTION; MALE; MORTALITY; MOUSE; NONHUMAN; PLANT; RAT;

ANIMALS; BIOTRANSFORMATION; DRUGS, CHINESE HERBAL; ETHANOL; FECES; GLYCOSIDES; HUMANS; INTESTINES; ISOFLAVONES; LIVER DISEASES; MALE; MICE; MICE, INBRED ICR; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0346245127     PISSN: 13478613     EISSN: None     Source Type: Journal    
DOI: 10.1254/jphs.93.331     Document Type: Article

References (15)

1. Kim TJ. Korean Resources Plants, Vol. II. Seoul: Seoul National University Press; 1985. p 322.
2. Niiho Y, Yamazaki T, Nakajima Y, et al. Pharmacological studies on Puerariae Flos. I. The effects of Puerariae Flos on alcoholic metabolism and spontaneous movement in mice. Yakugaku Zasshi. 1989;109:424-431. (text in Japanese with English abstract)
3. Niiho Y, Yamazaki T, Nakajima Y, et al. Pharmacological studies on Puerariae Flos. II. The effects of Puerariae flos on alcohol-induced unusual metabolism and experimental liver injury in mice. Yakugaku Zasshi. 1990;110:604-611. (text in Japanese with English abstract)
4. Jang M-H, Shin M-C, Chung J-H, et al. Effect of Puerariae Radix on cell proliferation and nitric oxide synthatase expression in dentate gyrus of alcohol-intoxificated Sprague-Dawley rats. Jpn J Pharmacol. 2002;88:355-358.
5. Yamazaki T, Nakjima Y, Niiho Y, et al. Pharmacological studies on Puerariae flos. III: Protective effects of kakkalide on ethanol-induced lethality and acute hepatic injury in mice. J Pharm Pharmacol. 1997;49:831-833.
6. Bae EA, Han MJ, Lee KT, Choi JW, Park HJ, Kim D-H. Metabolism of 6″-O-xylosyltectoridin and tectoridin by human intestinal bacteria and their hypoglycemic and in vitro cytotoxic activities. Biol Pharm Bull. 1999;22:1314-1318.
7. Bae EA, Han MJ, Kim D-H. In vitro anti-Helicobacter pylori activity of irisolidone isolated from the flowers and rhizomes of Pueraria thunbergiana. Planta Med. 2000;67:161-163.
8. Hattori M, Shu Y-Z, Shimizu M, et al. Metabolism of paeoniflorin and related compounds by human intestinal bacteria. Chem Pharm Bull. 1985;33:3838-3846.
9. Kurihara T, Kikuchi M. [Studies on the constituents of floweres. I. On the components of flower of Pueraria thungergiana Benth.] Yakugaku Zasshi. 1973;93:1201-1205. (in Japanese)
10. Kurihara T, Kikuchi M. [Studies on the constituents of floweres. V. On the components of flower of Pueraria thungergiana Benth (2). Isolation of a new isoflavone glycoside.] Yakugaku Zasshi. 1975;95:1283-1285. (in Japanese)
11. Reitman S, Frankel S. A colorimetric method for the determination of serum glutamic oxaloacetate and glutamic pyruvic transaminases. Am J Clin Pathol. 1957;28:56-63.
12. Bucher T, Redetski H. Eine spezifische photometrische Bestimmung von Athylalkohol auf fermentativen Wege. Klin Wochenschr. 1951;29:615-620. (in German)
13. Suda T, Bun Y, Matsui T, et al. Effects of amino acid on ethanol-induced hepatic injury. In: Alcohol Metabolism and the Liver. Vol. 5. Tokyo: Press of Tokyo Company; 1986. p. 207-214.
14. Klingman GL, Haag HB. Studies on severe on alcohol intoxification in dogs. I. Blood and urinary changes in lethal intoxification. Q J Stud Alcohol. 1958;19:203-225.
15. Yoshihara H, Sato N, Matsumura T, et al. Studies of the relationship between the concentrations of blood catecholamine and hepatocellular injury. In: Alcohol Metabolism and the Liver. Vol. 5. Tokyo: Press of Tokyo Company; 1986. p. 313-320.