Influence of pentoxifylline, A-802710, propentofylline and A-802715 (Hoechst) on the expression of cell cycle blocks and S-phase content after irradiation damage

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1499, Issue 1-2, 2000, Pages 1-10

  Bohm, L ^a   Theron, T ^a   Binder, A ^a  

^a UNIVERSITY OF STELLENBOSCH   (South Africa)

Author keywords

G2 M block abrogation; Methylxanthine; S phase progression

Indexed keywords

A 802710; A 802715; BROXURIDINE; CAFFEINE; FUNCTIONAL GROUP; METHYLXANTHINE DERIVATIVE; PENTOXIFYLLINE; PROPENTOFYLLINE; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG STRUCTURE; HUMAN; HUMAN CELL; MELANOMA; MITOSIS INHIBITION; PRIORITY JOURNAL; RADIATION INJURY; RADIOSENSITIZATION; SQUAMOUS CELL CARCINOMA; STRUCTURE ACTIVITY RELATION;

CAFFEINE; CELL CYCLE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; G2 PHASE; GENTIAN VIOLET; GROWTH INHIBITORS; HUMANS; INDICATORS AND REAGENTS; MITOSIS; MOLECULAR STRUCTURE; NOCODAZOLE; PENTOXIFYLLINE; RADIATION-SENSITIZING AGENTS; S PHASE; TIME FACTORS; TUMOR CELLS, CULTURED; XANTHINES;

EID: 0034639239     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4889(00)00074-4     Document Type: Article

References (44)

1. Efficacy of pentoxifylline as a modulator of alkylating agent activity in vitro and in vivo
2. Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline
3. Preferential radiosensitization of G1 checkpoint-deficient cells by methylxanthines
4. Effect of pentoxifylline on radiation-induced G2-phase delay and radiosensitivity of human colon and cervical cancer cells
5. Wild-type p53 is a cell cycle checkpoint determinant following irradiation
6. Enhancement of radiation response on human carcinoma cells in culture by pentoxifylline
7. 1 checkpoint-competent cells
8. Selective radiosensitization of p53-deficient cells by caffeine-mediated activation of p34cdc2 kinase
9. Participation of p53 protein in the cellular response to DNA damage
10. Control of G1 arrest after DNA damage
11. Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines
12. p53-Dependent G1 arrest involves pRb-related proteins and is disrupted by the human papillomavirus 16 E7 component
13. Relationship between radiation-induced G1 phase arrest and p53 function in human tumour cells
14. Genetic instability as a consequence of inappropriate entry into and progression through S-phase
15. Effects of ionizing radiation on cell cycle progression. A review
16. Diminished capacity for p53 in mediating a radiation-induced G1 arrest in established human tumor cell lines
17. Radiation induced G1-block and p53 status in six human cell lines
18. Cytogenetic damage and the radiation-induced G1-phase checkpoint
19. The p53 tumour suppressor gene: A mediator of a G1 growth arrest and of apoptosis
20. Cell cycle arrest defect in Li-Fraumeni Syndrome: A mechanism of cancer predisposition?
21. Dissociation between cell cycle arrest and apotosis can occcur in Li-Fraumeni cells heterozygous for p53 mutations
22. Differential cell cycle checkpoint response in normal human keratinocytes and fibroblasts
23. In vivo and in vitro enhanced antitumor effects by pentoxifylline in human cancer cells treated with thiotepa
24. G2/M block abrogation enhances the cytotoxicity of Melphalan, Daunorubucin and Cisplatin in human tumour cells
25. Retrovirally mediated wild-type p53 restores S-phase modulation without inducing WAF1 mRNA in breast carcinoma cells containing mutant p53
26. Xanthine derivatives: Comparison between suppression of tumour necrosis factor-α production and inhibition of cAMP phosphodiesterase activity
27. Phosphodiesterase inhibitory profile of some related xanthine derivatives pharmacologically active on the peripheral microcirculation
28. Use of the methylxanthine derivative A802715 in transplantation immunology: I. Strong in vitro inhibitory effects on CD-28-costimulated T cell activities
29. Propentofylline: A nucleoside transport inhibitor with neuroprotective effects in cerebral ischema
30. 2 delay
31. Analysis of DNA-general methods
32. Analysis of DNA-measurement of cell kinetics by the bromodeoxyuridine antibromodeoxyuridine method
33. Inhibitory effect of caffeine on potentially lethal damage repair in cisplatin-treated human osteosarcoma cells
34. Reducing the radiation-induced G2 delay causes HeLa cells to undergo apoptosis instead of mitotic death
35. Effect of caffeine on gamma-ray induced G2 arrest in well-synchronized Chinese hamster ovary cells in vitro
36. Modulation in cell cycle and cyclin B1 expression in irradiated HeLa cells and normal human skin fibroblasts treated with staurosporine and caffeine
37. Caffeine induces S-phase apotosis in cis-diamminedichloroplatinum-treated cells, whereas cis-diamminechloroplatinum induces a block in G2/M
38. Influence of pentoxifylline on renal function in HIV-seropositive patients
39. Inhibition of endogenous TNF formation by pentoxifylline
40. Principles of CDK regulation
41. DNA damage-associated cell cycle and cell death control is differentially modulated by caffeine in clones with p53 mutations
42. Cyclin B1 expression in response to abrogation of the radiation-induced G2/M block in HeLa cells
43. G2 delay induced by nitrogen mustard in human cells affects cyclin A/CdK2 and cyclin B1/CDC-2 kinase complexes differently
44. Influence of the G2 cell cycle block abrogator pentoxifylline on the expression and subcellular location of cyclin B1 and p34(cdc2) in HeLa cervical carcinoma cells