Abrogation of G2/M-phase block enhances the cytotoxicity of daunorubicin, melphalan and cisplatin in TP53 mutant human tumor cells

Radiation Research

Volumn 154, Issue 6, 2000, Pages 640-649

  Binder, A B ^a   Serafin, A M ^a   Bohm, L J F ^a  

^a Department of Radiation Oncology ^*  (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; DAUNORUBICIN; MELPHALAN; PENTOXIFYLLINE;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE G2 PHASE; CELL DAMAGE; CELL SURVIVAL; COLONY FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG SENSITIVITY; HUMAN; HUMAN CELL; IRRADIATION; MITOSIS; PRIORITY JOURNAL; RADIOSENSITIZATION;

EID: 0033653311     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/0033-7587(2000)154[0640:AOGMPB]2.0.CO;2     Document Type: Article

References (49)

1. 1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein
2. p53 in signaling checkpoint arrest or apoptosis
3. Maintaining genetic stability through TP53 mediated checkpoint control
4. Human papillomavirus E6 and E7 oncoproteins alter cell cycle progression but not radiosensitivity of carcinoma cells treated with low-dose-rate radiation
5. Genetic instability as a consequence of inappropriate entry into and progression through S-phase
6. 1 cyclin-dependent kinase activity
7. Molecular and cellular responses to DNA damage in a munne pituitary adenoma cell line
8. 1 arrest
9. Ionizing radiation and the cell cycle: A review
10. Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage
11. DNA damage and p53-mediated cell cycle arrest: A reevaluation
12. Reversibility of inhibition of DNA double strand break repair by 2-deoxy-D-glucose in Ehrlich ascites tumour cells
13. An assay for quantifying DNA double-strand break repair that is suitable for small numbers of unlabeled cells
14. Association of protein phosphorylation and cell cycle progression after X-irradiation of two-cell mouse embryos
15. 2 blocks, cyclin B expression and cdc 2 expression in human squamous carcinoma cell lines with different radiosensitivities
16. 2-phase delay and radiosensitivity of human colon and cervical cancer cells
17. Effect of pentoxifylline on radiation damage and tumour growth
18. Effects of caffeine on protein phosphorylation and cell cycle progression in X-irradiated two-cell mouse embryos
19. 2/S delay
20. 1 checkpoint-competent cells
21. Modulation in cell cycle and cyclin B 1 expression in irradiated HeLa cells and normal human skin fibroblasts treated with staurosporine and caffeine
22. Isolation of radiosensitive and radioresistant mutants from a medulloblastoma cell line
23. Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline
24. 1 checkpoint-deficient cells by methylxanthines
25. 1 block and p53 status in six human cell lines
26. Radiosensitivity of human head and neck squamous cell carcinoma as a predictive assay of tumour radiocurability
27. Analysis of DNA - General methods
28. Analysis of DNA - Measurement of cell kinetics by the bromodeoxy-uridine antibromodeoxyuridine method
29. Differences in induction of p53, p21 WAF1 and apoptosis in relation to cell cycle phase of MCF- 7 cells treated with camptothecin
30. Terminal differentiation of human fibroblasts is induced by irradiation
31. p53 mutations in human cancers
32. Mutations in the p53 tumour suppressor gene: Clues to cancer etiology and molecular pathogenesis
33. p53 mutations associated with breast, colorectal, liver, lung and ovarian cancers
34. p53-null cells are more sensitive to ultraviolet light only in the presence of caffeine
35. Saturated and unsaturated repair of DNA strand breaks in CHO cells after X-irradiation with doses ranging from 3-90 Gy
36. 2 phase delay after irradiation
37. p53 and P-glycoprotein are often co-expressed and are associated with poor prognosis in breast cancer
38. Altered expression and function of P-glycoprotein (170 kDa), encoded by the MDR 1 gene, in T cell subsets from ageing humans
39. Structure of the multidrug resistance P-glycoprotein
40. Role of glutathione, glutathione S-transferases and multidrug resistance-related proteins in cisplatin sensitivity of head and neck cancer cell lines
41. Override of the radiation-induced mitotic block in human tumour cells by methylxanthines and its relationship to the potentiation of cytotoxicity
42. The p53 gene in breast cancer: Prognostic value of complementary DNA sequencing versus immunohistochemistry
43. Pentoxifylline: Its pharmacokinetics and ability to improve tumour perfusion and radiosensitivity in mice
44. Changes in tumour blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline
45. Inhibition of pro-inflammatory cytokine gene expression and papilloma growth during murine multistage carcinogenesis by pentoxifylline
46. Enhancement of radiation response on human carcinoma cells in culture by pentoxifylline
47. The influence of pentoxifylline on cell survival, DNA repair and apoptosis in four human tumour cell lines
48. Modification of the radiosensitivity of human testicular cancer cells by simian virus 40 sequences
49. 2 phase after 2 Gy of gamma irradiation is faster in radiosensitive human cells with high expression of the RAF1 proto-oncogene