Identification of a novel, orally bioavailable histamine H3 receptor antagonist based on the 4-benzyl-(1H-imidazol-4-yl) template

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 6, 2002, Pages 937-941

  Aslanian, Robert ^a   Mutahi, Mwangi W ^a   Shih, Neng Yang ^a   McCormick, Kevin D ^a   Piwinski, John J ^a   Ting, Pauline C ^a   Albanese, Margaret M ^a   Berlin, Michael Y ^a   Zhu, Xiaohong ^a   Wong, Shing Chun ^a   Rosenblum, Stuart B ^a   Jiang, Yueheng ^a   West, Robert ^a   She, Susan ^a   Williams, Shirley M ^a   Bryant, Matthew ^a   Hey, John A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 BENZYL (1H IMIDAZOL 4 YL); CARBAMIC ACID; CHEMICAL COMPOUND; HISTAMINE H3 RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; UREA; ANTIHISTAMINIC AGENT; HISTAMINE H3 RECEPTOR; IMIDAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG SELECTIVITY; DRUG SYNTHESIS; MONKEY; NONHUMAN; RAT; ANIMAL; BIOAVAILABILITY; DRUG EFFECT; HAPLORHINI; METABOLISM; ORAL DRUG ADMINISTRATION; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; HAPLORHINI; HISTAMINE ANTAGONISTS; IMIDAZOLES; PROTEIN BINDING; RATS; RECEPTORS, HISTAMINE H3; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 18344368989     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00055-0     Document Type: Article

References (19)