Inhibition of homologous recombination repair with Pentoxifylline targets G2 cells generated by radiotherapy and induces major enhancements of the toxicity of cisplatin and melphalan given after irradiation

Radiation Oncology

Volumn 1, Issue 1, 2006, Pages

  Bohm, Lothar ^a  

^a UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

[No Author keywords available]

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ARTICLE;

EID: 33846963422     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/1748-717X-1-12     Document Type: Review

References (65)

1. Assaad NA Zeng Z Guan J Thacke J Iliakis G Homologous recombination as a potential target for caffeine radiosensitisation in mammalian cells reduced caffeine radiosensitisation in XRSS2 and XRSCC 3 mutants Oncogene 2000 129 5788-5800 10.1038/sj.onc.1203953
2. Bache M Pigorsch S Dunst J Wurl P Meyer A Bartel F Schmidt H Rath FW Taubert H Loss of G2/M arrest correlates with radiosensitisation in 2 human sarcoma cell lines with mutant p53 Int J Cancer 2001 96 110-117 10.1002/ijc.1002 11291094
3. Binder A Bohm L Influence of irradiation and pentoxifylline on histone H3 phosphorylation in human tumour cell lines Cell Prolif 2002 35 37-47 10.1046/j.1365-2184.2002.00224.x 11856177
4. Binder A Serafin AM Bohm L Abrogation of the G2/M phase block enhances the cytotoxicity of Danourubucin, Melphalan and cisplatin in p53 mant human tumour cells Radiat Res 2000 154 640-649 11096420
5. Binder A Theron T Donninger H Parker MI Bohm L Radiosensitization and DNA repair inhibition by Pentoxifylline in NIH 3T3 p53 transfectants Int J Radiat Biol 2002 78 991-1000 10.1080/0955300021000016369 12456286
6. Bohm L Roos WP Serafin AM Inhibition of DNA repair by Pentoxifylline and related methylanthine derivatives Toxicology 2003 193 153-160 10.1016/ S0300-483X(03)00294-4 14599774
7. Bohm L Theron T Binder A Influence of Pentoxifylline, A-802710 Propentofylline and A-802715 (Hoechst) on the expression of cell cycle blocks and S-phase content after irradiation damage Biochim Biophys Acta 2000 1499 1-10 10.1016/S0167-4889(00)00074-4 11118634
8. Bryant HE Schultz N Thomas HD Parker KM Flower D Lopez E Kyle S Meuth M Curtin NJ Helleday T Specific cell killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose)polymerase Nature 2005 434 913-917 10.1038/nature03443 15829966
9. Busse PM Bose SK Jones RW Tolmach LJ The action of caffeine on X-irradiated cells. II Synergistic lethality Radiat Res 1977 71 666-677 911393
10. Collinridge DR Rockwell S Pentoxifylline improves the oxygenation and irradiation response of BA 1112 rat rhabdomyosarcomas and EMT 6 mouse mammary carcinomas Int J Cancer (Radiat Oncol Invest) 2000 90 256-264 10.1002/1097-0215(20001020)90:5<256::AID-IJC2>3.0.CO;2-R
11. De Frank JS Tang W Powell SN p53 null cells are more sensitive to UV-light only in the presence of caffeine Cancer Res 1996 56 5365-5368 8968086
12. Durante M Furusawa Y Majiama H Kawata T Gotoh E Association between G2-phase block and repair of radiation induced chromosome fragments in human lymphocytes Radiat Res 1999 151 670-676 10360786
13. Eley KW Benedict SH Chung TDK Kavanagh BD Broaddus WC Schmidt-Ullrich RPK Lin PS The effects of pentoxifylline on the survival of human glioma cells with continuous and intermittent stereotactic surgery irradiation Int J Radiat Oncology Biol Phys 2002 54 42-556
14. Ely H Is Pentoxifylline the drug of the decade? J Am Acad Dermatology 1994 30 603-621
15. Fan S Smith ML Rivet DJ Duba D Zhan Q Kohn KW Fornace AJ O'Connor PMO Disruption of p53 sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline Cancer Res 1995 55 1649-1654 7712469
16. Farmer H McCabe N Lord CJ Tutt ANJ Johnson DA Richardson TB Santarosa M Dillon KJ Hickson I Knights C Martin NMB Jackson SP Smith GCM Ashworth A Targeting the DNA repair effect in BRCA mutant cells as a therapeutic strategy Nature 2005 434 917-921 10.1038/nature03445 15829967
17. Fingert HJ Pu AT Chen Z Googe PB Alley MC Pardee AB In vivo and in vitro enhanced antitumour effect by Pentoxifylline in human cancer cells treated with Thiothepa Cancer Res 1986 48 4375-4381
18. Gurley LR D'Anna JA Barham SS Deaven LL Tobey RA Histone phosphorylation and chromatin structure during mitosis in Chinese Hamster cells Eur J Biochem 1978 84 1-15 10.1111/j.1432-1033.1978.tb12135.x 206429
19. Iliakis G Nusse M Effects of caffeine on x-irradiated synchronous, asynchronous and plateau phase mouse ascites cells: The importance of progression through the cell cycle for caffeine enhancement of cell killing Int J Radiat Biol 1983 43 649-663
20. Kaina B DNA damage-triggered apoptosis: Criticial role of DNA repair, double strand breaks, cell proliferation and signalling Biochem Pharm 2003 66 1547-1554 10.1016/S0006-2952(03)00510-0 14555233
21. Kastan MB Lim DS The many substrates and functions of ATM Nat Rev Mol Cell Biol 2000 1 179-186 10.1038/35043058 11252893
22. Kastan MB Onyekwere O Sidranski D Vogelstein B Craig RW Participation of p53 protein in the cellular response to DNA damage Cancer Res 1991 51 6304-6311 1933891
23. Kelleher DK Thews O Vaupel P Regional perfusion and oxygenation of tumours upon methylxanthine derivative administration Int J Radiat Oncology Biol Phys 1998 42 861-864 10.1016/S0360-3016(98)00318-6
24. Lavin MF Radiosensitivity and oxidative signalling in Ataxia telangiectasia: An update Radiother Ocol 1998 47 113-123 10.1016/ S0167-8140(98)00027-9
25. Lee I Kim JH Levitt SH Song CW Increase in tumour responses by Pentoxifylline alone or in combination with Nicotinamide Int J Radiat Oncology Biol Phys 1992 22 425-429
26. Lee I Biaglow JE Lee J Cho M Physiological mechanisms of radiation sensitisation by Pentoxifylline Anticancer Research 2000 20 4605-4610 11205310
27. Lee I Boucher Y Demhartner TJ Jam RK Changes in tumour blood flow oxygenation and interstitial fluid pressure induced by pentoxifylline Br J Cancer 1994 69 492-496 8123479
28. Lehmann AR Effect of caffeine on DNS synthesis in mammalian cells Biophys J 1972 12 1316-1325 4672620
29. Li Y Sun L Weber-Johnson K Pashoud N Coucke P Potentiation of cytotoxicity and radiosensitisation of 2-doxy-2′(fluoro-methylene)cytidine by pentoxifylline in vitro Int J Cancer 1999 80 155-160 10.1002/ (SICI)1097-0215(19990105)80:1<155::AID-IJC27>3.0.CO;2-A 9935246
30. Li Y Weber-Johnson K Sun L Pashoud N Mirimanoff R Coucke PA Effect of Pentoxifylline on radiation induced G2-phase delay and radiosensitivity of human colon and cervical cancer cells Radiat Res 1998 149 338-342 9525497
31. Link CJ Orren D Muldoon R Cook JA Bohr VA Pentoxifylline inhibits gene specific repair of UV-induced damage in hamster cells Radiat Oncol Invest 1996 4 115-121 10.1002/ (SICI)1520-6823(1996)4:3<115::AID-ROI3>3.0.CO;2-0
32. Morrison C Sonoda E Takao N Shinohara A Yamato KI Takeda The controlling influence of ATM in homologous recombination repair of DNA damage EMBO-J 2000 19 463-471 305583 10654944 10.1093/emboj/19.3.463
33. Muller WU Bauch T Wojcik A Bocker W Streffer C Comet assay studies indicates that caffeine mediated increase in irradiation risk of embryos is due to inhibition of DNA repair Mutagenesis 1996 11 57-60 8671716
34. Murray AW Creative blocks: Cell cycle checkpoints and feedback controls Nature 1992 359 599-604 10.1038/359599a0 1406993
35. Musk SRR Reduction of radiation induced cell cycle blocks by caffeine does not necessarily lead to increased cell killing Radiat Res 1991 125 262-266 2000449
36. Musk SRR Steel GG Override of the irradiation induced mitotic block in human tumour cells by methylxanthines and its relationship to the potentiation of cytotoxicity Int J Radiat Biol 1990 57 1105-1112 1971837
37. O'Connor PMO Mammalian G1 and G2 phase checkpoints Cancer Surgery 1997 29 151-182
38. Powell SN de Frank JS Connel P Eogan M Preffer F Dombkowski D Tang W Friend S Differential sensitivities of p 53 (-) and P53 (+) cells to caffeine induced radiosensitisation and override of G2 delay Cancer Res 1995 55 1643-1648 7712468
39. Russel KJ Wiens LW Demers GW Galloway DA Le T Rice GC Bianco JA Singer JW Groudine M Preferential radiosensitisation of G1 checkpoint deficient cells by methylxanthines Int J Radiation Oncology Biol Phys 1996 36 1099-1106 10.1016/S0360-3016(96)00432-4
40. Serafin AM Binder A Bohm L Chemosensitivity of prostatic tumour cell lines under conditions of G2 block abrogation Urol Res 2001 29 221-227 10.1007/s002400100186 11482451
41. Song CW Hasegawa T Kwon HC Lyons JC Levitt SA Increase in tumour oxygenation and radiosensitivity caused by Pentoxifylline Radiat Res 1992 130 205-210 1574576
42. Song CW Makepeace CM Griffin RJ Hasegawa T Osborn JL Choi IB Nah BS Increase in tumour blood flow by Pentoxifylline Int J Radiat Oncology Biol Phys 1994 29 433-437
43. Theron T Bohm L Cyclin B1 expression in response to abrogation of the irradiation induced G2 block in Hela cells Cell Prolif 1998 31 49-57 10.1046/j.1365-2184.1998.00107.x 9745615
44. Theron T Bohm L Influence of the G2 cell cycle block abrogator Pentoxifylline on the expression and subcellular location of cyclin B1 and p34 CDC-2 in Hela cervical carcinoma cells Cell Prolif 2000 33 39-50 10.1046/j.1365-2184.2000.00160.x 10741643
45. Theron T Binder A Verheye-Dua F Bohm L The role of G2 block abrogation, DNA double strand break repair and apoptosis in the radiosensitization of melanoma and squamous cell carcinoma cell lines Int J Radiat Biol 2000 76 1197-1208 10.1080/09553000050134438 10993631
46. Tolmach LJ Busse PW The action of caffeine on X-irradiated Hela cells. IV. Progression delays and enhanced cell killing at high caffeine concentrations Radiat Res 1980 82 374-392 7375638
47. Vernimmen F Verheye-Dua F du Toit H Bohm L Effect of Pentoxifylline on irradiation damage and tumour growth Strahlenther Onkol 1994 170 595-601 7974171
48. Wang H Wang X Iliakis G Wang Y Caffeine could not effectively sensitize homologous recombination repair deficient cells to ionizing radiation induced cell killing Radiat Res 2003 159 420-425 12600245
49. Wang X Wang H Iliakis G Wang Y Caffeine induced radiosensitisation is independent of non-homologous end joining of DNA double strand breaks Radiat Res 2003 159 426-432 12600246
50. Ward A Clissold SP Pentoxifylline: A review of the pharmacokinetic properties and therapeutic efficacy Drugs 1987 34 50-97 3308412
51. Zhou BBS Elledge SJ The DNA damage response: Putting checkpoints into perspective Nature 2000 408 433-439 10.1038/35044005 11100718
52. Zywietz F Bohm L Sagowski C Pentoxifylline enhances tumour oxygenation and radiosensitivity in rat rhabdomyosarcomas during continuous hyperfractionated irradiation Strahlenther Onkol 2004 180 306-314 10.1007/s00066-004-1198-1 15127161
53. Horsman M Bohm L Margison GP Milas L Rosier JF Safrany G Selzer E Verheij M Hendry JH Tumour radiosenstizers - the current status of development of various approaches: Report of an IAEA meeting Int J Radiat Oncol Biol Phys 2006 64 551-561 10.1016/j.ijrobp.2005.09.032 16414371
54. Bohm L Inhibition of homologous recombination repair with pentoxifylline targets G2 cells generated by radiotherapy Molecular Radiation Biology/ Oncology 6/2005: 30 (abstract)
55. Diggle CP Bentley J Knowles MA Kiltie AE Inhibition of double-strand break non-homologous end-joining by cisplatin adducts in human cell extracts Nucleic Acids Res 2005 33 2531-2539 1088968 15872216 10.1093/ nar/gki528
56. Raaphorst GP Leblanc M Li LF A comparison of response to cisplatin, radiation and combined treatment for cells deficient in recombination repair pathways Anticancer Res 2005 25 53-58 15816518
57. Kwon HC Kim SK Chung WK Cho MJ Kim JS Moon SR Park WY Ahn SJ Oh YK Yun HG Na BS Effect of Pentoxifylline on radiation response of nonsmall cell lung cancer: A Phase III randomised multicenter trial Radiother Oncol 2000 56 175-179 10.1016/S0167-8140(00)00221-8 10927136
58. Johnson FE Harrison BR McKirgan LW Raju PI Roy TK Virgo KS A phase II evaluation of Pentoxifylline combined with radiation in the treatment of brain metastases Int J Oncol 1998 13 801-805 9735411
59. Stewart DJ Dahrouge S Agboola O Girard A Cranial radiation and concomitant cisplatin and mitomycin-C plus resistance modulators for malignant gliomas J Neurooncol 1997 32 161-168 10.1023/A:1005788121043 9120546
60. Amirkhosavri A Meyer T Warnes G Amaya M Malik Z Biggerstaff JP Siddiqui FA Sheramn P Francis JL Pentoxifylline inhibits hypoxia induced upregulation of tumour cell tissues factorand vascular endothelial growth factor Thromb Haematost 1998 80 598-602
61. Ayenc E Celikkanat S Kaymakci M Aksaray F Ozdem C Prophylactic effect of Pentoxifylline on radiotherapy complications: A clinical study Otolaryngology Head and Neck Surgery 2004 130 351-356 10.1016/ j.otohns.2003.08.015
62. Hille A Christiansen H Pradier O Herrmann RM Siekmeyer B Weiss E Hilgers R Hess CF Schmidberger H Effect of Pentoxifylline and Tocopherol on radiation proctitis/enteritis Strahlenther Onkol 2005 181 606-614 10.1007/s00066-005-1390-y 16170489
63. Delanian S Porcher R Ball-Mekias S Lefaix JL Randomized, placebo-controlled trial of combined Pentoxifylline and Tocopherol for regression of superficial radiation induced fibrosis J Clin Oncol 2003 21 2545-2550 10.1200/JCO.2003.06.064 12829674
64. Wlodek D Banath J Olive PL Comparison between pulsed field and constant field gel electrophoresis for measurement of DNA double-strand breaks in irradiated Chinese hamster ovary cells Intern J Radiat Biol 1991 60 779-790
65. Dikomey E Dahm-Daphi J Brammer I Martensen R Kaina B Correlation between cellular radiosensitivity and non-repaired double-strand breaks studied in nine mammalian cell lines Int J Radiat Biol 1998 73 269-278 10.1080/ 095530098142365 9525255