4-[6-(2-Aminoethyl)naphthalen-2-yl]benzonitriles are potent histamine H3 receptor antagonists with high CNS penetration

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 5, 2007, Pages 1443-1446

  Black, Lawrence A ^a   Nersesian, Diana L ^a   Sharma, Padam ^a   Ku, Yi Yin ^a   Bennani, Youssef L ^a   Marsh, Kennan C ^a   Miller, Thomas R ^a   Esbenshade, Timothy A ^a   Hancock, Arthur A ^a   Cowart, Marlon ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

High CNS penetration; Histamine H3 receptor antagonists; Naphthalene

Indexed keywords

BENZOFURAN DERIVATIVE; HISTAMINE H3 RECEPTOR ANTAGONIST; NAPHTHALENE DERIVATIVE; PYRROLIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG CONFORMATION; DRUG DESIGN; DRUG PENETRATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; LIPOPHILICITY; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CENTRAL NERVOUS SYSTEM; HISTAMINE ANTAGONISTS; HUMANS; HYDROPHOBICITY; NAPHTHALENES; NITRILES; PERMEABILITY; PROTEIN BINDING; RATS; RECEPTORS, HISTAMINE H3; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 33846997920     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.11.073     Document Type: Article

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